CN102589929B - A kind of sample collection pick-up unit - Google Patents
A kind of sample collection pick-up unit Download PDFInfo
- Publication number
- CN102589929B CN102589929B CN201110009577.5A CN201110009577A CN102589929B CN 102589929 B CN102589929 B CN 102589929B CN 201110009577 A CN201110009577 A CN 201110009577A CN 102589929 B CN102589929 B CN 102589929B
- Authority
- CN
- China
- Prior art keywords
- sample
- test chamber
- chamber
- test
- liquid level
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Abstract
The invention provides a kind of device collected and detect sample, comprise sample chamber and test chamber, wherein test chamber is connected with sample chamber; In addition, this device also comprises the device controlling liquid level in test chamber, and this control device is connected in test chamber.The present invention controls by the device controlling liquid level in test chamber the sample size entering test chamber, further, can also control the time that sample enters test chamber.Therefore, apparatus of the present invention can realize the quantitative detection of sample, meanwhile, while meeting quantitatively detection, time delay can also detect sample.
Description
Technical field
The present invention relates to the apparatus and method of a kind of sample collection and detection, especially after sample collection, quantitatively detect the apparatus and method of sample.
Background technology
At medical diagnostic field, it is more common detection that body fluid detects.Whether utilize pick-up unit or detect cup to collect tracer liquid sample, and judge containing analyte in liquid sample, be a kind of commonplace method.Such pick-up unit or detect cup General Requirements sample cup and be collected in sample container, person skilled insert one detect reagent strip and a part of submergence making reagent strip in the sample, take out reagent strip after the some time and read testing result.The detection of this mode, technician may touch sample, and crisis is healthy or make sample contaminated.In order to avoid this risk, need on sample collection container, add the laggard line operate of closure body.At present, have many obturators, as US Patent No. 4,976,923, US5,429,804, and US6,726,879 devices disclosed.These devices are fixed on the lid of pick-up unit test strip.During use, container upset or inclination are made sample infiltrate detection reagent strip and detect.U.S. Patent application US2003/0027359A1 disclosed in 6 days February in 2003 discloses a kind of detection urine cup.This detection urine cup still needs promote pillar piston movement with push rod and fluid sample is flowed out and moistening detecting element from cup cavity after lid lid to the opening of cup.Chinese patent application 200510113911.5 discloses a kind of pick-up unit for liquid sample, in this device, detecting reagent strip is positioned on bowl cover, has a pipe between bowl cover and cup, makes liquid enter bowl cover to detect by liquid sample being pressed into pipe.In the application of reality, not only qualitative analysis is carried out to sample, also need quantitatively to detect.In addition, part sample does not need to detect immediately after collection, until after the regular hour, then carries out detection and the interpretation of result of sample.
Summary of the invention
The problem to be solved in the present invention is to provide a kind of sample collection and pick-up unit, when using this device, the sample of some can be made to enter test chamber, and at this point fixing sample size detects.Namely the detection limit of sample can be fixing, can detect quantitative sample.
On the one hand, the invention provides a kind of device, comprise sample chamber and test chamber, wherein test chamber is connected by passage with sample chamber; In addition, this device also comprises the device controlling liquid level in test chamber, and this control device is connected in test chamber.In an embodiment, in this control test chamber, the device of liquid level makes sample have primary importance in test chamber.
In the present invention, after liquid sample enters sample chamber, the passage that this sample can be communicated with along test chamber with sample chamber enters test chamber, when sample enter test chamber reach a certain amount of after, the device being connected to liquid level in the control test chamber in test chamber makes test chamber become a seal chamber.And when the gas in sealing cavity and fluid pressure reach equilibrium state, the liquid sample in sample chamber would not enter the test chamber of sealing again, sample forms a liquid level in test chamber, i.e. the primary importance of sample in test chamber.After sample is fixed on primary importance, the sample size in test chamber can not change, and therefore, can quantitatively detect.In common pick-up unit, the sample size that in sample chamber, the liquid level difference of sample can cause entering in test chamber is different, thus make the position of sample in test chamber can because of sample add number and different.Such pick-up unit does not just reach the quantitative detection of fixed amount, is difficult to be applied to non-professional operator yet.And the gas flow controlled in apparatus of the present invention when position that the device of liquid level in test chamber is arranged on test chamber can determine that test chamber becomes seal chamber in cavity, thus determine sample primary importance.Therefore, the sample in test chamber can not be how many and change with the sample in sample chamber, realize real quantitative pattern detection; Meanwhile, different people operates this device also can reach identical result, is specially adapted to family or non-specialist operators's use.
In one preferred embodiment, in order to ensure the sample obtaining stabilizing amount, the device position be connected in test chamber of this control liquid level is not less than the communicating passage of sample chamber and test chamber.When this device and passage contour time, sample is after entering test chamber, and sample enters the increase of sample chamber along with sample, the device of passage and this control liquid level all seal by sample, test chamber is sealed; And when this device is higher than communicating passage, after sample enters test chamber, first this interface channel can be sealed, now, test chamber only can be communicated with the external world by the device controlling liquid level, when sample increases again, the device controlling liquid level in test chamber is sealed, thus makes test chamber become a seal chamber.Two kinds of modes all make test chamber be sealed, and when the pressure of liquid sample in the test chamber entering sealing and the gaseous tension of sealing reach balance, sample no longer enters test chamber, form fixing liquid level, complete quantitative detection.
In another embodiment, in control test chamber of the present invention, the device of liquid level can also make sample have the second place in test chamber.Namely in this control test chamber, the device of liquid level cover degree can make sample in test chamber, have primary importance and the fixing sample size of the second place two.In the present embodiment, sample enters sample chamber and enters test chamber by passage, when after sample sealing communicating passage, the device of this control liquid level makes test chamber become a seal chamber, and liquid sample rests on the second place because of the gas-liquid pressure balance in seal chamber.When needs increase sample size, the device controlling liquid level makes test chamber communicate with ambient atmos, and the air pressure in test chamber reduces, and liquid sample enters test chamber further because the air pressure in cavity reduces.When controlling the device of liquid level again behind sealing detection chamber, the gas-liquid pressure balance in this new seal chamber makes sample remain on the liquid level of the second place.In this embodiment, the sample size not only entering test chamber can control, and can realize quantitatively detecting.And the time entering test chamber because of sample also can control, can realize the collection of sample and detect split and carry out, namely the collection of sample and testing process can separate, can detect, also first can collect sample while collecting, after detect; And time delay can detect sample.
In a preferred embodiment, in this control test chamber, the device of liquid level is between the primary importance and the second place of test chamber.
In the present invention, in this control test chamber, the device of liquid level has the function making the liquid entering test chamber be fixed on certain position, and this device has various ways to realize this function.In an embodiment, use the valve installation having and open and close function in test chamber, controlled the amount of liquid in test chamber by the opening and closing of valve.
In another embodiment, in this control test chamber, the device of liquid level can comprise the parts of permeable watertight, and these permeable watertight parts have can make gas pass through, but can not make the function that liquid passes through.These parts are arranged in test chamber, can ensure that test chamber communicates with ambient atmos and liquid in chamber does not flow out to the external world by these parts.After liquid sample adds apparatus of the present invention, flow into test chamber by sample chamber and passage, because of the existence of permeable watertight parts, test chamber communicates with ambient atmosphere, and air pressure is identical, namely also identical with the air pressure in sample chamber; Now, because of in sample chamber with the relation of liquid level difference in test chamber, liquid sample enters test chamber always.When liquid arrives these permeable watertight parts, because of its waterproof function, liquid can not flow or penetrate into outside test chamber.When liquid increases further, these permeable watertight parts by hydraulic seal, test chamber becomes seal chamber.When reaching gas-liquid pressure balance in seal chamber, liquid sample rests on the certain position in test chamber, i.e. primary importance.In some embodiments, these permeable watertight parts are that the material with this function is made, as teflon (PTFE) series of micropores film, polyurethane (TPU) series of micropores film etc.; In another specific embodiment, these permeable watertight parts are the aperture be arranged in test chamber, and this hole diameter is not more than the diameter of the film that liquid is formed because of surface tension.
In the embodiment that another one is more excellent, the device of this control liquid level ventilative but fluid-tight parts and seal element can combine by one, and seal element is used for sealing the parts of this permeable watertight.Permeable watertight parts and seal element can be bonded together, and also can split and come.When both be bonded together be connected in test chamber time, can make sample in test chamber, have set, i.e. a second place; After the two is separated, can make sample in test chamber, have another position, i.e. primary importance.After liquid sample adds sample chamber, enter test chamber through passage.Now, because of permeable watertight parts cover by seal element and seal, test chamber communicates with the external world by means of only passage, when the sample of q.s enters test chamber, after sealing up the communicating passage of sample chamber and test chamber, test chamber becomes a seal chamber, and intracavity liquid rests on fixing position, i.e. the second place after reaching gas-liquid pressure balance.After the seal element on permeable watertight parts is separated, the test chamber of sealing is communicated with ambient atmos by permeable watertight parts, chamber internal gas pressure reduces, the further test chamber of liquid was not until had this parts, test chamber is sealed again, new gas-liquid pressure balance in seal chamber makes sample remain on a new liquid level, i.e. primary importance.In some embodiments, these permeable watertight parts are that the material with this function is made, as teflon (PTFE) series of micropores film, polyurethane (TPU) series of micropores film etc.; And seal element can be made for the glue with viscosity, as used the strong viscosity adhesive sticker that synthetic paper or plastic sheeting material (PET, PP, PE, PVC etc.) are surface layer.One more specifically in embodiment, adhesive sticker covers device microporous barrier being formed this control liquid level.
Sample chamber of the present invention for collecting sample, especially liquid sample.Its profile is unrestricted, can have any shape, and can meet the function of undertaking sample, particularly liquid sample, as circle, oval or square etc.The material making sample chamber is also unrestricted, as hard plastic, and PVC; Or, also can be soft material and make, as plastic sheeting etc.Test chamber is used for laying testing element, and completes the detection of sample.Its profile is also unrestricted, meets and can lay testing element and accept sample function.The material making test chamber can be identical with test chamber.As: PVC, plastics etc.
The connected mode of test chamber and sample chamber is various, can directly connect, and also can indirectly connect.As in one embodiment, test chamber and sample chamber are integrated, and are positioned at same cavity, are communicated with by perforate mode on the sidewall at the two interval.Separately in one embodiment, test chamber is connected in bottom with sample chamber, forms a passage.In another embodiment, sample chamber and test chamber are connected by valve and are communicated with.
In apparatus of the present invention, the testing element being positioned at test chamber can for one or more.In an embodiment, testing element can be test strips.In an embodiment, in order to ensure the accuracy of testing effect and test result, the position of test strips in test chamber is that its mark zone is higher than the primary importance of sample in test chamber.In a more excellent embodiment, in order to realize the function that time delay detects, the second place of sample absorbance district higher than test chamber of test strips can be made.
In one embodiment, this sample collection pick-up unit also comprises lid, and lid is for sealing sample chamber.After sample is positioned at sample chamber, cover lid, sample chamber is sealed to ensure that sample is sealed in sample chamber.The closed mode of lid and sample chamber is various, preferably, can adopt the lid of press-button type.Specifically, lid installs a clasp, the sidewall of sample chamber installs a clasp, and clasp and clasp are worked in coordination, and can reach the object of closed sample chamber opening during cooperation.Preferred in addition, the closed mode of lid and sample chamber, screw type in addition.As in a specific embodiment, the sidewall inwall of lid and cavity is respectively arranged with screw thread, works in coordination between screw thread and reach the object of closed sample chamber opening.In order to ensure lid and sample chamber sealing, seal element can be used.In an embodiment, sealing element is " O " type ring, is positioned at cover bottom and sample chamber accent intersection.
In order to ensure that the liquid level that liquid sample enters in test chamber is fixed, in an embodiment, the parts of permeable watertight can be installed on the lid of sealing sample chamber.Such as: use teflon (PTFE) the series of micropores film, polyurethane (TPU) series of micropores film etc. with this function.In a specific embodiment, lid installs microporous barrier, after lid covers sample chamber, the remainder of lid, the part particularly contacted with sample chamber seals sample chamber, to ensure that sample can not leak into outside.Now, microporous barrier makes sample chamber identical with ambient pressure, and the air pressure in sample chamber can not increasing or reducing and change because of liquid.When the device controlling liquid level in test chamber works, the liquid sample amount entering test chamber only controls along with the device controlling liquid level and changes, and can not change because of the air pressure in sample chamber.Thus make the primary importance of liquid sample in test chamber or the second place arbitrarily can not change because of the liquid level in the sample chamber of sealing and air pressure, reach the object controlling fixing liquid level, also ensure that the fixing of sample size in test chamber.
On the other hand, the present invention also provides a kind of and collects and the method for tracer liquid sample, comprises the test chamber providing sample chamber and be communicated with sample chamber by passage; Make sample enter sample chamber and enter test chamber along passage; Sample is made to arrive the primary importance of test chamber.In an embodiment, the device being connected to the control test chamber liquid level in test chamber makes sample arrive primary importance.More excellent, in this control test chamber, the device of liquid level can make sample before arriving primary importance, first arrive the second place of test chamber, even if sample enters sample chamber and enter test chamber along passage; Sample is made to arrive the second place of test chamber; Sample is made to arrive the primary importance of test chamber again.
In an embodiment, the position controlling the device of liquid level in test chamber is not less than described passage.
In another embodiment, the device controlling liquid level in test chamber comprises permeable watertight parts.More excellent, this device is made up of permeable watertight parts and the seal element for sealing these permeable watertight parts.
In an embodiment, when sample arrives primary importance, liquid sample infiltrates testing element, and testing element detects sample.
In another embodiment, after sample enters sample chamber, lid is combined and seals sample chamber.One preferred embodiment in, the gas permeable devices of lid makes sample chamber communicate with ambient atmosphere.As being provided with the parts of a permeable watertight on lid.Such as, microporous barrier etc.
Beneficial effect
The present invention controls by the device controlling liquid level in test chamber the sample size entering test chamber, further, can also control the time that sample enters test chamber.Therefore, apparatus of the present invention can realize the quantitative detection of sample, meanwhile, while meeting quantitatively detection, time delay can also detect sample.
Accompanying drawing explanation
Fig. 1 is the diagrammatic cross-section of apparatus of the present invention
Fig. 2 is that in apparatus of the present invention, sample adds sample chamber and arrives the diagrammatic cross-section of the second place
Fig. 3 is the diagrammatic cross-section of apparatus of the present invention cover lid
Fig. 4 is the diagrammatic cross-section controlling the separation of liquid level apparatus structure in apparatus of the present invention
Fig. 5 is the diagrammatic cross-section that in apparatus of the present invention, sample arrives primary importance
The explanation of accompanying drawing mark
This device 800; Sample chamber 100; Sample chamber accent 103; At the bottom of sample chamber chamber 102, sample chamber sidewall 101; Test chamber 200; Test chamber and sample chamber joint 201, another sidewall 202 of test chamber; Control the device 300 of liquid level; Permeable watertight parts 301; Seal member 302; Testing element 400; Testing element sample absorbance district 401; Testing element mark zone 403; Testing element results display area 404; Testing element pad 402; Sample chamber and test chamber passage 700; Sample is in the second place 601 of test chamber; Sample is in the primary importance 602 of test chamber; Lid 500, on lid, permeable watertight parts 501 are described further the technical term that structure or these of liquid-sample collection device use below.Sample
" sample " that the present invention refers to refers to any material whether needs chemical examination exists and (or) analyze analyte concentration, or need to determine whether one or more samples exist and (or) the material of analyte of quantity, or need the material carrying out qualitative evaluation.Sample can be fluid sample, such as liquid sample.Liquid sample comprises body fluid, such as blood, serum, blood plasma, saliva, urine, tears, seminal fluid and marrow; Liquid sample also can be water sample, such as seawater, river, river etc., or from domestic water, municipal water use or service water resource, runoff water or sewage; Sample can be food sample, such as milk and wine.Mucus, semisolid or solid sample can be used for making liquid, eluate, suspending liquid or leachate equal samples.Such as, throat or genitals sample may be dipped in liquid and make sample.Sample can comprise the potpourri of liquid, solid and gas or any relevant potpourri, the cell suspending liquid in such as dilution or solution.Sample comprises biological substance, such as cell, microorganism, organelle and biochemical complexes.Liquid sample can be produced from solid, semisolid or high-viscosity materials such as such as soil, ight soil, tissue, organ, biological fluid or other occurring in nature non-liquid samples.Such as, these solids or semi-solid samples can mix by the solution suitable with dilution one class.Sample can be macerated, freezing and thaw, or other extracting method form liquid sample.Remaining particulate material can use the method that filtration or precipitation etc. are traditional to remove.In an example specifically implemented, the sample for detecting is urine.
testing element
" testing element " is any element performing test.In one embodiment, testing element is test-strips.This test-strips can comprise thereon for the material pair with specific binding of immunoassay.Test-strips can be a kind of change by color upon completion of the assays or the test chemical bar of other signal intensity judged results.Be suitable for the sample that the present invention carries out detecting and include but not limited to body fluid, the sample be separated from biological tissue or body fluid.Such as, sample can be saliva, blood, serum, blood plasma, urine, excreta, spinal fluid, vaginal secretion, mucus and tissue.Testing element is not limited to one, can be that two or more testing element is arranged in pick-up unit simultaneously, respectively different component in test sample book.
Embodiment
In the following detailed description, accompanying drawing and corresponding explanatory note are only illustrate that the present invention can the mode of actable specific concrete scheme by way of example.We do not get rid of the present invention can also without prejudice to any other embodiment within the scope of the claims in the present invention.
In the device 800 of one embodiment of the present of invention, by sample chamber 100, test chamber 200 forms with the device 300 controlling liquid level in test chamber, as shown in Figure 1 and Figure 5.Sample chamber 100 by sidewall 101, at the bottom of chamber 102 and accent 103 form.Test chamber is by sidewall, and top 201 and bottom are formed.In a specific embodiment, sample chamber 100 and test chamber 200 are positioned at same cavity, as shown in Figure 1, test chamber 200 shares a sidewall 101 and bottom 102 with sample chamber 100, test chamber top 201 is connected with sample chamber accent 103 and seals, and itself and sample chamber are separated by another sidewall 202 of test chamber.The device 300 controlling liquid level in test chamber is connected with test chamber 200, and as shown in Figure 1, this device 300 can be arranged on the sidewall 101 of test chamber 200.In this control test chamber, the device 300 of liquid level can make the sample entered in test chamber remain on primary importance 602; Meanwhile, this device also can make sample in test chamber, have two fixing liquid levels: primary importance 602 and the second place 601.
Sample chamber 100 of the present invention is unrestricted with test chamber 200 profile, meets the function accepted sample and detect sample.As in a specific embodiment, sample chamber 100 is cylindrical, and test chamber 200 is positioned at sample chamber, is arc-shaped structure.Sample chamber 100 and test chamber 200 material can be PVC, plastic cement, plastics etc., and sample chamber 100 and test chamber 200 also can be out of shape or soft material formation for having, e.g., and plastic sheeting, soft pvc etc.This sample chamber 100 and test chamber 200 can also be made for transparent material, " transparent " represent a kind of light can through material, thus under general indoor light, the bore hole of people can see transparent material object below, and uses the people of this device 800 can see sample size under this transparency window or test result.
Sample chamber 100 and test chamber 200 are connected by passage and are communicated with, and the mode of this passage 700 is not limit, but the liquid sample that must meet in sample chamber can by the function of this channel flow to test chamber.Therefore, passage 700 can be direct channel, also can be indirect path.Such as, when sample chamber and test chamber are integral type, can connect by connecting side-wall hole mode, a special channel connection also can be set between, then or, control being communicated with of the two in test chamber with mounted valve in sample chamber.When sample chamber and test chamber are split type, be communicated with by tubular conduit, also in tubular conduit, the two connection can be controlled by mounted valve.In an embodiment, test chamber 200 and sample chamber 100 are connected perforate 700 on sidewall 202 by the two another and are communicated with.This interface channel 700 can be positioned at the bottom of sample chamber 100, as shown in Figure 1.Preferably, this passage 700 is not higher than the device 300 controlling liquid level in test chamber.
In a specific embodiment, in this control test chamber, the device 300 of liquid level is permeable watertight parts 301, these permeable watertight parts 301 are arranged on test chamber sidewall 101, and now, test chamber 200 communicates with ambient atmosphere by means of only these parts 301 and passage 700.After liquid sample is added into this device 800, sample enters sample chamber 100.Sample chamber 100 communicates with air, and test chamber 200 is also communicated with air by passage 700 and permeable watertight parts 301, and namely test chamber 200 is identical with the gaseous tension in sample chamber 100.Like this, sample flows into test chamber 200 higher than test chamber 200 liquid level by the passage 700 bottom sample chamber because of sample chamber 100 liquid level.Along with increasing of sample, passage 700 gradually seal by sample, now, test chamber 200 also communicates with ambient atmos by permeable watertight parts 301, so test chamber 200 internal gas pressure is still identical with in sample chamber 100, sample continues to enter test chamber 200 because of the relation of liquid level.When the sample in test chamber 200 be increased to cover these permeable watertight parts 301 time, these parts 301 no longer communicate with ambient atmosphere, and test chamber 200 is sealed.Now, sample continues the test chamber 200 entering sealing, until when gas and liquid reach pressure equilibrium in this cavity 200, sample no longer flows into test chamber 200, remains on a fixed position in test chamber 200, i.e. the primary importance 602 of test chamber.
In another specific embodiment, in this control test chamber, by one, ventilative but fluid-tight parts 301 and seal member 302 combine the device 300 of liquid level.When permeable watertight parts 301 are bonded together with seal member 302, test chamber 200 is sealed by this device 300, does not communicate with the external world; After sample enters sample chamber 100, can be arrived by passage 700 and remain on the second place 601 of test chamber 200, as shown in Figure 2.And after permeable watertight parts 301 and seal member 302 split and come, as Fig. 4, by this device 300, test chamber 200 and ambient atmos can circulate, but liquid does not circulate with extraneous by this device 300, now, test chamber 200 is communicated with ambient atmosphere by this device 300, and sample can continue to enter test chamber 200, until liquid sample sealing permeable watertight parts 301, last sample arrives and remains on the primary importance 602 of test chamber 200, as shown in Figure 5.
Be provided with testing element 400 in test chamber 200, testing element 400 can be one or more, detects existence or the content of multiple analyte in a certain liquid sample simultaneously.In one embodiment, this testing element can be specially test strips 400, test strips 400 has the sample absorbance district 401 and mark zone 403 that add sample and the region 404 shown test results.
In an embodiment, in order to ensure testing result, the mark zone 403 of testing element 400 can be made to be positioned on the primary importance 602 of test chamber.In one more specifically embodiment, have a pad 402 in the bottom of testing element, this pad can make the mark zone 403 of testing element 400 be positioned on primary importance 602.More excellent, this pad 402 makes the sample absorbance district 401 of test strips higher than the second place 601 simultaneously.This pad 402 can be installed or be placed in test chamber 200; Also can be connected as a single entity with test chamber 200, e.g., pad 402 and test chamber 200, or pad 402 and test chamber 200, sample chamber 100 is single injection-molded.Pad 402 can adopt not absorbing fluid sample and the material that chemistry or biological respinse do not occur with liquid sample is made.
Device 800 of the present invention can also comprise lid 500, this lid 500 for sealing sample chamber 100, as shown in Figure 3.Lid 500 engages with the accent 103 of sample chamber 100 and is formed and seals.In a specific embodiment, lid 500 is with sample chamber 100 for spiral is connected, and lid 500 madial wall has screw-in screw thread, and accent 103 lateral wall of sample chamber 100 has reception screw thread.In order to ensure that sample can not leak from sample chamber accent 103, seal element can be added in lid 500, as "O"-ring.When lid 500 covers sample chamber, this "O"-ring seals up the accent of sample chamber.
In order to ensure that the air pressure in sample chamber 100 can not change because of cover lid 500, a ventilative device 501 can be provided with on lid 500, sample chamber 100 is communicated with air always.Meanwhile, in order to the sample ensureing to enter this pick-up unit 800 can not seepage, this gas permeable devices 501 needs to have fluid-tight function simultaneously.As in an embodiment, be equipped with at the top of lid 500 and breathe freely but fluid-tight parts 501, make sample chamber after lid 500 seals sample chamber accent 103, chamber air communicates with ambient atmosphere.
Below in conjunction with shown in Fig. 1 to Fig. 5, describe the collection of this device specific embodiment in detail and detect the idiographic flow of sample.As shown in Figure 1, test chamber 200 is positioned at sample chamber 100, test chamber 200 shares a sidewall 101 with sample chamber 100, another sidewall 202 separates test chamber 200 and sample chamber 100, test chamber top 201 is connected with sample chamber accent 103 and seals, and test chamber 200 is connected by opening 700 in the bottom of sidewall 202 with sample chamber 100.In the control test chamber be made up of microporous barrier 301 and adhesive sticker 302, the device 300 of liquid level is arranged on test chamber and the common sidewall 101 of sample chamber.Testing element 400 is positioned at test chamber 200, and pad 402 is positioned at the bottom of testing element 400.When original state, adhesive sticker 302 covers on microporous barrier 301 and forms sealing, and now, test chamber 200 communicates with the external world by means of only passage 700.
By liquid sample, as urine, add sample chamber 100 from sample chamber accent 103, because sample chamber 100 is connected with test chamber 200, the passage 700 that liquid sample can be connected along the two enters test chamber 200, as shown in Figure 2.Increase gradually when entering the liquid sample in test chamber 100, finally can seal up passage 700, now, the unique and extraneous opening 700 communicated of test chamber 200 seal by sample, test chamber 200 becomes a seal chamber, in sealing cavity 200, when the pressure of gas and liquid reaches balance, the liquid sample in sample chamber 100 will no longer enter test chamber 200, thus form a fixing liquid level, the i.e. second place 601 of sample in test chamber, to be shown in Fig. 2 shown in 601 positions.Now, be positioned at the bottom of the testing element 400 of test chamber 200 and sample absorbance district 401 second place 601 higher than test chamber, namely higher than sample liquid level, therefore, testing element 400 does not touch sample, does not carry out analysis and detects.
Will with permeable watertight parts 501, the accent 103 of the sample chamber 100 after the lid 500 as microporous barrier covers and adds sample, sample chamber 100 is covered rear formation liquid sealing by lid 500.Sample chamber 100 because lid 500 there being ventilative microporous barrier 501 exist, sample chamber 100 communicated with ambient atmosphere, so can not change before and after lid 500 covers with the liquid level in test chamber 200.As shown in Figure 3, the liquid level in test chamber still remains on the second place 601.
Now, adhesive sticker 302 is torn from microporous barrier 301, as shown in Figure 4, after adhesive sticker 302 is separated with microporous barrier 301, the microporous barrier 301 with permeable watertight performance makes test chamber 200 communicate with ambient atmosphere, now, gaseous tension in test chamber 200 is reduced to atmospheric pressure, identical with the air pressure in sample chamber 100, and liquid level is higher than liquid level in test chamber 100 in sample chamber 100, form pressure reduction, this pressure reduction makes the liquid sample in sample chamber 100 again be flowed in test chamber 200 by passage 700.When liquid sample increases to when sealing up microporous barrier 301 in test chamber 200, test chamber 200 becomes the cavity of a sealing again.In this seal chamber 200, when liquid reach a certain amount of after, reach new vapor liquid equilibrium, now, liquid forms another fixing liquid level in test chamber 200, i.e. the primary importance 602 of sample in test chamber, as shown in Figure 5.
When sample flows from the second place to primary importance, infiltrate the sample absorbance district 401 being positioned at the testing element of test chamber 200, testing element 400 receives sample, carries out sample analysis and completes detection.
Claims (7)
1. a sample collection pick-up unit, comprising:
Sample chamber, test chamber, the two passes through channel connection; And the device of liquid level in control test chamber, this device is connected with test chamber: it is characterized in that, the device controlling liquid level in test chamber comprises permeable watertight parts and the seal element for sealing permeable watertight parts; This sample collection pick-up unit comprises the lid of sealing sample chamber; Described lid comprises the parts of permeable watertight.
2. device as claimed in claim 1, it is characterized in that, in this control test chamber, the device of liquid level makes sample have primary importance in test chamber; After in control test chamber, the permeable watertight parts of the device of liquid level are separated with seal element, sample has primary importance in test chamber.
3. device as claimed in claim 2, is characterized in that, the position controlling the device of liquid level in test chamber is not less than described passage.
4. device as claimed in claim 2 or claim 3, it is characterized in that, in this control test chamber, the device of liquid level also makes sample have the second place in test chamber; Control after the permeable watertight parts of the device of liquid level in test chamber and seal element seal and combine, sample has the second place in test chamber.
5. device as claimed in claim 4, is characterized in that, comprises the test strips detecting sample in test chamber.
6. device as claimed in claim 5, is characterized in that, test strips mark zone is detecting intracavitary locations higher than primary importance.
7. device as claimed in claim 6, it is characterized in that, the position of test strips sample absorbance district in test chamber is higher than the second place.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110009577.5A CN102589929B (en) | 2011-01-15 | 2011-01-15 | A kind of sample collection pick-up unit |
| CN201610101325.8A CN105716905B (en) | 2011-01-15 | 2011-01-15 | A kind of sample collection detection method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110009577.5A CN102589929B (en) | 2011-01-15 | 2011-01-15 | A kind of sample collection pick-up unit |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610101325.8A Division CN105716905B (en) | 2011-01-15 | 2011-01-15 | A kind of sample collection detection method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102589929A CN102589929A (en) | 2012-07-18 |
| CN102589929B true CN102589929B (en) | 2016-03-30 |
Family
ID=46478874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110009577.5A Active CN102589929B (en) | 2011-01-15 | 2011-01-15 | A kind of sample collection pick-up unit |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102589929B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103575575A (en) * | 2012-07-23 | 2014-02-12 | 艾博生物医药(杭州)有限公司 | Device |
| CN112611858B (en) * | 2020-10-20 | 2022-03-18 | 浙江省海洋水产研究所 | Toxicity experimental device for volatile organic compounds |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201156047Y (en) * | 2008-03-04 | 2008-11-26 | 艾博生物医药(杭州)有限公司 | Cup cover for sample detection |
| US7458942B2 (en) * | 2004-09-22 | 2008-12-02 | Medtox | Systems and methods for collecting, testing and transporting liquid biological specimens |
| CN101556277A (en) * | 2009-01-05 | 2009-10-14 | 艾博生物医药(杭州)有限公司 | Detecting device |
| CN201464268U (en) * | 2009-04-23 | 2010-05-12 | 艾博生物医药(杭州)有限公司 | Liquid sample collection and detection cup |
| CN101876661A (en) * | 2009-05-08 | 2010-11-03 | 艾博生物医药(杭州)有限公司 | Device for analyzing analyte in liquid sample |
| CN201974305U (en) * | 2011-01-15 | 2011-09-14 | 艾博生物医药(杭州)有限公司 | Device for collecting and detecting samples |
-
2011
- 2011-01-15 CN CN201110009577.5A patent/CN102589929B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7458942B2 (en) * | 2004-09-22 | 2008-12-02 | Medtox | Systems and methods for collecting, testing and transporting liquid biological specimens |
| CN201156047Y (en) * | 2008-03-04 | 2008-11-26 | 艾博生物医药(杭州)有限公司 | Cup cover for sample detection |
| CN101556277A (en) * | 2009-01-05 | 2009-10-14 | 艾博生物医药(杭州)有限公司 | Detecting device |
| CN201464268U (en) * | 2009-04-23 | 2010-05-12 | 艾博生物医药(杭州)有限公司 | Liquid sample collection and detection cup |
| CN101876661A (en) * | 2009-05-08 | 2010-11-03 | 艾博生物医药(杭州)有限公司 | Device for analyzing analyte in liquid sample |
| CN201974305U (en) * | 2011-01-15 | 2011-09-14 | 艾博生物医药(杭州)有限公司 | Device for collecting and detecting samples |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102589929A (en) | 2012-07-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2004291923B2 (en) | Sample collection cup with integrated activatable sample analysis system | |
| AU2007208334B2 (en) | Rapid test apparatus | |
| US7098040B2 (en) | Self-contained swab-based diagnostic systems | |
| US20080286831A1 (en) | Sample collector and tester | |
| CN101389965A (en) | Rapid test apparatus | |
| CN102466581B (en) | A kind of device | |
| CN102589929B (en) | A kind of sample collection pick-up unit | |
| CN105716905B (en) | A kind of sample collection detection method | |
| US20110097820A1 (en) | Swab-Based Diagnostic Systems | |
| CN101943696B (en) | Detection device for analyzing analyte in liquid sample | |
| CN201974305U (en) | Device for collecting and detecting samples | |
| US20150185114A1 (en) | Specimen processing device | |
| CN111871474A (en) | Detachable detection device | |
| CN202119661U (en) | Device and box for treating samples | |
| CN202141619U (en) | Sample processing device and box employing same | |
| CN102338799A (en) | Detector | |
| CN202033218U (en) | Sample collection and testing device | |
| CN206177971U (en) | Collection detection device of fluid sample | |
| WO2017084540A1 (en) | Collection and detection device for fluid samples | |
| CN109443851A (en) | A kind of bottom of bottle influent stream formula water sample acquisition device and method | |
| CN217385513U (en) | Microfluidic chip card for fluorescence immunoassay analyzer | |
| WO2022213407A1 (en) | Blood collection structure, and whole blood and fingerstick blood detection device and method | |
| CN204882591U (en) | Abuse pharmaceutical analysis system | |
| CN114849802A (en) | Self-testing type micro-fluidic detection device | |
| CN107782883A (en) | A kind of collection and detection device of fluid sample |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |