CN102589929A - Sample collecting and detecting device - Google Patents
Sample collecting and detecting device Download PDFInfo
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- CN102589929A CN102589929A CN2011100095775A CN201110009577A CN102589929A CN 102589929 A CN102589929 A CN 102589929A CN 2011100095775 A CN2011100095775 A CN 2011100095775A CN 201110009577 A CN201110009577 A CN 201110009577A CN 102589929 A CN102589929 A CN 102589929A
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Abstract
The invention provides a sample collecting and detecting device. The sample collecting and detecting device comprises a sample cavity and a detection cavity which are communicated with each other; moreover, the device also comprises a device for controlling the height of the liquid level in the detection cavity; and the control device is connected with the detection cavity. The amount of samples entering the detection cavity is controlled by the device for controlling the height of the liquid level in the detection cavity, and the time when samples enter the detection cavity can be controlled further. Therefore, the samples can be detected quantitatively, and the detection of the samples can be delayed while quantitative detection is achieved.
Description
Technical field
The present invention relates to the apparatus and method of a kind of sample collection and detection, especially the apparatus and method of detection by quantitative sample behind the sample collection.
Background technology
In the medical diagnosis field, it is more common detection that body fluid detects.Utilizing pick-up unit or detection cup to collect the tracer liquid sample, and judge whether contain analyte in the liquid sample, is a kind of commonplace method.Such pick-up unit or detection cup generally require sample cup to be collected in the sample container, and person skilled is inserted a detectable bar and the part of reagent strip is immersed in the sample, take out reagent strip after the some time and read testing result.The detection of this mode, the technician may touch sample, and crisis is healthy or make sample contaminated.For fear of this risk, need on sample collection container, add the laggard line operate of closure body.At present, had many obturators, like U.S. Pat 4,976,923, US 5,429, and 804 and the device that disclosed of US 6,726,879.These devices are that test strip is fixed on the lid of pick-up unit.During use, sample infiltration detectable bar is detected container upset or inclination.U.S. Patent No. application on the 6th February in 2003 US2003/0027359A1 has disclosed a kind of detection urine cup.This detection urine cup still needs to promote the pillar piston motion and fluid sample is flowed out and moistening detecting element from the cup cavity with push rod cover the opening of cup at lid after.One Chinese patent application 200510113911.5 discloses a kind of pick-up unit that is used for liquid sample; In this device; The detectable bar is positioned on the bowl cover, and a pipe is arranged between bowl cover and the cup, through liquid sample being pressed into pipe liquid entering bowl cover is detected.In the application of reality, not only sample is carried out qualitative analysis, also need carry out detection by quantitative.In addition, the part sample does not need to detect immediately after collection, by the time after the regular hour, carry out the detection and the interpretation of result of sample again.
Summary of the invention
The problem that the present invention will solve provides a kind of sample collection and pick-up unit, when using this device, can make the sample of some get into test chamber, and fixing at this point sample size detects.The detection limit that is sample can be fixing, can detect quantitative sample.
On the one hand, the present invention provides a kind of device, comprises sample chamber and test chamber, and wherein test chamber is connected through passage with sample chamber; In addition, this device also comprises the device of control detection intraluminal fluid face height, and this control device is connected on the test chamber.In the embodiment, the device of this control detection intraluminal fluid face height makes sample in test chamber, have primary importance.
Among the present invention; After liquid sample gets into sample chamber; The passage that this sample can be communicated with sample chamber along test chamber gets into test chamber, when sample get into test chamber reach a certain amount of after, the device that is connected the control detection intraluminal fluid position height on the test chamber makes test chamber become a seal chamber.And when the gas in the sealing cavity and fluid pressure reached equilibrium state, the liquid sample in the sample chamber just can not get into the test chamber of sealing again, and sample forms a liquid level in test chamber, i.e. the primary importance of sample in test chamber.After sample was fixed on primary importance, the sample size in the test chamber can not change, and therefore, can carry out detection by quantitative.In the common pick-up unit, the sample size that the liquid level difference of sample can cause getting in the test chamber in the sample chamber is different, thus make that the position of sample in the test chamber can add because of sample what are different.Pick-up unit does not just reach the detection by quantitative of fixed amount like this, is difficult to be applied to non-professional operator yet.And the position that the device of control detection intraluminal fluid position height is installed in test chamber in apparatus of the present invention gas flow in the cavity can determine that test chamber becomes seal chamber time the, thereby decision sample primary importance.Therefore, the sample in the test chamber can not change with the sample in the sample chamber, realizes real quantitative pattern detection; Simultaneously, different people operates this device also can reach identical result, is specially adapted to family or amateur operator and uses.
One preferred embodiment in, in order to guarantee to obtain the sample of stabilizing amount, the device of this control liquid level is connected the communication passage that position on the test chamber is not less than sample chamber and test chamber.When this device and height such as passage grade, sample is after getting into test chamber, and sample gets into the increase of sample chamber along with sample, and the device of passage and this control liquid level is all sealed by sample, and test chamber is sealed; And when this device is higher than communication passage; Sample at first can seal this interface channel, at this moment after getting into test chamber; Test chamber only can communicate with the external world through the device of control liquid level; When sample increased again, the device of control detection intraluminal fluid position height was sealed, thereby made test chamber become a seal chamber.Dual mode all makes test chamber sealed, and when the pressure of the liquid sample in getting into the test chamber that seals and the gaseous tension of sealing reached balance, sample no longer got into test chamber, formed fixedly liquid level, accomplished detection by quantitative.
In another embodiment, the device of control detection intraluminal fluid face height of the present invention can also make sample in test chamber, have the second place.Promptly the device of this control detection intraluminal fluid cover degree can make sample that primary importance and two fixing sample sizes of the second place are arranged in test chamber.In this embodiment; Sample gets into sample chamber and gets into test chamber through passage; After sample sealing communication passage, the device of this control liquid level makes test chamber become a seal chamber, and liquid sample rests on the second place because of the gas-liquid pressure balance in the seal chamber.When needs increased sample size, the device of control liquid level made test chamber communicate with ambient atmos, and the air pressure in the test chamber reduces, and liquid sample reduces further to get into test chamber because of the air pressure in the cavity.When the device of control liquid level once more behind the sealing detection chamber, the gas-liquid pressure balance in this new seal chamber makes sample remain on the liquid level of the second place.In this embodiment, the sample size that not only gets into test chamber can be controlled, and can realize detection by quantitative.And the time that gets into test chamber because of sample also can control, can realize the collection of sample and detect split and carry out that promptly the collection of sample and testing process can be separated, and can in collection, detect, and also can collect sample earlier, after detect; And can delay time and detect sample.
In the preferred embodiment, the device of this control detection intraluminal fluid face height is between the primary importance and the second place of test chamber.
Among the present invention, the device of this control detection intraluminal fluid face height has makes the liquid that gets into test chamber be fixed on the function of certain position, and this device has multiple mode and realizes this function.In the embodiment, use the valve with opening and closing function to be installed on the test chamber, the opening and closing through valve come the amount of liquid in the control detection chamber.
In another embodiment, the device of this control detection intraluminal fluid face height can comprise that the parts of permeable watertight, these permeable watertight parts have can make gas pass through, but the function that liquid is passed through.These parts are installed on the test chamber, can guarantee that test chamber communicates with ambient atmos and liquid in the chamber can not flow out to the external world through these parts.After liquid sample adds apparatus of the present invention, flow into test chamber through sample chamber and passage, because of the existence of permeable watertight parts, test chamber communicates with ambient atmosphere, air pressure is identical, promptly with sample chamber in air pressure also identical; At this moment, because of in the sample chamber with test chamber in the relation of liquid level difference, liquid sample gets into test chamber always.When liquid arrived these permeable watertight parts, because of its waterproof function, liquid that can not flowed or is penetrated into outside the test chamber.When liquid further increases, these permeable watertight parts by hydraulic seal, test chamber becomes seal chamber.When reaching the gas-liquid pressure balance in the seal chamber, liquid sample rests on the certain position in the test chamber, i.e. primary importance.In some embodiments, these permeable watertight parts are processed for having this materials with function, like polytetrafluoroethylene (PTFE) series microporous barrier, the serial microporous barrier of polyurethane (TPU) etc.; In another specific embodiment, these permeable watertight parts are the aperture that is installed on the test chamber, and this hole diameter is not more than the diameter of liquid because of the film of surface tension formation.
In the more excellent embodiment of another one, the device of this control liquid level can be combined by ventilative but fluid-tight parts and a seal element, and seal element is used for sealing the parts of this permeable watertight.Permeable watertight parts and seal element can be bonded together, and also can split and come.When both bond together when being connected on the test chamber, can make sample in test chamber, have set, i.e. a second place; After the two separates, can make sample in test chamber, have another position, i.e. primary importance.After liquid sample adds sample chamber, get into test chamber through passage.At this moment; Because of the permeable watertight parts are covered and seal by seal element, test chamber only communicates with the external world through passage, when the sample entering test chamber of q.s; After sealing up the communication passage of sample chamber and test chamber; Test chamber becomes a seal chamber, and intracavity liquid rests on fixing position, the i.e. second place after reaching the gas-liquid pressure balance.After the seal element on the permeable watertight parts is separated; The test chamber of sealing communicates with ambient atmos through the permeable watertight parts; The chamber internal gas pressure reduces, and the further test chamber of liquid was not until having this parts, and test chamber is sealed once more; New gas-liquid pressure balance in the seal chamber makes sample remain on new liquid level, i.e. a primary importance.In some embodiments, these permeable watertight parts are processed for having this materials with function, like polytetrafluoroethylene (PTFE) series microporous barrier, the serial microporous barrier of polyurethane (TPU) etc.; And seal element can be processed for the glue with viscosity, as uses synthetic paper or plastic sheeting material (PET, PP, PE, PVC etc.) the strong viscosity adhesive sticker as surface layer.One more specifically among the embodiment, adhesive sticker covers the device that forms this control liquid level on the microporous barrier.
Sample chamber of the present invention is used to collect sample, especially liquid sample.Its profile is unrestricted, can have any shape, and can satisfy and accept sample, and particularly the function of liquid sample gets final product, like circle, oval or square or the like.The material of making sample chamber is also unrestricted, like hard plastic, and PVC; Perhaps, also can be soft material, like plastic sheeting etc.Test chamber is used to lay testing element, and accomplishes the detection of sample.Its profile is also unrestricted, satisfies can lay testing element and accept the sample function to get final product.The material of making test chamber can be identical with test chamber.As: PVC, plastics or the like.
The connected mode of test chamber and sample chamber is various, can directly connect, and also can connect indirectly.As in one embodiment, test chamber and sample chamber are one, are positioned at same cavity, are communicated with through perforate mode on the two sidewall at interval.In addition in one embodiment, test chamber is connected in the bottom with sample chamber, forms a passage.In another embodiment, sample chamber is connected and is communicated with through valve with test chamber.
In apparatus of the present invention, the testing element that is positioned at test chamber can be for one or more.In the embodiment, testing element can be test strips.In an embodiment, in order to guarantee to test effect and precision of test result, the position of test strips in test chamber is that its mark zone is higher than the primary importance of sample in test chamber.In a more excellent embodiment,, can make the sample uptake zone of test strips be higher than the second place of test chamber for the function that realizes delaying time and detect.
In one embodiment, this sample collection pick-up unit also comprises lid, and lid is used to seal sample chamber.After sample is positioned at sample chamber, cover lid, sample chamber is sealed to guarantee that sample is sealed in the sample chamber.The sealing mode of lid and sample chamber is various, and is preferred, can adopt the lid of press-button type.Specifically, a clasp is installed on lid, a clasp is installed on the sidewall of sample chamber, clasp and clasp are worked in coordination, and can reach the purpose of sealing sample chamber opening during cooperation.Preferred in addition, the sealing mode of lid and sample chamber, screw type in addition.As in a concrete embodiment, be respectively arranged with screw thread on the sidewall inwall of lid and cavity, working in coordination between the screw thread reaches the purpose of sealing sample chamber opening.In order to guarantee lid and sample chamber sealing, can use seal element.In the embodiment, the sealing element is " O " type ring, is positioned at cover bottom and sample chamber accent intersection.
In order to guarantee that the liquid level that liquid sample gets in the test chamber fixes, in the embodiment, the parts of permeable watertight can be installed on the lid of sealing sample chamber.Such as: use the serial microporous barrier of the polytetrafluoroethylene (PTFE) with this function, the serial microporous barrier of polyurethane (TPU) etc.In the specific embodiment, microporous barrier is installed on lid, after lid covers sample chamber, the remainder of lid, the part that particularly contacts with sample chamber sealing sample chamber can not leak into the outside to guarantee sample.At this moment, microporous barrier makes sample chamber identical with ambient pressure, and the air pressure in the sample chamber can not increasing or reducing and change because of liquid.When the device of control detection intraluminal fluid position height worked, the liquid sample amount that gets into test chamber only changed along with the device control of control liquid level, can not change because of the air pressure in the sample chamber.Thereby make primary importance or the second place of liquid sample in test chamber can arbitrarily not change because of liquid level and the air pressure in the sample chamber of sealing, and reached the fixedly purpose of liquid level of control, also guaranteed the fixing of the interior sample size of test chamber.
On the other hand, the present invention also provides a kind of also method of tracer liquid sample of collecting, and comprises the test chamber that sample chamber is provided and is communicated with sample chamber through passage; Make sample entering sample chamber and get into test chamber along passage; Make sample arrive the primary importance of test chamber.In the embodiment, the device that is connected the control detection chamber liquid level on the test chamber makes sample arrive primary importance.More excellent, the device of this control detection intraluminal fluid position height can make the second place of sample elder generation's arrival test chamber before arriving primary importance, even sample gets into sample chamber and gets into test chamber along passage; Make sample arrive the second place of test chamber; Make sample arrive the primary importance of test chamber again.
In the embodiment, the position of the device of control detection intraluminal fluid position height is not less than said passage.
In another embodiment, the device of control detection intraluminal fluid position height comprises the permeable watertight parts.More excellent, this device by the permeable watertight parts and the seal element that is used to seal these permeable watertight parts constitute.
In the embodiment, when sample arrived primary importance, liquid sample soaked into testing element, and testing element detects sample.
In another embodiment, after sample gets into sample chamber, lid is combined and the sealing sample chamber.One preferred embodiment in, the gas permeable devices of lid makes sample chamber communicate with ambient atmosphere.As the parts of a permeable watertight are installed on lid.Such as, microporous barrier etc.
Beneficial effect
The present invention controls the sample size that gets into test chamber through the device of control detection intraluminal fluid face height, further, can also control the time that sample gets into test chamber.Therefore, apparatus of the present invention can realize the detection by quantitative of sample, simultaneously, when satisfying detection by quantitative, the detection sample of can also delaying time.
Description of drawings
Fig. 1 is the diagrammatic cross-section of apparatus of the present invention
Fig. 2 is the diagrammatic cross-section that sample adds the sample chamber and the arrival second place in apparatus of the present invention
Fig. 3 is the diagrammatic cross-section of apparatus of the present invention cover lid
Fig. 4 is the diagrammatic cross-section that control liquid level apparatus structure separates in apparatus of the present invention
Fig. 5 is the diagrammatic cross-section that sample arrives primary importance in apparatus of the present invention
The explanation of accompanying drawing sign
This device 800; Sample chamber 100; Sample chamber accent 103; At the bottom of the sample chamber chamber 102, sample chamber sidewall 101; Test chamber 200; Test chamber and sample chamber joint 201, another sidewall 202 of test chamber; The device 300 of control liquid level; Permeable watertight parts 301; Seal member 302; Testing element 400; Testing element sample uptake zone 401; Testing element mark zone 403; Testing element results display area 404; Testing element pad 402; Sample chamber and test chamber passage 700; Sample is in the second place 601 of test chamber; Sample is in the primary importance 602 of test chamber; Lid 500, permeable watertight parts 501 times are done further explanation in the face of structure or these employed technical terms of liquid-sample collection device on the lid.Sample
" sample " that the present invention refers to refer to needs chemical examinations whether exist with (or) analyze any material of analyte concentration; Maybe need confirm one or more samples whether exist with (or) material of the analyte of quantity, maybe need carry out the material of qualitative evaluation.Sample can be fluid sample, for example liquid sample.Liquid sample comprises body fluid, such as blood, serum, blood plasma, saliva, urine, tears, seminal fluid and marrow; Liquid sample also can be a water sample, such as seawater, river, river etc., perhaps from domestic water, municipal water use or service water resource, runoff water or sewage; Sample can be a food sample, such as milk and wine.Mucus, semisolid or solid sample can be used for making liquid, eluate, suspending liquid or leachate equal samples.For example, throat or genitals sample may be dipped in and process sample in the liquid.Sample can comprise potpourri or any relevant potpourri of liquid, solid and gas, such as the cell suspending liquid in dilution or the solution.Sample comprises biological substance, such as cell, microorganism, organelle and biochemical complexes.Liquid sample can be from producing such as solid, semisolid or high-viscosity materials such as soil, ight soil, tissue, organ, biological fluid or other occurring in nature non-liquid samples.For example, these solids or semi-solid samples can be mixed with one type of suitable solution of dilution.Sample can be macerated, freezing and thaw, perhaps other method for distilling form liquid samples.Remaining particulate material can use traditional method such as filtration or deposition to remove.In the example of a practical implementation, the sample that is used to detect is a urine.
Testing element
" testing element " is any element of carrying out test.In one embodiment, testing element is a test-strips.This test-strips can comprise that the material with specificity combination that is used for immunoassay above that is right.Test-strips can be a kind of test chemical bar that after detecting completion, passes through change color or other signals variation judged results.The sample that suitable the present invention detects includes but not limited to body fluid, separated sample from biological tissue or body fluid.For example, sample can be a saliva, blood, serum, blood plasma, urine, excreta, spinal fluid, vaginal secretion, mucus and tissue.Testing element is not limited to one, can be that two or more testing elements are arranged in pick-up unit simultaneously, respectively different component in the test sample book.
Embodiment
In following detailed description, the explanation of accompanying drawing and corresponding character only is a mode of explaining that by way of example the present invention can actable specific concrete scheme.We do not get rid of the present invention can also be in any other embodiment in claim scope of the present invention.
In the device 800 of one embodiment of the present of invention, by sample chamber 100, the device 300 of test chamber 200 and control detection intraluminal fluid face height is formed, like Fig. 1 and shown in Figure 5.Sample chamber 100 is by sidewall 101, and 102 constitute with accent 103 at the bottom of the chamber.Test chamber is by sidewall, and top 201 constitutes with the bottom.In the specific embodiment; Sample chamber 100 is positioned at same cavity with test chamber 200; As shown in Figure 1; A shared sidewall 101 and the bottom 102 of test chamber 200 and sample chamber 100, test chamber top 201 is connected with sample chamber accent 103 and seals, and another sidewall 202 of test chamber is separated itself and sample chamber.The device 300 of control detection intraluminal fluid position height is connected with test chamber 200, and is as shown in Figure 1, and this device 300 can be installed on the sidewall 101 of test chamber 200.The device 300 of this control detection intraluminal fluid position height can make the sample that gets in the test chamber remain on primary importance 602; Simultaneously, this device also can make sample in test chamber, have two fixing liquid levels: the primary importance 602 and the second place 601.
In the specific embodiment; The device 300 of this control detection intraluminal fluid position height is permeable watertight parts 301; These permeable watertight parts 301 are installed on the test chamber sidewall 101, and at this moment, test chamber 200 only communicates with ambient atmosphere with passage 700 through these parts 301.After liquid sample was added into this device 800, sample got into sample chamber 100.Sample chamber 100 and atmosphere, test chamber 200 be also through passage 700 and permeable watertight parts 301 and atmosphere, and promptly the interior gaseous tension of test chamber 200 and sample chamber 100 is identical.Like this, sample is higher than the passage 700 inflow test chamber 200 that test chamber 200 liquid levels are passed through the sample chamber bottom because of sample chamber 100 liquid levels.Along with increasing of sample; Passage 700 is sealed by sample gradually, and at this moment, test chamber 200 can also communicate with ambient atmos through permeable watertight parts 301; So still identical in test chamber 200 internal gas pressures and the sample chamber 100, sample continues to get into test chamber 200 because of the relation of liquid level.When the sample in the test chamber 200 is increased to when covering these permeable watertight parts 301, these parts 301 no longer communicate with ambient atmosphere, and test chamber 200 is sealed.At this moment, sample continues to get into the test chamber 200 of sealing, and when gas and liquid reached pressure equilibrium in this cavity 200, sample no longer flowed into test chamber 200, remains on a fixed position in the test chamber 200, i.e. the primary importance 602 of test chamber.
In another specific embodiment, the device 300 of this control detection intraluminal fluid position height is breathed freely by one but fluid-tight parts 301 combine with seal member 302.When permeable watertight parts 301 and seal member 302 were bonded together, test chamber 200 was not communicated with the external world by these device 300 sealings; After sample gets into sample chamber 100, can arrive and remain on the second place 601 of test chamber 200 through passage 700, as shown in Figure 2.And after permeable watertight parts 301 and seal member 302 fractionations are come, like Fig. 4, through this device 300; Test chamber 200 can circulate with ambient atmos, but liquid can not be through this device 300 and extraneous circulation, at this moment; Test chamber 200 communicates with ambient atmosphere through this device 300, and sample can continue to get into test chamber 200, until liquid sample sealing permeable watertight parts 301; Last sample arrives and remains on the primary importance 602 of test chamber 200, as shown in Figure 5.
Among the embodiment,, the mark zone 403 of testing element 400 is positioned on the primary importance 602 of test chamber in order to guarantee testing result.At one more specifically in the embodiment, there are a pad 402, this pad that the mark zone 403 of testing element 400 is positioned on the primary importance 602 in the bottom of testing element.More excellent, this pad 402 makes the sample uptake zone 401 of test strips be higher than the second place 601 simultaneously.This pad 402 can be installed or be placed in the test chamber 200; Also can be connected as a single entity with test chamber 200, like, pad 402 and test chamber 200, perhaps pad 402 and test chamber 200, sample chamber 100 is a single injection-molded.Pad 402 can adopt not the absorption liquid sample body and not process with the material of liquid sample generation chemistry or biological respinse.
In order to guarantee that the air pressure in the sample chamber 100 can not be provided with a ventilative device 501 by lid 500 because of cover lid 500 changes, make sample chamber 100 always with atmosphere.Simultaneously, can seepage for the sample that guarantees to get into this pick-up unit 800, this gas permeable devices 501 need have fluid-tight function simultaneously.In an embodiment, be equipped with ventilative but fluid-tight parts 501 at the top of lid 500, make sample chamber behind lid 500 sealing sample chamber accents 103, air communicates with ambient atmosphere in the chamber.
To shown in Figure 5, describe the collection of a specific embodiment of this device and the idiographic flow of detection sample below in conjunction with Fig. 1 in detail.As shown in Figure 1; Test chamber 200 is positioned at sample chamber 100; Test chamber 200 and sample chamber 100 shared sidewalls 101; Another sidewall 202 separates test chamber 200 and sample chamber 100, and test chamber top 201 is connected with sample chamber accent 103 and seals, and test chamber 200 is connected through opening 700 with the bottom of sample chamber 100 at sidewall 202.The device 300 of the control detection intraluminal fluid position height of being made up of microporous barrier 301 and adhesive sticker 302 is installed on the common sidewall 101 of test chamber and sample chamber.Testing element 400 is positioned at test chamber 200, and pad 402 is positioned at the bottom of testing element 400.When original state, adhesive sticker 302 covers and forms sealing on the microporous barrier 301, and at this moment, test chamber 200 only communicates with the external world through passage 700.
With liquid sample, like urine, add sample chamber 100 from sample chamber accent 103, because of sample chamber 100 and test chamber 200 are connected, liquid sample can get into test chamber 200 along the two passage that is connected 700, and is as shown in Figure 2.Liquid sample in getting into test chamber 100 increases gradually, can seal up passage 700 at last, at this moment; Unique and the extraneous opening that communicates of test chamber 200 700 is sealed by sample, and test chamber 200 becomes a seal chamber, in sealing cavity 200; When the pressure of gas and liquid reaches balance, the liquid sample in the sample chamber 100 will no longer get into test chamber 200, thereby form a fixing liquid level; Be the second place 601 of sample in test chamber, see among Fig. 2 shown in 601 positions.At this moment, be positioned at bottom and the second place 601 that sample uptake zone 401 is higher than test chamber of the testing element 400 of test chamber 200, promptly be higher than the sample liquid level, therefore, testing element 400 does not touch sample, does not carry out analyzing and testing.
To have permeable watertight parts 501, and cover the accent 103 that adds the sample chamber 100 behind the sample like the lid 500 of microporous barrier, sample chamber 100 is covered the back by lid 500 and forms liquid sealing.Because of there being ventilative microporous barrier 501 to exist on the lid 500, make sample chamber 100 communicate, so sample chamber 100 can not change before and after lid 500 covers with test chamber 200 interior liquid levels with ambient atmosphere.As shown in Figure 3, the liquid level in the test chamber still remains on the second place 601.
At this moment, adhesive sticker 302 is torn from microporous barrier 301, as shown in Figure 4; When adhesive sticker 302 with after microporous barrier 301 separates; Microporous barrier 301 with permeable watertight performance makes test chamber 200 communicate with ambient atmosphere, and at this moment, the gaseous tension in the test chamber 200 is reduced to atmospheric pressure; Identical with the air pressure in the sample chamber 100; And liquid level is higher than liquid level in the test chamber 100 in the sample chamber 100, forms pressure reduction, and this pressure reduction makes the liquid sample in the sample chamber 100 flow in test chamber 200 through passage 700 once more.When liquid sample increases in test chamber 200 when sealing up microporous barrier 301, test chamber 200 becomes a hermetic cavity body once more.In this seal chamber 200, when liquid reach a certain amount of after, reach new vapor liquid equilibrium, at this moment, liquid forms another fixing liquid level in test chamber 200, promptly the primary importance 602 of sample in test chamber is as shown in Figure 5.
When sample from the second place when primary importance flows, soak into the sample uptake zone 401 of the testing element that is positioned at test chamber 200, testing element 400 receives sample, carries out sample analysis and accomplishes detection.
Claims (20)
1. sample collection pick-up unit comprises:
Sample chamber, test chamber, the two passes through channel connection;
And the device of control detection intraluminal fluid face height, this device is connected with test chamber.
2. device as claimed in claim 1 is characterized in that, the device of this control detection intraluminal fluid face height makes sample in test chamber, have primary importance.
3. device as claimed in claim 2 is characterized in that, the position of the device of control detection intraluminal fluid face height is not less than said passage.
4. like claim 2 or 3 described devices, it is characterized in that the device of this control detection intraluminal fluid face height can also make sample have the second place in test chamber.
5. device as claimed in claim 4 is characterized in that, the device of control detection intraluminal fluid face height comprises the permeable watertight parts.
6. device as claimed in claim 4 is characterized in that, the device of control detection intraluminal fluid face height comprises the parts and the seal element that is used to seal the permeable watertight parts of permeable watertight.
7. device as claimed in claim 4 is characterized in that, comprises the test strips that detects sample in the test chamber.
8. device as claimed in claim 7 is characterized in that, position in test chamber, test strips mark zone is higher than primary importance.
9. device as claimed in claim 8 is characterized in that, the position of test strips sample uptake zone in test chamber is higher than the second place.
10. device as claimed in claim 1 is characterized in that this device can comprise the lid that seals sample chamber.
11. device as claimed in claim 10 is characterized in that, comprises the parts of permeable watertight on the said lid.
12. collect the also method of tracer liquid sample, the test chamber that sample chamber is provided and is communicated with sample chamber for one kind through passage;
Make sample entering sample chamber and get into test chamber along passage;
Make sample arrive the primary importance of test chamber.
13. method as claimed in claim 12 is characterized in that, the device that is connected the control detection chamber liquid level on the test chamber makes sample arrive primary importance.
14. method as claimed in claim 13 is characterized in that, the position of the device of said control detection intraluminal fluid position height is not less than said passage.
15. method as claimed in claim 14 is characterized in that, the device of this control detection intraluminal fluid position height can make sample before arriving primary importance, arrive the second place of test chamber earlier.That is:
Make sample entering sample chamber and get into test chamber along passage;
Make sample arrive the second place of test chamber;
Make sample arrive the primary importance of test chamber again.
16. method as claimed in claim 14 is characterized in that, the device of said control detection intraluminal fluid position height comprises the permeable watertight parts.
17. method as claimed in claim 15 is characterized in that, the device of said control detection intraluminal fluid position height comprises permeable watertight parts and the seal element that is used to seal these permeable watertight parts.
18. method as claimed in claim 14 is characterized in that, when sample arrived primary importance, sample soaked into testing element, and testing element detects sample.
19. method as claimed in claim 12 is characterized in that, after sample gets into sample chamber, lid is combined and the sealing sample chamber.
20. method as claimed in claim 19 is characterized in that, the gas permeable devices of lid makes sample chamber communicate with ambient atmosphere.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610101325.8A CN105716905B (en) | 2011-01-15 | 2011-01-15 | A kind of sample collection detection method |
| CN201110009577.5A CN102589929B (en) | 2011-01-15 | 2011-01-15 | A kind of sample collection pick-up unit |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110009577.5A CN102589929B (en) | 2011-01-15 | 2011-01-15 | A kind of sample collection pick-up unit |
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| CN201610101325.8A Division CN105716905B (en) | 2011-01-15 | 2011-01-15 | A kind of sample collection detection method |
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| CN102589929A true CN102589929A (en) | 2012-07-18 |
| CN102589929B CN102589929B (en) | 2016-03-30 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103575575A (en) * | 2012-07-23 | 2014-02-12 | 艾博生物医药(杭州)有限公司 | Device |
| CN112611858A (en) * | 2020-10-20 | 2021-04-06 | 浙江省海洋水产研究所 | Toxicity experimental device for volatile organic compounds |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201156047Y (en) * | 2008-03-04 | 2008-11-26 | 艾博生物医药(杭州)有限公司 | Cup cover for sample detection |
| US7458942B2 (en) * | 2004-09-22 | 2008-12-02 | Medtox | Systems and methods for collecting, testing and transporting liquid biological specimens |
| CN101556277A (en) * | 2009-01-05 | 2009-10-14 | 艾博生物医药(杭州)有限公司 | Detecting device |
| CN201464268U (en) * | 2009-04-23 | 2010-05-12 | 艾博生物医药(杭州)有限公司 | Liquid sample collection and detection cup |
| CN101876661A (en) * | 2009-05-08 | 2010-11-03 | 艾博生物医药(杭州)有限公司 | Device for analyzing analyte in liquid sample |
| CN201974305U (en) * | 2011-01-15 | 2011-09-14 | 艾博生物医药(杭州)有限公司 | Device for collecting and detecting samples |
-
2011
- 2011-01-15 CN CN201110009577.5A patent/CN102589929B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7458942B2 (en) * | 2004-09-22 | 2008-12-02 | Medtox | Systems and methods for collecting, testing and transporting liquid biological specimens |
| CN201156047Y (en) * | 2008-03-04 | 2008-11-26 | 艾博生物医药(杭州)有限公司 | Cup cover for sample detection |
| CN101556277A (en) * | 2009-01-05 | 2009-10-14 | 艾博生物医药(杭州)有限公司 | Detecting device |
| CN201464268U (en) * | 2009-04-23 | 2010-05-12 | 艾博生物医药(杭州)有限公司 | Liquid sample collection and detection cup |
| CN101876661A (en) * | 2009-05-08 | 2010-11-03 | 艾博生物医药(杭州)有限公司 | Device for analyzing analyte in liquid sample |
| CN201974305U (en) * | 2011-01-15 | 2011-09-14 | 艾博生物医药(杭州)有限公司 | Device for collecting and detecting samples |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103575575A (en) * | 2012-07-23 | 2014-02-12 | 艾博生物医药(杭州)有限公司 | Device |
| CN112611858A (en) * | 2020-10-20 | 2021-04-06 | 浙江省海洋水产研究所 | Toxicity experimental device for volatile organic compounds |
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| CN102589929B (en) | 2016-03-30 |
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