CN102585357B - Material special for seamless polypropylene infusion bag - Google Patents
Material special for seamless polypropylene infusion bag Download PDFInfo
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- CN102585357B CN102585357B CN201110450421.0A CN201110450421A CN102585357B CN 102585357 B CN102585357 B CN 102585357B CN 201110450421 A CN201110450421 A CN 201110450421A CN 102585357 B CN102585357 B CN 102585357B
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Abstract
The invention belongs to the technical field of medical infusion bags, and in particular relates to a material special for a seamless polypropylene infusion bag. On the premise that the self-drainage function of the material is ensured, the consumption of styrene-ethylene/ butene-styrene block copolymer (SEBS) is reduced, and a softening agent such as white oil is not added; and the material special for the seamless polypropylene infusion bag is safe and does not leak liquid.
Description
Technical field
The invention belongs to the technical field of medical infusion bags, be specifically related to a kind of material special for seamless polypropylene infusion bag.
Background technology
The infusion products of main flow is mainly divided into two kinds of forms in the market: i.e. half-open infusion model and closed infusion model.
The former take vial or common plastics bottle is representative, is domestic clinical most popular infusion model at present, because material is rigidity or semi-rigid, during use, cannot realize real self-constriction, if do not import air, its discharge opeing residual quantity is very large.So must constantly import to liquid the normal infusion of air guarantee liquid, but this process may produce secondary pollution to liquid, has larger potential safety hazard.
The latter take " multi-layer co-extrusion infusion with bag " be representative, adopts three layers or five-layer co-squeezing film to form through high temperature heat seal, due to material softness relatively, in infusion process, without importing air, can realize self-constriction, and discharge opeing residual quantity is little, infusion process is comparatively safe.But this product bag periphery, because adopting welding fabrication, exists mechanics thin spot, in transhipment, storage, leakage risk is larger.
For addressing this problem, can adopt modified polypropene pellet with injection stretch blow moulding direct production self-constriction transfusion bag, because bag is that blowing is one-body molded, bag is seamless, there is no mechanics thin spot, do not have " bag for multi-layer co-extrusion infusion " problem that bag ftractures when sterilizing or transportation use.Due to its seamless design, and good crushing resistance, when running into emergency situation (as Emergency relief) and need to drop, also can bring into play the unrivaled advantage of other packaging material.
In current known technology, modified polypropene pellet for the production of self-constriction transfusion bag generally makes by add one or more thermoplastic elastomers in polypropylene, modal additive is styrene-ethylene-butylene-styrene multipolymer (being called for short SEBS), and interpolation scope is between 5 weight part～50 weight parts.
Facts have proved, in order to ensure polypropylene and elastomeric mixing uniformity, generally need add a certain amount of tenderizer (as white oil), along with SEBS ratio improves, the consumption of tenderizer also needs to strengthen thereupon, and this migrates into the risk of liquid by increasing tenderizer before product is used; Meanwhile, if SEBS ratio is too high, because material pliability strengthens greatly, the broken bag rate of blowing bag process also will increase greatly, and then improve production cost; In addition, evidence, the content of SEBS is higher, and the transmittance of bag is less, and then the inconvenient quality of liquid medicine of directly observing.
Summary of the invention
The present invention is directed to the defect that prior art exists, when guaranteeing the self-constriction function that Realization of Product is suitable with " bag for multi-layer co-extrusion infusion ", reduce the consumption of SEBS, and do not add the tenderizers such as white oil, a kind of safety and without leakage material special for seamless polypropylene infusion bag are more provided.
The present invention seeks to be achieved through the following technical solutions:
A material special for seamless polypropylene infusion bag, this PP Pipe Compound is comprised of polypropylene and SEBS, and it specifically consists of: polypropylene: 100 weight parts, SEBS:1.0～4.5 weight part.
Preferably, consisting of of material special for seamless polypropylene infusion bag: polypropylene: 100 weight parts, SEBS:2.0～4.0 weight part.
Preferably, consisting of of material special for seamless polypropylene infusion bag: polypropylene: 100 weight parts, SEBS:2.5～3.5 weight part.
Preferably, consisting of of material special for seamless polypropylene infusion bag: polypropylene: 100 weight parts, SEBS:2.4 weight part.
Preferably, consisting of of material special for seamless polypropylene infusion bag: polypropylene: 100 weight parts, SEBS:3.0 weight part.
The preparation technology of this material special for seamless polypropylene infusion bag comprises the steps:
(1) by formula raw materials weighing;
(2) in high speed mixer by the raw material blending weighing up, mixing time is at 2～3min;
(3) mixed raw material is passed through to twin screw extruder extruding pelletization, granulation melt temperature is 170 ℃～190 ℃, and screw speed is 300～400rpm, more obtains infusion bag PP Pipe Compound by recirculated water cooling, air-dry, mechanical pelletizing.
The method that adopts PP Pipe Compound of the present invention to prepare seamless polypropylene infusion bag is:
Under the air ambient through purifying, infusion bag PP Pipe Compound is dropped in injecting machine material tube, heat to 170 ℃～220 ℃ formation melts, under 130～180MPa high pressure, melting pellet is injected in bag mold tool and form tubular shape base, keep injection pressure also bag base to be carried out cooling simultaneously, open the bag base that mould takes out moulding; The bag base preparing is dropped in blow moulding machine hopper, manager base cylinder and mechanical manipulator are delivered to the preheating tunnel of heating, bag base is heated to above 10 ℃～40 ℃ of softening temperature, pass into pressurized air and carry out blowing, open mould after cooling, obtain seamless polypropylene infusion bag, prepared seamless polypropylene infusion bag, cross section is oval, and the ratio of its major axis and minor axis is 2.0～3.5:1, and thickness is 0.2～0.5mm.
experimental example one: the self-constriction effect detection of the prepared infusion bag of PP Pipe Compound of the present invention
Get SEBS addition in the polypropylene of 100 weight parts and be respectively 0 weight part, 1.0 weight parts (embodiment 3), 2.0 weight parts (embodiment 4), 2.4 weight parts (embodiment 2), 3.0 weight parts (embodiment 1), 4.5 weight parts (embodiment 6), 5.0 weight part, 25 weight parts, (SEBS addition is 25 weight parts to the pellet of 50 weight parts, the pellet of 50 weight parts, by SEBS charging capacity, add respectively the white oil of equivalent), according to 1 below method of embodiment, make same specification with bag shape seamless polypropylene infusion bag, separately get same specification three-layer extrusion film infusion bag, difference filling 5% glucose injection (100ml:5g), respectively get 10 bags and under liftoff 1.2m height, carry out discharge opeing completeness test (during test, temperature is 20 ℃), in discharge opeing process, must not insert exhaust needle and palpus closed infusion set venting hole, and make the flow regulator of transfusion device in full-gear, transfusion needle thrusts combination cover completely, when no longer instiling, be considered as discharge opeing terminal, now extract transfusion needle and with syringe, the glucose injection remaining in bag taken out quantitatively.The better discharge opeing residual quantity of self-constriction effect is less, otherwise larger, result shows, in 100 weight part polypropylene, SEBS addition is the suitable from discharge opeing effect of the infusion bag made of the pellet of 1.0 weight parts, 2.0 weight parts, 2.4 weight parts, 3.0 weight parts, 4.5 weight parts, 5.0 weight parts, 25 weight parts, 50 weight parts and three-layer extrusion film infusion bag, is all obviously better than the infusion bag that SEBS addition is 0 weight part.The results detailed in Table 1.
table 1, discharge opeing residual quantity comparison report
the detection of experimental example two, infusion bag PP Pipe Compound of the present invention broken bag rate when being blow molded into infusion bag
Get SEBS addition in the polypropylene of 100 weight parts and be respectively 0 weight part, 1 weight part (embodiment 3), 2.4 weight parts (embodiment 2), 3.0 weight parts (embodiment 1), 4.5 weight parts (embodiment 6), 5.0 weight part, 25 weight parts, (SEBS addition is 25 weight parts to the pellet of 50 weight parts, the pellet of 50 weight parts, by SEBS charging capacity, add respectively the white oil of equivalent), according to 1 lower method of embodiment, make respectively each 1000 of bag bases, the bag base preparing is dropped in blow moulding machine hopper, manager base cylinder and mechanical manipulator are delivered to the preheating tunnel of heating, bag base is heated to above 10～40 ℃ of softening temperature, by mechanical manipulator, be delivered to blowing district matched moulds, pass into the pressurized air through purification filtering, after cooling, obtain infusion bag, whether observe bag breaks, and record broken bag quantity.Test-results refers to table 2.
table 2, broken bag quantity statistics
Assay shows: in the polypropylene of the present invention's 100 weight parts, SEBS addition is that the broken bag rate of the infusion bag made of the pellet of 1.0 weight parts, 2.4 weight parts, 3.0 weight parts, 4.5 weight parts is suitable with the infusion bag of not adding SEBS, and is better than the infusion bag that SEBS addition is 5.0 weight parts, 25 weight parts and 50 weight parts.
the transport test of the infusion bag that experimental example three, PP Pipe Compound of the present invention are made
Get SEBS addition in the polypropylene of 100 weight parts and be respectively 0 weight part, 1 weight part (embodiment 3), 2.4 weight parts (embodiment 2), 3.0 weight parts (embodiment 1), 4.5 weight parts (embodiment 6), 5.0 weight part, (SEBS addition is the pellet of 25 weight parts to the pellet of 25 weight parts, by SEBS charging capacity, add respectively the white oil of equivalent), according to the method under 1 of embodiment, make same specification with a bag shape seamless polypropylene infusion bag, separately get same specification three-layer extrusion film infusion bag, difference filling 5% glucose injection (100ml:5g), in the Corrugated Box of same size, neatly put respectively above-mentioned sample, 100 bags, every case, every layer of 40 case, totally 5 layers, amount to 200 casees, above-mentioned three kinds of samples are placed in respectively to the test of transporting for long-distance in automobile.
On May 25th, 2011, sample mail to Lhasa from Binzhou, Shandong through Chengdu, and after arrival, former road is returned immediately, on June 14th, 2011, returned to Binzhou, Shandong, company location, and round-trip distance amounts to approximately 7900 kilometers, approximately 25 days consuming time.
After transportation, Corrugated Box opened and taken out infusion bag from outer bag, being placed on dry testing table, whether range estimation has unlatching leakage, if leakage is judged to defective; As not leakage, infusion bag is placed on universal testing machine platform, apply the interior pressure of about 67kpa, maintain about 15s, if leakage, be judged to defective, otherwise be qualified.Test-results is in Table 3.
the transport test result of the infusion bag that table 3, PP Pipe Compound of the present invention are made
Test-results shows, in the polypropylene of the present invention's 100 weight parts, SEBS addition is that leakage does not all occur the infusion bag that the infusion bag that the pellet of 1.0 weight parts, 2.4 weight parts, 3.0 weight parts and 4.5 weight parts is made is 0 weight part, 5.0 weight parts and 25 weight parts with SEBS addition after simulate, is all being better than three-layer extrusion film infusion bag controlling aspect leak-off pocket rate.
the infusion bag transmittance that experimental example four, PP Pipe Compound of the present invention are made detects
Get SEBS addition in the polypropylene of 100 weight parts and be respectively 1.0 weight parts (embodiment 3), 2.4 weight parts (embodiment 2), 3.0 weight parts (embodiment 1), 4.5 weight parts (embodiment 6), 5.0 weight part, 25 weight parts, (dosage is 25 weight parts to the pellet of 50 weight parts, the pellet of 50 weight parts, by SEBS charging capacity, add respectively the white oil of equivalent), according to 1 below method of embodiment, make same specification with bag shape seamless polypropylene infusion bag, get the smooth position of infusion bag, be cut into the section of 5 0.9 ㎝ * 4 ㎝, along incident light vertical direction, put into cuvette respectively, topped up with water, and using water as blank, according to spectrophotometry (two appendix IV A of Pharmacopoeia of People's Republic of China version in 2010), at 450nm place, measure transmittance.
the infusion bag transmittance detected result that table 4, PP Pipe Compound of the present invention are made
Test-results shows, along with the increase of SEBS addition, the transmittance of infusion bag reduces gradually, the SEBS ratio contained due to the present invention is lower, transmittance is relatively high, is conducive to quality inspection personnel and medical and nursing work person and observes the visible foreign matters in liquid, improves the security that product is used.
Beneficial effect of the present invention is: infusion bag PP Pipe Compound SEBS content of the present invention is low, and transmittance is high, can be cross section that injection stretch blow moulding produces and provides the function of self-constriction completely for oval-shaped infusion bag; The bag of infusion bag of the present invention adopts solderless seam, greatly reduces the risk of weld leakage; Without adding white oil, safe in formula.
embodiment
Below in conjunction with embodiment, technical scheme of the present invention is described in detail, but is not limited to this.
embodiment 1: the preparation of material special for seamless polypropylene infusion bag of the present invention and infusion bag
The quality proportion relation of infusion bag PP Pipe Compound is:
Medical grade polypropylene 100 weight parts, medical grade SEBS(styrene-ethylene-butylene-styrene multipolymer) 3.0 weight parts.
The technique manufacture of material special for seamless polypropylene infusion bag comprises the steps:
(1) by formula, weigh;
(2) in high speed mixer by the raw material blending weighing up, mixing time is at 2～3min;
(3) mixed raw material is passed through to twin screw extruder extruding pelletization, granulation melt temperature is 170 ℃～190 ℃, and screw speed is 300～400rpm, more obtains infusion bag PP Pipe Compound by recirculated water cooling, air-dry, mechanical pelletizing;
Adopt the preparation method of seamless polypropylene infusion bag prepared by this PP Pipe Compound to be:
Under the air ambient through purifying, throw infusion bag PP Pipe Compound and enter injecting machine material tube, heat to 170 ℃～220 ℃ formation melts, under 130～180MPa high pressure, molten plastic is injected in bag mold tool and form tubular shape base, keep injection pressure also bag base to be carried out cooling simultaneously, open the bag base that mould takes out moulding; The bag base preparing is dropped in blow moulding machine hopper, and manager's base cylinder and mechanical manipulator are delivered to the preheating tunnel of heating, and bag base is heated to above 10 ℃～40 ℃ of softening temperature, pass into pressurized air and carry out blowing, open mould after cooling, obtain infusion bag.
The seamless polypropylene infusion bag making, cross section is oval, and the ratio of its major axis and minor axis is 2.5:1, and bag mean thickness is 0.35mm.
embodiment 2: the preparation of material special for seamless polypropylene infusion bag of the present invention
The quality proportion relation of infusion bag PP Pipe Compound is:
Medical grade polypropylene 100 weight parts, medical grade SEBS(styrene-ethylene-butylene-styrene multipolymer) 2.4 weight parts.
The technique manufacturing step of material special for seamless polypropylene infusion bag of the present invention is with embodiment 1, and the preparation method of seamless polypropylene infusion bag is with embodiment 1.
The seamless polypropylene infusion bag making, cross section is oval, and the ratio of its major axis and minor axis is 2.8:1, and bag mean thickness is 0.34mm.
embodiment 3: the preparation of material special for seamless polypropylene infusion bag of the present invention
The quality proportion relation of infusion bag PP Pipe Compound is:
Medical grade polypropylene 100 weight parts, medical grade SEBS(styrene-ethylene-butylene-styrene multipolymer) 1.0 weight parts.
The technique manufacturing step of material special for seamless polypropylene infusion bag of the present invention is with embodiment 1, and the preparation method of seamless polypropylene infusion bag is with embodiment 1.
The seamless polypropylene infusion bag making, cross section is oval, and the ratio of its major axis and minor axis is 3.0:1, and bag mean thickness is 0.33mm.
embodiment 4: the preparation of material special for seamless polypropylene infusion bag of the present invention
The quality proportion relation of infusion bag PP Pipe Compound is:
Medical grade polypropylene 100 weight parts, medical grade SEBS(styrene-ethylene-butylene-styrene multipolymer) 2.0 weight parts.
The technique manufacturing step of material special for seamless polypropylene infusion bag of the present invention is with embodiment 1, and the preparation method of seamless polypropylene infusion bag is with embodiment 1.
The seamless polypropylene infusion bag making, cross section is oval, and the ratio of its major axis and minor axis is 2.8:1, and bag mean thickness is 0.34mm.
embodiment 5: the preparation of material special for seamless polypropylene infusion bag of the present invention
The quality proportion relation of infusion bag PP Pipe Compound is:
Medical grade polypropylene 100 weight parts, medical grade SEBS(styrene-ethylene-butylene-styrene multipolymer) 4.0 weight parts.
The technique manufacturing step of material special for seamless polypropylene infusion bag of the present invention is with embodiment 1, and the preparation method of seamless polypropylene infusion bag is with embodiment 1.
The seamless polypropylene infusion bag making, cross section is oval, and the ratio of its major axis and minor axis is 2.6:1, and bag mean thickness is 0.35mm.
embodiment 6: the preparation of material special for seamless polypropylene infusion bag of the present invention
The quality proportion relation of infusion bag PP Pipe Compound is:
Medical grade polypropylene 100 weight parts, medical grade SEBS(styrene-ethylene-butylene-styrene multipolymer) 4.5 weight parts.
The technique manufacturing step of material special for seamless polypropylene infusion bag of the present invention is with embodiment 1, and the preparation method of seamless polypropylene infusion bag is with embodiment 1.
The seamless polypropylene infusion bag making, cross section is oval, and the ratio of its major axis and minor axis is 2.4:1, and bag mean thickness is 0.34mm.
Above embodiment is exemplarily described the present invention; but the specific embodiment of the invention is not subject to the restriction of foregoing; as long as adopted the transformation of the various unsubstantialities that method of the present invention design and technical scheme carry out; or without improving, design of the present invention and technical scheme are directly applied to other occasions, all within protection scope of the present invention.
Claims (1)
1. a material special for seamless polypropylene infusion bag, this PP Pipe Compound is comprised of polypropylene and SEBS, it is characterized in that, specifically consists of: polypropylene: 100 weight parts, SEBS:1.0～4.5 weight part.
2. material special for seamless polypropylene infusion bag as claimed in claim 1, is characterized in that material special for seamless polypropylene infusion bag consists of: polypropylene: 100 weight parts, SEBS:2.0～4.0 weight part.
3. material special for seamless polypropylene infusion bag as claimed in claim 2, is characterized in that material special for seamless polypropylene infusion bag consists of: polypropylene: 100 weight parts, SEBS:2.5～3.5 weight part.
4. material special for seamless polypropylene infusion bag as claimed in claim 2, is characterized in that material special for seamless polypropylene infusion bag consists of: polypropylene: 100 weight parts, SEBS:2.4 weight part.
5. material special for seamless polypropylene infusion bag as claimed in claim 3, is characterized in that material special for seamless polypropylene infusion bag consists of: polypropylene: 100 weight parts, SEBS:3.0 weight part.
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| CN201110450421.0A CN102585357B (en) | 2011-12-29 | 2011-12-29 | Material special for seamless polypropylene infusion bag |
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| CN101780855B (en) * | 2010-02-09 | 2014-06-18 | 南京大冢泰邦科技有限公司 | Five-layer coextrusion transfusion medicine packing film and manufacturing method thereof |
| CN101851370A (en) * | 2010-05-19 | 2010-10-06 | 安徽双鹤药业有限责任公司 | Material special for medicinal transfusion bag |
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