CN103087408A - Infusion bag capable of providing self-contraction function and special material for infusion bag - Google Patents
Infusion bag capable of providing self-contraction function and special material for infusion bag Download PDFInfo
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- CN103087408A CN103087408A CN2011103497313A CN201110349731A CN103087408A CN 103087408 A CN103087408 A CN 103087408A CN 2011103497313 A CN2011103497313 A CN 2011103497313A CN 201110349731 A CN201110349731 A CN 201110349731A CN 103087408 A CN103087408 A CN 103087408A
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- 238000001802 infusion Methods 0.000 title claims abstract description 103
- 239000000463 material Substances 0.000 title claims abstract description 13
- -1 polypropylene Polymers 0.000 claims abstract description 44
- 229920006124 polyolefin elastomer Polymers 0.000 claims abstract description 39
- 239000004743 Polypropylene Substances 0.000 claims abstract description 37
- 229920001155 polypropylene Polymers 0.000 claims abstract description 34
- 238000001816 cooling Methods 0.000 claims abstract description 25
- 239000002253 acid Substances 0.000 claims abstract description 21
- 239000002516 radical scavenger Substances 0.000 claims abstract description 21
- 239000002994 raw material Substances 0.000 claims abstract description 20
- 238000002156 mixing Methods 0.000 claims abstract description 17
- 238000000071 blow moulding Methods 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
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- 238000000034 method Methods 0.000 claims abstract description 7
- 150000001875 compounds Chemical class 0.000 claims description 48
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- 230000003647 oxidation Effects 0.000 claims description 18
- 238000007254 oxidation reaction Methods 0.000 claims description 18
- 238000005453 pelletization Methods 0.000 claims description 16
- 238000012360 testing method Methods 0.000 claims description 16
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 12
- 238000000465 moulding Methods 0.000 claims description 9
- 230000015572 biosynthetic process Effects 0.000 claims description 8
- 238000007664 blowing Methods 0.000 claims description 8
- 239000012467 final product Substances 0.000 claims description 8
- 238000005469 granulation Methods 0.000 claims description 8
- 230000003179 granulation Effects 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 8
- 239000007924 injection Substances 0.000 claims description 8
- 238000002347 injection Methods 0.000 claims description 8
- 239000000155 melt Substances 0.000 claims description 8
- 239000004033 plastic Substances 0.000 claims description 8
- 229920003023 plastic Polymers 0.000 claims description 8
- 150000004645 aluminates Chemical class 0.000 claims description 6
- 150000004677 hydrates Chemical class 0.000 claims description 6
- 239000001095 magnesium carbonate Substances 0.000 claims description 6
- 229960001708 magnesium carbonate Drugs 0.000 claims description 6
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 6
- 235000014380 magnesium carbonate Nutrition 0.000 claims description 6
- OUHCLAKJJGMPSW-UHFFFAOYSA-L magnesium;hydrogen carbonate;hydroxide Chemical compound O.[Mg+2].[O-]C([O-])=O OUHCLAKJJGMPSW-UHFFFAOYSA-L 0.000 claims description 6
- 235000019260 propionic acid Nutrition 0.000 claims description 6
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 6
- 239000002131 composite material Substances 0.000 claims description 5
- KWKAKUADMBZCLK-UHFFFAOYSA-N 1-octene Chemical compound CCCCCCC=C KWKAKUADMBZCLK-UHFFFAOYSA-N 0.000 claims description 4
- 238000007334 copolymerization reaction Methods 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 239000000178 monomer Substances 0.000 claims description 2
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 claims description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 238000001746 injection moulding Methods 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 abstract description 2
- 238000003466 welding Methods 0.000 abstract description 2
- 238000007605 air drying Methods 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
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- 229920001971 elastomer Polymers 0.000 abstract 1
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- 238000002360 preparation method Methods 0.000 description 13
- 101000748141 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 32 Proteins 0.000 description 10
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- 239000008354 sodium chloride injection Substances 0.000 description 7
- 229920006132 styrene block copolymer Polymers 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
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- 238000005516 engineering process Methods 0.000 description 5
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- 238000003556 assay Methods 0.000 description 4
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- 230000001988 toxicity Effects 0.000 description 4
- 231100000419 toxicity Toxicity 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 238000001125 extrusion Methods 0.000 description 3
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
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- 238000001514 detection method Methods 0.000 description 2
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- 239000000203 mixture Substances 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
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- 229920001935 styrene-ethylene-butadiene-styrene Polymers 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
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- 239000005977 Ethylene Substances 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical group C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
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- MEYZYGMYMLNUHJ-UHFFFAOYSA-N tunicamycin Natural products CC(C)CCCCCCCCCC=CC(=O)NC1C(O)C(O)C(CC(O)C2OC(C(O)C2O)N3C=CC(=O)NC3=O)OC1OC4OC(CO)C(O)C(O)C4NC(=O)C MEYZYGMYMLNUHJ-UHFFFAOYSA-N 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
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Abstract
The invention relates to an infusion bag capable of providing a self-contraction function and a material special for the infusion bag. The material special for the infusion bag comprises medical-grade high-temperature-resistant polypropylene, medical-grade polyolefin elastomer, antioxidant and acid scavenger. The process for manufacturing the infusion bag comprises the following steps: weighing according to the formula; uniformly mixing the raw materials; and then extruding and granulating through a double-screw extruder, cooling by circulating water, air-drying and mechanically granulating to obtain the finished product. According to the material special for the infusion bag, the POE elastomer is added into the raw materials, so that the flexibility of the infusion bag is improved, the self-contractible function can be provided for the infusion bag with the oval cross section produced by injection molding, stretching and blow molding processes, the bag body prepared from the material special for the infusion bag is free of welding seams, and the risk of liquid leakage is greatly reduced.
Description
Technical field
The present invention relates to a kind of infusion bag and infusion bag PP Pipe Compound thereof that the self-constriction function is provided.
Background technology
Medical non-PVC (polyvinyl chloride) transfusion flexible bag is mainly to be formed through the high temperature heat seal by three layers or five-layer co-squeezing film, present three-layer co-extruded infusion film or the main dependence on import of five-layer coextrusion transfusion film, and after the bag moulding, the leakage situation easily occurs in the weld, especially with the infusion connector weld; In addition, three layers or five-layer coextrusion transfusion film are generally by the binding agent combination between layers, and liquid in bag is formed potential pollution risk; Each tunic generally can increase gentle effect to reach by adding the elastomerics (as SEB etc.) that contains benzene, but this has equally also increased the security risk of infusion bag.
Existing infusion bag PP Pipe Compound probably is divided into two classes, and a class is pure polypropylene, and another kind of is to add the elastomeric modified polypropene of styrene block copolymer (as SEBS).Because pure polypropylene rigidity is larger, snappiness is relatively poor, therefore can not provide the self-constriction function for infusion bag.
For the modified polypropene that adds styrene block copolymer (as SEBS), facts have proved, styrene block copolymer and polyacrylic consistency are not good, its dispersion effect extreme difference of direct physical blend, must add man-hour a kind of oils (as white oil) just can reach certain mixture homogeneity adding, yet because the medicine that must cause in infusion bag that adds of small molecules oily substance is in direct contact with it, if the control of the amount of oily substance is improper like this, will increase the clinical application risk of infusion bag; Owing to unavoidably containing styrene monomer (being classified as carcinogenic substance by FDA) in styrene block copolymer, therefore be used in the potential risks that exist in medical infusion bags in addition; Rebound resilience due to styrene block copolymer is good at last, infusion bag should be avoided the blood back phenomenon as far as possible after requiring infusion-completed in clinical use, this just requires infusion bag itself to have good snappiness and non-rebound resilience, so styrene block copolymer is not the choosing of the best as the toughner of infusion bag.
It is verified that plain polypropylene infusion bottle cross section in the market mostly is circular (seeing Fig. 2) a large amount of clinical uses, its bottle self-constriction fully itself, still need to pass into air and could realize normal infusion, and through experiment confirm, the many height of toughner ratio that add in formula all can not make bottle realize complete self-constriction in infusion process.
Commercially available PP TYPE infusion bag can be realized the function (seeing Fig. 3) of complete self-constriction, is mainly because will realize that complete self-constriction function must possess two conditions: 1, cross section is for oval; 2, bag itself has certain snappiness.But commercially available PP TYPE infusion bag also has its shortcoming that can not evade at present, and namely the bag periphery needs through welding fabrication, and it is larger in transfer and transportation leakage risk.Therefore be badly in need of that a kind of cost is low, transfer and the little infusion bag with self-constriction function of transportation leakage risk.
Summary of the invention
The object of the invention is to provide a kind of infusion bag PP Pipe Compound that the self-constriction function is provided, and another purpose of the present invention is to provide the infusion bag of this infusion bag PP Pipe Compound preparation of a kind of use.
The present invention seeks to be achieved through the following technical solutions:
Infusion bag PP Pipe Compound composition material of the present invention is medical grade fire resistant polypropylene, medical grade polyolefin elastomer, oxidation inhibitor, acid scavenger.
In the present invention, the concrete quality proportioning of medical grade fire resistant polypropylene and medical grade polyolefin elastomer, oxidation inhibitor, acid scavenger is:
Medical grade fire resistant polypropylene: 80 weight parts～95 weight parts, medical grade polyolefin elastomer 5 weight parts～20 weight parts, oxidation inhibitor 0～0.2 weight part, acid scavenger 0.005～0.2 weight part; The consumption of above-mentioned PP Pipe Compound composition material adds up to 100 weight parts.
Preferably, medical grade fire resistant polypropylene: 85 weight parts～90 weight parts; Medical grade polyolefin elastomer 10 weight parts～15 weight parts, oxidation inhibitor 0.03～0.15 weight part, acid scavenger 0.01～0.1 weight part; The consumption of above-mentioned PP Pipe Compound composition material adds up to 100 weight parts.
Preferably, medical grade fire resistant polypropylene: 85.88 weight parts; Medical grade polyolefin elastomer 13.97 weight parts, oxidation inhibitor 0.12 weight part, acid scavenger 0.03 weight part.
Preferably, medical grade fire resistant polypropylene: 92 weight parts; Medical grade polyolefin elastomer 7.92 weight parts, acid scavenger 0.08 weight part.
Preferably, medical grade fire resistant polypropylene: 91.95 weight parts; Medical grade polyolefin elastomer 7.92 weight parts, oxidation inhibitor 0.05 weight part, acid scavenger 0.08 weight part.
Described oxidation inhibitor refers to [β-(3,5 di-t-butyl 4-hydroxyl-phenyl) propionic acid] pentaerythritol ester or tricresyl phosphite (2,4-di-tert-butyl) ester.
Described acid scavenger refers to aluminate hydrates magnesiumcarbonate.
Wherein, the melt flow index of medical grade fire resistant polypropylene should 5～10g/10min (test condition be 230 ℃/2.16kg), preferably, melt flow index should be 6～8g/10min (test condition be 230 ℃/2.16kg).
The medical grade polyolefin elastomer comprises POE and POP etc., and the copolymerization octene monomer content of medical grade polyolefin elastomer is between 15%～24%..
The technique manufacturing of infusion bag of the present invention comprises the steps:
(1) by the formula weighing;
(2) in high speed mixer with the raw material blending that weighs up, mixing time is at 2～3min;
(3) mixed raw material is passed through the twin screw extruder extruding pelletization, the granulation melt temperature is 170 ℃～190 ℃, and screw speed is 300～400rpm, more namely gets the infusion bag PP Pipe Compound by recirculated water cooling, air-dry, mechanical pelletizing; Under through the air ambient that purifies, throw the infusion bag PP Pipe Compound and enter injecting machine material tube, heat to 170 ℃～220 ℃ formation melts, molten plastic is injected in bag mold tool under 130～180MPa high pressure and form the tubular shape base, keep injection pressure also simultaneously the bag base to be carried out cooling, open the bag base that mould takes out moulding; The bag base for preparing is dropped in the blow moulding machine hopper, and manager's bottle cylinder and mechanical manipulator are delivered to the preheating tunnel of heating, and the bag base is heated to more than softening temperature 10 ℃～40 ℃, pass into pressurized air and carry out blowing, open mould after cooling, and get final product.
Infusion bag cross section of the present invention is oval.
Medical grade polyolefin elastomer (POE) belongs to polyolefin elastomer, is to adopt the ethene of metallocene catalyst and the thermoplastic elastomer that octene is realized in-situ polymerization, is characterized in:
(1) ethylene chain of the flexible chain coiled structure of octene and crystallization as the physical crosslinking point, makes the toughness of its existing excellence that good processibility be arranged again.
(2) there is no unsaturated double-bond in the POE molecular structure, have good ageing-resistant performance.
(3) POE narrow molecular weight distribution has mobility preferably, and is good with compatible polyolefin.
(4) good mobility can be improved the dispersion effect of filler, also can improve the weld mark strength of goods simultaneously.Along with the increase of POE content, shock strength and the elongation at break of system improve a lot.
Owing to only containing C, two kinds of elements of H in the POE chemical structure, do not contain unsaturated link(age) and strong polar link, stable chemical nature, toughening effect is good but its rebound resilience is not good, blood back phenomenon in the time of can also avoiding the infusion bag infusion-completed when can provide the self-constriction function for infusion bag as toughner, in addition, POE also includes on European Pharmacopoeia 3.1.3, therefore, the infusion bag PP Pipe Compound of the prepared POE of containing of the present invention can be used as the raw material of the medical infusion bags of desirable safety.
Infusion bag PP Pipe Compound of the present invention, add the POE elastomerics in raw material, increased the snappiness of " infusion bag ", the cross section that can be injection moulding, stretching, blow molding process production is oval-shaped infusion bag (seeing Fig. 4) but the function of self-constriction is provided, with the bag solderless seam of infusion bag PP Pipe Compound preparation of the present invention, greatly reduce the risk of leakage.
Description of drawings
Fig. 1 the present invention can provide the manufacturing process flow diagram of the infusion bag PP Pipe Compound of self-constriction function
Fig. 2 cross section is circular infusion bottle
The cross section of Fig. 3 PP TYPE infusion bag
Fig. 4 cross section is oval-shaped infusion bag
The chemical structure of Fig. 5 POE
Fig. 6 styrene block copolymer chemical structure
The below's experiment and embodiment are used for further illustrating but being not limited to the present invention.
Experimental example one: self-constriction effect detection of the present invention
infusion bag of the present invention (embodiment one preparation) with same specification, polypropylene transfusion bottle, three-layer extrusion film infusion bag is can sodium chloride injection (100ml respectively, 0.9g), respectively get 10 bags (bottles) and carry out the test of discharge opeing completeness under liftoff 1.2m height, must not insert exhaust needle or closed infusion set venting hole in the discharge opeing process, and make the flow regulator of transfusion device be in full-gear, transfusion needle thrusts combination cover fully, be considered as the discharge opeing terminal point when no longer instiling, the sodium chloride injection of extracting transfusion needle this moment and remaining in bag (bottle) body with syringe takes out quantitatively.The better discharge opeing residual quantity of self-constriction effect is less, otherwise larger, the results detailed in following table 1.
Table 1, discharge opeing residual quantity comparison report
Experimental example two, the present invention leak-off pocket rate after transport test detects:
Infusion bag of the present invention (embodiment one preparation), polypropylene transfusion bottle, three-layer extrusion film infusion bag difference can sodium chloride injection (100ml with same specification, 0.9g), neatly put respectively above-mentioned sample in the Corrugated Box of same size, 100 bags, every case (bottle), every layer of 40 case, totally 5 layers, amount to 200 casees, above-mentioned three kinds of samples are placed in respectively the test of transporting for long-distance in automobile.
Sample mail to Xinjiang Urumqi since on November 15th, 2010 from the Chengdu Xindu District, returns immediately after arrival, returned to Chengdu, company location Xindu District on December 8th, 2010, came and went to amount to approximately 24 days.
Detection method: transport complete after, Corrugated Box is opened and taken out respectively sample from outer bag, be placed on dry testing table, whether range estimation has leakage, records leakage bag number; As not leakage, test sample is placed on the universal testing machine platform, apply the approximately interior pressure of 20kpa, keep approximately 15s, observe whether leakage is arranged, and record leakage bag number.Test-results sees table 2 for details.
Table 2, leak-off pocket quantity statistics
Assay shows: stopping property of the present invention and polypropylene transfusion bottle are suitable, and are better than three-layer extrusion film infusion bag.
The biological test of experimental example three, infusion bag of the present invention
Infusion bag of the present invention (embodiment one preparation) is according to American Pharmacopeia USP32＜88〉and YBB00012003, YBB00032003, YBB00052003 standard test, assay meets the regulation of above-mentioned standard, assay sees table 3 for details.
Table 3, biological test of the present invention report
| Sequence number | The Interventions Requested title | Inspecting standard | Technical requirements | Assay |
| 1 | General toxicity (0.9% sodium chloride injection) | USP32<88> | Should be up to specification | Up to specification |
| 2 | General toxicity (poly(oxyethylene glycol) 400) | USP32<88> | Should be up to specification | Up to specification |
| 3 | General toxicity (ethanol: 0.9% sodium chloride injection=1: 20) | USP32<88> | Should be up to specification | Up to specification |
| 4 | General toxicity (vegetables oil) | USP32<88> | Should be up to specification | Up to specification |
| 5 | Intracutaneous stimulates (0.9% sodium chloride injection) | USP32<88> | Should be up to specification | Up to specification |
| 6 | Intracutaneous stimulates (poly(oxyethylene glycol) 400) | USP32<88> | Should be up to specification | Up to specification |
| 7 | Intracutaneous stimulates (ethanol: 0.9% sodium chloride injection=1: 20) | USP32<88> | Should be up to specification | Up to specification |
| 8 | Intracutaneous stimulates (vegetables oil) | USP32<88> | Should be up to specification | Up to specification |
| 9 | Implant | USP32<88> | Should be up to specification | Up to specification |
| 10 | Cytotoxicity | YBB00012003 | Should be up to specification | Up to specification |
| 11 | Sensitization test | YBB00052003 | Sensitivity response must not be crossed the I degree | Up to specification |
| 12 | Hemolytic test | YBB00032003 | Hemolysis rate must not cross 5% | 0.3％ |
Following experimental example and embodiment are used for further illustrating but being not limited to the present invention.
Embodiment 1: the preparation of infusion bag of the present invention
The quality proportion relation of infusion bag PP Pipe Compound is:
Medical grade fire resistant polypropylene: 86 kilograms; 14 kilograms of medical grade polyolefin elastomers, [β-(3,5 di-t-butyl 4-hydroxyl-phenyl) propionic acid] 0.12 kilogram of pentaerythritol ester, 0.03 kilogram, aluminate hydrates magnesiumcarbonate.
The preparation technology of infusion bag is:
(1) by the formula weighing;
(2) in high speed mixer with the raw material blending that weighs up, mixing time is at 2～3min;
(3) mixed raw material is passed through the twin screw extruder extruding pelletization, the granulation melt temperature is 170 ℃～190 ℃, and screw speed is 300～400rpm, more namely gets the infusion bag PP Pipe Compound by recirculated water cooling, air-dry, mechanical pelletizing; Under through the air ambient that purifies, the infusion bag PP Pipe Compound that throwing is up to the standards enters injecting machine material tube, heat (170 ℃～220 ℃) form melt, under high pressure (130～180MPa) inject formation tubular shape base in bag mold tool with molten plastic, keep injection pressure also simultaneously the bag base to be carried out cooling, open the bag base that mould takes out moulding; The bag base for preparing is dropped in the blow moulding machine hopper, and manager's bottle cylinder and mechanical manipulator are delivered to the preheating tunnel of heating, and the bag base is heated to more than softening temperature 10 ℃～40 ℃, pass into pressurized air and carry out blowing, open mould after cooling, and get final product.
Embodiment 2: the preparation of infusion bag of the present invention
The quality proportion relation of infusion bag PP Pipe Compound is:
Medical grade fire resistant polypropylene: 92 kilograms; 12 kilograms of medical grade polyolefin elastomers, [β-(3,5 di-t-butyl 4-hydroxyl-phenyl) propionic acid] 0.05 kilogram of pentaerythritol ester, 0.08 kilogram, aluminate hydrates magnesiumcarbonate.
The preparation technology of infusion bag is:
(1) by the formula weighing;
(2) in high speed mixer with the raw material blending that weighs up, mixing time is at 2～3min;
(3) mixed raw material is passed through the twin screw extruder extruding pelletization, the granulation melt temperature is 170～190 ℃, and screw speed is 300～400rpm, more namely gets the infusion bag PP Pipe Compound by recirculated water cooling, air-dry, mechanical pelletizing; Under through the air ambient that purifies, the infusion bag PP Pipe Compound that throwing is up to the standards enters injecting machine material tube, heat (170 ℃～220 ℃) form melt, under high pressure (130～180MPa) inject formation tubular shape base in bag mold tool with molten plastic, keep injection pressure also simultaneously the bag base to be carried out cooling, open the bag base that mould takes out moulding; The bag base for preparing is dropped in the blow moulding machine hopper, and manager's bottle cylinder and mechanical manipulator are delivered to the preheating tunnel of heating, and the bag base is heated to more than softening temperature 10 ℃～40 ℃, pass into pressurized air and carry out blowing, open mould after cooling, and get final product.
Embodiment 3: the preparation of infusion bag of the present invention
The quality proportion relation of infusion bag PP Pipe Compound is:
Medical grade fire resistant polypropylene: 82 kilograms; 17 kilograms of medical grade polyolefin elastomers, [β-(3,5 di-t-butyl 4-hydroxyl-phenyl) propionic acid] 0.14 kilogram of pentaerythritol ester, 0.15 kilogram, aluminate hydrates magnesiumcarbonate.
The preparation technology of infusion bag is:
(1) by the formula weighing;
(2) in high speed mixer with the raw material blending that weighs up, mixing time is at 2～3min;
(3) mixed raw material is passed through the twin screw extruder extruding pelletization, the granulation melt temperature is 170～190 ℃, and screw speed is 300～400rpm, more namely gets the infusion bag PP Pipe Compound by recirculated water cooling, air-dry, mechanical pelletizing; Under through the air ambient that purifies, the infusion bag PP Pipe Compound that throwing is up to the standards enters injecting machine material tube, heat (170 ℃～220 ℃) form melt, under high pressure (130～180MPa) inject formation tubular shape base in bag mold tool with molten plastic, keep injection pressure also simultaneously the bag base to be carried out cooling, open the bag base that mould takes out moulding; The bag base for preparing is dropped in the blow moulding machine hopper, and manager's bottle cylinder and mechanical manipulator are delivered to the preheating tunnel of heating, and the bag base is heated to more than softening temperature 10 ℃～40 ℃, pass into pressurized air and carry out blowing, open mould after cooling, and get final product.
Embodiment 4: the preparation of infusion bag of the present invention
The quality proportion relation of infusion bag PP Pipe Compound is:
Medical grade fire resistant polypropylene: 88 kilograms; 9 kilograms of medical grade polyolefin elastomers, [β-(3,5 di-t-butyl 4-hydroxyl-phenyl) propionic acid] 0.18 kilogram of pentaerythritol ester, 0.1 kilogram, aluminate hydrates magnesiumcarbonate.
The preparation technology of infusion bag is:
(1) by the formula weighing;
(2) in high speed mixer with the raw material blending that weighs up, mixing time is at 2～3min;
(3) mixed raw material is passed through the twin screw extruder extruding pelletization, the granulation melt temperature is 170～190 ℃, and screw speed is 300～400rpm, more namely gets the infusion bag PP Pipe Compound by recirculated water cooling, air-dry, mechanical pelletizing; Under through the air ambient that purifies, the infusion bag PP Pipe Compound that throwing is up to the standards enters injecting machine material tube, heat (170 ℃～220 ℃) form melt, under high pressure (130～180MPa) inject formation tubular shape base in bag mold tool with molten plastic, keep injection pressure also simultaneously the bag base to be carried out cooling, open the bag base that mould takes out moulding; The bag base for preparing is dropped in the blow moulding machine hopper, and manager's bottle cylinder and mechanical manipulator are delivered to the preheating tunnel of heating, and the bag base is heated to more than softening temperature 10 ℃～40 ℃, pass into pressurized air and carry out blowing, open mould after cooling, and get final product.
Claims (14)
1. the infusion bag PP Pipe Compound that the self-constriction function can be provided, is characterized in that this infusion bag PP Pipe Compound composition material is medical grade fire resistant polypropylene, medical grade polyolefin elastomer, oxidation inhibitor, acid scavenger.
2. the infusion bag PP Pipe Compound that the self-constriction function is provided as claimed in claim 1, is characterized in that the concrete quality proportioning of medical grade fire resistant polypropylene and medical grade polyolefin elastomer, oxidation inhibitor, acid scavenger is: the medical grade fire resistant polypropylene: 80 weight parts～95 weight parts, medical grade polyolefin elastomer 5 weight parts～20 weight parts, oxidation inhibitor 0～0.2 weight part, acid scavenger 0.005～0.2 weight part; The consumption of above-mentioned PP Pipe Compound composition material adds up to 100 weight parts.
3. the infusion bag PP Pipe Compound that the self-constriction function is provided as claimed in claim 1, is characterized in that the concrete quality proportioning of medical grade fire resistant polypropylene and medical grade polyolefin elastomer, oxidation inhibitor, acid scavenger is: the medical grade fire resistant polypropylene: 85 weight parts～90 weight parts, medical grade polyolefin elastomer 10 weight parts～15 weight parts, oxidation inhibitor 0.03～0.15 weight part, acid scavenger 0.01～0.1 weight part.
4. the infusion bag PP Pipe Compound that the self-constriction function is provided as claimed in claim 1, is characterized in that the concrete quality proportioning of medical grade fire resistant polypropylene and medical grade polyolefin elastomer, oxidation inhibitor, acid scavenger is: the medical grade fire resistant polypropylene: 85.88 weight parts, medical grade polyolefin elastomer 13.97 weight parts, oxidation inhibitor 0.12 weight part, acid scavenger 0.03 weight part.
5. the infusion bag PP Pipe Compound that the self-constriction function is provided as claimed in claim 1, is characterized in that the concrete quality proportioning of medical grade fire resistant polypropylene and medical grade polyolefin elastomer, oxidation inhibitor, acid scavenger is: 92 weight parts; Medical grade polyolefin elastomer 7.92 weight parts, acid scavenger 0.08 weight part.
6. the infusion bag PP Pipe Compound that the self-constriction function is provided as claimed in claim 1, is characterized in that the concrete quality proportioning of medical grade fire resistant polypropylene and medical grade polyolefin elastomer, oxidation inhibitor, acid scavenger is: the medical grade fire resistant polypropylene: 91.95 weight parts, medical grade polyolefin elastomer 7.92 weight parts, oxidation inhibitor 0.05 weight part, acid scavenger 0.08 weight part.
7. the described infusion bag PP Pipe Compound that the self-constriction function is provided as arbitrary in claim 1-6, it is characterized in that described oxidation inhibitor refers to [β-(3,5 di-t-butyl 4-hydroxyl-phenyl) propionic acid] pentaerythritol ester or tricresyl phosphite (2,4-di-tert-butyl) ester; Described acid scavenger refers to aluminate hydrates magnesiumcarbonate.
8. the described infusion bag PP Pipe Compound that the self-constriction function is provided as arbitrary in claim 1-6, is characterized in that the melt flow index of medical grade fire resistant polypropylene at 5～10g/10min, and test condition is 230 ℃/2.16kg.
9. the infusion bag PP Pipe Compound that the self-constriction function is provided as claimed in claim 7, is characterized in that the melt flow index of medical grade fire resistant polypropylene at 5～10g/10min, and test condition is 230 ℃/2.16kg.
10. the infusion bag PP Pipe Compound that the self-constriction function is provided as claimed in claim 8, the melt flow index that it is characterized in that the medical grade fire resistant polypropylene is 6～8g/10min, test condition is 230 ℃/2.16kg.
11. the described infusion bag PP Pipe Compound that the self-constriction function is provided as arbitrary in claim 1-6 is characterized in that the medical grade polyolefin elastomer comprises POE and POP, the copolymerization octene monomer content of medical grade polyolefin elastomer is between 15%～24%.
12. the described infusion bag PP Pipe Compound that the self-constriction function is provided as arbitrary in claim 1-6 prepares the method for infusion bag, it is characterized in that comprising the steps:
(1) by the formula weighing;
(2) in high speed mixer with the raw material blending that weighs up, mixing time is at 2～3min;
(3) mixed raw material is passed through the twin screw extruder extruding pelletization, the granulation melt temperature is 170 ℃～190 ℃, and screw speed is 300～400rpm, more namely gets the infusion bag PP Pipe Compound by recirculated water cooling, air-dry, mechanical pelletizing; Under through the air ambient that purifies, the infusion bag PP Pipe Compound that throwing is up to the standards enters injecting machine material tube, heat to 170 ℃～220 ℃ formation melts, molten plastic is injected in bag mold tool under 130～180MPa high pressure and form the tubular shape base, keep injection pressure also simultaneously the bag base to be carried out cooling, open the bag base that mould takes out moulding; The bag base for preparing is dropped in the blow moulding machine hopper, and manager's bottle cylinder and mechanical manipulator are delivered to the preheating tunnel of heating, and the bag base is heated to more than softening temperature 10 ℃～40 ℃, pass into pressurized air and carry out blowing, open mould after cooling, and get final product.
13. the infusion bag PP Pipe Compound that the self-constriction function is provided as claimed in claim 7 prepares the method for infusion bag, it is characterized in that comprising the steps:
(1) by the formula weighing;
(2) in high speed mixer with the raw material blending that weighs up, mixing time is at 2～3min;
(3) mixed raw material is passed through the twin screw extruder extruding pelletization, the granulation melt temperature is 170 ℃～190 ℃, and screw speed is 300～400rpm, more namely gets the infusion bag PP Pipe Compound by recirculated water cooling, air-dry, mechanical pelletizing; Under through the air ambient that purifies, the infusion bag PP Pipe Compound that throwing is up to the standards enters injecting machine material tube, heat to 170 ℃～220 ℃ formation melts, molten plastic is injected in bag mold tool under 130～180MPa high pressure and form the tubular shape base, keep injection pressure also simultaneously the bag base to be carried out cooling, open the bag base that mould takes out moulding; The bag base for preparing is dropped in the blow moulding machine hopper, and manager's bottle cylinder and mechanical manipulator are delivered to the preheating tunnel of heating, and the bag base is heated to more than softening temperature 10 ℃～40 ℃, pass into pressurized air and carry out blowing, open mould after cooling, and get final product.
14. the infusion bag PP Pipe Compound that the self-constriction function is provided as described in claim 9 or 10 prepares the method for infusion bag, it is characterized in that comprising the steps:
(1) by the formula weighing;
(2) in high speed mixer with the raw material blending that weighs up, mixing time is at 2～3min;
(3) mixed raw material is passed through the twin screw extruder extruding pelletization, the granulation melt temperature is 170 ℃～190 ℃, and screw speed is 300～400rpm, more namely gets the infusion bag PP Pipe Compound by recirculated water cooling, air-dry, mechanical pelletizing; Under through the air ambient that purifies, the infusion bag PP Pipe Compound that throwing is up to the standards enters injecting machine material tube, heat to 170 ℃～220 ℃ formation melts, molten plastic is injected in bag mold tool under 130～180MPa high pressure and form the tubular shape base, keep injection pressure also simultaneously the bag base to be carried out cooling, open the bag base that mould takes out moulding; The bag base for preparing is dropped in the blow moulding machine hopper, and manager's bottle cylinder and mechanical manipulator are delivered to the preheating tunnel of heating, and the bag base is heated to more than softening temperature 10 ℃～40 ℃, pass into pressurized air and carry out blowing, open mould after cooling, and get final product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110349731.3A CN103087408B (en) | 2011-11-08 | 2011-11-08 | Infusion bag capable of providing self-contraction function and special material for infusion bag |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110349731.3A CN103087408B (en) | 2011-11-08 | 2011-11-08 | Infusion bag capable of providing self-contraction function and special material for infusion bag |
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| CN103087408A true CN103087408A (en) | 2013-05-08 |
| CN103087408B CN103087408B (en) | 2016-06-22 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104497415A (en) * | 2014-11-28 | 2015-04-08 | 湖北恒泰橡塑有限公司 | Thermoplastic elastomer for transfusion bag and preparation method of thermoplastic elastomer for transfusion bag |
| CN108785077A (en) * | 2018-05-31 | 2018-11-13 | 湖北科伦药业有限公司 | A kind of Ribavirin ampoule bottle and its production technology |
| CN111171445A (en) * | 2020-01-14 | 2020-05-19 | 王玲 | Preparation method of soft infusion bag |
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| CN1676544A (en) * | 2004-04-02 | 2005-10-05 | 中国石化上海石油化工股份有限公司 | Polypropylene resin for manufacturing medical transfusion container |
| CN1803914A (en) * | 2005-01-07 | 2006-07-19 | 住友化学株式会社 | Polypropylene resin composition and formed article |
| CN102070834A (en) * | 2010-12-29 | 2011-05-25 | 上海日之升新技术发展有限公司 | High-performance odorless colorfast thermoplastic elastomer (TPE) and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1676544A (en) * | 2004-04-02 | 2005-10-05 | 中国石化上海石油化工股份有限公司 | Polypropylene resin for manufacturing medical transfusion container |
| CN1803914A (en) * | 2005-01-07 | 2006-07-19 | 住友化学株式会社 | Polypropylene resin composition and formed article |
| CN102070834A (en) * | 2010-12-29 | 2011-05-25 | 上海日之升新技术发展有限公司 | High-performance odorless colorfast thermoplastic elastomer (TPE) and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104497415A (en) * | 2014-11-28 | 2015-04-08 | 湖北恒泰橡塑有限公司 | Thermoplastic elastomer for transfusion bag and preparation method of thermoplastic elastomer for transfusion bag |
| CN104497415B (en) * | 2014-11-28 | 2017-07-21 | 湖北恒泰橡塑有限公司 | Infusion bag thermoplastic elastomer (TPE) and preparation method thereof |
| CN108785077A (en) * | 2018-05-31 | 2018-11-13 | 湖北科伦药业有限公司 | A kind of Ribavirin ampoule bottle and its production technology |
| CN111171445A (en) * | 2020-01-14 | 2020-05-19 | 王玲 | Preparation method of soft infusion bag |
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|---|---|
| CN103087408B (en) | 2016-06-22 |
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