CN102580069B - 用于治疗性免疫接种的含共聚物1的滴眼用疫苗 - Google Patents

用于治疗性免疫接种的含共聚物1的滴眼用疫苗 Download PDF

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Publication number
CN102580069B
CN102580069B CN201110438909.1A CN201110438909A CN102580069B CN 102580069 B CN102580069 B CN 102580069B CN 201110438909 A CN201110438909 A CN 201110438909A CN 102580069 B CN102580069 B CN 102580069B
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copolymer
disease
purposes
eye
iop
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CN102580069A (zh
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M·埃森巴奇-施瓦茨
S·巴卡拉斯
V·富加
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Yeda Research and Development Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/02Peptides of undefined number of amino acids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/193Colony stimulating factors [CSF]
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/2013IL-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • A61K38/217IFN-gamma
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
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    • A61K9/00Medicinal preparations characterised by special physical form
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Endocrinology (AREA)
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CN201110438909.1A 2003-01-07 2004-01-06 用于治疗性免疫接种的含共聚物1的滴眼用疫苗 Expired - Fee Related CN102580069B (zh)

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US43831003P 2003-01-07 2003-01-07
US60/438310 2003-01-07
CNA2004800062290A CN1758922A (zh) 2003-01-07 2004-01-06 用于治疗性免疫接种的含共聚物1的滴眼用疫苗

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CN102580069B true CN102580069B (zh) 2015-09-30

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CNA2004800062290A Pending CN1758922A (zh) 2003-01-07 2004-01-06 用于治疗性免疫接种的含共聚物1的滴眼用疫苗

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US (2) US20070248569A1 (https=)
EP (1) EP1583506B1 (https=)
JP (1) JP5291878B2 (https=)
CN (2) CN102580069B (https=)
AT (1) ATE548045T1 (https=)
AU (1) AU2004203772B2 (https=)
CA (1) CA2512735C (https=)
ES (1) ES2386435T3 (https=)
IL (1) IL169552A (https=)
MX (1) MXPA05007329A (https=)
WO (1) WO2004060265A2 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007264682B2 (en) * 2006-06-28 2012-09-06 Yeda Research & Development Co. Ltd Method of treatment of age-related macular degeneration
WO2009040814A1 (en) 2007-09-24 2009-04-02 Hadasit Medical Research Services & Development Ltd Use of copolymer 1 for treatment of muscular dystrophy
EP2326342B1 (en) 2008-08-15 2021-10-06 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods for using interferon gamma to absorb fluid from the subretinal space
US11673914B2 (en) 2009-11-10 2023-06-13 Allegro Pharmaceuticals, LLC Peptide therapies for reduction of macular thickening
MX346362B (es) 2009-11-10 2017-03-15 Allegro Pharmaceuticals Inc * Composiciones y metodos para inhibir la adhesion celular o dirigir agentes de diagnostico o terapeuticos a sitios de enlace rgd.
USRE49251E1 (en) 2010-01-04 2022-10-18 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
US8759302B2 (en) * 2010-03-16 2014-06-24 Teva Pharmaceutical Industries, Ltd. Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis
CA2814500A1 (en) 2010-10-11 2012-04-19 Teva Pharmaceutical Industries Ltd Cytokine biomarkers as predictive biomarkers of clinical response for glatiramer acetate
WO2012143924A1 (en) 2011-04-21 2012-10-26 Mapi Pharma Ltd. Random pentapolymer for treatment of autoimmune diseases
HK1200274A1 (en) 2011-10-10 2015-08-07 Teva Pharmaceutical Industries Ltd. Single nucleotide polymorphisms useful to predict clinical response for glatiramer acetate
WO2015038891A2 (en) * 2013-09-13 2015-03-19 The Penn State Research Foundation Functional peptide analogs of pedf
US12097292B2 (en) 2016-08-28 2024-09-24 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
CN109982712A (zh) 2016-08-31 2019-07-05 Mapi医药公司 包含醋酸格拉替雷的储库系统
CN106491614A (zh) * 2016-12-06 2017-03-15 郑州郑先医药科技有限公司 一种用于治疗脊髓损伤的西药组合及用途
EP3570867A4 (en) * 2017-01-19 2020-12-23 Allegro Pharmaceuticals, LLC THERAPEUTIC PEPTIDES AND NEUROPROTECTORS
CN110382052A (zh) 2017-03-26 2019-10-25 Mapi医药公司 用于治疗进展型形式的多发性硬化症的格拉替雷储库系统
US11692029B2 (en) 2018-03-05 2023-07-04 The Schepens Eye Research Institute, Inc. Therapy for glaucoma and optic neuropathy by targeting colony stimulating factors
US20230181458A1 (en) * 2020-04-30 2023-06-15 Jeffrey E. Koziol Micro dosing of viral vaccines

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE147633T1 (de) 1988-10-27 1997-02-15 Univ Minnesota Immunhilfsmittel aus liposome enthaltend lymphokin il -2
ZA93216B (en) 1992-01-17 1993-08-18 Solvay Animal Health Inc Vaccine containing acemannan as an adjuvant.
US5571515A (en) * 1994-04-18 1996-11-05 The Wistar Institute Of Anatomy & Biology Compositions and methods for use of IL-12 as an adjuvant
IL113812A (en) 1994-05-24 2000-06-29 Yeda Res & Dev Copolymer-1 pharmaceutical compositions containing it and its use
US6214791B1 (en) * 1997-01-10 2001-04-10 Yeda Research And Development Co. Ltd. Treatment of multiple sclerosis through ingestion or inhalation of copolymer-1
US6153182A (en) * 1997-12-19 2000-11-28 Uab Research Foundation Lymphotactin as an adjuvant
EP1054880A1 (en) * 1998-02-13 2000-11-29 Autoimmune, Inc. TREATMENT OF MULTIPLE SCLEROSIS USING COP-1 AND Th2-ENHANCING CYTOKINES
US6616925B1 (en) * 1998-04-02 2003-09-09 I.D.M. Immuno-Designed Molecules Combined preparation for the treatment of neoplasic diseases or of infectious diseases
CA2361377C (en) * 1999-02-05 2009-02-03 Alk-Abello A/S Novel mucosal delivery system
IL148247A0 (en) * 1999-08-24 2002-09-12 Teva Pharma A vaccine composition and method of using the same
JP4328050B2 (ja) 2000-01-20 2009-09-09 イエダ リサーチ アンド デベロップメント カンパニー リミテッド 神経保護療法のためのコポリマー1、関連ペプチド及びポリペプチドならびにそれらによって処理されたt細胞の使用
EP1294390B1 (en) * 2000-06-07 2006-01-04 YEDA RESEARCH AND DEVELOPMENT CO., Ltd. The use of copolymer 1 and related peptides and polypeptides and t cells treated therewith for neuroprotection from glutamate toxicity
US7351686B2 (en) 2001-12-06 2008-04-01 Yeda Research And Development Co. Ltd. Method for neuronal protection in amyotrophic lateral sclerosis by a vaccine comprising Copolymer-1 or Copolymer-1 related peptides
WO2005030955A1 (ja) 2003-09-29 2005-04-07 Chugai Seiyaku Kabushiki Kaisha Nk細胞に発現するタンパク質
JP4501562B2 (ja) 2004-07-09 2010-07-14 旭硝子株式会社 積層膜付き基材およびその製造方法

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CA2512735C (en) 2016-03-08
WO2004060265A2 (en) 2004-07-22
AU2004203772A1 (en) 2004-07-22
WO2004060265A3 (en) 2005-09-22
AU2004203772B2 (en) 2009-07-16
US8895501B2 (en) 2014-11-25
EP1583506A4 (en) 2009-01-07
CN1758922A (zh) 2006-04-12
MXPA05007329A (es) 2005-09-30
ES2386435T3 (es) 2012-08-21
EP1583506B1 (en) 2012-03-07
EP1583506A2 (en) 2005-10-12
CA2512735A1 (en) 2004-07-22
US20090214470A1 (en) 2009-08-27
IL169552A (en) 2012-05-31
JP2006515870A (ja) 2006-06-08
JP5291878B2 (ja) 2013-09-18
HK1084034A1 (en) 2006-07-21
ATE548045T1 (de) 2012-03-15
US20070248569A1 (en) 2007-10-25
CN102580069A (zh) 2012-07-18

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