CN102579825A - Compound hyacinth bletilla enema - Google Patents
Compound hyacinth bletilla enema Download PDFInfo
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- CN102579825A CN102579825A CN2012100451223A CN201210045122A CN102579825A CN 102579825 A CN102579825 A CN 102579825A CN 2012100451223 A CN2012100451223 A CN 2012100451223A CN 201210045122 A CN201210045122 A CN 201210045122A CN 102579825 A CN102579825 A CN 102579825A
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Abstract
The invention relates to a compound hyacinth bletilla enema for treating acute and chronic colitis, ulcerative colitis and ulcerative proctitis. The enema is prepared from the following components in parts by weight: 1-10 parts of berberine hydrochloride, 0.1-3 parts of procaine, 5-35 parts of chlorhexidine acetate, 0.5-5 parts of ephedrine, 1-10 parts of borneol and 10-50 parts of hyacinth bletilla. The enema provided by the invention has the effects of absorbing moisture, arresting bleeding, astringing intestine to correct diarrhea, removing rot muscles to promote tissue regeneration, clearing away heat and alleviating pain, diminishing inflammation, resisting infection and relieving mucosal hyperemia in the intestine, can be used for treating acute and chronic inflammations and ulcers in the recta and colon, and has the advantages of obvious curative effect, high operational convenience, quick effect taking, high safety, no pain and the like. The effective rate is up to 100%.
Description
Technical field
The present invention relates to medical invention field, be specifically related to a kind of compound recipe Pseudobulbus Bletillae (Rhizoma Bletillae) enema and preparation method thereof.
Background technology
Colitis is claimed nonspecific ulcerative colitis again, and how slow onset is, and state of an illness weight differs, and diarrhoea is cardinal symptom, discharges bloody purulent stool, mucosanguineous feces or hemafecia, often accompanies tenesmus, and the characteristics of meaning → defecation → alleviation of stomachache → are just arranged.
Mostly colitis stomachache generally is dull pain or angor often to be positioned at left lower quadrant or lower abdomen.Other performance has inappetence, abdominal distention, feels sick, vomiting and hepatomegaly etc.; Left lower quadrant can have tenderness, can touch the colon of spasm sometimes.Common General Symptoms becomes thin, weak, heating, anemia etc.Few part patient is arranged in the chronic course of disease; The state of an illness worsens suddenly or first attack just is fulminant, and performance is diarrhoea seriously, every day 10-30 time; Discharge contains blood, pus; Mucous feces, and hyperpyrexia, vomiting, tachycardia, depletion, dehydration, electrolyte disturbance, coma even colonic perforation are arranged, untimely treatment can cause death.
Chronic colitis belongs to a kind of of intestinal tract disease, is to be the anorectal disease of site of pathological change with colon, sigmoid colon and rectum.Symptom is that left lower quadrant is painful, diarrhoea, tenesmus, the time bad when just being stained with liquid, constipation down or having loose bowels alternately property generation, fashion, touching disconnected down, show effect repeatedly.
Chronic colitis patient often has symptoms such as diarrhoea, stomachache, abdominal distention, dyspepsia.Chinese medicine thinks that chronic colitis " diarrhoea " belongs to " chronic diarrhea " category, mainly due to insufficiency of the spleen and lose due to the normal fortune function.If the fluctuation person that promptly needs the defecation that is in a bad mood is " hyperactive liver-QI attacking the spleen "; And the person that all needs the defecation early morning every day then is " asthenia of both the spleen and kidney ".In treatment, need take the method for warm spleen invigorating sun, soothing liver and strengthening spleen and warming and recuperating the spleen and kidney respectively, assistant is with the relieving diarrhea with astringents medicine, and treating both the principal and secondary aspects of a disease often can be obtained curative effect preferably.
Ulcerative colitis is a kind of mucous membrane of colon and submucosal inflammatory process of being confined to.The sick multidigit that gets also may extend to descending colon in sigmoid colon and rectum, even whole colon.Pathology is very long, the Chang Fanfu outbreak.Primary disease is shown in any age, but 20-30 year sees at most.
Clinical manifestation: 1, onset is slow, is chronic, delay property, repeated relapsing more.2, digestive system performance: stomachache and diarrhoea are the most common, and stomachache is positioned at left lower quadrant, dull pain, angor.3, General Symptoms: anemia, become thin, hypoproteinemia, Water-Electrolyte is disorderly, anxiety.4, intestinal shows outward: arthritis is often arranged, erythema nodosum, chronic active hepatitis, oral ulcer etc.5, left lower quadrant tenderness; 6, the corresponding performance of complication.
Proctitis ulcerosa is a kind of common form of proctitis, generally shows as the rectum dysfunction clinically.Left lower quadrant pain, constipation and row hemafecia in a small amount are typical case's performances of proctitis ulcerosa.Sometimes proctitis ulcerosa hemafecia not, and just defecation frequency increases, and mostly occur (diarrhea before dawn) in the morning, arrange 2-3 not molding soft stool, then the same all the other times of one day with the normal person.Primary disease is severe bleeding not, also epicolic performance can be arranged, but reaches rarely, and the course of disease is intermittently outbreak, is difficult for healing, even chronic, canceration does not take place yet.
The medicine of the treatment gastroenteropathy on the existing market takes with Western medicine mainly that antibiotic carries out anti-inflammatory analgetic, anti-infective therapy is main, takes antibiotic and can only take stopgap measures and can not effect a permanent cure; Take for a long time; Harm to health is huge, and especially dysbacteriosis is uncertain.Chinese medicine compound such as gentamycin sulfate and bismuth subcarbonate capsules, the intestines and stomach are fitted capsule, intestinal health sheet, KUIYANGLING JIAONANG, can be pacified again, the intestines and stomach spirit sheet, Berberine Tablet, fragrant fluidization stagnate medicines such as sheet, whole intestinal ball; Have only the effect of short term efficacy or relief of symptoms, can not effect a radical cure, the course of treatment is long; Be difficult to cure, and compound recipe is comparatively general.
To the shortcoming of above-mentioned Chinese medicine, Western medicine, be badly in need of a kind of medicine of treating acute and chronic colitis, ulcerative colitis and proctitis ulcerosa.
Summary of the invention
The purpose of this invention is to provide a kind of effective enema of treating acute and chronic colitis, ulcerative colitis and proctitis ulcerosa.
Another object of the present invention has provided the method for preparing of above-mentioned enema.
Another order of the present invention has provided the application of above-mentioned enema.
The enema of the acute and chronic colitis of treatment provided by the invention, ulcerative colitis and proctitis ulcerosa; Composition by water and following weight portion is processed: berberine hydrochloride 1-10 part; Procaine 0.1-3 part; Chlorhexidine acetate 5-35 part, ephedrine 0.5-5 part, Borneolum Syntheticum 1-10 part and Pseudobulbus Bletillae (Rhizoma Bletillae) 10-50 part.
Preferably, this enema is processed by the composition of water and following weight portion: berberine hydrochloride 3-8 part, procaine 0.5-2 part, chlorhexidine acetate 10-30 part, ephedrine 1-3 part, Borneolum Syntheticum 3-8 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 20-40 part.
Further preferably, this enema is processed by the composition of water and following weight portion: 5 parts of berberine hydrochloride, 1.5 parts of procaines, 20 parts of chlorhexidine acetates, 2 parts of ephedrines, 30 parts of 5 parts of Borneolum Syntheticums and Pseudobulbus Bletillae (Rhizoma Bletillae).
The present invention also provides the method for preparing above-mentioned enema, and this method may further comprise the steps:
1) berberine hydrochloride, procaine, chlorhexidine acetate, ephedrine, Borneolum Syntheticum dosage are mixed according to the equivalent mode of progressively increasing after, oven dry is ground into fine powder, crosses the 40-400 mesh sieve, and is subsequent use;
2) with the weight ratio 1 of Rhizoma Bletillae powder by itself and water: 1-100 boils, and gets its supernatant after leaving standstill, and adds the fine powder of step 1) preparation, and mixing adds the entry mixing, both.
In the said method:
The weight ratio of Rhizoma Bletillae powder and water is 1: 20-70 further is preferably 1: 30-60.
Time of repose is 12-36 hour.
Said water is purified water, distilled water or water for injection.
The present invention also provides the application of above-mentioned enema in the medicine of preparation treatment acute colitis disease, chronic colitis disease, ulcerative colitis and proctitis ulcerosa.
The advantage of enema provided by the invention is:
1) enema provided by the invention can be attached to the intestinal wall affected part, has solved that enteral illness general oral medicine onset is slow, difficult to be absorbed and common enema is difficult for being attached to the defective of intestinal wall, and easy to use, do not decrease body.
2) enema provided by the invention has the effect that restrains moisture absorption, the astringing intestine to stop diarrhea that stops blooding, the necrotic tissue and promoting muscle growing that disappears, clearing away heat to alleviate pain, antiinflammatory infection, alleviates the enteral mucous hyperemia; Can be used for that treatment is straight, the acute and chronic inflammation of colonic, ulcer, have evident in efficacy, easy to use, onset rapidly, advantage such as safety is painless.Effective percentage reaches 100%.
The specific embodiment
Following examples are used to explain the present invention, but are not used for limiting scope of the present invention.
Embodiment 1: enema
1, form: berberine hydrochloride 5g, procaine 1.5g, chlorhexidine acetate 20g, ephedrine 2g, Borneolum Syntheticum 5g, Pseudobulbus Bletillae (Rhizoma Bletillae) 30g is with purified water preparation 1000ml enema.
2, method for preparing:
1) after the ratio dosage equivalent mode of progressively increasing formed in prescription of the coarse powder raw medicinal material of berberine hydrochloride, procaine, chlorhexidine acetate, ephedrine, Borneolum Syntheticum is mixed, dry, be ground into 200 mesh sieves that sieve behind the fine powder, subsequent use;
2) with Rhizoma Bletillae powder and water according to 1: 20 after slow fire boils 30 minutes, left standstill 24 hours, get its supernatant, add the fine powder after the above-mentioned pulverizing in proportion, mixing adds 1000ml purified water mixing, promptly gets.
Embodiment 2: enema
1, form: berberine hydrochloride 5g, procaine 3g, chlorhexidine acetate 10g, ephedrine 1g, Borneolum Syntheticum 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 20g is with water for injection preparation 1000ml enema.
2, method for preparing:
1) coarse powder of berberine hydrochloride, procaine, chlorhexidine acetate, ephedrine, Borneolum Syntheticum is formed consumption according to the equivalent method mix homogeneously that progressively increases according to it, dries, is ground into 200 mesh sieves that sieve behind the fine powder, and is subsequent use;
2) with Rhizoma Bletillae powder and water according to 1: 50 after slow fire boils 30 minutes, left standstill 12 hours, get its supernatant, add the fine powder after the above-mentioned pulverizing in proportion, mixing adds 1000ml water for injection mixing, promptly gets.
Embodiment 3: enema
1, form: berberine hydrochloride 8g, procaine 2g, chlorhexidine acetate 15g, ephedrine 3g, Borneolum Syntheticum 5g, Pseudobulbus Bletillae (Rhizoma Bletillae) 20g is with purified water preparation 1000ml enema.
2, method for preparing:
1) coarse powder of berberine hydrochloride, procaine, chlorhexidine acetate, ephedrine, Borneolum Syntheticum is formed consumption according to the equivalent method mix homogeneously that progressively increases according to it, dries, is ground into 60 mesh sieves that sieve behind the fine powder, and is subsequent use;
2) with Rhizoma Bletillae powder and water according to 1: 60 after slow fire boils 30 minutes, left standstill 24 hours, get its supernatant, add the fine powder after the above-mentioned pulverizing in proportion, mixing adds 1000ml purified water mixing, promptly gets.
Embodiment 4: enema
1, form: berberine hydrochloride 10g, procaine 1g, chlorhexidine acetate 30g, ephedrine 1g, Borneolum Syntheticum 8g, Pseudobulbus Bletillae (Rhizoma Bletillae) 25g is with purified water preparation 1000ml enema.
2, method for preparing:
1) coarse powder of berberine hydrochloride, procaine, chlorhexidine acetate, ephedrine, Borneolum Syntheticum is formed consumption according to the equivalent method mix homogeneously that progressively increases according to it, dries, is ground into 100 mesh sieves that sieve behind the fine powder, and is subsequent use;
2) with Rhizoma Bletillae powder and water according to 1: 45 after slow fire boils 30 minutes, left standstill 24 hours, get its supernatant, add the fine powder after the above-mentioned pulverizing in proportion, mixing adds 1000ml purified water mixing, promptly gets.
Embodiment 5: enema
1, form: berberine hydrochloride 3g, procaine 2g, chlorhexidine acetate 10g, ephedrine 3g, Borneolum Syntheticum 3g, Pseudobulbus Bletillae (Rhizoma Bletillae) 40g is with distilled water preparation 1000ml enema.
2, method for preparing:
1) coarse powder of berberine hydrochloride, procaine, chlorhexidine acetate, ephedrine, Borneolum Syntheticum is formed consumption according to the equivalent method mix homogeneously that progressively increases according to it, dries, is ground into 400 mesh sieves that sieve behind the fine powder, and is subsequent use;
2) with Rhizoma Bletillae powder and water according to 1: 30 after slow fire boils 30 minutes, left standstill 24 hours, get its supernatant, add the fine powder after the above-mentioned pulverizing in proportion, mixing adds 1000ml distilled water mixing, promptly gets.
Comparative Examples 1: enema
1, form: berberine hydrochloride 5g, procaine 1.5g, chlorhexidine acetate 20g, ephedrine 2g, Borneolum Syntheticum 5g is with purified water preparation 1000ml enema.
2, manufacture method
The coarse powder raw medicinal material of berberine hydrochloride, procaine, chlorhexidine acetate, ephedrine, Borneolum Syntheticum is after the dosage equivalent mode of progressively increasing is mixed in proportion, dries, is ground into behind the fine powder subsequent use; Fine powder after the above-mentioned pulverizing is added to 1000ml distilled water mixing, promptly get.
Experimental example: the clinical observation of treating acute and chronic colitis and enteral ulcer
1, clinical data:
540 examples are divided into two groups at random, treatment 1-5 group and each 90 example of matched group.
2, intend research method and the technology path that adopts
1) include the case standard in:
A consciousness is clear, the patient that can clearly express operating position;
The B age is at 18-65 between year;
C patient knows the inside story and agrees.
2) get rid of the case standard:
A. the enteropathy patient who merges malignant tumor;
B. suffers from serious skin disease patient;
C. can't take care of oneself, the slurred speech patient.
3, therapeutic evaluation standard:
(version in 2006) efficacy evaluation is as the criterion execution by " up-to-date hospital clinical medical diagnosis on disease foundation and healing improvement manual of standards ":
Produce effects: patient's colic symptoms disappears, and symptom of diarrhea disappears; Mirror is observed the enteral ulcer surface down and is obviously healed, and ulcer point obviously reduces.
Effectively: patient's stomachache alleviates, and diarrhoea takes a turn for the better; Mirror is observed the enteral ulcer surface down and is healed on a small quantity, and ulcer point is a small amount of to be reduced.
Invalid: treatment back above-mentioned symptom does not have improvement.
4, clinical observation:
The treatment group: according to the enema that embodiment 1-5 in the test method prepares, slowly pour into enemator every day and get rid of after stopping 10 minutes to enteral, 1 time on the one, 1 time 30 milliliters, logotype 14 days.
Matched group: according to the enema that Comparative Examples in the test method 1 prepares, slowly pour into enemator every day and get rid of after stopping 10 minutes to enteral, 1 time on the one, 1 time 30 milliliters, logotype 14 days.
5, result of the test: treatment 1-5 group is seen table 1-6 with the matched group Comparison of therapeutic.
Table 1: treat 1 group of experimental result
Table 2: treat 2 groups of experimental results
Table 3: treat 3 groups of experimental results
Table 4: treat 4 groups of experimental results
Table 5: treat 5 groups of experimental results
Table 6: matched group experimental result
Conclusion: shown in table 1-6, treatment group and matched group have notable difference on total effective rate, and from clinical observation, the treatment group is at hemostasis, short wound healing, reach in that medicinal liquid is remained in all obviously to be superior to matched group on the time of enteral affected part.
Though, used general explanation, the specific embodiment and test in the preceding text, the present invention has been done detailed description, on basis of the present invention, can to some modifications of do or improvement, this will be apparent to those skilled in the art.Therefore, these modifications or the improvement on the basis of not departing from spirit of the present invention, made all belong to the scope that requirement of the present invention is protected.
Claims (8)
- One kind the treatment acute and chronic colitis, ulcerative colitis and proctitis ulcerosa compound recipe Pseudobulbus Bletillae (Rhizoma Bletillae) enema; It is characterized in that; This enema is processed by the composition of water and following weight portion: berberine hydrochloride 1-10 part, procaine 0.1-3 part, chlorhexidine acetate 5-35 part; Ephedrine 0.5-5 part, Borneolum Syntheticum 1-10 part and Pseudobulbus Bletillae (Rhizoma Bletillae) 10-50 part.
- 2. enema according to claim 1 is characterized in that, this enema is processed by the composition of water and following weight portion: berberine hydrochloride 3-8 part; Procaine 0.5-2 part; Chlorhexidine acetate 10-30 part, ephedrine 1-3 part, Borneolum Syntheticum 3-8 part and Pseudobulbus Bletillae (Rhizoma Bletillae) 20-40 part.
- 3. enema according to claim 2 is characterized in that, this enema is processed by the composition of water and following weight portion: 5 parts of berberine hydrochloride, 1.5 parts of procaines, 20 parts of chlorhexidine acetates, 2 parts of ephedrines, 5 parts of Borneolum Syntheticums, 30 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
- 4. a method for preparing each said enema of claim 1-3 is characterized in that, this method may further comprise the steps:1) berberine hydrochloride, procaine, chlorhexidine acetate, ephedrine, Borneolum Syntheticum are mixed according to the equivalent mode of progressively increasing after, oven dry is ground into fine powder, crosses the 40-400 mesh sieve, and is subsequent use;2) with the weight ratio 1 of Rhizoma Bletillae powder by itself and water: 1-100 boils, and gets its supernatant after leaving standstill, and adds the fine powder of step 1) preparation, and mixing adds the entry mixing, promptly gets.
- 5. method according to claim 4 is characterized in that, the weight ratio of said Rhizoma Bletillae powder and water is 1: 20-70.
- 6. method according to claim 4 is characterized in that, the weight ratio of said Rhizoma Bletillae powder and water is for being 1: 30-60.
- 7. method according to claim 4 is characterized in that, said water is purified water, distilled water or water for injection.
- 8. the application in the medicine of each said enema preparation treatment acute colitis disease of claim 1-3, chronic colitis disease, ulcerative colitis and proctitis ulcerosa.
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| CN2012100451223A CN102579825A (en) | 2012-02-24 | 2012-02-24 | Compound hyacinth bletilla enema |
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| CN2012100451223A CN102579825A (en) | 2012-02-24 | 2012-02-24 | Compound hyacinth bletilla enema |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210393549A1 (en) * | 2018-09-08 | 2021-12-23 | Tan WEN | New use of R-enantiomer of adrenergic beta 2 receptor agonists for treatment of inflammatory bowel disease and its extra intestinal manifestations |
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|---|---|---|---|---|
| CN1278727C (en) * | 2003-01-02 | 2006-10-11 | 李又平 | Colonitis enteroclysm |
| CN101301380A (en) * | 2008-06-14 | 2008-11-12 | 河南九势制药有限公司 | Chinese medicinal compound formulation for treating ulcerative colitis |
| CN101919807A (en) * | 2010-07-16 | 2010-12-22 | 钟术光 | Suppository composition |
| CN101961454A (en) * | 2010-05-31 | 2011-02-02 | 王雪明 | Application of resina draconis to preparing compound enema for treating ulcerative colitis |
-
2012
- 2012-02-24 CN CN2012100451223A patent/CN102579825A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1278727C (en) * | 2003-01-02 | 2006-10-11 | 李又平 | Colonitis enteroclysm |
| CN101301380A (en) * | 2008-06-14 | 2008-11-12 | 河南九势制药有限公司 | Chinese medicinal compound formulation for treating ulcerative colitis |
| CN101961454A (en) * | 2010-05-31 | 2011-02-02 | 王雪明 | Application of resina draconis to preparing compound enema for treating ulcerative colitis |
| CN101919807A (en) * | 2010-07-16 | 2010-12-22 | 钟术光 | Suppository composition |
Non-Patent Citations (3)
| Title |
|---|
| 《中国医院药学杂志》 19841231 章顺德 复方白芨保留灌肠剂的配制 第25页左栏，附表 1-8 第4卷, 第3期 * |
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| 章顺德: "复方白芨保留灌肠剂的配制", 《中国医院药学杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210393549A1 (en) * | 2018-09-08 | 2021-12-23 | Tan WEN | New use of R-enantiomer of adrenergic beta 2 receptor agonists for treatment of inflammatory bowel disease and its extra intestinal manifestations |
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Application publication date: 20120718 |