Summary of the invention
It is not enough that the inventor finds that in daily medical diagnosis on disease process the medicine of existing treatment hypertension, hyperlipidemia, hyperglycemia exists above-mentioned defective; Through exploration development and clinical trial for many years; Also do not find relevant relevant report of the present invention, technical problem to be solved by this invention provides a kind of hypertension, hyperlipidemia, hyperglycemia good effect, little chrysanthemum fiber crops Chinese hypotensor preparation of side effect of treating.
For solving the problems of the technologies described above, the technical scheme that the present invention taked is that the chrysanthemum fiber crops Chinese hypotensor preparation of being developed is formulated by following weight portion raw material Chinese medicine:
Folium Apocyni Veneti 6-10 part, Radix Ginseng 3-7 part, Radix Notoginseng Rhizoma panacis majoris 2-5 part, Folium Kaki 6-9 part, green tea 1-4 part, Flos Chrysanthemi 5-10 part, Radix Puerariae 3-6 part, Radix Rhodiolae 2-6 part, Herb Gynostemmae Pentaphylli 4-7 part, Folium Nelumbinis 2-6 part.
Preferably, the technical scheme that the present invention taked is that the chrysanthemum fiber crops Chinese hypotensor preparation of being developed is formulated by following weight portion raw material Chinese medicine:
8 parts of Folium Apocyni Venetves, 5 parts of Radix Ginsengs, 3 parts of Radix Notoginseng Rhizoma panacis majoris, 7 parts of Folium Kaki, 2 parts of green teas, 8 parts of Flos Chrysanthemis, 4 parts of Radix Puerariaes, 5 parts of Radix Rhodiolaes, 5 parts of Herb Gynostemmae Pentaphylli, 4 parts on Folium Nelumbinis.
Chinese medicine composition of the present invention is that the inventor sums up out through clinical practice for many years, is monarch drug with Herba Apocyni veneti, Radix Ginseng, Radix Notoginseng Rhizoma panacis majoris, blood circulation promoting and blood stasis dispelling, clearing away heat and promoting diuresis, tonifying QI to produce body fluid; With Folium Kaki, green tea, Flos Chrysanthemi, Radix Puerariae is ministerial drug, and suppressing the hyperactive liver makes eye bright, dredge the meridian passage; With Radix Rhodiolae, Herb Gynostemmae Pentaphylli, Folium Nelumbinis is adjuvant drug, clearing away heat and eliminating dampness, benefiting QI for activating blood circulation.Said medicine collocation rationally, all medicine synergism, promoting blood circulation to remove blood stasis, the collateral dredging arteries and veins can bring high blood pressure down, blood fat and blood glucose effectively.Wherein:
Folium Apocyni Veneti, nature and flavor are sweet, bitter, cold.Return Liver Channel.Have suppressing the hyperactive liver and calm the nerves, the function of clearing away heat and promoting diuresis.Be used for dizziness due to hyperactivity of liver-YANG, palpitation and insomnia, edema oliguria; Hypertension, neurasthenia, nephritis edema.Modern medicine study shows; Folium Apocyni Veneti contains chemical analysis such as a large amount of flavone, triterpene, organic acid, aminoacid; Further research flavone chemical constitution is Quercetin and isoquercitin glycoside; Its pharmacological action has blood pressure lowering, blood fat reducing, increase coronary flow, to hypertension, hyperlipidemia, curative effect is preferably arranged, especially to dizzy symptom, improve sleep quality positive effect arranged; Have effects such as enhance immunity, preventing cold, antiasthmatic-antitussive, elimination depression, the skin care of invigorating blood circulation, relieving alcoholism and protecting the liver, degraded tobacco poisoning, vessel softening, relieving constipation diuresis simultaneously, above symptom is had the curative effect more than 80%.
Radix Ginseng is the drying of Araliaceae Radix Ginseng Panax ginseng C.A.Mey., sweet, the little hardship of nature and flavor, tepor.Return spleen, lung, the heart, kidney channel.Have strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid and nourishes blood, the effect of the Fructus Alpiniae Oxyphyllae of calming the nerves.Be used for weak body and prostration, the cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, deficiency of qi and blood, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb.Modern pharmacological research thinks that Radix Ginseng has sedation to the central nervous system, has the raising body's immunological function, has protection, blood pressure lowering, blood fat reducing, blood sugar lowering, antioxidative effect to cardiac muscle.
The Radix Notoginseng Rhizoma panacis majoris, sweet, the little hardship of nature and flavor, temperature.Return liver, stomach warp.Have the dissipating blood stasis hemostasis, the effect of subduing swelling and relieving pain cures mainly spitting of blood, spits blood, and epistaxis is had blood in stool, metrorrhagia, and traumatic hemorrhage, breast ventral spine pain, tumbling down swells and ache.The effect of Radix Notoginseng Rhizoma panacis majoris can blood vessel dilating, bring high blood pressure down microcirculation improvement, blood flow increasing, prevention and treatment heart and brain tissues ischemia, anoxia; Promote the blood cell metabolism, the balance adjustment blood cell; Hemostasis, blood circulation promoting and blood stasis dispelling; Two-ways regulation blood glucose, blood fat reducing, cholesterol, inhibition arteriosclerosis, slow down aging, enhancing human body immunity function.
Folium Kaki is the blade of Ebenaceae plant Fructus Kaki, and nature and flavor are bitter, and are cold in nature, nontoxic.Return lung meridian.Have the cough with asthma of controlling, lung qi expands, the effect of various internal hemorrhages.Flavonoid glycoside in the Folium Kaki can also increase coronary flow by blood pressure lowering, and Folium Kaki is made tea and can be strengthened blood vessel elasticity by vessel softening, and from the physiology adjust blood pressure, hypertension, hypotension are also had good effect; Can blood fat reducing, blood sugar lowering prevents cerebral arteriosclerosis, coronary heart disease etc.; Can the diuresis relieving constipation, detumescence, fat-reducing; Can the human body immunity improving function etc.
Green tea, the alkaloid in the green tea particularly aminophylline promote urine to form through the nephrectasia capillary vessel on the one hand, stimulate bladder, the discharge that helps urinating on the one hand.Modern medicine study proves, many person in middle and old age's commonly encountered diseases are all relevant with hyperlipidemia like cerebral hemorrhage, coronary heart disease, thrombosis etc.Lipid in the blood plasma comprises cholesterol, triglyceride and free fatty etc., catechin in the green tea can and contaminated with lipid, and excrete through feces.
Flos Chrysanthemi, Flos Chrysanthemi are the dry capitulums of feverfew Flos Chrysanthemi Chrysanthemum morifolium Ramat, are Chinese conventional Chinese medicines, and nature and flavor are sweet, bitter, be slightly cold.Return lung, Liver Channel.Have diffusing wind heat clearing away, suppressing the hyperactive liver makes eye bright, the effect of heat-clearing and toxic substances removing.Be used for anemopyretic cold, it is dizzy to have a headache, conjunctival congestion and swelling pain, and eyes is dim-sighted, sore and toxic.Modern pharmacological research shows, Flos Chrysanthemi has treatment coronary heart disease, brings high blood pressure down, prevents hyperlipidemia, antibiotic, antiviral, antiinflammatory, the anti-ageing multiple pharmacologically active of waiting for a long time.The expansible coronary artery of Flos Chrysanthemi, blood flow increasing brings high blood pressure down, to coronary heart disease, hypertension, arteriosclerosis, hypercholesterolemia disease all have better curative effect.
Radix Puerariae, nature and flavor are sweet, hot, cool.Return spleen, stomach, lung, warp.Has expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, rash, yang invigorating antidiarrheal, dredge the meridian passage, deinebriating effect.Be used for the fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea is had loose bowels, dizziness and headache, apoplectic hemiplegia, obstruction of qi in the chest and cardialgia, damage of the spleen and stomach caused by alcoholism.According to authoritative data books such as Compendium of Material Medica, " Chinese medicine voluminous dictionary ", " functional foods "; Radix Puerariae and goods thereof relieve inflammation or internal heat, toxin expelling, blood fat reducing, blood pressure lowering, cholesterol reducing, blood sugar lowering, fat-reducing, relieving constipation, prevention alzheimer disease; Prevent arteriosclerosis, prevent the good effect of cardiovascular and cerebrovascular diseases such as cerebral thrombosis.Radix Puerariae includes 12% flavone compound, and modern medicine study shows: the isoflavonoid puerarin in the Radix Puerariae has certain curative effect to hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular disease.
Radix Rhodiolae, nature and flavor are sweet, and hardship is flat.Return lung, heart channel.Has benefiting QI for activating blood circulation, the effect of promoting blood circulation and relievining asthma.Be used for blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, asthenia asthma.Pharmacy worker both domestic and external has in recent years carried out deep research to Radix Rhodiolae, has proposed Radix Rhodiolae and has had the effect of " the adaptation former state " of similar Radix Ginseng " strengthening the body resistance ", and also be superior to Radix Ginseng in some aspects, does not have the strong excessively deficiency of Radix Ginseng excitation.The contained effective ingredient of Radix Rhodiolae has the heart tonifying calmness, regulates the effect of metabolism, nervous system regulation and hormonal system two-ways regulation blood glucose, blood pressure; Be used to treat cerebrovascular disease; Diseases such as senile myocardial failure, diabetes, hypotension, it is empty, old, neural weak etc. also to be used for after being ill body.
Herb Gynostemmae Pentaphylli, nature and flavor are bitter, little sweet, and cold is nontoxic.Return lung, spleen, kidney channel.Has blood pressure regulation, blood fat reducing, blood sugar regulation, the effect of promotion urate excretion.Be used for blood fat, blood pressure, blood glucose, too high, the high or unusual person of blood uric acid.Herb Gynostemmae Pentaphylli tea also has more than 50 kind of Saponin except that containing sterol, sugar part, pigment, comprise tetracyclic triterpenoids compound.Gypenoside (GP), the same with the ginsenoside, can make platelet aggregation, prevent atherosclerosis, sufficient foster part of cell is provided.The assurance blood flow is unobstructed.Reduce the cardiovascular and cerebrovascular vessel sickness rate.Because it also contains the saponin different with the ginsenoside, so Herb Gynostemmae Pentaphylli has calmness again, the effect of YIN nourishing has no side effect, and is suitable long-term edible.Clinical trial certificate; Herb Gynostemmae Pentaphylli not only has health-care effects such as allaying tiredness, appetite strengthening, tranquilizing soporific, slow down aging; Aspect preventing and treating diseases such as hypertension, hyperlipidemia, coronary heart disease, diabetes, asthma, infectious hepatitis, migraine, remarkable effect is arranged also simultaneously.
Folium Nelumbinis, nature and flavor are bitter, and are flat.Return liver, spleen, stomach warp.Has clearing away heat and eliminating dampness, sending up the lucid YANG, the effect of cooling blood for hemostasis.Be used for the summer-heat excessive thirst, diarrhea due to summer heat and dampness, diarrhea due to hypofunction of the spleen, heat in blood is told nosebleed, the metrorrhagia of having blood in stool.The Chinese medicine modern study is the result show, Folium Nelumbinis has the effect of blood fat reducing, cholesterol reducing, and is effective to treatment hyperlipemia, atherosclerosis, coronary heart disease.At present, Folium Nelumbinis has been used to treat diseases such as hyperlipemia, obesity, fatty liver clinically.
Indication of the present invention: be used for the treatment of hypertension, hyperlipidemia and hyperglycemia and the relevant disease that causes thus.
The treatment by Chinese herbs cycle of the present invention: 2-6 the course of treatment, be 30 days per course of treatment.
Chinese medicine of the present invention can be made into the regular dosage form of technical field of Chinese patent medicine.
Medicine of the present invention is nontoxic, have no side effect, and shows that through a large amount of clinical practices can reduce patient's blood pressure, blood fat and blood glucose effectively fast, after patient took half a year continuously, patient's state of an illness of 90% did not recur.
Clinical trial data
Chrysanthemum fiber crops Chinese hypotensor preparation of the present invention is accepted patient's 162 examples for medical treatment through long-time observation on Clinical Application, and most of patient suffers from one or more in hypertension, hyperlipidemia, the hyperglycemia, 67 years old patient's mean age; Maximum patient is 83 years old, and minimum patient is 41 years old, and the male patient has 95 examples; Female patient 67 examples are taken Chinese medicine of the present invention, every day three times; Taking medicine before meal usefulness, is taken 2-6 the course of treatment continuously at 30 days one courses of treatment.Select medical history, the state of an illness, age, sex simultaneously and suitable with routine treatment suffer from hypertension, hyperlipidemia, hyperglycemic patients 93 examples as matched group; 63.5 years old patient's mean age; Maximum patient is 81 years old, and minimum patient is 43 years old, and the male patient has 56 examples; Female patient 37 examples compare observation according to the Therapeutic Method of routine.
The clinical diagnosis standard:
Hypertension: systolic pressure meets or exceeds 21.3kPa (160mmHg) and diastolic pressure meets or exceeds 12.7kPa (95mm Hg).
Hyperlipidemia: T-CHOL surpasses 5.72mmol/L in the serum, and triglyceride surpasses 1.70mmol/L.
Hyperglycemia: surpass 11.1 mmol/L above 7.0mmol/L or 2 hours after the meal blood glucose like fasting glucose.
Efficacy assessment standard:
Hypertension: recovery from illness, controlling of blood pressure is below horizontal at 140/90mmHg, does not have obvious clinical symptoms; Produce effects, controlling of blood pressure is below horizontal at 140/90mmHg, and obviously clinical symptoms is most of disappears; Effectively, controlling of blood pressure is below horizontal at 140/90mmHg, and obviously clinical symptoms partly disappears; Invalid, blood pressure does not reach above-mentioned level, and clinical symptoms is obvious.
Hyperlipidemia: recovery from illness, clinical symptoms, sign disappear or basic the disappearance, and the syndrome integration reduces >=95%; Produce effects, clinical symptoms, sign are obviously improved, and the syndrome integration reduces >=70%; Effectively, clinical symptoms, sign all take a favorable turn. and the syndrome integration reduces >=30%; Invalid, clinical symptoms, sign do not have obvious improvement, even increase the weight of, the syndrome integration reduces less than 30%.
Hyperglycemia: recovery from illness, fasting glucose and 2 hours after the meal blood glucose drop to normal range, or fasting glucose and 2 hours after the meal blood glucose values descend and surpass 50% before the treatment, and the glycolated hemoglobin value drops to normally; Produce effects, fasting glucose and 2 hours after the meal blood glucose drop to normal range, or fasting glucose and 2 hours after the meal blood glucose values descend and surpass 40% before the treatment, and the glycolated hemoglobin value drops to normally, or descend surpass treatment preceding 30%. Effectively, fasting glucose and 2 hours after the meal sugar descends and surpasses 20% before the treatment, but does not reach the produce effects standard, and the glycolated hemoglobin value descends and surpasses 10% before the treatment, but does not reach the produce effects standard; Invalid, tcm clinical practice symptom, sign all do not have obvious improvement, even increase the weight of, the disease integration reduces less than 30%; Fasting glucose and 2 hours after the meal blood glucose do not have decline, or descend and do not reach effective standard, and the glycolated hemoglobin value does not have decline, or descend and do not reach effective standard.
Efficacy result: treatment group and matched group curative effect relatively see the following form.
Group |
Case load |
Invalid |
Effectively |
Produce effects |
Cure |
Effective percentage |
Cure rate |
The treatment group |
162 |
4 |
29 |
76 |
53 |
98% |
33% |
Matched group |
93 |
13 |
14 |
47 |
19 |
86% |
20% |
Further prove through above clinical trial, Chinese medicine blood circulation promoting and blood stasis dispelling of the present invention, dredge the meridian passage, benefiting QI for activating blood circulation, tonifying QI to produce body fluid can bring high blood pressure down, blood fat and blood glucose effectively.
The specific embodiment
Chinese medicine of the present invention is formulated by following weight portion raw material Chinese medicine:
Folium Apocyni Veneti 6-10 part, Radix Ginseng 3-7 part, Radix Notoginseng Rhizoma panacis majoris 2-5 part, Folium Kaki 6-9 part, green tea 1-4 part, Flos Chrysanthemi 5-10 part, Radix Puerariae 3-6 part, Radix Rhodiolae 2-6 part, Herb Gynostemmae Pentaphylli 4-7 part, Folium Nelumbinis 2-6 part.
Embodiment 1
Chinese medicine of the present invention is formulated by following weight portion raw material Chinese medicine:
6 parts of Folium Apocyni Venetves, 3 parts of Radix Ginsengs, 2 parts of Radix Notoginseng Rhizoma panacis majoris, 6 parts of Folium Kaki, 1 part of green tea, 5 parts of Flos Chrysanthemis, 3 parts of Radix Puerariaes, 2 parts of Radix Rhodiolaes, 4 parts of Herb Gynostemmae Pentaphylli, 2 parts on Folium Nelumbinis.
Embodiment 2
10 parts of Folium Apocyni Venetves, 7 parts of Radix Ginsengs, 5 parts of Radix Notoginseng Rhizoma panacis majoris, 9 parts of Folium Kaki, 4 parts of green teas, 10 parts of Flos Chrysanthemis, 6 parts of Radix Puerariaes, 6 parts of Radix Rhodiolaes, 7 parts of Herb Gynostemmae Pentaphylli, 6 parts on Folium Nelumbinis.
Embodiment 3
Medicine is formulated by following weight portion raw material Chinese medicine among the present invention:
8 parts of Folium Apocyni Venetves, 5 parts of Radix Ginsengs, 3 parts of Radix Notoginseng Rhizoma panacis majoris, 7 parts of Folium Kaki, 2 parts of green teas, 8 parts of Flos Chrysanthemis, 4 parts of Radix Puerariaes, 5 parts of Radix Rhodiolaes, 5 parts of Herb Gynostemmae Pentaphylli, 4 parts on Folium Nelumbinis.
Enumerate some model cases below, so that curative effect of the present invention to be described.
Model case
Case 1. patients open XX, man, 64 years old, people from Nanyang; Be engaged in mental work before the retirement, inspection is hypertension before 9 years, and blood pressure often maintains 170/100mmHg; Often take the Western medicine blood pressure lowering, private prosecution is had a headache at ordinary times, dizzy, nauseating, insomnia and dreamful sleep, and electrocardiogram is abnormal change not; Edema of lower limbs, it is light to give up fat color, stringy and thready pulse.Inactive Western medicine changes clothes Chinese medicine of the present invention after course of treatment, and blood pressure drops is 130/90 mmHg, and continued was taken three months, and blood pressure often is stabilized in 125/93 mmHg, and drug withdrawal is blood pressure stabilization so far, does not occur the hypertension state of an illness again.
Case 2. patient field XX, man, 56 years old, Nanyang people from government's bank; Patient's private prosecution is dizzy to have half a year many, sensation of oppression over the chest with shortness of breath, and more very, warp is measured blood pressure 165/103 mmHg during work; Stringy and thready pulse, body of the tongue is dim red, through chemical examination, cholesterol 320mg/dl; Low density lipoprotein, LDL 153.9 mg/dl, three acid glycerols, 97 mg/dl are diagnosed as hyperlipidemia and vascular hypertension.After taking Chinese medicine one and a half months of the present invention, blood pressure drops to 126/85 mmHg, and the arteries and veins tongue is normal; Patient's sensory symptoms is eliminated basically, through chemical examination, cholesterol 290mg/dl; Low density lipoprotein, LDL 142.9 mg/dl, three acid glycerols, 80 mg/dl, drug withdrawal is so far; Blood pressure, blood fat are stablized, and patient health in order.
Case 3. patient Lee XX, woman, 71 years old, oil field, Nanyang retired employees; Patient's private prosecution myasthenia of limbs, shank is too fat to move, and hospital's chemical examination blood glucose is empty stomach 12mmol/L in the oil field, Nanyang; Glycosuria +++, be diagnosed as diabetes, with taking hypoglycemic medicine; Though blood glucose has decline, side effect is obvious, and blood glucose raises again after the drug withdrawal.Upon somebody's introduction, take Chinese medicine of the present invention after course of treatment, fasting glucose between 7-9 mmol/L, glycosuria ++; After continuing to take two courses of treatment, fasting glucose maintains between the 4-7 mmol/L, and glycosuria is normal; Shank swelling disappears, and spirit multiplication, drug withdrawal be not recurrence so far more than a year.
Case 4. patients are XX once, the woman, and 55 years old, people from Tanghe County, Nanyang, the figure becomes thin; Often dizzy, spiritlessness and weakness, insomnia forgetfulness, numb limbs and tense tendons, walking disorder; Cardiopalmus, warp is in the laboratory examination of local hospital, and T-CHOL and content of triglyceride are all high in the serum, and T-CHOL is 6.13mmol/L; Triglyceride is 1.90mmol/L, is diagnosed as the mixed type hyperlipidemia, takes a large amount of Western medicine, poor effect.After take course of treatment of Chinese medicine of the present invention, disease obviously changes, T-CHOL is 5.93mmol/L, triglyceride is 1.80mmol/L, continue to take a course of treatment after, T-CHOL is 5.30mmol/L, triglyceride is 1.58mmol/L, disease is eliminated basically.