CN102574869A - 2-氧代-1-吡咯烷基咪唑并噻二唑衍生物 - Google Patents
2-氧代-1-吡咯烷基咪唑并噻二唑衍生物 Download PDFInfo
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- CN102574869A CN102574869A CN2010800476319A CN201080047631A CN102574869A CN 102574869 A CN102574869 A CN 102574869A CN 2010800476319 A CN2010800476319 A CN 2010800476319A CN 201080047631 A CN201080047631 A CN 201080047631A CN 102574869 A CN102574869 A CN 102574869A
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- China
- Prior art keywords
- methyl
- pyrrolidin
- thiadiazoles
- imidazo
- trifluoromethyl
- Prior art date
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- -1 2-oxo-1-pyrrolidinyl imidazothiadiazole derivatives Chemical class 0.000 title claims description 37
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09173912.8 | 2009-10-23 | ||
| EP09173912 | 2009-10-23 | ||
| PCT/EP2010/006434 WO2011047860A1 (en) | 2009-10-23 | 2010-10-21 | 2-oxo-1-pyrrolidinyl imidazothiadiazole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102574869A true CN102574869A (zh) | 2012-07-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010800476319A Pending CN102574869A (zh) | 2009-10-23 | 2010-10-21 | 2-氧代-1-吡咯烷基咪唑并噻二唑衍生物 |
Country Status (30)
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107827870A (zh) * | 2017-10-24 | 2018-03-23 | 深圳探影生物科技有限公司 | 一种正电子药物[18f]fpmmp及其制备方法与中间体 |
| CN110869375A (zh) * | 2017-07-10 | 2020-03-06 | Ucb生物制药有限责任公司 | 2-氧代-1-咪唑烷基咪唑并噻二唑衍生物 |
| CN110869374A (zh) * | 2017-07-10 | 2020-03-06 | Ucb生物制药有限责任公司 | 2-氧代-1,3-噁唑烷基咪唑并噻二唑衍生物 |
| CN113549052A (zh) * | 2021-07-09 | 2021-10-26 | 首都医科大学脑重大疾病研究中心(北京脑重大疾病研究院) | 4-苯基-1-（吡啶-4-基甲基）吡咯烷-2-酮衍生物及其制备方法和应用 |
| CN119606962A (zh) * | 2025-02-17 | 2025-03-14 | 中国人民解放军总医院第三医学中心 | padsevonil在制备治疗TFE3重排性肾细胞癌的药物中的应用 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2699581T3 (en) * | 2011-04-18 | 2016-01-11 | Ucb Biopharma Sprl | 2-oxo-1-IMIDAZOLIDINYLIMIDAZOTHIADIAZOLDERIVATIVER |
| US9581654B2 (en) | 2013-02-12 | 2017-02-28 | Johnson Controls Technology Company | Vehicle battery monitoring system |
| KR20200126026A (ko) | 2014-01-21 | 2020-11-05 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
| MY203464A (en) | 2014-01-21 | 2024-06-28 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
| BR112020009880A2 (pt) * | 2017-12-12 | 2020-11-03 | UCB Biopharma SRL | derivados de 2-oxo-1-pirrolidinila imidazotiadiazol |
| EP3790885B1 (en) | 2018-05-08 | 2023-04-19 | UCB Biopharma SRL | 1-imidazothiadiazolo-2h-pyrrol-5-one derivatives |
| WO2025132331A1 (en) | 2023-12-21 | 2025-06-26 | UCB Biopharma SRL | Compounds for treatment of a hyperkinetic movement disorder |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1404469A (zh) * | 2000-02-23 | 2003-03-19 | Ucb公司 | 2－氧代－1－吡咯烷衍生物、其制备方法和用途 |
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| CN110869375A (zh) * | 2017-07-10 | 2020-03-06 | Ucb生物制药有限责任公司 | 2-氧代-1-咪唑烷基咪唑并噻二唑衍生物 |
| CN110869374A (zh) * | 2017-07-10 | 2020-03-06 | Ucb生物制药有限责任公司 | 2-氧代-1,3-噁唑烷基咪唑并噻二唑衍生物 |
| CN110869375B (zh) * | 2017-07-10 | 2022-08-30 | Ucb生物制药有限责任公司 | 2-氧代-1-咪唑烷基咪唑并噻二唑衍生物 |
| CN107827870A (zh) * | 2017-10-24 | 2018-03-23 | 深圳探影生物科技有限公司 | 一种正电子药物[18f]fpmmp及其制备方法与中间体 |
| CN107827870B (zh) * | 2017-10-24 | 2019-11-08 | 江苏仁明生物科技有限公司 | 一种正电子药物[18f]fpmmp及其制备方法与中间体 |
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| CN113549052B (zh) * | 2021-07-09 | 2022-09-02 | 首都医科大学脑重大疾病研究中心(北京脑重大疾病研究院) | 4-苯基-1-（吡啶-4-基甲基）吡咯烷-2-酮衍生物及其制备方法和应用 |
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