PE20121562A1 - Derivados de 2-oxo-1-pirrolidinila imidazotiadiazol - Google Patents
Derivados de 2-oxo-1-pirrolidinila imidazotiadiazolInfo
- Publication number
- PE20121562A1 PE20121562A1 PE2012000526A PE2012000526A PE20121562A1 PE 20121562 A1 PE20121562 A1 PE 20121562A1 PE 2012000526 A PE2012000526 A PE 2012000526A PE 2012000526 A PE2012000526 A PE 2012000526A PE 20121562 A1 PE20121562 A1 PE 20121562A1
- Authority
- PE
- Peru
- Prior art keywords
- metoximethyl
- ona
- imidazo
- pyrrolidin
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A UN COMPUESTO DERIVADO DE 2-OXO-1-PIRROLIDINIL IMIDAZOTIADIAZOL DE FORMULA (I) DONDE: R1 ES ALQUILO C1-4 QUE CONTIENE AL MENOS UN SUSTITUYENTE HALOGENO TALES COMO 2,2-DIFLUOROPROPILO, 2-CLORO-2,2-DIFLUOROETILO, ENTRE OTROS; R2 ES HALOGENO O ALQUILO C1-4 QUE CONTIENE AL MENOS UN SUSTITUYENTE HALOGENO TALES COMO CLORO, DIFLUOROMETILO, ENTRE OTROS; R3 ES ALQUILO C1-4 QUE CONTIENE AL MENOS UN SUSTITUYENTE HIDROXI O ALCOXI TALES COMO HIDROXIMETILO, METOXIMETILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-(2,2-DIFLUOROPROPIL)-1-{[2-(METOXIMETIL)-6-(TRIFLUOROMETIL)IMIDAZO[2,1-b][1,3,4]TIADIAZOL-5-IL]METIL}PIRROLIDIN-2-ONA; (4S)-4-(2-CLORO-2,2-DIFLUOROETIL)-1-{[2-(HIDROXIMETIL)-6-(TRIFLUOROMETIL)IMIDAZO[2,1-b][1,3,4]TIADIAZOL-5-IL]METIL}PIRROLIDIN-2-ONA; 1-{[6-CLORO-2-(METOXIMETIL)IMIDAZO[2,1-b][1,3,4]TIADIAZOL-5-IL]METIL}-4-(3,3,3-TRIFLUOROPROPIL)PIRROLIDIN-2-ONA; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHO COMPUESTO ES UTIL PARA EL TRATAMIENTO DE TRASTORNOS CONVULSIVOS, EPILEPSIA, CONVULSIONES REFRACTARIAS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09173912 | 2009-10-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20121562A1 true PE20121562A1 (es) | 2012-11-30 |
Family
ID=42034570
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2012000526A PE20121562A1 (es) | 2009-10-23 | 2010-10-21 | Derivados de 2-oxo-1-pirrolidinila imidazotiadiazol |
Country Status (29)
Country | Link |
---|---|
US (1) | US8822508B2 (es) |
EP (1) | EP2491045B1 (es) |
JP (1) | JP5808020B2 (es) |
KR (1) | KR20120102058A (es) |
CN (1) | CN102574869A (es) |
AR (1) | AR078722A1 (es) |
AU (1) | AU2010310100B2 (es) |
BR (1) | BR112012009310B8 (es) |
CA (1) | CA2778194C (es) |
CL (1) | CL2012001031A1 (es) |
CY (1) | CY1117288T1 (es) |
DK (1) | DK2491045T3 (es) |
EA (1) | EA201200616A1 (es) |
ES (1) | ES2565515T3 (es) |
HR (1) | HRP20160263T1 (es) |
HU (1) | HUE028668T2 (es) |
IL (1) | IL218696A0 (es) |
IN (1) | IN2012DN02793A (es) |
MA (1) | MA33679B1 (es) |
ME (1) | ME02355B (es) |
MX (1) | MX347070B (es) |
PE (1) | PE20121562A1 (es) |
PL (1) | PL2491045T3 (es) |
RS (1) | RS54595B1 (es) |
SI (1) | SI2491045T1 (es) |
SM (1) | SMT201600076B (es) |
TN (1) | TN2012000147A1 (es) |
TW (1) | TW201118103A (es) |
WO (1) | WO2011047860A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2699581T3 (en) * | 2011-04-18 | 2016-01-11 | Ucb Biopharma Sprl | 2-oxo-1-IMIDAZOLIDINYLIMIDAZOTHIADIAZOLDERIVATIVER |
US9581654B2 (en) | 2013-02-12 | 2017-02-28 | Johnson Controls Technology Company | Vehicle battery monitoring system |
HUE053734T2 (hu) | 2014-01-21 | 2021-07-28 | Janssen Pharmaceutica Nv | 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait tartalmazó kombinációk és alkalmazásuk |
EA201891617A3 (ru) | 2014-01-21 | 2019-04-30 | Янссен Фармацевтика Нв | Комбинации, содержащие положительные аллостерические модуляторы или ортостерические агонисты метаботропного глутаматергического рецептора 2 подтипа, и их применение |
RU2020104748A (ru) | 2017-07-10 | 2021-08-10 | Юсб Байофарма Срл | Производные 2-оксо-1-имидазолидинилимидазотиадиазола |
CA3069040A1 (en) | 2017-07-10 | 2019-01-17 | UCB Biopharma SRL | 2-oxo-1,3-oxazolidinyl imidazothiadiazole derivatives |
CN107827870B (zh) * | 2017-10-24 | 2019-11-08 | 江苏仁明生物科技有限公司 | 一种正电子药物[18f]fpmmp及其制备方法与中间体 |
WO2019115292A1 (en) | 2017-12-12 | 2019-06-20 | Ucb Biopharma Sprl | 2-oxo-1-pyrrolidinyl imidazothiadiazole derivatives |
CN112088160B (zh) * | 2018-05-08 | 2023-07-04 | Ucb生物制药有限责任公司 | 1-咪唑并噻二唑并-2h-吡咯-5-酮衍生物 |
CN113549052B (zh) * | 2021-07-09 | 2022-09-02 | 首都医科大学脑重大疾病研究中心(北京脑重大疾病研究院) | 4-苯基-1-(吡啶-4-基甲基)吡咯烷-2-酮衍生物及其制备方法和应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8412358D0 (en) | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
GB8412357D0 (en) | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
GB0004297D0 (en) * | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
ZA200604410B (en) | 2003-12-02 | 2008-09-25 | Ucb Sa | Imidazole derivatives, processes for preparing them and their uses |
JP2008542322A (ja) * | 2005-06-01 | 2008-11-27 | ユセベ ファルマ ソシエテ アノニム | 2−オキソ−1−ピロリジン誘導体 |
-
2010
- 2010-10-21 BR BR112012009310A patent/BR112012009310B8/pt active IP Right Grant
- 2010-10-21 PE PE2012000526A patent/PE20121562A1/es not_active Application Discontinuation
- 2010-10-21 EP EP10781818.9A patent/EP2491045B1/en active Active
- 2010-10-21 IN IN2793DEN2012 patent/IN2012DN02793A/en unknown
- 2010-10-21 US US13/502,546 patent/US8822508B2/en active Active
- 2010-10-21 MX MX2012003839A patent/MX347070B/es active IP Right Grant
- 2010-10-21 SI SI201031137T patent/SI2491045T1/sl unknown
- 2010-10-21 JP JP2012534579A patent/JP5808020B2/ja active Active
- 2010-10-21 DK DK10781818.9T patent/DK2491045T3/en active
- 2010-10-21 CA CA2778194A patent/CA2778194C/en active Active
- 2010-10-21 CN CN2010800476319A patent/CN102574869A/zh active Pending
- 2010-10-21 ES ES10781818.9T patent/ES2565515T3/es active Active
- 2010-10-21 WO PCT/EP2010/006434 patent/WO2011047860A1/en active Application Filing
- 2010-10-21 RS RS20160156A patent/RS54595B1/en unknown
- 2010-10-21 HU HUE10781818A patent/HUE028668T2/en unknown
- 2010-10-21 ME MEP-2016-44A patent/ME02355B/me unknown
- 2010-10-21 EA EA201200616A patent/EA201200616A1/ru unknown
- 2010-10-21 PL PL10781818T patent/PL2491045T3/pl unknown
- 2010-10-21 TW TW099135866A patent/TW201118103A/zh unknown
- 2010-10-21 AU AU2010310100A patent/AU2010310100B2/en active Active
- 2010-10-21 KR KR1020127013216A patent/KR20120102058A/ko not_active Application Discontinuation
- 2010-10-22 AR ARP100103864A patent/AR078722A1/es unknown
-
2012
- 2012-03-18 IL IL218696A patent/IL218696A0/en unknown
- 2012-03-29 TN TNP2012000147A patent/TN2012000147A1/en unknown
- 2012-04-19 MA MA34783A patent/MA33679B1/fr unknown
- 2012-04-23 CL CL2012001031A patent/CL2012001031A1/es unknown
-
2016
- 2016-03-14 HR HRP20160263TT patent/HRP20160263T1/hr unknown
- 2016-03-15 CY CY20161100217T patent/CY1117288T1/el unknown
- 2016-03-16 SM SM201600076T patent/SMT201600076B/xx unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |