CN102548945A - 作为抗癌剂的阿朴棉子酚酮衍生物 - Google Patents

作为抗癌剂的阿朴棉子酚酮衍生物 Download PDF

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CN102548945A
CN102548945A CN2010800451627A CN201080045162A CN102548945A CN 102548945 A CN102548945 A CN 102548945A CN 2010800451627 A CN2010800451627 A CN 2010800451627A CN 201080045162 A CN201080045162 A CN 201080045162A CN 102548945 A CN102548945 A CN 102548945A
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substituted
compound
bcl
replacing
cancer
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毛里西奥·佩莱基亚
魏军
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Sanford Burnham Prebys Medical Discovery Institute
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Sanford Burnham Prebys Medical Discovery Institute
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    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
    • C07C49/665—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system
    • C07C49/67—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system having two rings, e.g. tetralones
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    • C07C50/32—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having two rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2510/00—Detection of programmed cell death, i.e. apoptosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
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  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
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  • Urology & Nephrology (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2010800451627A 2009-10-08 2010-10-07 作为抗癌剂的阿朴棉子酚酮衍生物 Pending CN102548945A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24998209P 2009-10-08 2009-10-08
US61/249,982 2009-10-08
PCT/US2010/051845 WO2011044375A2 (en) 2009-10-08 2010-10-07 Apogossypolone derivatives as anticancer agents

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CN102548945A true CN102548945A (zh) 2012-07-04

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US (1) US8937193B2 (enExample)
EP (1) EP2485721A4 (enExample)
JP (1) JP2013507380A (enExample)
KR (1) KR20120060234A (enExample)
CN (1) CN102548945A (enExample)
AU (1) AU2010303324A1 (enExample)
BR (1) BR112012009388A2 (enExample)
CA (1) CA2773576C (enExample)
EA (1) EA201270347A1 (enExample)
IL (1) IL218500A0 (enExample)
IN (1) IN2012DN02816A (enExample)
MX (1) MX2012004064A (enExample)
WO (1) WO2011044375A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103265560A (zh) * 2013-05-17 2013-08-28 上海中科高等研究院 棉酚/棉酮衍生物及其制备方法和抗肿瘤药物中的应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013052608A1 (en) * 2011-10-07 2013-04-11 Sanford-Burnham Medical Research Institute Optically pure apogossypolone derivatives as pan-active inhibitors of anti-apoptotic bcl-2 family proteins
US10001485B2 (en) * 2011-11-07 2018-06-19 The Regents Of The University Of California Methods for sensitizing a quiescent cancer stem cell to a BCR-ABL inhibitor
CA2946538A1 (en) 2014-04-04 2015-10-08 Del Mar Pharmaceuticals Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer
JO3474B1 (ar) * 2014-08-29 2020-07-05 Amgen Inc مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1
US10195213B2 (en) 2015-03-13 2019-02-05 Unity Biotechnology, Inc. Chemical entities that kill senescent cells for use in treating age-related disease

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WO2005073158A1 (fr) * 2004-01-08 2005-08-11 Centre National De La Recherche Scientifique Derives du gossypol, leur methode d'obtention et leurs utilisations
CN101132783A (zh) * 2004-11-02 2008-02-27 密执安州立大学董事会 阿朴棉子酚酮及其用途
WO2009052443A1 (en) * 2007-10-19 2009-04-23 Burnham Institute For Medical Research Naphthalene-based inhibitors of anti-apoptotic proteins

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LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
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WO2005073158A1 (fr) * 2004-01-08 2005-08-11 Centre National De La Recherche Scientifique Derives du gossypol, leur methode d'obtention et leurs utilisations
CN101132783A (zh) * 2004-11-02 2008-02-27 密执安州立大学董事会 阿朴棉子酚酮及其用途
WO2009052443A1 (en) * 2007-10-19 2009-04-23 Burnham Institute For Medical Research Naphthalene-based inhibitors of anti-apoptotic proteins

Non-Patent Citations (2)

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ALAN A ARNOLD ET AL.: "Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model", 《MOLECULAR CANCER》, vol. 7, no. 20, 14 February 2008 (2008-02-14), pages 1 - 10, XP008153876, DOI: doi:10.1186/1476-4598-7-20 *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103265560A (zh) * 2013-05-17 2013-08-28 上海中科高等研究院 棉酚/棉酮衍生物及其制备方法和抗肿瘤药物中的应用

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US20110112112A1 (en) 2011-05-12
IN2012DN02816A (enExample) 2015-07-24
EA201270347A1 (ru) 2012-11-30
JP2013507380A (ja) 2013-03-04
CA2773576A1 (en) 2011-04-14
KR20120060234A (ko) 2012-06-11
US8937193B2 (en) 2015-01-20
IL218500A0 (en) 2012-07-31
EP2485721A4 (en) 2016-05-18
EP2485721A2 (en) 2012-08-15
AU2010303324A1 (en) 2012-04-05
CA2773576C (en) 2015-12-22
BR112012009388A2 (pt) 2016-06-14
WO2011044375A3 (en) 2011-06-03
MX2012004064A (es) 2012-06-08
WO2011044375A2 (en) 2011-04-14

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