KR20120060234A - 항암제로서의 아포고시폴론 유도체 - Google Patents
항암제로서의 아포고시폴론 유도체 Download PDFInfo
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- KR20120060234A KR20120060234A KR1020127010208A KR20127010208A KR20120060234A KR 20120060234 A KR20120060234 A KR 20120060234A KR 1020127010208 A KR1020127010208 A KR 1020127010208A KR 20127010208 A KR20127010208 A KR 20127010208A KR 20120060234 A KR20120060234 A KR 20120060234A
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- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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| WO2013052608A1 (en) * | 2011-10-07 | 2013-04-11 | Sanford-Burnham Medical Research Institute | Optically pure apogossypolone derivatives as pan-active inhibitors of anti-apoptotic bcl-2 family proteins |
| US10001485B2 (en) * | 2011-11-07 | 2018-06-19 | The Regents Of The University Of California | Methods for sensitizing a quiescent cancer stem cell to a BCR-ABL inhibitor |
| CN103265560B (zh) * | 2013-05-17 | 2016-05-04 | 中国科学院上海高等研究院 | 棉酚/棉酮衍生物及其制备方法和抗肿瘤药物中的应用 |
| KR102359214B1 (ko) | 2014-04-04 | 2022-02-07 | 델 마 파마슈티컬스 | 폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체 |
| JO3474B1 (ar) * | 2014-08-29 | 2020-07-05 | Amgen Inc | مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1 |
| US10195213B2 (en) | 2015-03-13 | 2019-02-05 | Unity Biotechnology, Inc. | Chemical entities that kill senescent cells for use in treating age-related disease |
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| US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
| LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
| US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
| US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| US5385936A (en) | 1990-07-12 | 1995-01-31 | The United States Of America As Represented By The Secretary Of The Department Of The Health And Human Services | Gossypol acetic acid for the treatment of cancer |
| ATE511856T1 (de) | 2000-03-13 | 2011-06-15 | Cornell Res Foundation Inc | Blockieren der leukozytenemigration und entzündung durch störung mit cd99/hec2 |
| ATE474568T1 (de) | 2001-05-30 | 2010-08-15 | Univ Michigan | Synergistische kombination von (-) -gossypol mit docetaxel oder paclitaxel zur behandlung von krebs. |
| PL1653943T6 (pl) | 2003-06-25 | 2009-02-27 | The Burnham Inst La Jolla | Pochodne katecholu do leczenia raka |
| FR2864955B1 (fr) * | 2004-01-08 | 2006-03-10 | Centre Nat Rech Scient | Derives du gossypol, leur methode d'obtention et leurs utilisations |
| US20060144723A1 (en) | 2004-11-02 | 2006-07-06 | Mary Fuller | Device for securing valuables |
| US9115061B2 (en) * | 2007-10-19 | 2015-08-25 | Burnham Institute For Medical Research | Naphthalene-based inhibitors of anti-apoptotic proteins |
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| WO2011044375A2 (en) | 2011-04-14 |
| IL218500A0 (en) | 2012-07-31 |
| BR112012009388A2 (pt) | 2016-06-14 |
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| WO2011044375A3 (en) | 2011-06-03 |
| AU2010303324A1 (en) | 2012-04-05 |
| EA201270347A1 (ru) | 2012-11-30 |
| JP2013507380A (ja) | 2013-03-04 |
| CA2773576A1 (en) | 2011-04-14 |
| EP2485721A4 (en) | 2016-05-18 |
| IN2012DN02816A (enExample) | 2015-07-24 |
| US20110112112A1 (en) | 2011-05-12 |
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| MX2012004064A (es) | 2012-06-08 |
| EP2485721A2 (en) | 2012-08-15 |
| CA2773576C (en) | 2015-12-22 |
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