CN102526612B - Traditional Chinese medicine composite for curing angina pectoris - Google Patents
Traditional Chinese medicine composite for curing angina pectoris Download PDFInfo
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- CN102526612B CN102526612B CN2011104533459A CN201110453345A CN102526612B CN 102526612 B CN102526612 B CN 102526612B CN 2011104533459 A CN2011104533459 A CN 2011104533459A CN 201110453345 A CN201110453345 A CN 201110453345A CN 102526612 B CN102526612 B CN 102526612B
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- angina pectoris
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Abstract
The invention discloses a traditional Chinese medicine composite for curing angina pectoris. The angina pectoris belongs to a range of 'chest apoplexy', 'cardiopalmus' and the like. The pathogenisis of the angina pectoris is deficiency in origin and excess in superficiality, wherein the deficiency in origin is yin-yang qi-blood deficiency, the excess in superficiality is qi stagnation, blood stagnate, phlegm, cold retention and the like, and qi deficiency and blood stagnation are clinical common types. The traditional Chinese medicine composite chooses codonopsis pilosula, astragalus mongholicus, mulberry, ligusticum walichii, radix curcumae, trogopterus dung, rose, semen litchi and agilawood to be produced into decoction in a hospital drug manufacturing room to supply to patients to take. Hospital clinical tests show that the traditional Chinese medicine composite is more excellent in treatment than a comparison group, has no obvious side effect, is safe and effective to cure angina pectoris and is worth popularizing and applying.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine preparation for the treatment of angina pectoris.
Background technology
Coronary heart disease is by coronary atherosclerosis, and blood supply of cardiac muscle and demand dysequilibrium bring out, and can cause angina pectoris, arrhythmia etc.Be mainly in the mid-aged population, also present at present the trend of rejuvenation, it is modal to be exactly angina pectoris, and that symptom shows as is nervous, breathe hard, dizziness etc.At present, the clinical medicine for the disease treatment of angina pectoris class of doctor trained in Western medicine mainly lays particular emphasis on the alleviation of acute symptom as nitroglycerin, persantin etc., and the treatment of the cause of disease is still lacked effective means, and the toxic and side effects of its medicine is also bigger.And the used Chinese patent medicine for the treatment of angina pectoris in the present clinical practice of the traditional Chinese medical science also exists the defective that medication is not comprehensive, curative effect is low, onset is slow as FUFANG DANSHEN PIAN, DANQI PIAN etc., and therefore, therapeutic effect is unsatisfactory.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of angina pectoris.Angina pectoris belongs to categories such as the traditional Chinese medical science " thoracic obstruction ", " cardiopalmus ".Its pathogenesis is deficiency in origin and excess in superficiality, and it is empty that deficiency in origin is that yang blood and qi loses, and mark is real to be that the stagnation of QI, blood stasis, expectorant are turbid, YIN-cold etc., and wherein Qi deficiency blood stasis type is clinical common type, for QI-blood circulation not smooth, due to the heart arteries and veins impatency.
The objective of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this treatment angina pectoris is made by following parts by weight of Chinese traditional medicine: Radix Codonopsis 8-12 part, Radix Astragali 10-15 part, Fructus Mori 10-15 part, Rhizoma Chuanxiong 15-20 part, Radix Curcumae 8-12 part, Oletum Trogopterori 9-12 part, Flos Rosae Rugosae 15-20 part, Semen Litchi 10-15 part, Lignum Aquilariae Resinatum 7-9 part.
Preferably, the Chinese medicine composition of this treatment angina pectoris is made by following parts by weight of Chinese traditional medicine: 10 parts of Radix Codonopsis, 13 parts of the Radixs Astragali, 13 parts of Fructus Mori, 17 parts of Rhizoma Chuanxiongs, 10 parts of Radix Curcumaes, 11 parts of Oletum Trogopteroris, 17 parts of Flos Rosae Rugosaes, 13 parts of Semen Litchis, 8 parts of Lignum Aquilariae Resinatum.
Above-mentioned Chinese medicine is fried in shallow oil into decoction by traditional method.
Radix Codonopsis invigorating the spleen and replenishing QI in the side, the spleen invigorating lung benefiting; Radix Codonopsis has the myocardial contraction of enhancing, increases cardiac output, antishock effect.Can obviously increase cardiac output and not influence heart rate for the anesthetized cat intravenous injection with the extract of Radix Codonopsis.The Radix Astragali has cardiotonic, and the heart contraction amplitude is increased, and output increases.The Fructus Mori YIN nourishing of enriching blood is promoted the production of body fluid and is moisturized; Fructus Mori has effect of gain to spleen, and reaction has potentiation to hemolytic, can prevent human body artery sclerosis, skeleton arthrosclerosis, enhances metabolism.The Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping; The Radix Curcumae regulating qi to disperse stagnation, heart fire-clearing upset-relieving.The Oletum Trogopterori promoting blood circulation to remove blood stasis is used for trusted subordinate's congestion and has a pain dysmenorrhea, blood stasis amenorrhea; Oletum Trogopterori 20mg/kg femoral artery injects anesthesia Canis familiaris L. femoral artery blood flow is increased, and vascular resistance reduces.Flos Rosae Rugosae promoting QI circulation for relieving depression, and blood, pain relieving; Have strong liver and nourishing stomach, promoting blood flow to regulate menstruation, loosening bowel to relieve constipation, the effect of resolving stagnation for tranquilization can chill out, balance endocrine, the gas of enriching blood, liver and stomach be had the effect of conditioning.The Semen Litchi promoting QI to circulate and dispersing the agglomeration of the pathogens, the cold relieving pain relieving; The Lignum Aquilariae Resinatum promoting the circulation of QI to relieve pain, the warming the kidney improving inspiration by invigorating kidney-QI.
Clinical data
1, physical data
120 examples are my the angina pectoris patient that in April, 2007-2008, year December was made a definite diagnosis of institute.Be divided into two groups at random, 60 examples are organized in treatment, male's 34 examples, women's 26 examples; Age 43-70 year, 56 years old mean age; The course of disease 4 months-18 years, average 7.5 years; Stable angina pectoris 32 examples wherein, unstable angina pectoris 28 examples.Matched group 60 examples, male's 32 examples, women's 28 examples; Age 41-72 year, average 58 years old; The course of disease 5 months-16 years, average 6.5 years.Stable angina pectoris 31 examples wherein, unstable angina pectoris 29 examples.Get rid of acute myocardial infarction, the heart disease of other types, gestation and women breast-feeding their children, hepatic and kidney function obstacle reach this medicine autopath.There was no significant differences (P＞0.05) such as two groups of ages, sex, angina pectoris type and orders of severity, the course of disease have comparability.
2, observation index
Observe uncomfortable in chest before and after the treatment, cardiopalmus, breathe hard, traditional Chinese medical science signs such as dizzy, dizzy, tinnitus, asthenia, body of the tongue, tongue fur, pulse condition; The change of the degree of the number of times of angina pectoris attacks every day, persistent period, outbreak; The variation of blood pressure, heart rate, the rhythm of the heart; The variation of resting electrocardiogram.
3, Therapeutic Method
The treatment group adopts Chinese medicine preparation of the present invention, and medicine is formed: Radix Codonopsis 10g, Radix Astragali 13g, Fructus Mori 13g, Rhizoma Chuanxiong 17g, Radix Curcumae 10g, Oletum Trogopterori 11g, Flos Rosae Rugosae 17g, Semen Litchi 13g, Lignum Aquilariae Resinatum 8g, make decoction, and take every day at twice.3 weeks were a course for the treatment of.Matched group gives FUFANG DANSHEN PIAN (GuangZhou BaiYunshan Chinese Medicine Factory production), and each 3, oral every day 3 times, 3 weeks were a course for the treatment of.
4, curative effect determinate standard
(1) curative effect to treat angina pectoris criterion: produce effects: equal tired degree does not cause that uncomfortable in chest, angina pectoris or angina pectoris attacks number of times are less than more than 80%.Effectively: uncomfortable in chest, angina pectoris attacks number of times reduces 50%～80%.Invalid: uncomfortable in chest, angina pectoris attacks number of times reduces less than 50%.
(2) ECG curative effect criterion: produce effects: tranquillization ECG recovers normal, and inferior limiting quantity exercise test transfers feminine gender or exercise tolerance rising secondary to by the positive.Effectively: tranquillization ECG ischemic ST descends.More than the treatment back rise 1.5mm, but abnormal, or the negative T wave that mainly leads shoals and reaches 50% or more or the T ripple is transferred to uprightly or exercise tolerance rising one-level by smooth.Invalid: tranquillization or inferior limiting quantity exercise test ECG are preceding basic identical with treatment.
5, therapeutic outcome
(1) curative effect to treat angina pectoris is relatively: 60 examples are organized in treatment, produce effects 28 examples (46.7%) wherein, and effective 29 examples (48.3%), invalid 3 examples (5.0%), total effective rate is 95.0%; Matched group 60 examples, produce effects 24 examples (40.0%) wherein, effective 25 examples (41.7%), invalid 11 examples (18.3%), total effective rate is 81.7%; Treatment group angina pectoris symptom improves total effective rate and obviously is better than matched group (P＜0.01).
(2) electrocardiogram changes relatively: 60 examples are organized in treatment, produce effects 27 examples (45.0%) wherein, and effective 26 examples (43.3%), invalid 7 examples (11.7%), total effective rate is 88.3%; Matched group 60 examples, produce effects 19 examples (31.7%) wherein, effective 24 examples (40.0%), invalid 17 examples (28.3%), total effective rate is 71.7%; Treatment group electrocardiogram improves total effective rate and is better than matched group (P＜0.05).
The specific embodiment
Embodiment one: take by weighing Radix Codonopsis 10g, Radix Astragali 13g, Fructus Mori 13g, Rhizoma Chuanxiong 17g, Radix Curcumae 10g, Oletum Trogopterori 11g, Flos Rosae Rugosae 17g, Semen Litchi 13g, Lignum Aquilariae Resinatum 8g, make decoction, take every day at twice.3 weeks were a course for the treatment of.
Embodiment two: take by weighing Radix Codonopsis 8g, Radix Astragali 15g, Fructus Mori 10g, Rhizoma Chuanxiong 20g, Radix Curcumae 8g, Oletum Trogopterori 9g, Flos Rosae Rugosae 15g, Semen Litchi 15g, Lignum Aquilariae Resinatum 9g, make decoction, take every day at twice.3 weeks were a course for the treatment of.
Embodiment three: take by weighing Radix Codonopsis 12g, Radix Astragali 10g, Fructus Mori 15g, Rhizoma Chuanxiong 15g, Radix Curcumae 12g, Oletum Trogopterori 12g, Flos Rosae Rugosae 20g, Semen Litchi 10g, Lignum Aquilariae Resinatum 7g, make decoction, take every day at twice.3 weeks were a course for the treatment of.
Claims (1)
1. Chinese medicine preparation for the treatment of angina pectoris is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight: Radix Codonopsis 10g, Radix Astragali 13g, Fructus Mori 13g, Rhizoma Chuanxiong 17g, Radix Curcumae 10g, Oletum Trogopterori 11g, Flos Rosae Rugosae 17g, Semen Litchi 13g, Lignum Aquilariae Resinatum 8g.
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| CN2011104533459A CN102526612B (en) | 2011-12-19 | 2011-12-19 | Traditional Chinese medicine composite for curing angina pectoris |
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| CN2011104533459A CN102526612B (en) | 2011-12-19 | 2011-12-19 | Traditional Chinese medicine composite for curing angina pectoris |
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| CN102526612A CN102526612A (en) | 2012-07-04 |
| CN102526612B true CN102526612B (en) | 2013-08-28 |
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| CN104352810A (en) * | 2014-10-27 | 2015-02-18 | 王志春 | Medicine for treating palpitation and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102114085A (en) * | 2010-06-11 | 2011-07-06 | 李银春 | Traditional Chinese medicine oral decoction for treating coronary heart disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102114085A (en) * | 2010-06-11 | 2011-07-06 | 李银春 | Traditional Chinese medicine oral decoction for treating coronary heart disease |
Non-Patent Citations (8)
| Title |
|---|
| 兰凤英.郁金的药理作用及临床应用.《长春中医药大学学报》.2009,第25卷(第1期),27-28页. |
| 张璐等.玫瑰花研究进展.《江西中医药》.2012,第43卷(第349期),第64-66页. |
| 李红念等.沉香的化学成分、药理作用和临床应用研究进展.《中国药房》.2011,第22卷(第35期),第3349-3351页. |
| 沉香的化学成分、药理作用和临床应用研究进展;李红念等;《中国药房》;20110919;第22卷(第35期);第3349-3351页 * |
| 玫瑰花研究进展;张璐等;《江西中医药》;20120131;第43卷(第349期);第64-66页 * |
| 荔枝和荔枝核的化学成分、生物活性及药理作用研究;郭洁文等;《中国新药杂志》;20060831;第15卷(第8期);第585-588页 * |
| 郁金的药理作用及临床应用;兰凤英;《长春中医药大学学报》;20090228;第25卷(第1期);27-28页 * |
| 郭洁文等.荔枝和荔枝核的化学成分、生物活性及药理作用研究.《中国新药杂志》.2006,第15卷(第8期),第585-588页. |
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