CN102526279A - Chinese medicinal composition for treating central high fever caused by acute cerebrovascular disease and preparation method for Chinese medicinal composition - Google Patents
Chinese medicinal composition for treating central high fever caused by acute cerebrovascular disease and preparation method for Chinese medicinal composition Download PDFInfo
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- CN102526279A CN102526279A CN2012100305161A CN201210030516A CN102526279A CN 102526279 A CN102526279 A CN 102526279A CN 2012100305161 A CN2012100305161 A CN 2012100305161A CN 201210030516 A CN201210030516 A CN 201210030516A CN 102526279 A CN102526279 A CN 102526279A
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Abstract
The invention relates to a Chinese medicinal composition for treating central high fever caused by acute cerebrovascular disease and a preparation method for the Chinese medicinal composition. The Chinese medicinal composition is prepared from the root of kudzu vine, honeysuckle, Scutellaria baicalensis, peach kernel, red paeony root, largetrifoliolious bugbane rhizome, cornu bubali, gardenia, golden thread, platycodon grandiflorum, incised notopterygium, isatis root and liquorice. The Chinese medicinal composition can be used for treating central high fever caused by acute cerebrovascular disease.
Description
Technical field
The invention belongs to the field of Chinese medicines, specifically, relate to a kind of Chinese medicine composition of treating the central high fever that ACVD causes and preparation method thereof.
Background technology
ACVD is a kind of disease of cerebral vessels circulatory disturbance of falling ill hurried, comprises cerebral hemorrhage that ischemic brain infarction that the sudden thrombosis of cerebrovascular, cerebral embolism cause and rupture of blood vessel in brain cause etc., and causes central high fever through regular meeting.Epidemiological study according in recent years shows that ACVD, heart disease and tumor have constituted the human three big causes of death.In the many areas of China, the ACVD height ranks first, and along with the rising of cerebrovascular sickness rate, and the central high fever that is caused by ACVD is and increases progressively trend.Mostly the central high fever that ACVD causes is directly to cause the infringement of thermotaxic centre because pathological changes injures brain stem, hypothalamus, causes fervescence; Simultaneously; Behind the cerebral hypoxia ischemia, generation such as neurocyte and neurogliocyte also discharges inflammatory cytokines such as interleukin II, tumor necrosis factor, has not only increased the weight of the rising of body temperature; And, inspire the formation of cerebral edema from having damaged neuronal cell to some extent.At present, relatively poor to the central high fever therapeutic effect of ACVD initiation clinically, conventional antipyretic is difficult to prove effective.
Summary of the invention
The objective of the invention is a kind of Chinese medicine composition of treating the central high fever that ACVD causes and preparation method thereof.
The objective of the invention is to realize through following technical scheme.
Chinese medicine composition of the present invention is processed by the Chinese medicine of following weight parts:
Radix Puerariae 10-15 part, Flos Lonicerae 20-30 part, Radix Scutellariae 10-15 part, Semen Persicae 8-12 part, Radix Paeoniae Rubra 10-15 part; Rhizoma Cimicifugae 20-30 part, Cornu Bubali 20-30 part, Fructus Gardeniae 10-15 part, Rhizoma Coptidis 10-15 part; Radix Platycodonis 6-10 part, Rhizoma Et Radix Notopterygii 10-15 part, Radix Isatidis 20-30 part, Radix Glycyrrhizae 6-10 part.
Preferably, process by the Chinese medicine of following weight parts:
10 parts of Radix Puerariaes, 30 parts of Flos Loniceraes, 12 parts of Radix Scutellariaes, 12 parts in Semen Persicae, 11 parts of Radix Paeoniae Rubra, 26 parts of Rhizoma Cimicifugaes, 30 parts of Cornu Bubalis, 15 parts of Fructus Gardeniaes, 15 parts of Rhizoma Coptidis, 8 parts of Radix Platycodoniss, 12 parts of Rhizoma Et Radix Notopterygiis, 25 parts of Radix Isatidis, 10 parts in Radix Glycyrrhizae.
The method for preparing of Chinese medicine composition of the present invention comprises following steps:
(1) takes by weighing each Chinese medicine by weight;
(2) Radix Puerariae, Flos Lonicerae, Radix Scutellariae, Semen Persicae, Radix Paeoniae Rubra, Rhizoma Cimicifugae, Fructus Gardeniae, Rhizoma Coptidis, Radix Platycodonis, Rhizoma Et Radix Notopterygii, Radix Isatidis and Radix Glycyrrhizae are pulverized, add the water of 2-4 times of volume, decocted 1.5-3.5 hour, decoction liquor removes slag subsequent use;
(3) Cornu Bubali is added 5-7 times of water, it is original half the decocting to the volume of solvent, and decoction liquor removes slag subsequent use;
(4) decoction liquor that removes slag with gained in step (2) and the step (3) merges, and concentrates, and processes solution or granule by conventional method.
Chinese medicine composition of the present invention can be processed common clinically pharmaceutical dosage form according to the conventional method of this area, and for example solution or granule are preferably solution.
Chinese medicine composition of the present invention has the effect of heat-clearing and toxic substances removing, eleminating phlegm and freeing channels, consciousness and resuscitation restoring, and the Flos Lonicerae in the prescription, Radix Scutellariae, Fructus Gardeniae, Radix Isatidis, Rhizoma Coptidis have very strong antibiotic, antiviral, antiinflammatory and antipyretic effect; Cornu Bubali can strengthen heat clearing away, the calmness that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., convulsion, heart tonifying are brought down a fever, and very strong maincenter sedation is arranged; Radix Scutellariae, Fructus Gardeniae, Radix Isatidis have clearing away heat-fire detoxifcation, cooling blood and removing stasis effect etc., and full side be a cube main idea with heat-clearing and toxic substances removing mainly, are mainly used in and treat the calentura coma, ischemic cerebrovascular is seen above-mentioned patient.In addition, technical scheme of the present invention has following beneficial effect:
1, rapid-action, therapeutic effect is good, patient's body temperature is descended, and in administration 48h, make patient's body temperature and vital signs stable;
2, preparation technology is simple, is easy to clinically use.
The specific embodiment
Embodiment 1: the preparation of solution
Weight according to following takes by weighing raw material of Chinese medicine:
Radix Puerariae 10 grams, Flos Lonicerae 30 grams, Radix Scutellariae 12 grams, Semen Persicae 12 grams, Radix Paeoniae Rubra 11 grams, Rhizoma Cimicifugae 26 grams, Cornu Bubali 20 grams, Fructus Gardeniae 11 grams, Rhizoma Coptidis 10 grams, Radix Platycodonis 8 grams, Rhizoma Et Radix Notopterygii 10 grams, Radix Isatidis 20 grams, Radix Glycyrrhizae 6 grams.
Radix Puerariae, Flos Lonicerae, Radix Scutellariae, Semen Persicae, Radix Paeoniae Rubra, Rhizoma Cimicifugae, Fructus Gardeniae, Rhizoma Coptidis, Radix Platycodonis, Rhizoma Et Radix Notopterygii, Radix Isatidis and Radix Glycyrrhizae are pulverized, add 300ml water, decocted 1.5 hours, decoction liquor removes slag subsequent use; Cornu Bubali is added 300ml water, decoct to 150ml, decoction liquor removes slag subsequent use; The decoction liquor that removes slag for twice in the above-mentioned steps is merged, be concentrated into the concentration of regulation, put coldly, canned, sterilization promptly gets solution.
Embodiment 2: the preparation of granule
Weight portion according to following takes by weighing raw material of Chinese medicine:
Radix Puerariae 15 grams, Flos Lonicerae 30 grams, Radix Scutellariae 14 grams, Semen Persicae 11 grams, Radix Paeoniae Rubra 15 grams, Rhizoma Cimicifugae 30 grams, Cornu Bubali 25 grams, Fructus Gardeniae 13 grams, Rhizoma Coptidis 15 grams, Radix Platycodonis 10 grams, Rhizoma Et Radix Notopterygii 13 grams, Radix Isatidis 30 grams, Radix Glycyrrhizae 10 grams.
Radix Puerariae, Flos Lonicerae, Radix Scutellariae, Semen Persicae, Radix Paeoniae Rubra, Rhizoma Cimicifugae, Fructus Gardeniae, Rhizoma Coptidis, Radix Platycodonis, Rhizoma Et Radix Notopterygii, Radix Isatidis and Radix Glycyrrhizae are pulverized, add 400ml water, decocted 1.5 hours, decoction liquor removes slag subsequent use; Cornu Bubali is added 400ml water, decoct to 200ml, decoction liquor removes slag subsequent use; Twice in the above-mentioned steps decoction liquor that removes slag being merged, be condensed into clear paste, add starch, is that the binding agent granulation promptly gets granule with ethanol.
Experimental example: the clinical observation on the therapeutic effect of the central high fever that traditional Chinese medicine composition for treating ACVD of the present invention causes
1, the physical data of experimental subject: adopt Chinese medicine composition of the present invention to treat 50 routine patients altogether, 50 routine patients are inpatient, wherein male 38 examples, and women 12 examples, the age is 52-76 year; Incidence type: drowsiness 28 examples, light coma 17 examples, deep coma 5 examples.
2, diagnosis basis: 50 examples all meet the dependent diagnostic standard that the 4th the cerebrovascular meeting in the nineteen ninety-five whole nation formulated, and all make a definite diagnosis with the head spiral CT, and persistent high fever occurring is 39-41.1 ℃, and should get rid of pyrogens such as pulmonary, urinary system infection because of.
3, Therapeutic Method: after giving oxygen uptake, keeping the Primary Care of routines such as water power medium acid-base balance; The solution of the embodiment of the invention 1 is carried out administration to the patient, and the knowledgeable's administered through oral administration intentionally is not intended to the knowledgeable through the nasal feeding administration; 2-3 administration on the one, each 10mL.
4, therapeutic evaluation standard:
Produce effects: body temperature is lower than 37 ℃ in the medication 48h, realize gradually clear, vital signs stable.
Effectively: in the medication 48h body temperature at 38-39 ℃, realize gradually clear, vital signs stable.
Invalid: body temperature does not have decline (still greater than 39 ℃) in the medication 48 hours, and consciousness can not be changeed clearly or the state of an illness increases the weight of.
5, therapeutic outcome
Observed the variation of Chinese medicine composition of the present invention to onset time, the effect of bringing down a fever and the vital sign of the central high fever that causes of treatment acute cerebrovascular disease respectively, the result sees table 1 and table 2.
Body temperature variation before and after table 1, the treatment (℃, meansigma methods ± standard deviation)
Changes of vital signs (meansigma methods ± standard deviation) before and after table 2, the treatment
| ? | Body temperature (℃) | Pulse (inferior/minute) | Breathe (inferior/minute) | Blood pressure (mmHg) |
| Before the treatment | 40.0±0.51 | 92±2 | 18±1.5 | 155±11.3 |
| After the treatment | 37.02±0.26 | 91±1 | 17±2.4 | 146±10.5 |
| The P value | ＜0.05 | ＞0.05 | ＞0.05 | ＞0.05 |
The result shows; Chinese medicine composition of the present invention can be lowered the temperature the central high fever patient that 2h causes acute cerebrovascular disease; And make patient's body temperature and vital sign be tending towards normal and stable at 8h, there were significant differences before and after the treatment, prevented that effectively conditions of patients from further worsening.
What should explain at last is: above embodiment is only in order to explaining technical scheme of the present invention, but not to its restriction; Although with reference to previous embodiment the present invention has been carried out detailed explanation, those of ordinary skill in the art is to be understood that: it still can be made amendment to the technical scheme that aforementioned each embodiment put down in writing, and perhaps part technical characterictic wherein is equal to replacement; And these are revised or replacement, do not make the spirit and the scope of the essence disengaging various embodiments of the present invention technical scheme of relevant art scheme.
Claims (4)
1. Chinese medicine composition of treating the central high fever that ACVD causes is characterized in that described Chinese medicine composition processed by the Chinese medicine of following weight parts:
Radix Puerariae 10-15 part, Flos Lonicerae 20-30 part, Radix Scutellariae 10-15 part, Semen Persicae 8-12 part, Radix Paeoniae Rubra 10-15 part; Rhizoma Cimicifugae 20-30 part, Cornu Bubali 20-30 part, Fructus Gardeniae 10-15 part, Rhizoma Coptidis 10-15 part; Radix Platycodonis 6-10 part, Rhizoma Et Radix Notopterygii 10-15 part, Radix Isatidis 20-30 part, Radix Glycyrrhizae 6-10 part.
2. the Chinese medicine composition of the central high fever that treatment ACVD according to claim 1 causes is characterized in that described Chinese medicine composition processed by the Chinese medicine of following weight parts:
10 parts of Radix Puerariaes, 30 parts of Flos Loniceraes, 12 parts of Radix Scutellariaes, 12 parts in Semen Persicae, 11 parts of Radix Paeoniae Rubra, 26 parts of Rhizoma Cimicifugaes, 30 parts of Cornu Bubalis, 15 parts of Fructus Gardeniaes, 15 parts of Rhizoma Coptidis, 8 parts of Radix Platycodoniss, 12 parts of Rhizoma Et Radix Notopterygiis, 25 parts of Radix Isatidis, 10 parts in Radix Glycyrrhizae.
3. the Chinese medicine composition of the central high fever that treatment ACVD according to claim 1 and 2 causes is characterized in that the dosage form of described Chinese medicine composition is solution or granule, is preferably solution.
4. a kind of method for preparing of treating the Chinese medicine composition of the central high fever that ACVD causes according to claim 1 is characterized in that described method for preparing comprises following steps:
(1) takes by weighing each raw material of Chinese medicine by weight;
(2) Radix Puerariae, Flos Lonicerae, Radix Scutellariae, Semen Persicae, Radix Paeoniae Rubra, Rhizoma Cimicifugae, Fructus Gardeniae, Rhizoma Coptidis, Radix Platycodonis, Rhizoma Et Radix Notopterygii, Radix Isatidis and Radix Glycyrrhizae are pulverized, add the water of 2-4 times of volume, decocted 1.5-3.5 hour, decoction liquor removes slag subsequent use;
(3) Cornu Bubali is added 5-7 times of water, it is original half the decocting to the volume of solvent, and decoction liquor removes slag subsequent use;
(4) decoction liquor that removes slag with gained in step (2) and the step (3) merges, and concentrates, and processes solution or granule by conventional method.
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