CN102526273A - Composition for treating functional dyspepsia and preparation method thereof - Google Patents
Composition for treating functional dyspepsia and preparation method thereof Download PDFInfo
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- CN102526273A CN102526273A CN2010105956136A CN201010595613A CN102526273A CN 102526273 A CN102526273 A CN 102526273A CN 2010105956136 A CN2010105956136 A CN 2010105956136A CN 201010595613 A CN201010595613 A CN 201010595613A CN 102526273 A CN102526273 A CN 102526273A
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Abstract
The invention relates to the field of medicines, and discloses a composition for treating functional dyspepsia and a preparation method thereof. According to the composition, the functional dyspepsia is treated by taking paederia scandens as an active ingredient, so the composition has a definite curative effect, does not have side effect, and is abundant in medicinal sources and easy to prepare and purify; and with 3 to 6 percent of raw rhubarb, the paederia scandens has a better effect on patients who suffer from constipation, and the composition does not have obvious adverse effect on people who do not suffer from the constipation due to small dose.
Description
Technical field
The present invention relates to field of medicaments, particularly the medicine and the technology of preparing thereof of treatment functional dyspepsia.
Background technology
Functional dyspepsia (Functional Dyspepsia is called for short " FD ") is one group of dyspepsia syndrome of getting rid of organic diseases such as stomach, liver, gallbladder, pancreas.Common symptoms: upper abdomen distension, dull pain, full, belch, indigestion and loss of appetite, heartburn, nauseating etc. early.Crowd's sickness rate is high.The Epidemiological study of functional dyspepsia is shown that its prevalence is up to 20% to 40% according to the foreign scholar, domestic have a report, and the prescription on individual diagnosis patient of functional dyspepsia accounts for about 40% of Gastroenterology Clinic.Everyone once had weight different in life, and the indigestion symptom that the persistent period is not waited influences quite big to people quality of life.
Present medical evidence, the big belly that functional dyspepsia showed, primary symptom such as full, belch early delay relevantly with gastric emptying, so doctor trained in Western medicine employing dynamics-promoting medicine is treated, its curative effect is proved.But the problem of dynamics-promoting medicine (like cisapride) is to cause serious adverse effects.
The traditional Chinese medical science adopts compound preparation that functional dyspepsia is treated, and certain curative effect is also arranged.Problem is that the flavour of a drug of compound preparation are numerous, the clinical strong specific aim of effect that needs.Should not be used for damp-heat type like warm type of prescription; Cold and cool type of prescription should not be used for asthenic cold type.Therefore clinical use limitation.Because of the compound preparation flavour of a drug are numerous, be difficult to reach efficient, low toxicity, low dose of target.
Summary of the invention
The object of the present invention is to provide a kind of composition and method of making the same of treating functional dyspepsia, functional dyspepsia is had clear and definite curative effect, non-evident effect, the medicine source is abundant, is easy to purify.
For solving the problems of the technologies described above, embodiment of the present invention provides a kind of compositions of treating functional dyspepsia, and said composition is made up of pharmaceutically acceptable carrier and active ingredient;
Active ingredient is a fevervine.
Embodiment of the present invention also provides a kind of preparation of compositions method of treating functional dyspepsia, comprises the steps:
Fevervine is mixed with pharmaceutically acceptable carrier, thereby obtain above-mentioned compositions.
Embodiment of the present invention also provides a kind of compositions of treating functional dyspepsia, and said composition is made up of pharmaceutically acceptable carrier and active ingredient, and wherein the weight proportion of active ingredient is:
Fevervine 94 to 97 weight portions, Radix Et Rhizoma Rhei 6 to 3 weight portions.
Embodiment of the present invention also provides a kind of preparation of compositions method of treating functional dyspepsia, comprises the steps:
The component of following weight proportion is mixed with pharmaceutically acceptable carrier, thereby obtains above-mentioned compositions:
The fevervine of 94 to 97 weight portions, the Radix Et Rhizoma Rhei of 6 to 3 weight portions.
Embodiment of the present invention compared with prior art, the main distinction and effect thereof are:
Treat functional dyspepsia with fevervine as active ingredient, curative effect is clear and definite, non-evident effect, and the medicine source is abundant, and preparation is simple, is easy to purify.
Further, in fevervine, add 3% to 6% Radix Et Rhizoma Rhei, constipation person is had better effect especially,, non-constipation person is not had bad influence yet because of dosage is little.
Further, in active ingredient, fevervine is 19 to 1 with the weight ratio of Radix Et Rhizoma Rhei, can obtain best effect.
The specific embodiment
In following narration, many ins and outs have been proposed in order to make the reader understand the application better.But, persons of ordinary skill in the art may appreciate that even without these ins and outs with based on the many variations and the modification of following each embodiment, also can realize each claim of the application technical scheme required for protection.
For making the object of the invention, technical scheme and advantage clearer, will combine accompanying drawing that embodiment of the present invention is done to describe in detail further below.
First embodiment of the invention relates to a kind of compositions of treating functional dyspepsia.The compositions said composition of this treatment functional dyspepsia is made up of pharmaceutically acceptable carrier and active ingredient, and wherein active ingredient is a fevervine.
Fevervine [Facdenia scandens (Lour) Merr] is the root of Rubiaceae Paederia plant, and sweet in the mouth, little hardship, property are put down.Expelling wind and activating blood circulation is arranged, the merit of promoting digestion and removing stagnation.Through modern pharmacological research, it has analgesia, convulsion, calmness, blood pressure lowering, antibacterial action, and particularly its antihistamine effect and the effect of removing smooth muscle spasm are similar a bit with Mei Shabili.Fevervine toxicity is low, and mouse stomach LD50 is 94.0g/kg, can be described as a kind of safe oral medicine
As a preferred scheme, active ingredient can 100% be made up of fevervine in this embodiment.
Treat functional dyspepsia with fevervine as active ingredient, curative effect is clear and definite, non-evident effect, and the medicine source is abundant, and preparation is simple, is easy to purify.
In each embodiment of the present invention, alleged compositions can be dosage forms such as concentrating agents, electuary, powder, oral liquid, tablet or capsule.
Second embodiment of the invention relates to a kind of compositions of treating functional dyspepsia.
Second embodiment improves on the basis of first embodiment, and main improvements are: the Radix Et Rhizoma Rhei of adding 3% to 6% in fevervine, this has better effect for constipation person, because of dosage is little, non-constipation person is not had bad influence yet.Specifically:
Active ingredient also comprises Radix Et Rhizoma Rhei except that fevervine, weight proportion is: fevervine 94 to 97 weight portions, Radix Et Rhizoma Rhei 6 to 3 weight portions.
The fevervine nature and flavor are dry partially, and the Radix Et Rhizoma Rhei nature and flavor are bitter, and low dose of Radix Et Rhizoma Rhei and fevervine coupling can make gastric qi descending, and the effect that is good for the stomach is arranged.If but the Radix Et Rhizoma Rhei ratio is excessive, possibly have slight diarrheal situation.
Third embodiment of the invention relates to a kind of compositions of treating functional dyspepsia.
The 3rd embodiment improves on the basis of second embodiment; Main improvements are: in active ingredient; Fevervine confirms as 19 to 1 with the weight ratio of Radix Et Rhizoma Rhei, that is to say that Radix Et Rhizoma Rhei accounts for about 5%, and the applicant finds that this ratio can obtain best effect.
Four embodiment of the invention relates to a kind of preparation of compositions method of treating functional dyspepsia.This method comprises the steps:
Fevervine is mixed with pharmaceutically acceptable carrier, thereby obtain the compositions in first embodiment.
Fifth embodiment of the invention relates to a kind of preparation of compositions method of treating functional dyspepsia.This method comprises the steps:
The component of following weight proportion is mixed with pharmaceutically acceptable carrier, thereby obtains the compositions in second embodiment:
The fevervine of 94 to 97 weight portions, the Radix Et Rhizoma Rhei of 6 to 3 weight portions.
Preferably, in order to reach best effect, fevervine is 95 to 5 with the weight proportion suggestion of Radix Et Rhizoma Rhei.
To different dosage forms, method for preparing has difference.Below be that example describes with the capsule.
Contain paederoside, fevervine time glycoside, volatilization wet goods in the fevervine medical material.In addition, auxiliary medical material (Radix Et Rhizoma Rhei) also contains volatile oil.Earlier volatile oil is proposed with the way of distillation, because of glycosides composition is dissolved in hot water, available decocting method.Specifically:
At first medical material is extracted, obtain extracting solution.The contained volatile oil of we's medical material is light oil, jointly distillation extraction.Add distilled water immersion 2-3 hour of 20 times of medical materials earlier, make to begin distillation after fully soaking into, receive oil, generally extracted 6 hours with volatile oil determination apparatus.Decocting liquid separated and collected behind the extraction volatile oil is preserved in other container, adds water to submerge medicinal residues again and decocts 30 minutes, obtains decocting liquid for the second time, adds water to submerge medicinal residues again and decocts 30 minutes, obtains decocting liquid for the third time.Merge three times decocting liquid, obtain extracting solution.
Then extracting solution is filtered, be condensed into concentrated solution.
Again concentrated solution is carried out drying under reduced pressure, obtain extract powder.Preferably control the extract powder water content in 2.5%.
It is dry extract powder to be granulated again, and the volatile oil that extract the spray front forms granule.
Granule is tested, and encapsulated, packing obtains finished product.Can select capsule when encapsulated for use No. 0, adorn 0.5 gram dry powder for every.Can certainly use the capsule of other model.
Above-mentionedly just to capsule method for preparing has been described, but the present invention is not limited to this dosage form of capsule, also concentrating agents, electuary, powder, oral liquid, tablet etc. can be with reference to the common process of these dosage forms on method for preparing.
Sixth embodiment of the invention is that the compositions in first, second or the 3rd embodiment is applied in the medicine of preparation treatment functional dyspepsia.
Be that compositions in first, second or the 3rd embodiment is in the effect of treatment functional dyspepsia below.
The inventor has selected 60 more complete examples of data in prescription on individual diagnosis case in 2009.Male's 26 examples wherein, women's 34 examples, age: 18 years old～40 years old 35 example, 25 examples more than 41 years old; The course of disease: 1 year～3 years 42 examples, 18 examples more than 3 years.
Diagnostic criteria: middle upper abdomen is glutted, dull pain, belch, indigestion and loss of appetite, early symptom such as full is shown effect more than 1 year repeatedly, continues outbreak person more than two months.Through gastroscope, B ultrasonic, stomach, liver, gallbladder, spleen, pancreas organic disease are got rid of in inspections such as biochemistry.
Therapeutic Method: with the capsule (inventor is called " capsule of gastric qi through ", every ball 0.5 gram) that the compositions in first, second or the 3rd embodiment is processed, each 3 balls, three times on the one, swallow with eliminating cold for resuscitation water ante cibum, one month is a course of treatment.
Criterion of therapeutical effect
(1) glutted, the dull pain of upper abdomen in, belch, indigestion and loss of appetite, early transference cure such as full is for curing.
(2) still have slight feeling of repletion after the food, belch reduces and eliminates fully to effective.
(3) above-mentioned symptom do not see obviously be improved as invalid.
Efficacy analysis
After a treatment in month, in 60 examples, 46 examples are cured, and 11 examples are effective, and 3 examples are invalid.The dissatisfactory case of curative effect all has mental maladjustment concurrently, should consider suitable compatibility.
Model case one: Shao X, woman, 45 years old.Live the airport town.First visit on March 11 in 2009.The main suit: middle upper abdomen is glutted, the pharyngeal plug sense of choking of dull pain, belch, companion, shows effect repeatedly 5 years, continues outbreak 4 months.Receive the food still can, two is just as usual.Health check-up: abdomen is soft, the liver spleen is too late, in go up the discomfort of abdominal pressure, the tympanitic resonance of kowtowing.Gastroscope shows, superficial gastritis, HP (), B ultrasonic, liver, gallbladder, spleen, pancreas no abnormality seen.Plan is examined: functional dyspepsia.Prescription: 3 of capsule of gastric qi through (every 0.5 gram), three times on the one, eliminating cold for resuscitation water is swallowed on an empty stomach, and the week of making up a prescription measures.
On March 17th, 2009, two examine.The main suit: behind the medicine three days, dull pain was promptly ended, and abdominal distention takes a turn for the better.Swallowing foreign body sensation alleviates.Medication takes effect, and continues to use 3 Zhou Eryu, follows up a case by regular visits to and does not send out in 1 year.
Model case two: king XX, man, 82 years old.Zhu Qiao town Venus three teams, first visit on August 12 in 2009, the main suit: glutted 6 years of middle upper abdomen, the time slow when sending out, the companion is early full, belch, idol has pantothenic acid.This outbreak three months.Gastroscope shows, superficial atrophic gastritis.B ultrasonic, liver, gallbladder, spleen, pancreas are not seen obviously unusual.Plan is examined functional dyspepsia.Prescription: 3 of capsule of gastric qi through (every 0.5 gram), three times on the one, the week of making up a prescription measures.
19 days two August in 2009 examined: the main suit: vow behind the medicine that gas is many, free movement of the bowels, the glutted obvious improvement of middle upper abdomen.Appetite increases.Continuous 3 weeks of making up a prescription measure, and back phone is followed up a case by regular visits to healing.
Compositions in first, second and third embodiment, its Main Ingredients and Appearance are fevervine, and the pathogenesis of functional dyspepsia is an incoordination between the liver and spleen, and gastric qi painful abdominal mass plug is stopped up middle Jiao that stagnates, and produces the clinical symptoms of a series of functional dyspepsias.Mechanism of qi one is opened, and gastric qi must be logical, takes charge of and falls, and its clinical symptoms thereupon more.No matter wet cold and heat eat stagnating, and change in invisible.Fevervine property is flat, sweet and slightly bitter taste, the merit of promoting the circulation of QI to relieve pain is grand and do not hinder healthy energy, behind the compatibility, control wet and not dry, strengthening the spleen to promote digestion.Distinguished and have no side effect to the functional dyspepsia curative effect.
Term in each embodiment of the present invention " pharmaceutically acceptable carrier " refers to be used for the carrier of therapeutic agent administration, comprises various excipient and diluent.This term refers to some medicament carriers like this: they itself are not necessary active component, and do not have undue toxicity after using.Suitable carriers is well known to those of ordinary skill in the art.(MackPub.Co. can find discussing fully about pharmaceutically acceptable excipient in N.J.1991) at Remington ' s Pharmaceutical Science.Acceptable carrier can comprise liquid on combination of Chinese medicine is learned, like water, saline, glycerol and ethanol.In addition, also possibly there is complementary material in these carriers, like disintegrating agent, wetting agent, emulsifying agent, pH buffer substance etc.
Be appreciated that in each embodiment of the present invention, except already mentioned component, can also contain submember a spot of and not shadow effective ingredient and/or impurity.For example, can contain sweeting agent to improve taste, antioxidant in case oxidation, and other this area additive commonly used.
Though through with reference to some preferred implementation of the present invention, invention has been described, those of ordinary skill in the art should be understood that and can do various changes to it in form with on the details, and without departing from the spirit and scope of the present invention.
Claims (8)
1. a compositions of treating functional dyspepsia is characterized in that, said composition is made up of pharmaceutically acceptable carrier and active ingredient;
Said active ingredient is a fevervine.
2. a compositions of treating functional dyspepsia is characterized in that, said composition is made up of pharmaceutically acceptable carrier and active ingredient, and wherein the weight proportion of active ingredient is:
Fevervine 94 to 97 weight portions,
Radix Et Rhizoma Rhei 6 to 3 weight portions.
3. the compositions of treatment functional dyspepsia according to claim 2 is characterized in that, in the said active ingredient, fevervine is 95 weight portions, and Radix Et Rhizoma Rhei is 5 weight portions.
4. according to the compositions of each described treatment functional dyspepsia in the claim 1 to 3, it is characterized in that said composition is concentrating agents, electuary, powder, oral liquid, tablet or capsule.
5. a preparation of compositions method of treating functional dyspepsia is characterized in that, comprises the steps:
Fevervine is mixed with pharmaceutically acceptable carrier, thereby obtain the described compositions of claim 1.
6. a preparation of compositions method of treating functional dyspepsia is characterized in that, comprises the steps:
The component of following weight proportion is mixed with pharmaceutically acceptable carrier, thereby obtains the described compositions of claim 2:
The fevervine of 94 to 97 weight portions, the Radix Et Rhizoma Rhei of 6 to 3 weight portions.
7. the preparation of compositions method of treatment functional dyspepsia according to claim 6 is characterized in that, said fevervine is 95 to 5 with the weight proportion of Radix Et Rhizoma Rhei.
8. like the application of each described compositions in the claim 1 to 3 in the medicine of preparation treatment functional dyspepsia.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104256808A (en) * | 2014-08-29 | 2015-01-07 | 广东岭南职业技术学院 | Affinal drug and diet drink and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104256808A (en) * | 2014-08-29 | 2015-01-07 | 广东岭南职业技术学院 | Affinal drug and diet drink and preparation method thereof |
| CN104256808B (en) * | 2014-08-29 | 2016-01-20 | 广东岭南职业技术学院 | A kind of integration of drinking and medicinal herbs beverage and preparation method thereof |
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Application publication date: 20120704 |