CN102526009A - Zinc calcium gluconate oral solution - Google Patents
Zinc calcium gluconate oral solution Download PDFInfo
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- CN102526009A CN102526009A CN201210039223XA CN201210039223A CN102526009A CN 102526009 A CN102526009 A CN 102526009A CN 201210039223X A CN201210039223X A CN 201210039223XA CN 201210039223 A CN201210039223 A CN 201210039223A CN 102526009 A CN102526009 A CN 102526009A
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Abstract
The invention relates to a zinc calcium gluconate oral solution. The zinc calcium gluconate oral solution is prepared from zinc calcium gluconate and cane sugar which serve as main raw materials and auxiliary materials in a certain ratio. According to the zinc calcium gluconate oral solution, ingredients and a process meet the specifications of Food Hygiene Law of the People's Republic of China and Provisions for Health Food Registration, so the zinc calcium gluconate oral solution has a good mouthfeel, is uniform and stable and can be absorbed by human bodies easily, and is suitable for the calcium supplement and zinc supplement of people.
Description
Technical field
The present invention relates to a kind of health product, is a kind of calcium-zinc gluconate oral administration solution of zinc supplement specifically.
Background technology
Zinc is a kind of of trace element; The intravital content of people and every day required intake all seldom; But the generation to the sexual development of body, sexual function, sexual cell can be played very important effect, so the title of " spark of life " and " marriage is harmonious plain " is arranged.The normal zinc content of human body is the 2-3 gram.All have the zinc of denier to distribute in the overwhelming majority tissue, wherein liver, muscle and bone content are higher.Zinc is the main component of tens of kinds of enzymes in the body.Zinc is also relevant with brain development and intelligence.University of the U.S. finds, clever, the teenager succeed in school, and the interior zinc content of body is all than fathead's height.Zinc promotes the effect of lymphopoiesis and mobility in addition, dermatosiss such as epithelium and mucosal tissue are normal to keeping, defense against bacterial, viral intrusion, promotion wound healing, minimizing acne, and the malfunctioning grade of the correction sense of taste all has magical effect.
Zinc deficiency in the body, many physiological functions all can be affected.Not only can cause the stagnation of growth promoter, and can influence physiological functions such as immune defence, wound healing, reproduction fertility.Simultaneously, various diseases can appear in child's zinc deficiency, and body weight not only of short and small stature does not increase, and yellow soft and withered its taste bud function of also can damaging of pachylosis, hair, and the sense of taste is changed, and poor appetite occurs, anorexia and different food.If at fetus and infantile stage zinc deficiency, also can cause the intelligence development obstacle.The experiment of animal and human's body confirms that all at the pregnancy period zinc deficiency, deformity will appear in its offspring who gives birth to, and the change of nervous function occurs as if parent.
Summary of the invention
The present invention slowly reaches the low problem of absorbance in order to solve existing zinc supplement product infiltration rate, and a kind of calcium-zinc gluconate oral administration solution of zinc supplement is provided.Zinc gluconate oral administration solution mouthfeel of the present invention is good, and solution is uniform and stable, is beneficial to absorption of human body.
The object of the invention can be realized through following technical proposal:
A kind of calcium-zinc gluconate oral administration solution; Said compositions comprises with the weight percent meter of its component: purified water 70%～90%; Adjuvant 10%～30%; The content of zinc is 20.925 mg/100ml ~ 34.875mg/100ml in the oral administration solution, and organic zinc content ratio >=85%, and said adjuvant comprises white sugar, citric acid, Mel, carboxymethyl cellulose, sucrose ester, gelatin, agar, sodium benzoate, potassium sorbate and correctives, sorbitol, apple essence, gelatin etc.
Earlier purified water, white sugar, citric acid, Mel, carboxymethyl cellulose, sucrose ester, gelatin being allocated post-heating to 65 ℃～95 ℃ of thermosols in proportion filters; The back adds material-compound tank after being cooled to room temperature; Stirring generates the batching of mixing, according to preset zinc content desired value 20.925 mg/100ml ~ 34.875mg/100ml.Fully the solution after the dissolving is through leaving standstill 2h～8h, with supernatant through 80 orders～150 order filtered through gauze after, pack into clean and the disinfectant vial in and capping, then, employing high temperature instantaneous sterilization, sterilization temperature is 100 ℃～120 ℃, 30 seconds～90 seconds time.The sense organ standard of final this oral liquid is: character is that liquid does not have deposition and impurity, and color and luster is a light brown, the sweet no odor smell of distinguishing the flavor of; The physical and chemical index of this oral liquid is a pH value 4.5 ~ 6.5; Soluble solid is more than or equal to 10%, and arsenic content is smaller or equal to 0.3mg/L, and lead content is smaller or equal to 0.5mg/L.
The specific embodiment
A kind of calcium-zinc gluconate oral administration solution is by comprising that adjuvants such as white sugar, citric acid, Mel, carboxymethyl cellulose, sucrose ester, gelatin, agar, sodium benzoate, potassium sorbate and correctives, sorbitol, apple essence, gelatin and calcium gluconate form.
Earlier purified water, white sugar, citric acid, Mel, carboxymethyl cellulose, sucrose ester, gelatin being allocated post-heating to 65 ℃～95 ℃ of thermosols in proportion filters; The back adds material-compound tank after being cooled to room temperature; Stirring generates the batching of mixing, according to preset zinc content desired value 20.925 mg/100ml ~ 34.875mg/100ml.Fully the solution after the dissolving is through leaving standstill 2h～8h, with supernatant through 80 orders～150 order filtered through gauze after, pack into clean and the disinfectant vial in and capping, then, employing high temperature instantaneous sterilization, sterilization temperature is 100 ℃～120 ℃, 30 seconds～90 seconds time.The sense organ standard of final this oral liquid is: character is that liquid does not have deposition and impurity, and color and luster is a light brown, the sweet no odor smell of distinguishing the flavor of; The physical and chemical index of this oral liquid is a pH value 4.5 ~ 6.5; Soluble solid is more than or equal to 10%, and arsenic content is smaller or equal to 0.3mg/L, and lead content is that total plate count is smaller or equal to 100cfu/mL smaller or equal to the 0.5mg/L. microbiological indicator; The large intestine bacterium colony is smaller or equal to 6 MPN/100Ml; Mycete is smaller or equal to 10 cfu/mL, and yeast is smaller or equal to 10 cfu/mL, and calcium-zinc gluconate oral liquid component of the present invention and technology meet the regulation of " Chinese name republic food hygiene law " and " health food registration management way "; Wherein the mensuration of zinc is measured according to the assay method of GB/T 5009.14-2003 " mensuration of zinc in the food ", and soluble solid is measured through compound microcapsule.
This oral liquid eating method and consumption be 1-10 year, more than 50 years old and the anemia of pregnant woman, every day 2 this, each 10ml, 10-50 year and wet nurse, every day 3 times, each 10ml.
The above; Be merely the specific embodiment of the present invention; But protection scope of the present invention is not limited thereto; Any those of ordinary skill in the art are in the technical scope that the present invention disclosed, and variation or the replacement that can expect without creative work all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain that claims were limited.
Claims (9)
1. calcium-zinc gluconate oral administration solution; It is characterized in that said compositions comprises with the weight percent meter of its component: purified water 70%～90%; Adjuvant 10%～30%; The content of zinc is 20.925 mg/100ml ~ 34.875mg/100ml in the oral administration solution; And organic zinc content ratio >=85%, said adjuvant comprises white sugar, citric acid, Mel, carboxymethyl cellulose, sucrose ester, gelatin, agar, sodium benzoate, potassium sorbate and correctives, sorbitol, apple essence, gelatin etc.
2. calcium-zinc gluconate oral administration solution as claimed in claim 1; It is characterized in that: earlier purified water, white sugar, citric acid, Mel, carboxymethyl cellulose, sucrose ester, gelatin are allocated the back thermosol in proportion and filter; The cooling back adds material-compound tank; Stirring generates the batching of mixing, according to preset zinc content desired value 20.925 mg/100ml ~ 34.875mg/100ml.
3. calcium-zinc gluconate oral administration solution as claimed in claim 2 is characterized in that: be heated to 65 ℃～95 ℃ during thermosol, stir 0.5h～1h and fully dissolve, add material-compound tank after being cooled to room temperature.
4. according to claim 1 or claim 2 calcium-zinc gluconate oral administration solution; It is characterized in that: fully the solution after the dissolving is through leaving standstill 2h～8h; With supernatant after 80 orders～150 order filtered through gauze, pack into clean and the disinfectant vial in and capping, then, adopt the high temperature instantaneous sterilization; Sterilization temperature is 100 ℃～120 ℃, 30 seconds～90 seconds time.
5. calcium-zinc gluconate oral administration solution as claimed in claim 4 is characterized in that: the sense organ standard of this oral liquid is: character is that liquid does not have deposition and impurity, and color and luster is a light brown, the sweet no odor smell of distinguishing the flavor of.
6. like the described calcium-zinc gluconate oral administration solution of the arbitrary claim of claim 1--5; It is characterized in that: the physical and chemical index of this oral liquid is a pH value 4.5 ~ 6.5; Soluble solid is more than or equal to 10%, and arsenic content is smaller or equal to 0.3mg/L, and lead content is smaller or equal to 0.5mg/L.
7. like the described calcium-zinc gluconate oral administration solution of the arbitrary claim of claim 1-5; It is characterized in that: the microbiological indicator of this oral liquid is that total plate count is smaller or equal to 100cfu/mL; The large intestine bacterium colony is smaller or equal to 6 MPN/100Ml; Mycete is smaller or equal to 10 cfu/mL, and yeast is smaller or equal to 10 cfu/mL.
8. according to claim 1 or claim 2 calcium-zinc gluconate oral administration solution, it is characterized in that: the mensuration of zinc is measured according to the assay method of GB/T 5009.14-2003 " mensuration of zinc in the food ".
9. according to claim 1 or claim 2 calcium-zinc gluconate oral administration solution is characterized in that: this oral liquid eating method and consumption be 1-10 year, more than 50 years old and the anemia of pregnant woman, every day 2 this, each 10ml, 10-50 year and wet nurse, every day 3 times, each 10ml.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210039223XA CN102526009A (en) | 2012-02-21 | 2012-02-21 | Zinc calcium gluconate oral solution |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210039223XA CN102526009A (en) | 2012-02-21 | 2012-02-21 | Zinc calcium gluconate oral solution |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104231099A (en) * | 2014-09-03 | 2014-12-24 | 佐源集团有限公司 | Inulin zinc and oral liquid containing same |
| CN104546818A (en) * | 2015-02-04 | 2015-04-29 | 澳诺（中国）制药有限公司 | Pharmaceutical composition with calcium supplement and zinc supplement effects and preparation of pharmaceutical composition |
| CN105077280A (en) * | 2015-09-01 | 2015-11-25 | 张伟 | Liquid preparation for supplementing zinc and preparation method thereof |
| CN105595346A (en) * | 2015-09-01 | 2016-05-25 | 张伟 | Liquid preparation for calcium supplementation and preparation method thereof |
| CN104231099B (en) * | 2014-09-03 | 2017-01-04 | 佐源集团有限公司 | A kind of inulin zinc and the oral liquid containing inulin zinc |
| CN110301648A (en) * | 2019-07-24 | 2019-10-08 | 杭州海王生物工程有限公司 | A kind of minerals class drops and preparation method thereof |
| CN115400075A (en) * | 2021-05-28 | 2022-11-29 | 北京诺康达医药科技股份有限公司 | Zinc gluconate oral solution and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1709234A (en) * | 2005-06-23 | 2005-12-21 | 武汉三精医药科技有限公司 | Calcium-zinc gluconate oral liquid component and its process |
| CN102038670A (en) * | 2010-12-16 | 2011-05-04 | 杭州洁康药业有限公司 | Calcium and zinc gluconate oral solution and preparation method thereof |
| CN102342396A (en) * | 2011-04-09 | 2012-02-08 | 常德市城头山绿色饮料有限公司 | Oral liquid containing xylitol zinc calcium |
-
2012
- 2012-02-21 CN CN201210039223XA patent/CN102526009A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1709234A (en) * | 2005-06-23 | 2005-12-21 | 武汉三精医药科技有限公司 | Calcium-zinc gluconate oral liquid component and its process |
| CN102038670A (en) * | 2010-12-16 | 2011-05-04 | 杭州洁康药业有限公司 | Calcium and zinc gluconate oral solution and preparation method thereof |
| CN102342396A (en) * | 2011-04-09 | 2012-02-08 | 常德市城头山绿色饮料有限公司 | Oral liquid containing xylitol zinc calcium |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104231099A (en) * | 2014-09-03 | 2014-12-24 | 佐源集团有限公司 | Inulin zinc and oral liquid containing same |
| CN104231099B (en) * | 2014-09-03 | 2017-01-04 | 佐源集团有限公司 | A kind of inulin zinc and the oral liquid containing inulin zinc |
| CN104546818A (en) * | 2015-02-04 | 2015-04-29 | 澳诺（中国）制药有限公司 | Pharmaceutical composition with calcium supplement and zinc supplement effects and preparation of pharmaceutical composition |
| CN105077280A (en) * | 2015-09-01 | 2015-11-25 | 张伟 | Liquid preparation for supplementing zinc and preparation method thereof |
| CN105595346A (en) * | 2015-09-01 | 2016-05-25 | 张伟 | Liquid preparation for calcium supplementation and preparation method thereof |
| CN110301648A (en) * | 2019-07-24 | 2019-10-08 | 杭州海王生物工程有限公司 | A kind of minerals class drops and preparation method thereof |
| CN115400075A (en) * | 2021-05-28 | 2022-11-29 | 北京诺康达医药科技股份有限公司 | Zinc gluconate oral solution and preparation method thereof |
| CN115400075B (en) * | 2021-05-28 | 2024-04-23 | 北京诺康达医药科技股份有限公司 | Zinc gluconate oral solution and preparation method thereof |
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Application publication date: 20120704 |