CN102512539A - Main drug Ginseng-based compound externally-used liniment for treating hair loss and preparation method - Google Patents
Main drug Ginseng-based compound externally-used liniment for treating hair loss and preparation method Download PDFInfo
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- CN102512539A CN102512539A CN201110457059XA CN201110457059A CN102512539A CN 102512539 A CN102512539 A CN 102512539A CN 201110457059X A CN201110457059X A CN 201110457059XA CN 201110457059 A CN201110457059 A CN 201110457059A CN 102512539 A CN102512539 A CN 102512539A
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Abstract
The invention relates to a traditional Chinese medicinal preparation, namely a main drug Ginseng-based compound externally-used liniment for treating hair loss and a preparation method. The compound externally-used liniment for treating hair loss is prepared by taking Ginseng as a main drug, compounding Ginseng with resorcinol, pepper, calcium pantothenate, castor oil and other medicines, and refining through a liquid-pan-extraction technology. The main drug Ginseng-based compound externally-used liniment for treating the hair loss has the effects of nourishing and growing hair, improving local blood circulation, nourishing hair follicles and promoting hair growth, is quick in curative effect, is easy, convenient and safe to use, and is free of any toxic side effect after a long-term use; and through clinical observation, the main drug Ginseng-based compound externally-used liniment for treating the hair loss has a significant effect on alopecia areata and seborrheic alopecia, with an effective rate of 91%.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, promptly a kind of is compound external-use liniment and the method for preparing that principal agent is used to treat alopecia with the Radix Ginseng.Effective in cure to treatment bald spot, seborrheic alopecia disease.Name of product is " a compound ginseng resorcinol liniment ", and commodity are called " it is gloomy to send out luxuriant ".
Background technology
Alopecia is a kind of common phenomena, and polyphyly causes by the skin and hair disease, and with factor affecting hair follicle blood supplies such as nervous and mental factors, endocrine, heredity, infection, immunity, self metabolism and environmental stimuli, cause the hair follicle malnutrition relevant.Undesired alopecia phenomenons such as seborrheic alopecia, bald spot often can take place in all reasons physiological or pathology.Hair is a beautiful symbol of youth, and alopecia brings mental burden to the patient, often influences working and learning.
According to research, the ginsenoside can promote hair growth, and good hair care effect is arranged.The Ma Shouwu of medical college Institute of Basic Medical Sciences, Beijing shows ginsenoside monomer Rg1, Rb in the autoradiography research that ginsenoside monomer Rg1, Rb1, Rb2 distribute in the mice body
1, Rb
2In hair follicle (Mus palpus hair follicle), the distribution of concentrating is very much arranged.According to reports such as the neat Teng Yang of Japan, the ginsenoside has the effect that strengthens neural growth factor (reinforcement nerve ending).Therefore, also has trichogenous effect.Practice shows that the ginsenoside can directly get into the inside of hair fiber, has increased the absorbability of hair to saponin, and the quantity of its absorption than the product Senior Three of proteolysis doubly.After hair absorbs the ginsenoside, in the saponin polyhydroxy again with the hair microfibre in polypeptide generate hydrogen bond, and borrow the effect of hydrogen bond to interconnect, thereby promote the tensile strength and the percentage elongation of hair, that is strengthened the toughness of hair, and be difficult for alopecia.Old friend's ginseng has good hair care effect again, and more more effective than protein hydrolysate.
So far,, produce little effect, especially treat the real specific drug of seborrheic alopecia though the medicine and the Therapeutic Method of treatment alopecia are many.
Summary of the invention:
The object of the invention is to provide that a kind of to have treatment bald spot, seborrheic alopecia curative effect of disease better a kind of be compound external-use liniment and the method for preparing that principal agent is used to treat alopecia with the Radix Ginseng.
Technical solution of the present invention is: be the compound external-use liniment that principal agent is used to treat alopecia with the Radix Ginseng, processed by the crude drug of following weight number: Radix Ginseng 10-150g, Oleum Ricini 1-50g, diethylstilbestrol 0.01-1g, pine tar 0.1-2.5g, salicylic acid 1-50g, Fructus Capsici 10-200g, cholesterol 0.1-2.5g, glycerol 10-250g, resorcinol 1-25g, Mentholum 1-10g, calcium pantothenate 0.1-0.5g, ethanol are an amount of.
Preferably: with the Radix Ginseng is the compound external-use liniment that principal agent is used to treat alopecia, processes 1000ml by the crude drug of following weight number: Radix Ginseng 30g, Oleum Ricini 10g, diethylstilbestrol 0.01g, tar oil 0.5g, salicylic acid, 10g, Fructus Capsici 40g, cholesterol 0.5g, glycerol 50g, resorcinol 5g, Mentholum 2g, calcium pantothenate 0.1g, ethanol are an amount of.
Be the method for preparing that principal agent is used to treat the compound external-use liniment of alopecia with the Radix Ginseng, it is characterized in that step is following:
(1) get Radix Ginseng, Fructus Capsici and place different liquid flooding extractors respectively, adding concentration respectively is 70%-95% ethanol, and volume is for dropping into volume of material 5-10 doubly; Be heated to 60 ℃-80 ℃; Add the steam entering condensing tube that hot ethanol produces, cooled liquid return to raw material packed layer is added to the medical material the inside as novel solvent; When upstream solvent vapo(u)r was enough big, the packed layer bottom just had the liquid flooding phenomenon and produces; Extract cooling in 2-4 hour continuously, filter, it is subsequent use to get extracting solution respectively.
(2) will write out a prescription in other solid drugs porphyrize, add ethanol and make it dissolving, add Radix Ginseng again and capsicum extract stirs, filtration adds ethanol to full dose, packing promptly gets.
Composition principle Radix Ginseng: by the dry root of Araliaceae Radix Ginseng, through extracting the refining yellowish-brown liquid that forms.Mainly contain the ginsenoside, volatilization wet goods composition.This prescription is with the main purpose of Radix Ginseng, absorbs through local penetration, improving parafollicular blood circulation, to increase the supply of hair follicle nutrition, thereby promotes the growth of hair.Radix Ginseng in this prescription is the growth to hair, the medicine that protection plays a major role.Resorcinol: chemistry adjacent antelope yl benzoic acid by name.Have effects such as dissolving skin keratin, antipruritic, antibacterial.So can prevent and treat follicular orifice hyperkeratosis and seborrheic alopecia.For some dermatopathy that causes in keratodermatitis because of fungus growth, influence the effect of medicine because of receiving cuticular protective effect, it can be removed horny layer, and strengthens the bacteriostasis of medicine and be beneficial to the performance of drug effect.Oleum Ricini: for squeezing in the euphorbia plant Semen Ricini mature seed and refining obtaining.Mainly contain fatty acid.Because the zest of Oleum Ricini own is less, only as the skin lubrication agent, and can make the hair softness in this prescription, and also glossy.Fructus Capsici: mainly contain capsicum oleoresin etc.Because of it has local irritant effect, can stimulate subcutaneously, improve local blood circulation, thereby promote the growth of hair.Diethylstilbestrol: have effects such as secretion of the androgen of inhibition and androgen antagonist.To because too much androgen stimulates sebaceous gland, promote smegma to increase, and sebaceous gland is blocked, influence the growth of hair, certain therapeutical effect is arranged.Calcium pantothenate: be vitamin drug.Be mainly used in the nutrition hair follicle cell in this prescription, simultaneously these article can form faint emulsifying agent with Oleum Ricini, emulsifying sebum and be beneficial to penetrating of medicine.Seborrheic alopecia there is the effect of auxiliary treatment.Pine tar: the Colophonium shape liquid that obtains through dry distilling for the timber of Pinaceae pine genus plant.Mainly contain volatile oil, oils and fats etc.Because of the tool antibacterial, effect such as antipruritic grade with the other medicines compatibility, can strengthen the drug effect of other medicines.Cholesterol: main nutrition hair follicle cell, and can replenish the needed nutrition of damaged hair.Experiment showed, impaired hair, it is strong more that its cortex, medullary substance layer absorb the nutritional substance ability.Thereby the effect of cholesterol is to supply with trichotrophy, thereby promotes the growth of hair.Mentholum: be a kind of saturated cyclic alcohol that from Oleum menthae, obtains.Because of it can alleviate the sense of the discomfort of some stimulating drug in the prescription, simultaneously also can be antipruritic, so medication aftersensation cool and comfortable.Glycerol: be mainly used in skin care, and can reduce alcoholic acid zest.
This prescription adopts ethanol to be for the solvent effect: most medicines dissolubility in water is all very little in (1) this prescription, adopts ethanol to do solvent, and the dissolubility of medicine is increased, and plays a role thereby be beneficial to medicine.(2) fungus generally parasitizes in the epidermis, and the keratin of epidermis can stop the infiltration of medicine, influences the performance of drug effect, does the penetrance that solvent can strengthen medicine with ethanol, can guarantee that medicine plays a role.
The medicine compatibility of below respectively distinguishing the flavor of just has blood nourishing and hair together, improves local blood circulation, increases the supply of hair follicle nutrition; Reduce sebum secretion; Prevention follicular orifice hyperkeratosis promotes the effect of the growth of hair, also has effects such as prevention alopecia, antipruritic, antibacterial simultaneously.
Function cures mainly: generating and nourishing hair, improve local blood circulation.Promote hair growth, reduce sebum secretion, prevention follicular orifice hyperkeratosis increases the supply of hair follicle nutrition, prevention alopecia, antipruritic, antibacterial, inhibition dandruff.Main treatment alopecia areata, seborrheic alopecia, premature hair loss, post disease alopecia, senile alopecia, the natural on-off cycles of hair growth function is not prosperous, and unnecessary survivor again comes off.
Usage and dosage: pick this medicine with cotton swab and be applied to the affected part, tunk gently,, increase drug osmotic and absorb every day 2-3 time with blood circulation promoting.To prevention alopecia person, mainly be applied to scalp front portion and middle part, once a day, about at every turn 1ml.
Advantage of the present invention: 1, the present invention is principal agent with the Radix Ginseng, and with multiple compatibility of drugs, the compatibility relationship that prescription has fully used Chinese medicine monarch, minister, helped, makes; Reasonable recipe; Improve local blood circulation thereby reach, the nutrition hair follicle promotes hair growth; Reduce sebum secretion, end bits, antipruritic, germ-resistant purpose.2, the present invention adopts modern preparation technology, and advanced technology is easy to use, safety, and life-time service is without any side effects, and bioavailability is high, and curative effect is fast, is the satisfied external used medicine of treatment alopecia areata, seborrheic alopecia.3, the present invention adopts the liquid flooding extraction method to extract, and the steam that it has been produced when having made full use of heated solvent has increased the less turbulence of liquid phase, has improved the diffusion rate of solute.Simultaneously,, make the higher Concentraton gradient of maintenance between solute and solvent, significantly improved alternate mass transfer force, extraction ratio is improved because constantly there is fresh solvent to add.Its method for distilling collection extracts, filters, concentrates in one, shortens the production cycle, and yield is high, and advanced technology is fit to suitability for industrialized production, has broad application prospects.4, confirm that through pharmacological action Radix Ginseng really can promote natural on-off cycles of hair growth, keep lubricity.The Radix Ginseng extractive solution plays metabolism to the hair follicle of trophophase.The present invention can promote the hypertrophy of mice hair follicle.The ginseng effective component can also have the distribution of concentrating very much in the mice hair follicle.Radix Ginseng extract can not only be anti-loss for hair protection aspect, can also improve the tensile strength and the ductility of hair.Through to 442 routine hair loss patient clinical practices, alopecia areata, seborrheic alopecia there are significant curative effect, total effective rate reaches 91%.
To combine embodiment that embodiment of the present invention is described in further detail below.
The specific embodiment
Embodiment 1
With the Radix Ginseng is the compound external-use liniment that principal agent is used to treat alopecia: Radix Ginseng 50g, Oleum Ricini 17g, diethylstilbestrol 0.02g, pine tar 0.9g, salicylic acid 17g, Fructus Capsici 70g, cholesterol 0.9g, glycerol 85g, resorcinol 8g, Mentholum 4g, calcium pantothenate 0.2g, ethanol are an amount of.
Embodiment 2
With the Radix Ginseng is the compound external-use liniment that principal agent is used to treat alopecia: Radix Ginseng 80g, Oleum Ricini 30g, diethylstilbestrol 0.03g, pine tar 1.5g, salicylic acid 30g, Fructus Capsici 110g, cholesterol 1.5g, glycerol 140g, resorcinol 15g, Mentholum 6g, calcium pantothenate 0.3g, ethanol are an amount of.
Embodiment 3
With the Radix Ginseng is the compound external-use liniment that principal agent is used to treat alopecia: Radix Ginseng 120g, Oleum Ricini 40g, diethylstilbestrol 0.04g, pine tar 2g, salicylic acid 40g, Fructus Capsici 160g, cholesterol 2.0g, glycerol 200g, resorcinol 20g, Mentholum 8g, calcium pantothenate 0.4g, ethanol are an amount of.
Embodiment 4
With the Radix Ginseng is the compound external-use liniment that principal agent is used to treat alopecia: Radix Ginseng 30g, Oleum Ricini 10g, diethylstilbestrol 0.01g, tar oil 0.5g, salicylic acid, 10g, Fructus Capsici 40g, cholesterol 0.5g, glycerol 50g, resorcinol 5g, Mentholum 2g, calcium pantothenate 0.1g, ethanol are an amount of, process 1000ml.
Embodiment 5
Be the method for preparing that principal agent is used to treat the compound external-use liniment of alopecia with the Radix Ginseng:
Radix Ginseng, the Fructus Capsici of getting ormal weight place different liquid flooding extractor equipment respectively, add 85%, 95% ethanol respectively, and volume is heated to 80 ℃ for 5 times of the input volume of material, extracts 2 hours.Cooling is filtered, and collects filtrating; Other solid drugs porphyrize in will writing out a prescription again adds an amount of ethanol and makes it dissolving, adds Radix Ginseng and capsicum extract (filtrating) again and stirs, and filters, and adds ethanol to full dose, and packing promptly gets.
Experimental example 1
Pharmacological action: the present invention is to be that primary raw material is equipped with the refining compound external-use liniment that forms of other ancillary drug with the Radix Ginseng; Have functions of nourishing hair and growing hair, improve local blood circulation, promote hair growth; Reduce sebum secretion; Prevention follicular orifice hyperkeratosis increases the supply of hair follicle nutrition, the effect of prevention alopecia, antipruritic, antibacterial, inhibition dandruff.Experiment shows, embrocates the mice hair follicle showed increased of this medicine after 30 days.
Experimental example 2
Toxicological effect: research shows, is coated with 25 days for animal continuously, finds that this medicine can make mouse skin hair follicle showed increased; Skin there is not the obvious stimulation effect; To the body weight gain of animal, routine blood test and liver, renal function all do not have influence, also do not cause anaphylactic type, delayed allergy.Therefore, can yet be regarded as a kind of external good medicine of safe, effective, the treatment alopecia that has no side effect of the present invention provides foundation for clinical safe medication simultaneously.
Experimental example 3
Clinical experiment:
1, alopecia diagnostic criteria:
(1) the hair bits increase, the scalp oils and fats is obvious, scalp itch.
(2) hair is sparse even bald.
(3) come off obviously the more preceding obvious minimizing of hair in the recent period.
(4) there be not the other diseases relevant in the recent period with alopecia.
(5) get rid of the alopecia congenital, that other chemical factors cause.
2, alopecia efficacy assessment standard:
(1) be almost recovered: the alopecia place is covered by bristle, but reinstatement person not as yet.
(2) produce effects: obvious hair growth promoting in alopecia district and new hair growth promoting be approaching normal person on color and luster, thickness, hardness.
(3) effective: the alopecia district is covered by new hair growth promoting basically, subjective symptoms disappearance person.
(4) invalid: treating continuously still to lose five courses of treatment has the New Development person of growing.
3, usage and dosage: pick this medicine with cotton swab and be applied to the affected part, tunk gently,, increase drug osmotic and absorb every day 2-3 time with blood circulation promoting.To prevention alopecia person, mainly be applied to scalp front portion and middle part, once a day, about at every turn 1ml.
4, through to 442 routine hair loss patient clinical practices, obtained gratifying curative effect, promptly the curative effect effective percentage reaches 91%.Therapeutic effect sees the following form.
Claims (4)
1. one kind is the compound external-use liniment that principal agent is used to treat alopecia with the Radix Ginseng, it is characterized in that being processed by the crude drug of following weight number: Radix Ginseng 10-150g, Oleum Ricini 1-50g, diethylstilbestrol 0.01-1g, pine tar 0.1-2.5g, salicylic acid 1-50g, Fructus Capsici 10-200g, cholesterol 0.1-2.5g, glycerol 10-250g, resorcinol 1-25g, Mentholum 1-10g, calcium pantothenate 0.1-0.5g, ethanol are an amount of.
2. described according to claim 1 is the compound external-use liniment that principal agent is used to treat alopecia with the Radix Ginseng; It is characterized in that Radix Ginseng 30g, Oleum Ricini 10g, diethylstilbestrol 0.01g, tar oil 0.5g, salicylic acid, 10g, Fructus Capsici 40g, cholesterol 0.5g, glycerol 50g, resorcinol 5g, Mentholum 2g, calcium pantothenate 0.1g, ethanol are an amount of, process 1000ml.
3. one kind is the method for preparing that principal agent is used to treat the compound external-use liniment of alopecia according to claim 1 or claim 2 with the Radix Ginseng, it is characterized in that step is following:
(1) get Radix Ginseng, Fructus Capsici and place different liquid flooding extractors respectively, add 70%-95% ethanol respectively, volume is for dropping into volume of material 5-10 doubly; Be heated to 60 ℃-80 ℃; Add the steam entering condensing tube that hot ethanol produces, cooled liquid return to raw material packed layer is added to the medical material the inside as novel solvent; When upstream solvent vapo(u)r was enough big, the packed layer bottom just had the liquid flooding phenomenon and produces; Extracted 2-4 hour continuously, cooling is filtered, and it is subsequent use to get extracting solution respectively;
(2) will write out a prescription in other solid drugs porphyrize, add ethanol and make it dissolving, add Radix Ginseng again and capsicum extract stirs, filtration adds ethanol to full dose, packing promptly gets.
According to claim 3 described said be the method for preparing that principal agent is used to treat the compound external-use liniment of alopecia with the Radix Ginseng, it is characterized in that step is following:
(1) get Radix Ginseng, Fructus Capsici and place different liquid flooding extractors respectively, add 85%, 95% ethanol respectively, volume is for dropping into 5 times of volume of material; Be heated to 80 ℃; Add the steam entering condensing tube that hot ethanol produces, cooled liquid return to raw material packed layer is added to the medical material the inside as novel solvent; When upstream solvent vapo(u)r was enough big, the packed layer bottom just had the liquid flooding phenomenon and produces; Extracted 2 hours continuously, cooling is filtered, and it is subsequent use to get extracting solution respectively;
(2) will write out a prescription in other solid drugs porphyrize, add ethanol and make it dissolving, add Radix Ginseng again and capsicum extract stirs, filtration adds ethanol to full dose, packing promptly gets.
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| WO2013059942A1 (en) * | 2011-10-28 | 2013-05-02 | Afexa Life Sciences Inc. | Use of a ginseng extract to prevent and treat alopecia areata |
| CN104644650A (en) * | 2013-11-18 | 2015-05-27 | 富力 | Application of 20(R)-ginsenoside Rg3 in preparation of medicine for improving and/or treating alopecia |
| CN105250152A (en) * | 2015-10-21 | 2016-01-20 | 珠海市时代经典化妆品有限公司 | Anti-hair-loss and hair-growing essence and preparation method thereof |
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