CN102511814B - Composition with lipase inhibiting effect and application of same - Google Patents
Composition with lipase inhibiting effect and application of same Download PDFInfo
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- CN102511814B CN102511814B CN2011104588502A CN201110458850A CN102511814B CN 102511814 B CN102511814 B CN 102511814B CN 2011104588502 A CN2011104588502 A CN 2011104588502A CN 201110458850 A CN201110458850 A CN 201110458850A CN 102511814 B CN102511814 B CN 102511814B
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Abstract
A composition a with lipase inhibiting effect particularly relates to the conjunctive use of two-dual herbs used as food and medicine and comprises tea leaves, lotus leaves, cassia seed, balsam pear and liquorice, wherein the tea leaves can be leaves of one or a plurality of black tea, green tea, oolong tea and Pu'er tea. The lipase activity inhibiting rate of the composition is above 60%, and the inhibition effect is better than the total of the lipase inhibiting effects of all single components; and the combination manner enables the lipase inhibiting effects of all components to be increased. The extracted composition can be manufactured intoto health-care food or ordinary food capable of facilitating weight lose or reducing lipid and in various forms like liquid drink, particle, soft capsule, hard capsule, effervescent tablet or buccal tablet.
Description
Technical field
The present invention relates to a kind of inhibiting composition of lipase that has, particularly adopt being used of food and medicine-food two-purpose medicinal material.The invention still further relates to the application of this composition in food and health food.
Technical background
Change along with people's dietary structure and custom, now increasing people increases the absorption of food rich in fat, superfluous fat can not be absorbed by the body and utilize and just make the people form the fat bodily form, tends to bring diseases such as hypertension, coronary heart disease, diabetes, hyperlipidemia, artery sclerosis, endocrine, metabolic disorder, disease in the liver and gallbladder.At present, the higher slimming medicine of occupation rate of market mainly is appetite-suppressing or realizes the purpose of losing weight by changing fat in the metabolism of human body and absorbing.Can increase people's feeling of repletion such as containing sibutramine class chemicals, lose weight thereby reduce feed indirectly, the blood pressure but this medicine can raise is for cardiovascular toxic side effect; Another kind of lipase inhibitor reduces the fat metabolism that enters in the body and reaches the fat-reducing purpose by suppressing lipase active.Inhibitor does not enter human vas and nervous system, and human body mineral homeostasis and sclerotin circulation are not all had influence.Compare with adjust the dietary structure fat-reducing singlely, lipase inhibitor also improves significantly to some obesity complication such as hypertension, high cholesterol and diabetes except losing weight.As the chemicals that contains the orlistat class passes through to suppress intestines and stomach lipase, especially pancreatic lipase, the blocking-up lipolysis is less absorbable triglycerides, thereby reduce the absorption of fat, body weight is controlled, but such medicine can cause functional disturbances of gastrointestinal tract, respiratory tract infection etc., also can influence the absorption of liposoluble vitamin, causes ill symptomses such as fat-soluble avitaminosis.
Use lipase inhibitor and can suppress effectively that lipase reaches the purpose that reduces fat absorption, control and treatment obesity to the decomposition catalytic action of fat in the enteron aisle.The source of lipase inhibitor mainly contains chemical synthesis, extracted form natural plant and microbial metabolism etc.More being not suitable for of the bad reaction of chemicals eats for a long time, the lipase inhibitor that derives from traditional medicinal material of some integration of drinking and medicinal herbs or natural products by contrast is more safe and reliable, be suitable for daily edible fat-reducing, antihyperlipidemic product by rational compatibility with extracting to process to develop, can when not limiting diet, control formation and the accumulation of body fat.
Summary of the invention
The present invention adopts the traditional Chinese medicine of integration of drinking and medicinal herbs and natural products to carry out compatibility, and the effect of giving full play to each component reaches the effect that suppresses lipase active.
A kind of inhibiting composition of lipase that has of the present invention is characterized in that part by balsam pear 3-8, lotus leaf 1-6 part, and cassia seed 2-5 part, tealeaves 0-7 part, Radix Glycyrrhizae 1-5 part is formed.
Cassia seed medicinal material flavor is sweet, bitter, salty in the composition, be slightly cold, but removing heat to brighten vision relaxes bowel.The flat energy of lotus leaf bitter clearing away summerheat, sending up the lucid yang, cooling blood and hemostasis.The Weight-reducing and lipid-lowering efficacy study of cassia seed, lotus leaf is more, but body fluid is hindered in single edible or edible improper meeting for a long time.Effects such as that balsam pear has is clearing heat and detoxicating, reduce blood sugar, antibiotic, immunological regulation.Active component in the balsam pear is of a great variety, has got number of chemical compositions such as triterpenes, alkaloids, steroid, carbohydrate, protein, organic acid and trace element.Efficacy study for balsam pear all concentrates on the hypoglycemic aspect, and experimental study of the present invention finds that the aqueous extract of balsam pear has certain lipase inhibitory action.The oxidation polymerization composition of the polyphenols in the tealeaves and catechin uses tealeaves in the composition because not only can strengthen the lipase inhibitory action of lotus leaf, cassia seed, balsam pear, can also be in harmonious proportion the meridian distribution of property and flavor of composition, enable to be tending towards gentle, add the mediation of Radix Glycyrrhizae and increase the flavor effect, make the present composition can the good lipase inhibitory action of reaching property, edible or can not bring bad reaction and side effect for tea-drinking for a long time.
It is in black tea, green tea, oolong tea, the Pu'er tea one or more that a kind of inhibiting composition of lipase that has of the present invention, tealeaves wherein can be selected from:
A kind of have an inhibiting composition of lipase, it is characterized in that comprising balsam pear 3-8 part, lotus leaf 1-6 part, cassia seed 2-5 part, black tea 0-7 part, Radix Glycyrrhizae 1-4 part.
A kind of have an inhibiting composition of lipase, it is characterized in that comprising balsam pear 3-8 part, lotus leaf 1-6 part, cassia seed 2-5 part, green tea 0-7 part, Radix Glycyrrhizae 2-5 part.
A kind of have an inhibiting composition of lipase, it is characterized in that comprising balsam pear 3-8 part, lotus leaf 1-6 part, cassia seed 2-5 part, oolong tea 0-5 part, Radix Glycyrrhizae 2-5 part.
A kind of have an inhibiting composition of lipase, it is characterized in that comprising balsam pear 3-8 part, lotus leaf 1-6 part, cassia seed 2-5 part, Pu'er tea 0-5 part, Radix Glycyrrhizae 1-4 part.
Tealeaves in the composition can also be the mixture of four kinds of teas, and a kind of have an inhibiting composition of lipase, by balsam pear 3-8 part, lotus leaf 1-6 part, cassia seed 2-5 part, tealeaves 0-7 part, Radix Glycyrrhizae 1-5 part is formed, and it is characterized in that tealeaves wherein can be that black tea, green tea respectively account for 50%; Perhaps black tea, Pu'er tea respectively account for 50%; Or black tea, oolong tea respectively account for 50%; Or black tea accounts for 30%, green tea accounts for 40%, Pu'er tea accounts for 30%.
A kind of inhibiting composition of lipase that has of the present invention, the prescription screening mainly can act on the ester bond of triglycerides according to lipase, make the triglycerides degraded, and different phase can discharge aliphatic acid, diglyceride, monoglyceride and glycerine.The aliphatic acid that fat splitting generates can be indicated the vigor of lipase with the aqueous slkali titration of standard.Composition of the present invention utilizes this effect of lipase, and pancreatic lipase catalysis lipolysis generates aliphatic acid, with the phenolphthalein agent of giving instruction, with standard NaOH solution titration of fatty acids, calculates lipase activity according to the consumption of NaOH.
Lipase activity determination: in 100 mL conical flasks, add 5mL 0. 025mol/L phosphate buffer (pH=7. 4) and 4 mL polyvinyl alcohol olein substrate emulsions (0. 229g/mL), place 37 ℃ of water bath heat preservation 10 min, add 1 mL enzyme liquid (2 mg/mL) then, react 15 min afterwards again, add 95% ethanol, 15 mL and stop enzyme reaction.Add 2 in phenolphthalein, with 0.025 mol/LNaOH standard solution titration to blush.
By relatively having or not under the inhibitor adding situation, the difference of lipase activity, lipase inhibiting rate that just can working sample.The lipase activity unit definition: under 7.4,37 ℃ of conditions of pH, per minute catalysis fat splitting generates the amount of the enzyme of 1 μ mol aliphatic acid, is defined as an enzyme activity unit.
Suppress measuring according to above-mentioned lipase active, independent lotus leaf, balsam pear, cassia seed and tealeaves all have lipase activity inhibition in various degree, and the inhibitory action to lipase after this different materials is mixed has according to a certain percentage exceeded simple each single material sum.From the compatibility of drugs angle, fever and chills are comprehensive flat, and the people who is fit to various physique is edible.Thing combined according to the invention and commercially available Weight-reducing and lipid-lowering class tea sample lipase inhibitory action compare, and the present composition has lipase activity inhibition preferably.
A kind of application with lipase inhibitory action composition of the present invention is characterized in that described composition is made liquid beverage, particle, soft capsule, hard shell capsules, effervescent tablet, buccal tablet, Film coated tablets.Beverage or the oral liquid of liquid will directly be mixed with as required after each component is extracted in the composition; Can also add auxiliary material or excipient and make particle or electuary according to the processing request of food or health food; Can also be through extracting the product that is processed into forms such as the soft capsule that is convenient for carrying and takes, hard shell capsules, effervescent tablet, buccal tablet after concentrated and purified.
A kind of application with lipase inhibitory action composition of the present invention is characterized in that described composition is for the preparation of the health food with antiobesity action.A kind of application with lipase inhibitory action composition of the present invention is characterized in that described composition is for the preparation of the food with the greasy effect of lipopenicillinase solution.Said composition is by suppressing the activity of lipase, so reduce fat in human body digestion and absorb the purpose that reaches lipopenicillinase, fat-reducing.Can will be condensed into thick paste after the said composition boiling or convection drying becomes powder, add suitable auxiliary material on this basis again and make particle, effervescent tablet or buccal tablet; Also can load into hard shell capsules or soft capsule.
The specific embodiment
The present invention is described further below in conjunction with embodiment, but be not limited to embodiment.
Embodiment 1:
A kind of have an inhibiting composition of lipase, it is characterized in that comprising 8 parts in balsam pear, 6 parts on lotus leaf, 5 parts of cassia seeds, 5 parts in Radix Glycyrrhizae.After taking by weighing the medicinal material of respectively distinguishing the flavor of by the prescription amount, twice of the water boiling and extraction that adds 15 times of amounts, each 30 minutes, merge and to put that 300 order filter clothes filter to the room temperature behind the extract, filtrate degree of being concentrated into is about 1.2 thick paste in the time of 45 ℃, press 6 times of thick pastes amount and add sucrose, make particle, be drying to obtain and have lipase inhibitory action particle.
Embodiment 2:
A kind of have an inhibiting composition of lipase, it is characterized in that comprising 8 parts in balsam pear, 6 parts on lotus leaf, 5 parts of cassia seeds, 7 parts of black tea, 4 parts in Radix Glycyrrhizae.After taking by weighing the medicinal material of respectively distinguishing the flavor of by the prescription amount, add the water boiling and extraction twice of 15 times of amounts, each 30 minutes, merge and put that 300 order filter clothes filter to the room temperature behind the extract, filtrate is diluted to 100 times of raw material weight, and the inhibiting rate of measuring lipase active is 64.2 ± 4.1%.
Embodiment 3:
A kind of have an inhibiting composition of lipase, it is characterized in that comprising 5 parts in balsam pear, 4 parts on lotus leaf, 3 parts of cassia seeds, 3 parts of black tea, 2 parts in Radix Glycyrrhizae.After taking by weighing the medicinal material of respectively distinguishing the flavor of by the prescription amount, the water boiling and extraction twice that adds 15 times of amounts each 30 minutes, merges and to put that 300 order filter clothes filter to the room temperature behind the extract, filtrate is diluted to 100 times of raw material weight, and the inhibiting rate of measuring lipase active is enzyme activity 73.2 ± 7.1.Filtrate interpolation is by volume measured 0.03% citric acid, 0.05% natrium citricum, 5% white granulated sugar, stirs after the dissolving fully, and packing namely gets the tea beverage with antiobesity action.
Embodiment 4:
A kind of have an inhibiting composition of lipase, it is characterized in that comprising 3 parts in balsam pear, 4 parts on lotus leaf, 3 parts of cassia seeds, 3 parts of black tea, 1.5 parts in Radix Glycyrrhizae.After taking by weighing the medicinal material of respectively distinguishing the flavor of by the prescription amount, add the water boiling and extraction twice of 15 times of amounts, each 30 minutes, merge and put that 300 order filter clothes filter to the room temperature behind the extract.Get filtrate and be diluted to 100 times of raw material weight, the inhibiting rate of measuring lipase active is enzyme activity 61.2 ± 5.2.Filtrate is condensed into the thick paste of density 1.2-1.3, suppresses in flakes after the starch of adding thick paste weight 30% and 5% sodium carboxymethylcellulose mixing are made particle, namely gets to have the inhibiting tablet of lipase behind film coating.
Embodiment 5:
A kind of have an inhibiting composition of lipase, it is characterized in that comprising 5 parts in balsam pear, 4 parts on lotus leaf, 3 parts of cassia seeds, 2 parts in Radix Glycyrrhizae.After taking by weighing the medicinal material of respectively distinguishing the flavor of by the prescription amount, the water boiling and extraction twice that adds 15 times of amounts, each 30 minutes, merge put behind the extract to the room temperature centrifugal in 4000r/min, get supernatant and be diluted to 100 times of raw material weight, the inhibiting rate of measuring lipase active is 65.2 ± 4.1.Filtrate interpolation is by volume calculated 0.02% citric acid, 0.05% vitamin C, 5% white granulated sugar, stirs after the dissolving fully, and packing namely gets has the inhibiting tea beverage of lipase.
Embodiment 6:
A kind of have an inhibiting composition of lipase, it is characterized in that comprising 3 parts in balsam pear, 1 part on lotus leaf, 2 parts of cassia seeds, 3 parts of green tea, 2 parts in Radix Glycyrrhizae.After taking by weighing the medicinal material of respectively distinguishing the flavor of by the prescription amount, twice of the water boiling and extraction that adds 15 times of amounts, each 30 minutes, merge and to put that 300 order filter clothes filter to the room temperature behind the extract, filtrate degree of being concentrated into is about 1.2 thick paste in the time of 45 ℃, adds the starch of thick paste amount 30%, 2.5% dolomol, make particle, dry back is loaded capsule and is namely got the capsule with antiobesity action.
Embodiment 7:
A kind of have an inhibiting composition of lipase, it is characterized in that comprising 8 parts in balsam pear, 6 parts on lotus leaf, 5 parts of cassia seeds, 7 parts of green tea, 5 parts in Radix Glycyrrhizae.After taking by weighing the medicinal material of respectively distinguishing the flavor of by the prescription amount, the water boiling and extraction twice that adds 15 times of amounts each 30 minutes, merges and to put that 300 order filter clothes filter to the room temperature behind the extract, filtrate is diluted to 100 times of raw material weight, and the inhibiting rate of measuring lipase active is enzyme activity 75.2 ± 6.8.Filtrate stirs after by volume measuring and calculate adding 0.04% malic acid, 0.02% Stevioside and an amount of anticorrisive agent dissolving fully, and packing namely gets has the inhibiting tea beverage of lipase.
Embodiment 8:
A kind of have an inhibiting composition of lipase, it is characterized in that comprising 3 parts in balsam pear, 1 part on lotus leaf, 2 parts of cassia seeds, 5 parts in oolong tea, 1 part in Radix Glycyrrhizae.After taking by weighing the medicinal material of respectively distinguishing the flavor of by the prescription amount, add the water boiling and extraction twice of 15 times of amounts, each 30 minutes, merge and put behind the extract to the room temperature centrifugally in 4000r/min, getting supernatant, to measure the inhibiting rate of lipase active be 65.5 ± 5.2.The powder of getting after the supernatant spray-drying by No. 6 sieves is standby, and the aperture of No. 6 sieves is about 150 microns.Get 15 parts of immersions of 10 parts of adding distil waters of gelatin and make the back of expanding add glycerine to stir for 8 parts and make the capsule material, according to pressing directly with spray dried powder compression moulding namely.
Embodiment 9:
A kind of have an inhibiting composition of lipase, it is characterized in that comprising 8 parts in balsam pear, 5 parts on lotus leaf, 5 parts of cassia seeds, 5 parts of Pu'er teas, 4 parts in Radix Glycyrrhizae.After taking by weighing the medicinal material of respectively distinguishing the flavor of by the prescription amount, add the water boiling and extraction twice of 15 times of amounts, each 30 minutes, merge and put behind the extract to the room temperature centrifugally in 4000r/min, getting supernatant, to measure the inhibiting rate of lipase active be 61.9 ± 5.1.The powder of getting after the supernatant spray-drying by No. 6 sieves is divided into two parts, and the aperture of No. 6 sieves is about 150 microns, and first part of adding citric acid, Stevioside, starch, superfine silica gel powder were pulverized sieve No. 6, used 75% alcohol granulation, and 60 ℃ of dryings, whole are standby; Second part adds the fine powder that polyethylene glycol 4000 miscible sodium acid carbonates are pulverized, mixes with first part of particle, dolomol mixing, compressing tablet and namely get the effervescent tablet with antiobesity action.
Embodiment 10:
A kind of have an inhibiting composition of lipase, it is characterized in that comprising 3 parts in balsam pear, 4 parts on lotus leaf, 3 parts of cassia seeds, 1.5 parts of black tea, 1.5 parts of green tea, 1.5 parts in Radix Glycyrrhizae.After taking by weighing the medicinal material of respectively distinguishing the flavor of by the prescription amount, the water boiling and extraction twice that adds 15 times of amounts each 30 minutes, merges and to put that 300 order filter clothes filter to the room temperature behind the extract, filtrate is diluted to 100 times of raw material weight, and the inhibiting rate of measuring lipase active is enzyme activity 67.2 ± 5.7.Add the citric acid of filtrate volume amount 0.03%, 0.05% natrium citricum, 10% xylitol, stir after the dissolving fully, packing namely gets has the inhibiting tea beverage of lipase.
Embodiment 11
A kind of have an inhibiting composition of lipase, it is characterized in that comprising 5 parts in balsam pear, 4 parts on lotus leaf, 3 parts of cassia seeds, 1 part of black tea, 1 part in oolong tea, 1 part in Radix Glycyrrhizae.After taking by weighing the medicinal material of respectively distinguishing the flavor of by the prescription amount, add the water boiling and extraction twice of 15 times of amounts, each 30 minutes, merge and put that 300 order filter clothes filter to the room temperature behind the extract.Filtrate is diluted to 100 times of raw material weight, and the inhibiting rate of measuring lipase active is enzyme activity 67.3 ± 5.1.Got the fine powder of No. 6 sieves after filtrate is spray-dried, the aperture of No. 6 sieves is about 150 microns, and the sweet mellow wine, 5% sucrose, 5% starch that add powder weight 30% mix, and granulates behind the adding powder weight 10% glucose syrup softwood processed, and 65 ℃ of dry backs are standby.On particle, compacting namely gets in flakes has the greasy buccal tablet of lipopenicillinase solution with an amount of ethanol dissolving back spray by particle weight 0.05% peppermint, 0.1% peppermint oil dementholized.
Embodiment 12
A kind of have an inhibiting composition of lipase, it is characterized in that comprising 3 parts in balsam pear, 4 parts on lotus leaf, 3 parts of cassia seeds, 1.5 parts of black tea, 1.5 parts of Pu'er teas, 2 parts in Radix Glycyrrhizae.After taking by weighing the medicinal material of respectively distinguishing the flavor of by the prescription amount, add the water boiling and extraction twice of 15 times of amounts, each 30 minutes, merge and put that 300 order filter clothes filter to the room temperature behind the extract.Filtrate is diluted to 100 times of raw material weight, and the inhibiting rate of measuring lipase active is enzyme activity 63.8 ± 4.3.Filtrate is condensed into the thick paste of density 1.2-1.3, suppresses in flakes after the starch of adding thick paste weight 30% and 5% sodium carboxymethylcellulose mixing are made particle, namely gets to have the inhibiting Film coated tablets of lipase behind film coating.
Embodiment 13
A kind of have an inhibiting composition of lipase, it is characterized in that comprising 5 parts in balsam pear, 4 parts on lotus leaf, 3 parts of cassia seeds, 0.8 part of green tea, 0.6 part of black tea, 0.6 part of Pu'er tea, 1 part in Radix Glycyrrhizae.After taking by weighing the medicinal material of respectively distinguishing the flavor of by the prescription amount, add the water boiling and extraction twice of 15 times of amounts, each 30 minutes, merge to put to room temperature behind the extract and add natural clarifying agent, filter with 300 order filter clothes after the standing over night.Get part filtrate and be diluted to 100 times of raw material weight in proportion, the inhibiting rate of measuring lipase active is enzyme activity 70.2 ± 3.8.Filtrate is diluted to 100 times of raw material weight in proportion, stirs after adding 0.04% the citric acid, 0.06% albumen sugar of solution total amount and an amount of anticorrisive agent dissolving fully, and packing namely gets the tea beverage with the greasy effect of lipopenicillinase solution.
Embodiment 14:
A kind of have an inhibiting composition of lipase, it is characterized in that comprising 3 parts in balsam pear, 1 part on lotus leaf, 2 parts of cassia seeds, 1 part in Radix Glycyrrhizae.After taking by weighing the medicinal material of respectively distinguishing the flavor of by the prescription amount, twice of the water boiling and extraction that adds 15 times of amounts, each 30 minutes, merge and to put that 300 order filter clothes filter to the room temperature behind the extract, filtrate degree of being concentrated into is about 1.2 thick paste in the time of 45 ℃, adds the starch of thick paste weight 10%, 20% dextrin, 2.5% dolomol is made particle, and dry back is loaded capsule and namely got the capsule with antiobesity action.
Embodiment 15
A kind of have an inhibiting composition of lipase, it is characterized in that comprising 8 parts in balsam pear, 6 parts on lotus leaf, 5 parts of cassia seeds, 5 parts in oolong tea, 5 parts in Radix Glycyrrhizae.After taking by weighing the medicinal material of respectively distinguishing the flavor of by the prescription amount, add the water boiling and extraction twice of 15 times of amounts, each 30 minutes, merge extract, filter with 300 order filter clothes after the standing over night.Get filtrate 1ml and be diluted to 100 times of raw material weight in proportion, the inhibiting rate of measuring lipase active is enzyme activity 70.2 ± 3.8.Stir after adding 0.03% citric acid, 0.02% natrium citricum, 5% the white granulated sugar of filtrate volume total amount and an amount of anticorrisive agent dissolving fully, packing namely gets the tea beverage with the greasy effect of lipopenicillinase solution.
Claims (10)
1. one kind has the inhibiting composition of lipase, it is characterized in that part by balsam pear 3-8, lotus leaf 1-6 part, and cassia seed 2-5 part, tealeaves 0-7 part, Radix Glycyrrhizae 1-5 part is formed.
2. a kind of inhibiting composition of lipase that has as claimed in claim 1 is characterized in that wherein tealeaves is the one or more combination in black tea, green tea, oolong tea, the Pu'er tea.
3. a kind of inhibiting composition of lipase that has as claimed in claim 2 is characterized in that part by balsam pear 3-8, lotus leaf 1-6 part, and cassia seed 2-5 part, black tea 0-7 part, Radix Glycyrrhizae 1-4 part is formed.
4. a kind of inhibiting composition of lipase that has as claimed in claim 2 is characterized in that part by balsam pear 3-8, lotus leaf 1-6 part, and cassia seed 2-5 part, green tea 0-7 part, Radix Glycyrrhizae 2-5 part is formed.
5. a kind of inhibiting composition of lipase that has as claimed in claim 2 is characterized in that part by balsam pear 3-8, lotus leaf 1-6 part, and cassia seed 2-5 part, oolong tea 0-5 part, Radix Glycyrrhizae 2-5 part is formed.
6. a kind of inhibiting composition of lipase that has as claimed in claim 2 is characterized in that part by balsam pear 3-8, lotus leaf 1-6 part, and cassia seed 2-5 part, Pu'er tea 0-5 part, Radix Glycyrrhizae 1-4 part is formed.
7. application with lipase inhibitory action composition, described composition be by balsam pear 3-8 part, lotus leaf 1-6 part, cassia seed 2-5 part, tealeaves 0-7 part, Radix Glycyrrhizae 1-5 part is formed, it is characterized in that, described composition is applied to preparation has the inhibiting food of lipase or health food.
8. a kind of application with lipase inhibitory action composition as claimed in claim 7 is characterized in that described composition is made liquid beverage, particle, soft capsule, hard shell capsules, effervescent tablet, buccal tablet.
9. a kind of application with lipase inhibitory action composition as claimed in claim 7 is characterized in that described composition is for the preparation of the health food with antiobesity action.
10. a kind of application with lipase inhibitory action composition as claimed in claim 7 is characterized in that described composition is for the preparation of having lipopenicillinase, separating the food of greasy effect.
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| CN102726559B (en) * | 2012-07-13 | 2014-03-26 | 林秀英 | Effervescent drink mixed by Pu'er tea fermented tea, sunning lotus leaves and sunning rhizoma zingiberis |
| CN103610172B (en) * | 2013-11-21 | 2014-12-17 | 济南凯因生物科技有限公司 | Preparation method of slimming health drink |
| CN104256257A (en) * | 2014-10-09 | 2015-01-07 | 云南白药天颐茶品有限公司 | Composition with function of adjusting constitution proportion of lipoprotein cholesterol and application thereof |
| CN104256602A (en) * | 2014-10-09 | 2015-01-07 | 云南白药天颐茶品有限公司 | Composition with function of reducing serum cholesterol and application thereof |
| CN104305193B (en) * | 2014-10-24 | 2017-01-11 | 云南白药天颐茶品有限公司 | Food having effect of promoting intestine propulsion and preparation method of food |
| CN106728464A (en) * | 2016-11-15 | 2017-05-31 | 东莞自然衡健康科技有限公司 | A kind of Chinese medicine compound prescription slimming health food and preparation method thereof |
| CN107582881A (en) * | 2017-08-23 | 2018-01-16 | 陈居旭 | A kind of Chinese medicine composition of blood fat-reducing blood pressure-decreasing and toxin expelling fat-reducing |
| CN116115686A (en) * | 2021-11-14 | 2023-05-16 | 湖北万松堂大健康医药集团有限公司 | Weight-losing and lipid-lowering capsule formula and preparation method thereof |
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| JP2006075083A (en) * | 2004-09-09 | 2006-03-23 | Toyo Shinyaku:Kk | Fermented product obtained from balsam pear |
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| CN101595927A (en) * | 2008-06-06 | 2009-12-09 | 刘泳宏 | A kind of natural lung-nourishing lipopenicillinase, hypoglycemic, blood-pressure decreasing tea and preparation method |
| CN101878831A (en) * | 2010-06-18 | 2010-11-10 | 杨勇 | Pu'er and bitter gourd tea and production method thereof |
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| JP2006075083A (en) * | 2004-09-09 | 2006-03-23 | Toyo Shinyaku:Kk | Fermented product obtained from balsam pear |
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Inventor after: Wang Lina Inventor after: Ma Yinhai Inventor after: Wei Jianrong Inventor after: Shen Fang Inventor after: Huang Weidong Inventor before: Wang Lina Inventor before: Ma Yinhai Inventor before: Wei Jianrong |
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