CN102499902B - Oral cavity care composition - Google Patents
Oral cavity care composition Download PDFInfo
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- CN102499902B CN102499902B CN201210002987.1A CN201210002987A CN102499902B CN 102499902 B CN102499902 B CN 102499902B CN 201210002987 A CN201210002987 A CN 201210002987A CN 102499902 B CN102499902 B CN 102499902B
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Abstract
The invention provides an oral cavity care composition which contains vitamin C and pearl hydrolysate which is prepared from sea pearl by a biochemical method. The oral cavity care composition can be applied to toothpaste, gel, mouth wash, powder, candy, lozenge and other oral cavity care products. The vitamin C and the pearl hydrolysate can be used together for improving the stability of the composition in a product shelf life, and can act synergistically to promote absorption, and have the effects of nourishing teeth and gum, caring oral cavity, strengthening gum and firming teeth, which are superior to those of a single active matter.
Description
Technical field
The present invention relates to a kind of oral care composition, more specifically the present invention relates to a kind of oral care composition that contains vitamin C and Margarita hydrolyzed solution.
Background technology
Vitamin C, is again ascorbic acid, is a kind of water soluble vitamins, and its structure is as follows:
Vitamin C is a kind of water miscible vitamin, can prevent gingival atrophy and hemorrhage.It is the essential material of collagen protein synthesis.Collagen protein is the key component of intercellular substance, and cell communication is got up in intercellular substance, forms tissue.Equally, collagen protein has also determined microvascular intensity, elasticity in blood vessel, has guaranteed blood vessel intensity, makes blood vessel be not easy to break.Healthy dental bed tightly encases each tooth.Gingiva is soft tissue, and vitamin C can prevent gingival atrophy and hemorrhage.In addition, vitamin C has very strong antioxygenic property, prevents the destruction of radical pair oral cavity tissue, contributes to prevent various oral diseases.Also there is at present patent that vitamin C is made an addition in oral care product, in toothpaste, add more complete needed by human body trace element and vitamin as disclosed in patent 92108108.1, can reduce the generation of oral disease.
But because vitamin C has stronger reproducibility, in aqueous solution, be very easily subject to the destruction of heat, light and oxygen, thereby its activity is weakened.Therefore contain ascorbic oral care implement, often due to the unstability of vitamin, cause the activity decreased of vitamin within the shelf-life.In addition, different due to the occupation mode of oral care implement, model of action and food, medicine, the action time of oral care product is short, uses ascorbic oral cavity residual quantity low, thereby has caused vitamin C absorbtivity in oral cavity low, and bioavailability is low.
Margarita hydrolyzed solution is by biochemical reaction, decomposition, extraction, and calcium carbonate a large amount of in Margarita powder is removed, and extracts its effective ingredient-several amino acids and other nutritional labelings.These aminoacid comprise 8 kinds of essential amino acids, wherein serine, the scalable human endocrines such as a word used in person's names propylhomoserin, enhancing immunity and removing free radical, antidotal effect.Also there is patent Margarita hydrolyzed solution to be applied in the oral care products such as toothpaste, in patent CN1148486A, a kind of toothpaste that contains water solutable component of pearl and collutory liquid are announced, this invention adds Margarita hydrolyzed solution in toothpaste and collutory, make it there is good clean and nutrition health-care functions to tooth and oral cavity, can prevent and treat various tooth diseases and oral disease.But because Margarita hydrolyzed solution has stronger reproducibility, being very easily subject to the destruction of heat, light and oxygen,, there is unstability in the oral care implement that contains Margarita hydrolyzed solution equally, and action time is short, the shortcoming that bioavailability is low.
In addition, aspect the free radical of removing oral cavity, vitamin C is mainly to remove peroxy radical, alkoxy free group and hydroxyl radical free radical.Margarita hydrolyzed solution can significantly improve the superoxide dismutase (SOD) in tissue, is mainly to remove alkoxy free group and nitric oxide free radical.And common free radical comprises peroxy radical in oral cavity, alkoxy free group, hydroxyl radical free radical, alkoxy free group and nitric oxide free radical.Contain single vitamin C or the product of Margarita hydrolyzed solution, in its removing oral cavity, free radical ability is inadequate, and the kind of removing free radical in oral cavity is not comprehensive, thereby has caused effect of product not strong yet, to not high of the preventive effect of tooth or oral disease.Single vitamin C, Margarita hydrolyzed solution all cannot be removed free radical several frequently seen in oral cavity, thereby causes the scarce capacity of its prophylaxis of teeth and oral disease.
Summary of the invention
The object of this invention is to provide a kind of oral care composition that contains vitamin C and Margarita hydrolyzed solution, the invention solves containing the oral care product of single vitamin C or Margarita hydrolyzed solution and cannot remove free radical several frequently seen in oral cavity, thereby cause the problem of the scarce capacity of its prophylaxis of teeth and oral disease.
A kind of oral care composition, described compositions contains vitamin C and Margarita hydrolyzed solution, and wherein the weight ratio of vitamin C and Margarita hydrolyzed solution is 0.001 ~ 1:1.It is 0.01 ~ 1:1 that described vitamin C and the weight ratio of Margarita hydrolyzed solution are preferably.Described vitamin C and more preferably 0.1 ~ 0.5:1 of the weight ratio of Margarita hydrolyzed solution.
Margarita hydrolyzed solution in described oral care composition is from sea water pearls, particularly Hepu Margarita.By biochemical method, through reaction, decomposition, extraction, calcium carbonate a large amount of in Margarita powder remove, and extract its effective ingredient-several amino acids and other nutritional labelings.In this Margarita hydrolyzed solution, contain 8 kinds of necessary aminoacid of human body, and kind more than ten and the closely-related aminoacid of human life metabolism.Wherein scalable human endocrine, enhancing immunity and the defying age such as serine, a word used in person's names propylhomoserin.
In described Margarita hydrolyzed solution, also contain a large amount of trace element, calcium, taurine and small active peptides.
In described Margarita hydrolyzed solution, the percentage by weight of calcium ion is 5%-8%, and the percentage by weight of micromolecule polypeptide is 1%-2%.
The preparation method of described oral care composition, comprises the following steps: (a) in Margarita, add and the citric acid of Margarita identical weight part and the water of twice Margarita weight portion, make it act at normal temperatures 1-2 hour; (b) be incorporated as the carase of Margarita weight 0.01%, at 60-70 ℃ of effect 4-6 hour; (c) supernatant of getting mixture obtains required Margarita hydrolyzed solution; (d) take vitamin C and under stirring condition, join in the Margarita hydrolyzed solution of corresponding weight ratio; (e) mixture in step (d) is uniformly mixed, can obtains described oral care composition.
Described oral care composition Margarita hydrolyzed solution used also can be by prior art method, and method as disclosed in CN1051394A is produced.
Described oral care composition can be added in oral care product, and described oral care product comprises the dosage form conventionally such as toothpaste, dentifrice, prophylaxis pastes, mouthwass, lozenge, chewing gum.
In different embodiments of the present invention, the oral care product of selected interpolation is preferably applied to the product of actinal surface regularly; The oral care product preferably using every day, continues many days at least once a day; Most preferably, described oral cavity composition is applied to actinal surface 1-3 time every day, continues at least 2 thoughtful 8 weeks or longer, as toothpaste, dentifrice etc.
In different embodiments, according to the form of the concentration of described oral care composition and described oral care product, the addition of described oral care composition is 0.0001% ~ 10% of oral care product weight; The addition of described oral care composition is preferably 0.001% ~ 5% of oral care product weight; The addition of described oral care composition more preferably oral care product weight 0.01% ~ 3%.
In described oral care composition, can add various other optional oral care actives, for example antibacterial, ascoxal, antitack agent (prevention bacterial plaque sticks to enamel surface), polyphenoils (as coenzyme Q10), caries preventive agent, desensitizer is (as potassium nitrate, Soluble tartar., potassium citrate and strontium chloride), brightening agent, tartar controlling agent, periodontal actives, chlorophyll compound, abrasive material, breath freshening controlling agent is (as zinc salt, for example zinc gluconate, zinc citrate, zinc chloride) and saliva stimulant (for example citric acid, lactic acid, malic acid), and well known by persons skilled in the art any other is applicable to the composition of mouth care.
Described oral care composition can add a kind of or its combination in viscosity modifier, diluent, surfactant, emulsifying agent, foam modifier, pH adjusting agent, abrasive material, wetting agent, softening agent, mouthfeel regulator, sweeting agent, flavoring agent, coloring agent, antiseptic.Although the general aspects of each class of above-mentioned substance classification can be different, also can have some common properties, and any given material can belong to two classes in these material classifications or multiclass more.Preferably, according to the material compatible with Margarita hydrolyzed solution with vitamin C of the present invention, as: sodium carboxymethyl cellulose, sodium lauryl sulphate, sorbitol, glycerol, saccharin sodium, sodium fluoride, silicon dioxide, sodium lauryl sulfate etc.
Beneficial effect of the present invention: the first, vitamin C and Margarita hydrolyzed solution stability in oral care product significantly improves, thereby guaranteed the stability of two kinds of active matters in shelf life of products; The second, two active component-vitamin Cs and Margarita hydrolyzed solution in this oral care composition can be brought into play synergism in product, and Margarita hydrolyzed solution can promote the absorption of vitamin C and several amino acids, increases ascorbic bioavailability.In this oral care composition, vitamin C and Margarita hydrolyzed solution can be removed free radical common in human oral cavity, and both bring into play synergism, promote to absorb.Add oral care product of the present invention, adopted reusable science using method within the period of many days, can help the required nutrition of growing up of supplementary tooth, for oral problem origin, to the nutrition of gingiva abundance, healthy mouth, strong gingiva, firm tooth.
With respect to prior art, the present invention has following characteristics: vitamin C and Margarita hydrolyzed solution have appropriate blend proportion, ascorbic amount is not more than the amount of Margarita hydrolyzed solution, owing to having a certain amount of calcium ion and micromolecule polypeptide in Margarita hydrolyzed solution, thereby guarantees ascorbic stability; Vitamin C and Margarita hydrolyzed solution combined effect, can remove free radical common in oral cavity, and the kind of removing free radical is better than single active component or other antioxidant.
The specific embodiment
One, the Preparation Example of oral care composition of the present invention:
Embodiment mono-:
1. prepare Margarita hydrolyzed solution: in Margarita, add and the citric acid of Margarita identical weight part and the water of twice Margarita weight portion, act at normal temperatures 1-2 hour, add again 0.01% carase, 60 ~ 70 ℃ of effects 4 ~ 6 hours, get the supernatant and obtain required Margarita hydrolyzed solution;
2. take 0.1g vitamin C, join in the Margarita hydrolyzed solution of 0.9g gained in step 1 under stirring condition, stir 10 minutes, room temperature preservation gets final product to obtain this oral care composition.
Embodiment bis-:
1. prepare Margarita hydrolyzed solution: in Margarita, add and the citric acid of Margarita identical weight part and the water of twice Margarita weight portion, act at normal temperatures 1-2 hour, add again 0.01% carase, 60 ~ 70 ℃ of effects 4 ~ 6 hours, get the supernatant and obtain required Margarita hydrolyzed solution;
2. take 0.25g vitamin C, under the condition stirring, join in the Margarita hydrolyzed solution of 1.0g, stir 15 minutes, room temperature preservation gets final product to obtain this oral care composition.
Embodiment tri-:
1. prepare Margarita hydrolyzed solution: in Margarita, add and the citric acid of Margarita identical weight part and the water of twice Margarita weight portion, act at normal temperatures 1-2 hour, add again 0.01% carase, 60 ~ 70 ℃ of effects 4 ~ 6 hours, get the supernatant and obtain required Margarita hydrolyzed solution;
2. take 0.5g vitamin C, under the condition stirring, join in the Margarita hydrolyzed solution of 1.0g, stir 15 minutes, room temperature preservation gets final product to obtain this oral care composition.
Oral care composition prepared by different embodiment is put in the baking oven of 40 ℃, investigates the stability of vitamin C and Margarita hydrolyzed solution.Experimental result is as shown in table 1:
The Detection of Stability of table 1 vitamin C and Margarita hydrolyzed solution different proportion
Table 1 result shows, the vitamin C that embodiment mono-follows in embodiment bis-, and aminoacid, in 40 ℃ of high temperature investigation processes, has all shown good stability, wherein in embodiment bis-, aminoacid and ascorbic stability are best.Can find out from experimental result, there is an optimal proportion value in vitamin C and Margarita hydrolyzed solution.
Two, the embodiment that this oral care composition is applied in oral care product:
Described interpolation oral care product of the present invention can assign to prepare by the described one-tenth of suitable mixing.
Embodiment mono-: this oral care composition is applied in toothpaste
The formulation of tooth-paste that table 2 contains oral care composition
Preparation technology is as follows:
(1) oral care composition that comprises vitamin C and Margarita hydrolyzed solution is dissolved in water by a certain amount of formula;
(2) various salt (comprising fluoride) and sweeting agent (for example saccharin sodium) are added in container 1, add water and stir;
(3) whole wetting agents and rubber powder are joined in container 2, the aqueous mixtures in step 2 is added in container 2;
(4) after said mixture is mixed with abrasive material, mixed at high speed 15 to 20 minutes under vacuum;
(5) finally add flavoring agent, active component and surfactant fully to mix, disperse under vacuum.
The toothpaste of preparing by above-mentioned technique, at the temperature of 40 ℃, accelerated ageing, after 3 months, detects vitamin C and amino acid whose content in toothpaste.Testing result is as table 3:
Table 3 vitamin C and the aminoacid Detection of Stability in toothpaste
The testing result of table 3 shows, vitamin C and amino acid whose having good stability in this toothpaste.This explanation, vitamin C and Margarita hydrolyzed solution reasonably combined, can promote both stability.Release its mechanism, may complex reaction occur due to calcium ion in Margarita hydrolyzed solution or micromolecule polypeptide and vitamin C, thereby play the effect of stable vitamin C.Meanwhile, ascorbic reproducibility has guaranteed that again the several amino acids in Margarita hydrolyzed solution is not oxidized.Both connect each other, react to each other, and have promoted both stability.
Vitamin C and Margarita hydrolyzed solution use simultaneously not only can improve the two stability in shelf life of products, more can synergism, and promote to absorb, and the nutrition tooth, the gingiva that are better than single-activity thing, healthy mouth, strong gingiva, the effect of firm tooth are provided.Add the oral care product of this oral care composition, adopted reusable science using method within the period of many days, can help the required nutrition of growing up of supplementary tooth, for oral problem origin, give the nutrition of gingiva abundance, healthy mouth, strong gingiva, firm tooth.
The toothpaste that use contains said composition is after 1 week, gingiva tissue, and the ascorbic content in oral mucosa is apparently higher than using only containing ascorbic toothpaste; The 3rd, said composition can effectively be removed the peroxy radical in oral cavity, alkoxy free group, and hydroxyl radical free radical, alkoxy free group and nitric oxide free radical, kind and ability that it removes free radical, be all obviously better than single active matter.
Embodiment bis-: the application of this oral care composition in collutory
The mouthwash formula that table 4 contains oral care composition
Choose 12 child experimenters, use and contain oral care composition of the present invention one week, every day 2 times.Get experimenter's saliva and level in gingival sulcus fluid, adopt HPLC(high performance liquid chromatography) detection ascorbic content wherein.Testing result is as shown in table 5:
The Clinical detection test of table 5 oral care composition
In table 5, result shows, uses the toothpaste that contains oral care composition of the present invention after one week, the vitamin C of the residual 0.02mg of difference and 0.004mg in saliva and level in gingival sulcus fluid.The vitamin C of this concentration can be removed 20% of free radical in oral cavity.Meanwhile, because Margarita hydrolyzed solution can significantly improve the superoxide dismutase (SOD) in tissue, remove alkoxy free group and nitric oxide free radical, both interact, and can effectively remove free radical unnecessary in oral cavity, nutrition gingiva, healthy mouth, contributes to prevent various oral diseases.
The announcement of book and instruction according to the above description, those skilled in the art in the invention can also change and revise above-mentioned embodiment.Therefore, the present invention is not limited to the specific embodiment disclosed and described above, also should fall in the protection domain of claim of the present invention modifications and changes more of the present invention.In addition,, although used some specific terms in this description, these terms just for convenience of description, do not form any restriction to the present invention.
Claims (10)
1. an oral care composition, is characterized in that: described compositions contains vitamin C and Margarita hydrolyzed solution, and wherein the weight ratio of vitamin C and Margarita hydrolyzed solution is 0.001～1:1;
Described Margarita hydrolyzed solution is prepared by the following method: (a) in Margarita, add and the citric acid of Margarita identical weight part and the water of twice Margarita weight portion, make it act at normal temperatures 1-2 hour;
(b) be incorporated as the carase of Margarita weight 0.01%, at 60-70 ℃ of effect 4-6 hour;
(c) supernatant of getting mixture obtains required Margarita hydrolyzed solution.
2. according to the oral care composition of claim 1, it is characterized in that: described vitamin C and the weight ratio of Margarita hydrolyzed solution are 0.01～1:1.
3. according to the oral care composition of claim 2, it is characterized in that: described vitamin C and the weight ratio of Margarita hydrolyzed solution are 0.1～0.5:1.
4. according to the arbitrary described oral care composition of claims 1 to 3, it is characterized in that: in described Margarita hydrolyzed solution, contain trace element, calcium, taurine and small active peptides.
5. according to the arbitrary described oral care composition of claims 1 to 3, it is characterized in that: in described Margarita hydrolyzed solution, the percentage by weight of calcium ion is 5%-8%, the percentage by weight of micromolecule polypeptide is 1%-2%.
6. the preparation method of oral care composition claimed in claim 1, is characterized in that, comprises the following steps:
(a) in Margarita, add and the citric acid of Margarita identical weight part and the water of twice Margarita weight portion, make it act at normal temperatures 1-2 hour;
(b) be incorporated as the carase of Margarita weight 0.01%, at 60-70 ℃ of effect 4-6 hour;
(c) supernatant of getting mixture obtains required Margarita hydrolyzed solution;
(d) take vitamin C and under stirring condition, join in the Margarita hydrolyzed solution of corresponding weight ratio, can obtain described oral care composition.
7. the purposes of oral care composition claimed in claim 1, it is for the preparation of oral care composition, it is characterized in that: described compositions is added in oral care product, described oral care product comprises toothpaste, dentifrice, prophylaxis pastes, mouthwass, lozenge, chewing gum.
8. according to the purposes of the oral care composition of claim 7, it is characterized in that: compositions addition is 0.0001%～10% of oral care product weight ratio.
9. the purposes of oral care composition according to Claim 8, is characterized in that: compositions addition is 0.001%～5% of oral care product weight ratio.
10. according to the purposes of the oral care composition of claim 9, it is characterized in that: compositions addition is 0.01%～3% of oral care product weight ratio.
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| CN201210002987.1A CN102499902B (en) | 2012-01-06 | 2012-01-06 | Oral cavity care composition |
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| CN201210002987.1A CN102499902B (en) | 2012-01-06 | 2012-01-06 | Oral cavity care composition |
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| CN102499902B true CN102499902B (en) | 2014-05-14 |
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| CN105534749A (en) * | 2015-12-25 | 2016-05-04 | 名臣健康用品股份有限公司 | Child intelligence benefiting toothpaste |
| CN105994922A (en) * | 2016-07-06 | 2016-10-12 | 安徽米乐食品有限公司 | Refreshing and antifatigue nutritive healthcare chewing gum and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101889969A (en) * | 2009-05-20 | 2010-11-24 | 广州薇美姿个人护理用品有限公司 | Natural fluorine-free edible transparent child nutrition toothpaste |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101889969A (en) * | 2009-05-20 | 2010-11-24 | 广州薇美姿个人护理用品有限公司 | Natural fluorine-free edible transparent child nutrition toothpaste |
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