CN102488841B - Capsule or tablet for assisting memory improvement and preparation method thereof - Google Patents
Capsule or tablet for assisting memory improvement and preparation method thereof Download PDFInfo
- Publication number
- CN102488841B CN102488841B CN 201110417676 CN201110417676A CN102488841B CN 102488841 B CN102488841 B CN 102488841B CN 201110417676 CN201110417676 CN 201110417676 CN 201110417676 A CN201110417676 A CN 201110417676A CN 102488841 B CN102488841 B CN 102488841B
- Authority
- CN
- China
- Prior art keywords
- tablet
- capsule
- test
- memory
- rhizoma polygonati
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 35
- 230000006993 memory improvement Effects 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 239000008187 granular material Substances 0.000 claims abstract description 41
- 238000009835 boiling Methods 0.000 claims abstract description 27
- 244000017020 Ipomoea batatas Species 0.000 claims abstract description 21
- 235000002678 Ipomoea batatas Nutrition 0.000 claims abstract description 20
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 17
- 238000002156 mixing Methods 0.000 claims abstract description 17
- 230000033001 locomotion Effects 0.000 claims abstract description 10
- 238000005469 granulation Methods 0.000 claims abstract description 9
- 230000003179 granulation Effects 0.000 claims abstract description 9
- 239000000314 lubricant Substances 0.000 claims abstract description 9
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 9
- 239000007921 spray Substances 0.000 claims abstract description 9
- 239000000080 wetting agent Substances 0.000 claims abstract description 9
- 239000000284 extract Substances 0.000 claims description 17
- 235000020710 ginseng extract Nutrition 0.000 claims description 17
- 239000000843 powder Substances 0.000 claims description 17
- 239000000463 material Substances 0.000 claims description 11
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
- 238000005453 pelletization Methods 0.000 claims description 8
- 239000011734 sodium Substances 0.000 claims description 8
- 229910052708 sodium Inorganic materials 0.000 claims description 8
- 238000005507 spraying Methods 0.000 claims description 8
- 238000012360 testing method Methods 0.000 abstract description 41
- 241000208340 Araliaceae Species 0.000 abstract description 9
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 abstract description 8
- 235000003140 Panax quinquefolius Nutrition 0.000 abstract description 8
- 235000008434 ginseng Nutrition 0.000 abstract description 8
- 230000006870 function Effects 0.000 abstract description 7
- 238000011160 research Methods 0.000 abstract description 7
- 231100000252 nontoxic Toxicity 0.000 abstract description 4
- 230000003000 nontoxic effect Effects 0.000 abstract description 4
- 231100000027 toxicology Toxicity 0.000 abstract description 3
- 239000003795 chemical substances by application Substances 0.000 abstract description 2
- 238000011049 filling Methods 0.000 abstract description 2
- 239000008176 lyophilized powder Substances 0.000 abstract 2
- 239000002994 raw material Substances 0.000 abstract 2
- 239000000654 additive Substances 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940079832 sodium starch glycolate Drugs 0.000 abstract 1
- 229920003109 sodium starch glycolate Polymers 0.000 abstract 1
- 239000008109 sodium starch glycolate Substances 0.000 abstract 1
- 238000009966 trimming Methods 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 description 14
- 230000015654 memory Effects 0.000 description 13
- 230000036541 health Effects 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 230000006386 memory function Effects 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 230000032683 aging Effects 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 230000037396 body weight Effects 0.000 description 5
- 230000007850 degeneration Effects 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 235000013402 health food Nutrition 0.000 description 5
- 102000010909 Monoamine Oxidase Human genes 0.000 description 4
- 108010062431 Monoamine oxidase Proteins 0.000 description 4
- 230000005856 abnormality Effects 0.000 description 4
- 229960004373 acetylcholine Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 210000002569 neuron Anatomy 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 208000024827 Alzheimer disease Diseases 0.000 description 3
- WSMYVTOQOOLQHP-UHFFFAOYSA-N Malondialdehyde Chemical compound O=CCC=O WSMYVTOQOOLQHP-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 102000019197 Superoxide Dismutase Human genes 0.000 description 3
- 108010012715 Superoxide dismutase Proteins 0.000 description 3
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 3
- 230000036772 blood pressure Effects 0.000 description 3
- 238000009534 blood test Methods 0.000 description 3
- 230000005779 cell damage Effects 0.000 description 3
- 208000037887 cell injury Diseases 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 230000005180 public health Effects 0.000 description 3
- 210000000278 spinal cord Anatomy 0.000 description 3
- 238000002562 urinalysis Methods 0.000 description 3
- 206010067484 Adverse reaction Diseases 0.000 description 2
- 241000756042 Polygonatum Species 0.000 description 2
- 241000037831 Polygonatum sibiricum Species 0.000 description 2
- 241000607142 Salmonella Species 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 208000006011 Stroke Diseases 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000006806 disease prevention Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000002481 ethanol extraction Methods 0.000 description 2
- 229940089161 ginsenoside Drugs 0.000 description 2
- 229930182494 ginsenoside Natural products 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002858 neurotransmitter agent Substances 0.000 description 2
- 230000000050 nutritive effect Effects 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 230000035882 stress Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 230000002110 toxicologic effect Effects 0.000 description 2
- 102000012440 Acetylcholinesterase Human genes 0.000 description 1
- 108010022752 Acetylcholinesterase Proteins 0.000 description 1
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010010144 Completed suicide Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- QGXBDMJGAMFCBF-UHFFFAOYSA-N Etiocholanolone Natural products C1C(O)CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CCC21 QGXBDMJGAMFCBF-UHFFFAOYSA-N 0.000 description 1
- 241000201295 Euphrasia Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 241000234280 Liliaceae Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 108010025020 Nerve Growth Factor Proteins 0.000 description 1
- 102000007072 Nerve Growth Factors Human genes 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 208000005374 Poisoning Diseases 0.000 description 1
- 241001468611 Polygonatum cyrtonema Species 0.000 description 1
- 206010036631 Presenile dementia Diseases 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- 102000004357 Transferases Human genes 0.000 description 1
- 108090000992 Transferases Proteins 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 229940022698 acetylcholinesterase Drugs 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 229930014669 anthocyanidin Natural products 0.000 description 1
- 150000001452 anthocyanidin derivatives Chemical class 0.000 description 1
- 235000008758 anthocyanidins Nutrition 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 210000004958 brain cell Anatomy 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 230000001713 cholinergic effect Effects 0.000 description 1
- 230000037326 chronic stress Effects 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- QGXBDMJGAMFCBF-LUJOEAJASA-N epiandrosterone Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC[C@H]21 QGXBDMJGAMFCBF-LUJOEAJASA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000000971 hippocampal effect Effects 0.000 description 1
- 210000004295 hippocampal neuron Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000007087 memory ability Effects 0.000 description 1
- 206010027175 memory impairment Diseases 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000002969 morbid Effects 0.000 description 1
- 210000003061 neural cell Anatomy 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 230000000508 neurotrophic effect Effects 0.000 description 1
- 239000003900 neurotrophic factor Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000003568 synaptosome Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a capsule or tablet for assisting memory improvement and a preparation method thereof. The capsule or tablet is prepared with ginseng extractive, rhizoma polygonati extractive and sweet potato lyophilized powder as main raw materials; the capsule or tablet is prepared by the following steps: throwing the ginseng extractive, rhizoma polygonati extractive and sweet potato lyophilized powder into a boiling nodulizer according to a proportion, staring the boiling nodulizer to fully and uniformly blend the raw materials and additives in the boiling nodulizer, performing spray granulation with alcohol as wetting agent, trimming the prepared granules by a straightening granulator through a sieve with 20 meshes, adding disintegrating agent sodium starch glycolate and lubricant magnesium stearate, fully and uniformly mixing the ingredients in a multi-direction movement mixer, and filling capsules or tabletting to obtain tablets. The capsule or tablet of the invention has the advantages of security, effectiveness and small dosage; as shown in the toxicology research, the capsule or tablet for assisting memory improvement is safe and non-toxic, and as shown in the function and human body foretaste test, the capsule or tablet has the function of assisting memory improvement.
Description
Technical field
The present invention relates to health product, relate in particular to a kind of capsule for auxiliary improving memory function or tablet and preparation method thereof.
Background technology
Along with the arrival of aging society, the incidence rate of degeneration sacred disease (Neurodegenerative disease, ND) is more and more higher, and it is the neuronal cell injury of a class brain and spinal cord and the morbid state of forfeiture.Brain and spinal cord are comprised of neuron, and neuron has different functions, such as controlled motion, process sensory information, and make decisions.The cell of brain and spinal cord generally can not regenerated, so excessive infringement may be destructive, irreversible.Common degeneration sacred disease has Alzheimer (Alzheimer ' s Disease, AD), parkinson (Parkinson ' s Disease, PD), apoplexy etc.Up-to-date census shows, the aging population of China more than 60 years old have 1.59 hundred million now, and China has stepped into aging society in advance.To reach 4.39 hundred million to the year two thousand fifty, account for 1/4 of total population.According to the statistics of up-to-date international senile dementia association, the whole world has more than 2,400 ten thousand people suffering the torment of AD at present, and with a newly-increased patient's in per 7 seconds speed increase.The number of patients of China AD and PD has reached more than 1,500 ten thousand people, and annual new stroke patient approximately is more than 200 ten thousand, surpasses the world average level.
The pathogenesis of degeneration sacred disease still imperfectly understands at present, also without effective Therapeutic Method, it will bring heavy burden and economic problems to family and society, be a serious social problem, become the most important public health problem that faces in the new millennium.Therefore the early prevention of degeneration sacred disease is particularly important.The degeneration sacred disease there is no effective prevention and Therapeutic Method at present; many-side seeks effective neurotrophy and the protectiveness factor is the effective way of clinical prevention health care and treatment, mainly comprises at present: cholinergic system medicine, neurotrophic factor, antioxidant, anti-inflammatory drug, calcium ion antagonist, the agent of brain metabolic activation and treatment by Chinese herbs etc.Be antecedent intervention and treatment to presenile dementia but at present scientist worries most, because a lot of people also fail to be familiar with this disease, it regarded as " a kind of Normal appearances of age ageing " and ignored early stage prevention and treatment.But along with the raising of people's living standard and the continuous enhancing of health care consciousness, and the aggravation of world population aging process, the demand of auxiliary improvement of memory class health food will constantly enlarge, and have boundless future develop and space.
The selected multi-flavor of the present invention has Chinese medicine and the article prescription of auxiliary improvement of memory effect, the health food with auxiliary improving memory function of making through modern crafts.
Wherein, sweet, the little hardship of Radix Ginseng, tepor are returned lung, spleen, the heart, kidney channel.Can pacify spirit, decide soul, spasmolytic is throbbed with fear, except pathogen, make eye bright, happy Fructus Alpiniae Oxyphyllae, clothes are made light of one's life by commiting suicide and are prolonged life for a long time.There are some researches show that Radix Ginseng extract can significantly improve superoxide dismutase (SOD) and glutathion-peroxidase (GSH-Px) content in mouse brain and the serum, reduce malonaldehyde (MDA) content, significantly improve the content of the interior acetylcholine (AChE) of brain and acetylcholine transferase (ChAT), reduce acetylcholinesterase (TChE) content, the activity that also can reduce monoamine oxidase, MAO (MAO) in the rat brain improves the content of monoamine neurotransmitter in the brain, thereby reaches the purpose that improves ability of learning and memory.Research finds that simultaneously Ginsenoside Rgl can significantly improve chronic stress space learning memory impairment, and the hippocampal neuron that simultaneously discovery stress cause is lost minimizing in a large number, and the high free calcium concentration in the Hippocampal Synaptosomes significantly descends.The ginsenoside also can improve the brain oxygen uptake capacity, makes animal brain more reasonably utilize the energy substance glucose, the oxidation production capacity, and synthetic more ATP is for activities such as learning and memories.
Rhizoma Polygonati is flat, sweet in the mouth, warm in nature, but settling five organs, flat filling blood.Have research to find that polygonatum polysaccharide can improve the brain tissue metabolism that cerebral ischemia causes movable, alleviate body under stress state radical damage and protect the brain cell membrane structure, keep the normal function of brain.Polygonatum polysaccharide also can significantly improve the content of SOD, GSH-Px, AChE and ChAT in mouse brain and the serum, reduce TChE, MDA content, the activity that also can reduce MAO in the rat brain improves the content of monoamine neurotransmitter in the brain, thereby improves ability of learning and memory.
Rhizoma Dioscoreae esculentae property is flat, and sweet in the mouth is nontoxic, cures mainly that tonify deficiency is weary, physical strength profiting, strengthening the spleen and stomach, kidney tonifying be cloudy.Rhizoma Dioscoreae esculentae not only contains abundant nutritional labeling such as carotenoid, dietary fiber, vitamin, sugar, aminoacid and some mineral etc., has very high nutritive value, simultaneously because it contains the deoxidation epiandrosterone, anthocyanidin, the material such as glycoprotein and organic acid also has very high health-care effect, its auxiliary improving memory function is also progressively being disclosed by people, there are some researches show Rhizoma Dioscoreae esculentae extract can the auxiliary improvement mice initiatively and the passive learning memory ability, can also promote the neuronal cell quantity of In vitro culture to breed and the projection elongation growth.Simultaneously glutamic acid is caused PC
12Neural cell injury and A β
25-35Due to the SK-N-SH neural cell injury have obvious protective effect, have certain neurotrophic effect.
Radix Ginseng extract
Radix Ginseng Pznax ginseng C.A.Mey.[P.schin-seng Nees] be the root of araliaceae ginseng plant's Radix Ginseng.Radix Ginseng is the article that can be used for health food of Ministry of Public Health approval, and the used Radix Ginseng extract of this product is that Radix Ginseng obtains behind the ethanol extraction concentrate drying.
Rhizoma Polygonati extract
Rhizoma Polygonati Polygonatum sibiricum Delar.ex Redoute[P.chinense Kunth] be the rhizome of Liliaceae Polygonatum plant Rhizoma Polygonati, Polygonatum cyrtonema Hua and Yunnan Rhizoma Polygonati.Rhizoma Polygonati is the article that can be used for health food of Ministry of Public Health approval, and the used Rhizoma Polygonati extract of this product is that Rhizoma Polygonati obtains behind the ethanol extraction concentrate drying.
Sweet potato frozen dried powder
Rhizoma Dioscoreae esculentae sweet potato is the root of Convolvulaceae sweet potato genus plant, and Rhizoma Dioscoreae esculentae is the grain that people extensively eat
Kind.The used sweet potato frozen dried powder of this product is that Rhizoma Dioscoreae esculentae obtains behind frozen drying.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, a kind of capsule for auxiliary improving memory function or tablet and preparation method thereof are provided.
The capsule of auxiliary improvement of memory or the component of tablet are: Radix Ginseng extract 1.0～5.0 weight portions, Rhizoma Polygonati extract 1.0～5.0 weight portions, sweet potato frozen dried powder 1.0～4.5 weight portions.
The preparation method of auxiliary improvement of memory capsule or tablet is: with 1.0～5.0 weight portion Radix Ginseng extracts; 1.0～5.0 weight portion Rhizoma Polygonati extracts; 1.0 the sweet potato frozen dried powder of～4.5 weight portions drops in the boiling granulating device; open the boiling granulating device with various supplementary materials the abundant mixing of boiling granulating device 5～10 minutes; then carry out spray granulation take ethanol as wetting agent; 80～90 ℃ of control inlet temperature; 35～40 ℃ of leaving air temps; check the granulating situation; 1.5～2 hours; stop spraying and detected moisture 5～7% in dry 0.5～1 hour; the granule of preparation is carried out granulate with the granule pelletizing machine with 20 mesh sieves; with granulate gained granule; add 0.01～0.05 weight portion disintegrator carboxymethylstarch sodium and 0.004～0.006 weight portion magnesium stearate lubricant abundant mixing in Mixers with Multi-direction Movement, encapsulating capsule or be pressed into tablet.
Described Rhizoma Polygonati extract, Radix Ginseng extract, sweet potato frozen dried powder sieve through 80 orders respectively.
The making of conventional health product adopts starch as adjuvant usually, in the modern life, along with people to the deepening continuously of Rhizoma Dioscoreae esculentae research, Rhizoma Dioscoreae esculentae exceeds the concept of grain on the traditional sense already, the nutritive value of Rhizoma Dioscoreae esculentae and health care be worth gradually by people cognition.Based on people the research of Rhizoma Dioscoreae esculentae auxiliary improving memory function is found, the present invention adopts sweet potato frozen dried powder to substitute common starch and makes health product, further increases the function of this health product auxiliary improvement of memory.Capsule or the tablet of the auxiliary improvement of memory of the present invention's preparation, safe and effective, taking dose is little.Show through toxicologic study, auxiliary improvement of memory capsule or tablet safety non-toxic, animal function assessment and human feeding trial show, successful has the function of auxiliary improvement of memory.
The specific embodiment
The capsule of auxiliary improvement of memory or the component of tablet are: Radix Ginseng extract 1.0～5.0 weight portions, Rhizoma Polygonati extract 1.0～5.0 weight portions, sweet potato frozen dried powder 1.0～4.5 weight portions.
The preparation method of auxiliary improvement of memory capsule or tablet is: with 1.0～5.0 weight portion Radix Ginseng extracts; 1.0～5.0 weight portion Rhizoma Polygonati extracts; 1.0 the sweet potato frozen dried powder of～4.5 weight portions drops in the boiling granulating device; open the boiling granulating device with various supplementary materials the abundant mixing of boiling granulating device 5～10 minutes; then carry out spray granulation take ethanol as wetting agent; 80～90 ℃ of control inlet temperature; 35～40 ℃ of leaving air temps; check the granulating situation; 1.5～2 hours; stop spraying and detected moisture 5～7% in dry 0.5～1 hour; the granule of preparation is carried out granulate with the granule pelletizing machine with 20 mesh sieves; with granulate gained granule; add 0.01～0.05 weight portion disintegrator carboxymethylstarch sodium and 0.004～0.006 weight portion magnesium stearate lubricant abundant mixing in Mixers with Multi-direction Movement, encapsulating capsule or be pressed into tablet.
Described Rhizoma Polygonati extract, Radix Ginseng extract, sweet potato frozen dried powder sieve through 80 orders respectively.
Elaborate below in conjunction with embodiment.
Embodiment 1
With 1.0 weight portion Radix Ginseng extracts; 1.0 weight portion Rhizoma Polygonati extract; 1.0 the sweet potato frozen dried powder of weight portion drops in the boiling granulating device; open the boiling granulating device with various supplementary materials the abundant mixing of boiling granulating device 5 minutes; then carry out spray granulation take ethanol as wetting agent; 80 ℃ of control inlet temperature; 35 ℃ of leaving air temps; check the granulating situation; 1.5 hour; stop spraying and detected moisture 7% in dry 0.5 hour; the granule of preparation is carried out granulate with the granule pelletizing machine with 20 mesh sieves; with granulate gained granule; add 0.01 weight portion disintegrator carboxymethylstarch sodium and 0.004 weight portion magnesium stearate lubricant abundant mixing in Mixers with Multi-direction Movement, encapsulating capsule or be pressed into tablet.
Embodiment 2
With 5.0 weight portion Radix Ginseng extracts; 5.0 weight portion Rhizoma Polygonati extract; 4.5 the sweet potato frozen dried powder of weight portion drops in the boiling granulating device; open the boiling granulating device with various supplementary materials the abundant mixing of boiling granulating device 10 minutes; then carry out spray granulation take ethanol as wetting agent; 90 ℃ of control inlet temperature; 40 ℃ of leaving air temps; check the granulating situation; 2 hours; stop spraying and detected moisture 5% in dry 1 hour; the granule of preparation is carried out granulate with the granule pelletizing machine with 20 mesh sieves; with granulate gained granule; add 0.05 weight portion disintegrator carboxymethylstarch sodium and 0.006 weight portion magnesium stearate lubricant abundant mixing in Mixers with Multi-direction Movement, encapsulating capsule or be pressed into tablet.
Embodiment 3
Radix Ginseng extract 3.0 weight portions, Rhizoma Polygonati extract 3.0 weight portions, sweet potato frozen dried powder 2.5 weight portions are dropped in the boiling granulating device in proportion, open the boiling granulating device with various supplementary materials the abundant mixing of boiling granulating device 6 minutes, then carry out spray granulation take ethanol as wetting agent, 85 ℃ of control inlet temperature, 37 ℃ of leaving air temps.Check the granulating situation, 1.7 hours, stop spraying and detected moisture 7% in dry 0.6 hour.The granule of preparation is carried out granulate with the granule pelletizing machine with 20 mesh sieves.With granulate gained granule, add 0.02 weight portion disintegrator carboxymethylstarch sodium and 0.005 weight portion magnesium stearate lubricant abundant mixing in Mixers with Multi-direction Movement, encapsulating capsule or be pressed into tablet.
Embodiment 4
Radix Ginseng extract 2.0 weight portions, Rhizoma Polygonati extract 2.0 weight portions, sweet potato frozen dried powder 1.8 weight portions are dropped in the boiling granulating device in proportion, open the boiling granulating device with various supplementary materials the abundant mixing of boiling granulating device 7 minutes, then carry out spray granulation take ethanol as wetting agent, 82 ℃ of control inlet temperature, 40 ℃ of leaving air temps.Check the granulating situation, 1.8 hours, stop spraying and detected moisture about 6% in dry 0.7 hour.The granule of preparation is carried out granulate with the granule pelletizing machine with 20 mesh sieves.With granulate gained granule, add 0.03 weight portion disintegrator carboxymethylstarch sodium and 0.0045 weight portion magnesium stearate lubricant abundant mixing in Mixers with Multi-direction Movement, encapsulating capsule or be pressed into tablet.
Embodiment 5
3.0 parts of 2.5 parts of Radix Ginseng extracts, 2.5 parts of Rhizoma Polygonati extracts, sweet potato frozen dried powder are dropped in the boiling granulating device in proportion, open the boiling granulating device with various supplementary materials the abundant mixing of boiling granulating device 8 minutes, then carry out spray granulation take ethanol as wetting agent, 83 ℃ of control inlet temperature, 39 ℃ of leaving air temps.Check the granulating situation, 1.6 hours, stop spraying and detected moisture 5.5% in dry 0.8 hour.The granule of preparation is carried out granulate with the granule pelletizing machine with 20 mesh sieves.With granulate gained granule, add 0.04 weight portion disintegrator carboxymethylstarch sodium and 0.0048 weight portion magnesium stearate lubricant abundant mixing in Mixers with Multi-direction Movement, encapsulating capsule or be pressed into tablet.
Capsule or tablet with the auxiliary improvement of memory of the present invention preparation are safe and effective, and taking dose is little.
1. (state food drug surveilance office assigned food health care detects unit) toxicologic study shows through the disease prevention and control center, Hunan Province:
1) acute toxicity: auxiliary improvement of memory capsule or tablet are to female, male its mouse oral LD
50Male and female belong to non-toxic type all greater than the 20g/kg body weight.
2) micronucleus test: auxiliary improvement of memory capsule or tablet are negative to PCEMNR micronucleus test testing result.
3) the abnormal property of mouse sperm test: auxiliary improvement of memory capsule or tablet are negative to mouse sperm deformity test testing result.
4) Salmonella reversion test: auxiliary improvement of memory capsule or tablet Salmonella reversion test result are negative.
5) 30 days feeding trials: 30 days feeding trials of auxiliary improvement of memory capsule or tablet have no laboratory animal and poisoning symptom occurs, and gross anatomy and tissue pathology checking no abnormality seen change, to rat body weight, food-intake,
Food utilization, hemogram, blood biochemistry all have no significant effect.
2. (state food drug surveilance office assigned food health care detects unit) human feeding trial studies show that through the disease prevention and control center, Hunan Province, and auxiliary improvement of memory capsule or tablet have the effect of auxiliary improvement of memory.Experimental result is as follows:
1) adopt counter point between own control and group, the trial volunteer of selecting to meet experimental condition was taken tested material 45 days, and 104 of experimenters are divided into each 52 of test-meal group, matched groups at random.Test-meal group 1 people and matched group 1 people do not participate in inspection when test-meal finishes.Test-meal group male 12 examples, women's 40 examples, 36.67 ± 11.04 years old mean age; Matched group male 11 examples, women's 41 examples, 36.38 ± 11.14 years old mean age, the front two groups of experimenter's schoolings of test-meal, equal no significant difference of age have comparability.Before and after the test-meal, experimenter's mental status, sleep state, diet, defecation situation no abnormality seen.
2) functional observation
1. point to memory
The sensing memory scale score and the matched group that take the front test group of sample compare, no significant difference (P〉0.05); Comparison before taking sensing memory scale score and the matched group of test group behind the sample and self taking sample, there are no significant for difference (P〉0.05), the results are shown in Table 1.
Table 1. product on the impact of pointing to the memory scale score (
± s)
| ? | Before the test | After the test |
| Matched group | 17.33±9.58 | 18.75±7.67 |
| Test group | 17.27±9.25 | 20.04±7.66 |
2. learning by association
The learning by association scale score and the matched group that take the front test group of sample compare, no significant difference (P〉0.05); Relatively, difference has significance (P＜0.05), the results are shown in Table 2 before taking the learning by association scale score of test group behind the sample and self taking sample.
The impact that table 2. product divides association's quantity of study table (
± s)
| ? | Before the test | After the test |
| Matched group | 23.25±6.21 | 26.02±7.82 |
| Test group | 23.29±7.39 | ?27.45±7.55 # |
With before self test-meal relatively, # P＜0.05
3. image is freed recall
Take before the sample image of test group free recall scale score and matched group comparison, no significant difference (P〉0.05); Take behind the sample free recall scale score and matched group and self of the image of test group and take before the sample relatively, there are no significant for difference (P〉0.05), the results are shown in Table 3.
Table 3. product on image free recall scale score impact (
± s)
| ? | Before the test | After the test |
| Matched group | 16.49±9.44 | 16.65±7.55 |
| Test group | 16.12±10.49 | 19.06±7.39 |
4. random shape is re-recognized
The random shape that takes the front test group of sample is re-recognized scale score and matched group comparison, no significant difference (P〉0.05); Take behind the sample random shape of test group and re-recognize scale score and matched group and self and take before the sample relatively, difference all without significance (P〉0.05), the results are shown in Table 4.
Table 4. product on random shape re-recognize scale score impact (
± s)
| ? | Before the test | After the test |
| Matched group | 12.00±5.44 | 13.18±4.57 |
| Test group | 12.18±5.14 | 14.02±4.82 |
5. the contact of portrait characteristics is recalled
The portrait characteristics contact memory scale score and the matched group that take the front test group of sample compare, no significant difference (P〉0.05); Comparison before the portrait characteristics contact that takes test group behind the sample is recalled scale score and matched group and self taken sample, difference all has significance (P＜0.05), the results are shown in Table 5.
Table 5. product on portrait characteristics contacts recall scale score impact (
± s)
| ? | Before the test | After the test |
| Matched group | 20.47±6.83 | 21.35±6.89 |
| Test group | 20.76±6.82 | ?25.08±7.63 *# |
With matched group relatively, * P＜0.05, with before self test-meal relatively, # P＜0.05
6. memory quotient
The memory quotient and the matched group that take the front test group of sample compare, no significant difference (P〉0.05); Relatively, difference all has significance (P＜0.05), the results are shown in Table 6 before taking memory quotient and the matched group of test group behind the sample and self taking sample.
Table 6. product on the impact of memory quotient (
± s)
| ? | Before the test | After the test |
| Matched group | 89.00±22.83 | 92.04±18.23 |
| Test group | 89.04±25.14 | ?99.33±17.13 *# |
With matched group relatively, * P＜0.05, with before self test-meal relatively, # P＜0.05
3) safety is observed
1. body weight, blood pressure, heart rate, routine urinalysis, stool routine examination, routine blood test and blood biochemistry index
Take before and after the tested material, test-meal group and matched group body weight, blood pressure, heart rate are showed no obvious abnormalities change, and routine urinalysis, stool routine examination, routine blood test and biochemical indicator all within normal range, the results are shown in Table 7.
Body weight before and after table 7. test-meal, blood pressure, heart rate, routine urinalysis, stool routine examination, routine blood test, changes of biochemical indexes situation (
± s)
2. electrocardiogram, Abdominal B type ultrasonography, Chest X-rays inspection is all within normal range.
3. have no obvious adverse reaction during the test-meal.
Human feeding trial is the result show, the experimenter takes the auxiliary improvement of memory tablet after 45 days continuously, and the contact of test group portrait characteristics relatively is improved before recalling scale score and memory quotient and matched group and self taking sample, and difference all has significance (P＜0.05).Relatively, difference has significance (P＜0.05) before test group learning by association scale score and the test-meal.The safety indexes such as blood, urine, stool routine examination, blood biochemistry, electrocardiogram, B ultrasonic are showed no obvious abnormalities change after the test-meal, do not find obvious adverse reaction during the test-meal.According to " health food check and assessment technique standard " (version in 2003) evaluation criterion, point out this product to have auxiliary improving memory function (adult's) effect.
Claims (3)
1. the capsule of an auxiliary improvement of memory or tablet is characterized in that its component is: Radix Ginseng extract 1.0～5.0 weight portions, Rhizoma Polygonati extract 1.0～5.0 weight portions, sweet potato frozen dried powder 1.0～4.5 weight portions.
2. preparation method of auxiliary improvement of memory capsule or tablet as claimed in claim 1; it is characterized in that 1.0～5.0 weight portion Radix Ginseng extracts; 1.0～5.0 weight portion Rhizoma Polygonati extracts; 1.0 the sweet potato frozen dried powder of～4.5 weight portions drops in the boiling granulating device; open the boiling granulating device with various supplementary materials the abundant mixing of boiling granulating device 5～10 minutes; then carry out spray granulation take ethanol as wetting agent; 80～90 ℃ of control inlet temperature; 35～40 ℃ of leaving air temps; check the granulating situation; 1.5～2 hours; stop spraying and detected moisture 5～7% in dry 0.5～1 hour; the granule of preparation is carried out granulate with the granule pelletizing machine with 20 mesh sieves; with granulate gained granule; add 0.01～0.05 weight portion disintegrator carboxymethylstarch sodium and 0.004～0.006 weight portion magnesium stearate lubricant abundant mixing in Mixers with Multi-direction Movement, encapsulating capsule or be pressed into tablet.
3. the preparation method of the capsule of a kind of auxiliary improvement of memory according to claim 2 or tablet is characterized in that described Rhizoma Polygonati extract, Radix Ginseng extract, sweet potato frozen dried powder sieve through 80 orders respectively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110417676 CN102488841B (en) | 2011-12-14 | 2011-12-14 | Capsule or tablet for assisting memory improvement and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110417676 CN102488841B (en) | 2011-12-14 | 2011-12-14 | Capsule or tablet for assisting memory improvement and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102488841A CN102488841A (en) | 2012-06-13 |
| CN102488841B true CN102488841B (en) | 2013-09-18 |
Family
ID=46180739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110417676 Active CN102488841B (en) | 2011-12-14 | 2011-12-14 | Capsule or tablet for assisting memory improvement and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102488841B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104524182A (en) * | 2014-12-08 | 2015-04-22 | 上海焦点生物技术有限公司 | Traditional Chinese medicine composition for improving memory |
| CN115212165A (en) * | 2022-08-19 | 2022-10-21 | 哈尔滨医科大学 | Gel for repairing nerve heat injury and preparation method and application thereof |
-
2011
- 2011-12-14 CN CN 201110417676 patent/CN102488841B/en active Active
Non-Patent Citations (4)
| Title |
|---|
| 孙丽华等.甘薯及其提取物辅助改善小鼠学习记忆功能实验研究.《药物生物技术》.2010,第17卷(第2期),157. |
| 甘薯及其提取物辅助改善小鼠学习记忆功能实验研究;孙丽华等;《药物生物技术》;20100228;第17卷(第2期);157 * |
| 老年学习记忆减退中医药治疗研究进展;邢长英等;《实用医学杂志》;20090715;第25卷(第13期);2187 * |
| 邢长英等.老年学习记忆减退中医药治疗研究进展.《实用医学杂志》.2009,第25卷(第13期),2187. |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102488841A (en) | 2012-06-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101869283A (en) | Assistant hypoglycemia healthcare food of mulberry-leaf extract and preparation method thereof | |
| CN102551065B (en) | Blood sugar reducing food series | |
| CN105962359A (en) | Composition with function of assisting in improving memory | |
| CN102488841B (en) | Capsule or tablet for assisting memory improvement and preparation method thereof | |
| CN111494360B (en) | Application of epimedin C in medicine for treating diabetic liver injury | |
| CN102488202B (en) | Medicinal composition for treating diabetes and preparation method thereof | |
| CN101904501B (en) | Functional food for relieving fatigue and preparation method thereof | |
| CN103736071A (en) | Composition having effect of assisting in decreasing blood sugar, and application and preparation method thereof | |
| CN101167846A (en) | Capsule with blood sugar reducing function and preparation method thereof | |
| CN108066384A (en) | A kind of Chinese medicine preparation with strengthen immunity and preparation method thereof | |
| CN106420955A (en) | Traditional Chinese medicine composition with blood glucose reduction assistance effect, preparation method and product of traditional Chinese medicine composition | |
| CN101869284A (en) | Health food for assisting blood pressure reduction by utilizing green tea extract and preparation method thereof | |
| CN102940782B (en) | Chinese medicinal composition for reducing blood sugar | |
| CN103720808B (en) | A kind of composition and use thereof, preparation method with relieving constipation effect | |
| CN112336802B (en) | Traditional Chinese medicine composition for improving glycolipidosis metabolism of diabetes and application thereof | |
| CN101564511A (en) | Natural protein product for treating diabetes and manufacture method | |
| WO2022061978A1 (en) | Compound composition with anti-oxidation and anti-aging effects, preparation method therefor and application thereof | |
| CN102048132B (en) | Health-care food for reducing blood sugar | |
| CN101647840B (en) | Chinese herbal medicine composition for controlling metabolic syndrome and preparation method thereof | |
| CN105456734A (en) | Traditional Chinese medicine for treating diabetes | |
| CN104887759A (en) | Ginseng powder wine and preparation method thereof | |
| CN103393938A (en) | Traditional Chinese medicine composition for reducing blood sugar | |
| CN102614404A (en) | Health product with auxiliary effect on reducing blood glucose and preparation method thereof | |
| CN100428951C (en) | Yuanhe tablet and process for preparing the same | |
| CN111346172B (en) | Pharmaceutical composition for improving immunity |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240508 Address after: 310000 Building 2, No. 2, Lvting Road, Cangqian street, Yuhang District, Hangzhou City, Zhejiang Province Patentee after: ZHEJIANG HOFON LIFE TECHNOLOGY CO.,LTD. Country or region after: China Address before: 310013 No. 182 Tianmu Mountain Road, Hangzhou, Zhejiang, Xihu District Patentee before: ZHEJIANG ACADEMY OF MEDICAL SCIENCES Country or region before: China |
|
| TR01 | Transfer of patent right |