CN104524182A - Traditional Chinese medicine composition for improving memory - Google Patents
Traditional Chinese medicine composition for improving memory Download PDFInfo
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- CN104524182A CN104524182A CN201410741780.5A CN201410741780A CN104524182A CN 104524182 A CN104524182 A CN 104524182A CN 201410741780 A CN201410741780 A CN 201410741780A CN 104524182 A CN104524182 A CN 104524182A
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- rhizoma polygonati
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- 239000000203 mixture Substances 0.000 title claims abstract description 114
- 241000005787 Cistanche Species 0.000 claims abstract description 104
- 241000218628 Ginkgo Species 0.000 claims abstract description 102
- 235000011201 Ginkgo Nutrition 0.000 claims abstract description 101
- 235000008100 Ginkgo biloba Nutrition 0.000 claims abstract description 101
- 230000000694 effects Effects 0.000 claims abstract description 13
- 241000220317 Rosa Species 0.000 claims abstract description 5
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 89
- 239000004615 ingredient Substances 0.000 claims description 59
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- 238000000605 extraction Methods 0.000 claims description 18
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
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- 238000000034 method Methods 0.000 claims description 4
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- HJORMJIFDVBMOB-UHFFFAOYSA-N rolipram Chemical compound COC1=CC=C(C2CC(=O)NC2)C=C1OC1CCCC1 HJORMJIFDVBMOB-UHFFFAOYSA-N 0.000 description 1
- 229950005741 rolipram Drugs 0.000 description 1
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/64—Orobanchaceae (Broom-rape family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A61K9/4858—Organic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
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Abstract
The invention relates to a traditional Chinese medicine composition for improving memory. The traditional Chinese medicine composition comprises active components such as cistanche or its extract, ginkgo leaf or its extract, polygonatum rhizome or its extract, and rose or its extract. Through synergism of all the components, the traditional Chinese medicine composition can improve memory. The traditional Chinese medicine composition has beneficial effects superior to those of a single-component agent. The traditional Chinese medicine composition has the advantages of simple production processes, taking easiness and substantial curative effects and is an ideal traditional Chinese medicine composition for improving memory.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition of Improving memory power.
Background technology
Rhythm of life along with the development of aged tendency of population, study and work is accelerated and the increase of life stress, and the people of hypomnesis gets more and more.A kind of medicine of urgent hope research and development can improve and improve man memory power.
Medicine in the market for auxiliary improvement of memory is some small-molecule drugs, but small-molecule drug is all had very strong toxic and side effects by clinical confirmation, as tacrine and rolipram and four hydroxylamino bifurcation pyridines etc., there are toxin for liver side effect and the reaction of serious intestines and stomach.This kind of medicine is only applicable to the treatment of cerebral lesion, and can not be used for daily Improving memory.
Summary of the invention
The object of the invention is the Chinese medicine composition that a kind of Improving memory power is provided for above-mentioned technical problem.
Object of the present invention can be achieved through the following technical solutions:
A kind of Chinese medicine composition of Improving memory power, the effective ingredient of this Chinese medicine composition is Herba Cistanches, Folium Ginkgo, Rhizoma Polygonati and Flos Rosae Rugosae, and forms by the raw material of following weight parts: Herba Cistanches 1 ~ 90 part, Folium Ginkgo 1 ~ 90 part, Rhizoma Polygonati 1 ~ 90 part and Flos Rosae Rugosae 1 ~ 90 part; The parts by weight of Herba Cistanches in the effective ingredient of preferably described Chinese medicine composition, Folium Ginkgo, Rhizoma Polygonati and Flos Rosae Rugosae are followed successively by 2 ~ 75 parts, 2 ~ 80 parts, 2 ~ 80 parts and 4 ~ 75 parts; The parts by weight of Herba Cistanches in the effective ingredient of further preferably described Chinese medicine composition, Folium Ginkgo, Rhizoma Polygonati and Flos Rosae Rugosae are followed successively by 20 ~ 40 parts, 20 ~ 40 parts, 20 ~ 40 parts and 5 ~ 15 parts; The parts by weight of Herba Cistanches in the effective ingredient of most preferably described Chinese medicine composition, Folium Ginkgo, Rhizoma Polygonati and Flos Rosae Rugosae are followed successively by 30 parts, 30 parts, 30 parts and 10 parts.
A Chinese medicine composition for Improving memory power, this Chinese medicine composition can also be any one in following compositions.
Any one in the effective ingredient of described Chinese medicine composition is effective ingredient with its extract, and combination is as follows:
The effective ingredient of this Chinese medicine composition is Herba Cistanches extract 1 ~ 90 part, Folium Ginkgo 1 ~ 90 part, Rhizoma Polygonati 1 ~ 90 part and Flos Rosae Rugosae 1 ~ 90 part; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches 1 ~ 90 part, Folium Ginkgo extract 1 ~ 90 part, Rhizoma Polygonati 1 ~ 90 part and Flos Rosae Rugosae 1 ~ 90 part; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches 1 ~ 90 part, Folium Ginkgo 1 ~ 90 part, Rhizoma Polygonati extract 1 ~ 90 part and Flos Rosae Rugosae 1 ~ 90 part; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches 1 ~ 90 part, Folium Ginkgo 1 ~ 90 part, Rhizoma Polygonati 1 ~ 90 part and Flos Rosae Rugosae extract 1 ~ 90 part;
Preferably the effective ingredient of this Chinese medicine composition is Herba Cistanches extract 2 ~ 75 parts, Folium Ginkgo 2 ~ 80 parts, Rhizoma Polygonati 2 ~ 80 parts and Flos Rosae Rugosae 4 ~ 75 parts; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches 2 ~ 75 parts, Folium Ginkgo extract 2 ~ 80 parts, Rhizoma Polygonati 2 ~ 80 parts and Flos Rosae Rugosae 4 ~ 75 parts; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches 2 ~ 75 parts, Folium Ginkgo 2 ~ 80 parts, Rhizoma Polygonati extract 2 ~ 80 parts and Flos Rosae Rugosae 4 ~ 75 parts; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches 2 ~ 75 parts, Folium Ginkgo 2 ~ 80 parts, Rhizoma Polygonati 2 ~ 80 parts and Flos Rosae Rugosae extract 4 ~ 75 parts.
Most preferably the effective ingredient of this Chinese medicine composition is Herba Cistanches extract 20 ~ 40 parts, Folium Ginkgo 20 ~ 40 parts, Rhizoma Polygonati 20 ~ 40 parts and Flos Rosae Rugosae 5 ~ 15 parts; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches 20 ~ 40 parts, Folium Ginkgo extract 20 ~ 40 parts, Rhizoma Polygonati 20 ~ 40 parts and Flos Rosae Rugosae 5 ~ 15 parts; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches 20 ~ 40 parts, Folium Ginkgo 20 ~ 40 parts, Rhizoma Polygonati extract 20 ~ 40 parts and Flos Rosae Rugosae 5 ~ 15 parts; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches 20 ~ 40 parts, Folium Ginkgo 20 ~ 40 parts, Rhizoma Polygonati 20 ~ 40 parts and Flos Rosae Rugosae extract 5 ~ 15 parts.
Any two kinds in the effective ingredient of described Chinese medicine composition are effective ingredient with its extract combination is as follows:
The effective ingredient of this Chinese medicine composition is Herba Cistanches extract 1 ~ 90 part, Folium Ginkgo extract 1 ~ 90 part, Rhizoma Polygonati 1 ~ 90 part and Flos Rosae Rugosae 1 ~ 90 part; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches extract 1 ~ 90 part, Folium Ginkgo 1 ~ 90 part, Rhizoma Polygonati extract 1 ~ 90 part and Flos Rosae Rugosae 1 ~ 90 part; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches extract 1 ~ 90 part, Folium Ginkgo 1 ~ 90 part, Rhizoma Polygonati 1 ~ 90 part and Flos Rosae Rugosae extract 1 ~ 90 part; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches 1 ~ 90 part, Folium Ginkgo extract 1 ~ 90 part, Rhizoma Polygonati extract 1 ~ 90 part and Flos Rosae Rugosae 1 ~ 90 part; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches 1 ~ 90 part, Folium Ginkgo extract 1 ~ 90 part, Rhizoma Polygonati 1 ~ 90 part and Flos Rosae Rugosae extract 1 ~ 90 part; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches 1 ~ 90 part, Folium Ginkgo 1 ~ 90 part, Rhizoma Polygonati extract 1 ~ 90 part and Flos Rosae Rugosae extract 1 ~ 90 part.
Preferably the effective ingredient of this Chinese medicine composition is Herba Cistanches extract 2 ~ 75 parts, Folium Ginkgo extract 2 ~ 80 parts, Rhizoma Polygonati 2 ~ 80 parts and Flos Rosae Rugosae 4 ~ 75 parts; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches extract 2 ~ 75 parts, Folium Ginkgo 2 ~ 80 parts, Rhizoma Polygonati extract 2 ~ 80 parts and Flos Rosae Rugosae 4 ~ 75 parts; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches extract 2 ~ 75 parts, Folium Ginkgo 2 ~ 80 parts, Rhizoma Polygonati 2 ~ 80 parts and Flos Rosae Rugosae extract 4 ~ 75 parts; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches 2 ~ 75 parts, Folium Ginkgo extract 2 ~ 80 parts, Rhizoma Polygonati extract 2 ~ 80 parts and Flos Rosae Rugosae 4 ~ 75 parts; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches 2 ~ 75 parts, Folium Ginkgo extract 2 ~ 80 parts, Rhizoma Polygonati 2 ~ 80 parts and Flos Rosae Rugosae extract 4 ~ 75 parts; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches 2 ~ 75 parts, Folium Ginkgo 2 ~ 80 parts, Rhizoma Polygonati extract 2 ~ 80 parts and Flos Rosae Rugosae extract 4 ~ 75 parts.
Most preferably the effective ingredient of this Chinese medicine composition is Herba Cistanches extract 20 ~ 40 parts, Folium Ginkgo extract 20 ~ 40 parts, Rhizoma Polygonati 20 ~ 40 parts and Flos Rosae Rugosae 1 ~ 15 part; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches extract 20 ~ 40 parts, Folium Ginkgo 20 ~ 40 parts, Rhizoma Polygonati extract 20 ~ 40 parts and Flos Rosae Rugosae 1 ~ 15 part; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches extract 20 ~ 40 parts, Folium Ginkgo 20 ~ 40 parts, Rhizoma Polygonati 20 ~ 40 parts and Flos Rosae Rugosae extract 1 ~ 15 part; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches 20 ~ 40 parts, Folium Ginkgo extract 20 ~ 40 parts, Rhizoma Polygonati extract 20 ~ 40 parts and Flos Rosae Rugosae 1 ~ 15 part; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches 20 ~ 40 parts, Folium Ginkgo extract 20 ~ 40 parts, Rhizoma Polygonati 20 ~ 40 parts and Flos Rosae Rugosae extract 1 ~ 15 part; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches 20 ~ 40 parts, Folium Ginkgo 20 ~ 40 parts, Rhizoma Polygonati extract 20 ~ 40 parts and Flos Rosae Rugosae extract 1 ~ 15 part.
Any three kinds in the effective ingredient of described Chinese medicine composition are effective ingredient with its extract combination is as follows:
The effective ingredient of this Chinese medicine composition is Herba Cistanches extract 1 ~ 90 part, Folium Ginkgo extract 1 ~ 90 part, Rhizoma Polygonati extract 1 ~ 90 part and Flos Rosae Rugosae 1 ~ 90 part; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches extract 1 ~ 90 part, Folium Ginkgo extract 1 ~ 90 part, Rhizoma Polygonati 1 ~ 90 part and Flos Rosae Rugosae extract 1 ~ 90 part; The effective ingredient of this Chinese medicine composition is Herba Cistanches 1 ~ 90 part, Folium Ginkgo extract 1 ~ 90 part, Rhizoma Polygonati extract 1 ~ 90 part and Flos Rosae Rugosae extract 1 ~ 90 part.
The effective ingredient of preferred above-mentioned Chinese medicine composition is Herba Cistanches extract 2 ~ 75 parts, Folium Ginkgo extract 2 ~ 80 parts, Rhizoma Polygonati extract 2 ~ 80 parts and Flos Rosae Rugosae 4 ~ 75 parts; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches extract 2 ~ 75 parts, Folium Ginkgo extract 2 ~ 80 parts, Rhizoma Polygonati 2 ~ 80 parts and Flos Rosae Rugosae extract 4 ~ 75 parts; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches 2 ~ 75 parts, Folium Ginkgo extract 2 ~ 80 parts, Rhizoma Polygonati extract 2 ~ 80 parts and Flos Rosae Rugosae extract 4 ~ 75 parts.
Most preferably the effective ingredient of this Chinese medicine composition is Herba Cistanches extract 20 ~ 40 parts, Folium Ginkgo extract 20 ~ 40 parts, Rhizoma Polygonati extract 20 ~ 40 parts and Flos Rosae Rugosae 1 ~ 15 part; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches extract 20 ~ 40 parts, Folium Ginkgo extract 20 ~ 40 parts, Rhizoma Polygonati 20 ~ 40 parts and Flos Rosae Rugosae extract 1 ~ 15 part; Or the effective ingredient of this Chinese medicine composition is Herba Cistanches 20 ~ 40 parts, Folium Ginkgo extract 20 ~ 40 parts, Rhizoma Polygonati extract 20 ~ 40 parts and Flos Rosae Rugosae extract 1 ~ 15 part.
Four kinds in the effective ingredient of described Chinese medicine composition are effective ingredient with its extract combination is as follows:
The effective ingredient of this Chinese medicine composition is Herba Cistanches extract 1 ~ 90 part, Folium Ginkgo extract 1 ~ 90 part, Rhizoma Polygonati extract 1 ~ 90 part and Flos Rosae Rugosae extract 1 ~ 90 part; Preferably this Chinese medicine composition is Herba Cistanches extract 2 ~ 75 parts, Folium Ginkgo extract 2 ~ 80 parts, Rhizoma Polygonati extract 2 ~ 80 parts and Flos Rosae Rugosae extract 4 ~ 75 parts; Most preferably the effective ingredient of this Chinese medicine composition is Herba Cistanches extract 20 ~ 40 parts, Folium Ginkgo extract 20 ~ 40 parts, Rhizoma Polygonati extract 20 ~ 40 parts and Flos Rosae Rugosae extract 1 ~ 15 part.
The extract of organic solvent that described Herba Cistanches extract is Herba Cistanches water or dissolves each other with water.
The extract of organic solvent that described Folium Ginkgo extract is Folium Ginkgo water or dissolves each other with water.
The extract of organic solvent that described Rhizoma Polygonati extract is Rhizoma Polygonati water or dissolves each other with water.
The extract of organic solvent that described Flos Rosae Rugosae extract is rose wate or dissolves each other with water.
The described organic solvent dissolved each other with water is any one in methanol, ethanol, acetone.
Extracting method used be decoct in extraction, reflux, extract, soak extraction, supersound extraction or seepage pressure effects any one or a few.
After effective ingredient mixing in above-mentioned composition, add the acceptable adjuvant of pharmaceutics, make clinical acceptable dosage form; Described dosage form is the preparation of peroral dosage form, Tabules or capsule formulation.
Chinese medicine composition described in technical solution of the present invention is preparing the purposes in Improving memory force health-care medicine.
Herba Cistanches described in technical solution of the present invention is Orobanchaceae Cistanche deserticola, and described Herba Cistanches comprises after processing is refined Herba Cistanches extract, various forms after grinding in Herba Cistanches fine powder or Herba Cistanches growth course.
Folium Ginkgo described in technical solution of the present invention belongs to Ginkgoaceae Ginkgo.Be a kind of plant with very high medical value, but eat raw poisonous, mildly bitter flavor, property is put down.There is the beneficial heart, promoting blood circulation and stopping pain, astringe the lung relieving asthma, effect of removing dampness antidiarrheal.Described Folium Ginkgo comprises after processing is refined Folium Ginkgo extract, various forms after grinding in Folium Ginkgo fine powder or Folium Ginkgo growth course.
Rhizoma Polygonati described in technical solution of the present invention is that Liliaceae belongs to Polygonatum.Medicinal plants, has spleen reinforcing, the effect of the lung moistening and production of body fluid promoting.Described Rhizoma Polygonati comprises after processing is refined Rhizoma Polygonati extract, various forms after grinding in Rhizoma Polygonati fine powder or Rhizoma Polygonati growth course.
Flos Rosae Rugosae described in technical solution of the present invention is for belonging to Rosales.Flos Rosae Rugosae sweet and slightly bitter taste, slightly warm in nature, return liver, spleen, stomach warp.Described Flos Rosae Rugosae comprises after processing is refined Flos Rosae Rugosae extract, various forms after grinding in Flos Rosae Rugosae fine powder or Flos Rosae Rugosae growth course.
After in the present invention, the definition of " collaborative raising " can be understood as the combination of several medical material, its drug effect is relative to improve when being used alone; Drug effect is more lasting; Compositions produces beyond thought effect in new control or healthcare field.
Inventor is found by test, and compositions of the present invention has the function of Improving memory power.These single doses by after a certain proportion of compositions to the beneficial effect of human body effect be single dose incomparable.
Compositions of the present invention also can be processed into slow releasing preparation or quick releasing formulation.Wherein said pharmaceutically acceptable carrier or excipient are selected according to different dosage forms.These carriers used or excipient can determine for the those of ordinary skill of pharmaceutical field.
The preparation method of oral liquid, can but be not only confined to following one, after active component is mixed, decoct with water, decoction liquor is filtered, obtain solution, obtain extractum by concentrated for gained solution, then gained extractum is dissolved in the concentration of extractum weight 5-10 times weight is in the ethanol water according to weighing scale 95%, is uniformly mixed, quantitative separating, obtains oral liquid formulations.
The preparation method of tablet is sieved by active component mixture, and after pulverizing at the auxiliary agent conventional with preparing tablet, fully mixing homogeneously, mistake 40-80 eye mesh screen, is pressed into tablet by tabletting by direct for dry powder machine.
The preparation technology of capsule preparations can be sieved by active component mixture, and after pulverizing at the auxiliary agent conventional with preparing tablet, fully mixing homogeneously, cross 40-80 eye mesh screen, by granulating, drying, fills with capsule, polishing after the operations such as granulate, packs, gets product.
Beneficial effect of the present invention:
Pharmaceutical composition of the present invention with Herba Cistanches or its extract, Folium Ginkgo or its extract, Rhizoma Polygonati or its extract and Flos Rosae Rugosae or its extract for effective ingredient, by the mutual synergistic function between component, to the Chinese medicine composition of Improving memory power.The beneficial effect of this Chinese medicine composition to human body effect be single dose incomparable.The production technology of this medicine is simple, be easy to take, evident in efficacy, be a kind of Chinese medicine composition of desirable Improving memory power.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, but protection scope of the present invention is not limited thereto:
Embodiment 1
Crude drug forms: Herba Cistanches extract 20g, Folium Ginkgo extract 40g, Rhizoma Polygonati extract 40g and Flos Rosae Rugosae extract 5g.
Prepared by Herba Cistanches water extract: Herba Cistanches is soaked 40 minutes, the water surface is higher than raw material Chinese medicine, add 8 times that water inventory is total dose, after boiling, little fire boils state, maintain liquid level higher than raw material Chinese medicine height, decoct 2 hours, cross leaching filtrate, add the water of 6 times of total dose again, after boiling, little fire boils state, maintains liquid level higher than raw material Chinese medicine height, decoct 2 hours, filter merging twice filtrate, be Herba Cistanches water extract through concentrating under reduced pressure (pressure 0.06Mpa, temperature 65 DEG C) to the dry cream of Herba Cistanches;
Prepared by Folium Ginkgo water extract: Folium Ginkgo is soaked 40 minutes, the water surface is higher than raw material Chinese medicine, add 8 times that water inventory is total dose, after boiling, little fire boils state, maintain liquid level higher than raw material Chinese medicine height, decoct 2 hours, cross leaching filtrate, add the water of 6 times of total dose again, after boiling, little fire boils state, maintains liquid level higher than raw material Chinese medicine height, decoct 2 hours, filter merging twice filtrate, be Folium Ginkgo water extract through concentrating under reduced pressure (pressure 0.06Mpa, temperature 65 DEG C) to the dry cream of Folium Ginkgo;
Prepared by Rhizoma Polygonati water extract: Rhizoma Polygonati is soaked 40 minutes, the water surface, higher than raw material Chinese medicine, adds 8 times that water inventory is total dose, after boiling, little fire boils state, maintains liquid level higher than raw material Chinese medicine height, decocts 2 hours, cross leaching filtrate, add the water of 6 times of total dose again, after boiling, little fire boils state, maintains liquid level higher than raw material Chinese medicine height, decoct 2 hours, filter merging twice filtrate, be Rhizoma Polygonati water extract through concentrating under reduced pressure (pressure 0.06Mpa, temperature 65 DEG C) to the dry cream of Rhizoma Polygonati;
Prepared by rose wate extract: Flos Rosae Rugosae is soaked 40 minutes, the water surface is higher than raw material Chinese medicine, add 8 times that water inventory is total dose, after boiling, little fire boils state, maintain liquid level higher than raw material Chinese medicine height, decoct 2 hours, cross leaching filtrate, add the water of 6 times of total dose again, after boiling, little fire boils state, maintains liquid level higher than raw material Chinese medicine height, decoct 2 hours, filter merging twice filtrate, be rose wate extract through concentrating under reduced pressure (pressure 0.06Mpa, temperature 65 DEG C) to Rose Blume Getrocknete cream;
Finally Herba Cistanches extract 20g, Folium Ginkgo extract 40g, Rhizoma Polygonati extract 40g and Flos Rosae Rugosae extract 5g are mixed, the concentration of water-soluble extract gross weight 5-10 times weight is in the ethanol water according to weighing scale 95%, be uniformly mixed, quantitative separating, obtain oral liquid formulations.
Embodiment 2
Crude drug forms: Herba Cistanches 20g, Folium Ginkgo 40g, Rhizoma Polygonati 40g and Flos Rosae Rugosae 5g.
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Embodiment 3
Crude drug forms: Herba Cistanches extract 40g, Folium Ginkgo extract 20g, Rhizoma Polygonati extract 20g and Flos Rosae Rugosae extract 15g.
Prepared by desertliving cistanche alcohol extract: adopted by Herba Cistanches 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Herba Cistanches extract.
Prepared by Folium Ginkgo ethanol extraction: adopted by Folium Ginkgo 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Folium Ginkgo extract.
Prepared by Rhizoma Polygonati ethanol extraction: adopted by Rhizoma Polygonati 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Rhizoma Polygonati extract.
Prepared by Flos Rosae Rugosae ethanol extraction: adopted by Flos Rosae Rugosae 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Flos Rosae Rugosae extract.
Herba Cistanches extract 40g, Folium Ginkgo extract 20g, Rhizoma Polygonati extract 20g be dry, pulverize into fine powder respectively with Flos Rosae Rugosae extract 15g, sieve, mixing, granulate, be pressed into tablet.
Embodiment 4
Crude drug forms: Herba Cistanches 40g, Folium Ginkgo 20g, Rhizoma Polygonati 20g and Flos Rosae Rugosae 15g.Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Embodiment 5
Crude drug forms: Herba Cistanches extract 30g, Folium Ginkgo extract 30g, Rhizoma Polygonati extract 30g and Flos Rosae Rugosae 10g.
Herba Cistanches gets the preparation of thing: adopted by Herba Cistanches 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Herba Cistanches extract.
The preparation of Folium Ginkgo extract: adopted by Folium Ginkgo 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, get clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Folium Ginkgo extract.
The preparation of Rhizoma Polygonati extract: adopted by Rhizoma Polygonati 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, get clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Rhizoma Polygonati extract.
Aforementioned Herba Cistanches extract 30g, Folium Ginkgo extract 30g, Rhizoma Polygonati extract 30g and Flos Rosae Rugosae 10g are ground into fine powder, sieve, mixing, adds the magnesium stearate of gross weight 2%, incapsulates.
Embodiment 6
Crude drug forms: Herba Cistanches 30g, Folium Ginkgo 30g, Rhizoma Polygonati 30g and Flos Rosae Rugosae 10g.
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Embodiment 7
Crude drug forms: Herba Cistanches 75g, Folium Ginkgo extract 2g, Rhizoma Polygonati extract 2g and Flos Rosae Rugosae 75g.
The preparation of Folium Ginkgo extract: adopted by Folium Ginkgo 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, get clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Folium Ginkgo extract.
The preparation of Rhizoma Polygonati extract: adopted by Rhizoma Polygonati 60% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, get clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Rhizoma Polygonati extract.
Herba Cistanches 75g, Folium Ginkgo extract 2g, Rhizoma Polygonati extract 2g and Flos Rosae Rugosae 75g mixing is broken into fine powder, sieves, add the magnesium stearate of gross weight 2%, incapsulate.
Embodiment 8
Crude drug forms: Herba Cistanches 75g, Folium Ginkgo 2g, Rhizoma Polygonati 2g and Flos Rosae Rugosae 75g.
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Embodiment 9
Crude drug forms: Herba Cistanches extract 2g, Folium Ginkgo 80g, Rhizoma Polygonati 80g and Flos Rosae Rugosae extract 4g.
Prepared by Flos Rosae Rugosae extract: adopted by Flos Rosae Rugosae 70% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Flos Rosae Rugosae extract.
Prepared by Herba Cistanches extract: adopted by Herba Cistanches 70% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Herba Cistanches extract.
Herba Cistanches extract 2g, Folium Ginkgo 80g, Rhizoma Polygonati 80g and Flos Rosae Rugosae extract 4g are dried and crushed into fine powder, sieve, mixing, granulate, be pressed into tablet.
Embodiment 10
Crude drug forms: Herba Cistanches 2g, Folium Ginkgo 80g, Rhizoma Polygonati 80g and Flos Rosae Rugosae 4g.
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
Embodiment 11
Crude drug forms: Herba Cistanches extract 37g, Folium Ginkgo 40g, Rhizoma Polygonati 40g and Flos Rosae Rugosae 38g.
Herba Cistanches gets thing preparation: adopted by Herba Cistanches 90% alcohol heating reflux to extract or supersound extraction 1 ~ 3 time, each 1-3 hour, extracting solution concentrating under reduced pressure, centrifugal or filter, and gets clear liquor or filtrate; Clear liquor or the upper anion-exchange resin column of filtrate, with 40% ~ 70% ethanol elution, collect eluent; Macroporous resin column on eluent, first rinses with water, then uses 40% ~ 70% ethanol elution, collect ethanol elution; Eluent concentrating under reduced pressure, dry, obtain Herba Cistanches extract.
Herba Cistanches extract 37g, Folium Ginkgo 40g, Rhizoma Polygonati 40g and Flos Rosae Rugosae 38g mixing is broken into fine powder, sieves, add the magnesium stearate of gross weight 2%, incapsulate.
Embodiment 12
Crude drug forms: Herba Cistanches 37g, Folium Ginkgo 40g, Rhizoma Polygonati 40g and Flos Rosae Rugosae 38g.
Aforementioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing, granulate, be pressed into tablet.
1, Ergonomy experiment
Testing sample used is pharmaceutical composition of the present invention;
Selected mice is SPF level Kunming mouse;
Dosage choice: respectively with 0.28,0.7, dosage gavage mice l.4g/kgBW, be made into respective concentration with distilled water,
Matched group gavage distilled water, gavage capacity is identical with animal subject group, continuous gavage 30 days.
1) toxicity test of Chinese medicine composition of the present invention:
Invention formulation (embodiment 1 ~ 12) detects its acute toxicity, three mutagenesis and improving water flood, draw following result: the preparation of technical solution of the present invention is to other SPF level Kunming mouse Oral toxicity of both sexes, one time gavage amount reaches 10.0g/kg.bw, in one week, animal is showed no obvious poisoning symptom, without animal dead, by acute toxicity grading criteria regulation, this animal subject belongs to nontoxic level.Three project mutagenicity tests (mice bone marrow micronucleus, mouse inbred strain, Salmonella reversion test) result is feminine gender; Within 30 days, feeding trial result shows: this tested material all has no significant effect the clinical examination of wistar rat, hematology, biochemical, organ weights and the index such as coefficient and histopathology by 0.28 (low dose group), 0.70 (middle dosage group), 1.40g/kg.bw (high dose group) dosage (being equivalent to 20,50,100 times of recommendation crowd daily intaking amount 0.014g/kg.bw respectively), does not find that animal subject has obvious toxic action.
2) Chinese medicine composition of the present invention reproduces the improvement result-water maze test of obstacle to mouse memory
Water maze test: animal is selected, test grouping, dosage, approach, time all same step down test.Continuous gavage starts training after 30 days, training period successive administration, once a day.Labyrinth swimming lane depth of water 9cm, water temperature 25 ± 1 DEG C.Before first time training, animal is placed near ladder, makes it automatically climb up 3 times, before each training, animal is placed near ladder later, makes it automatically climb up 1 time.Training is carried out stage by stage, and apparent motion thing school grade progressively increases lengthening distance.Start at A place during first time training, second time training lengthens distance, and from B place, this distance about trains 3 times, trains 4 times altogether, reaches home to more than 80% animal.Last is trained from starting point, the errors number recording every animal, the time of reaching home and number of animals.Carry out memory after one week to disappear test.
Selected Chinese medicine composition is the Chinese medicine composition that the embodiment of the present invention 6 prepares.
Table 1 Chinese medicine composition of the present invention reproduces the impact of obstacle to mouse memory
From table 1, the continuous gavage of pharmaceutical composition of the present invention is after 30 days, and the time that active experiment (water maze test) each dosage group mice is reached home and errors number are all less than matched group, wherein, middle and high dosage group compares with matched group, and difference all has significance.
Inventor finds at the improvement result-water maze test of Study Mouse reproducibility dysmnesia, take the Chinese medicine composition that any one of embodiment 1 ~ 4 prepares, the time that after adopting said method, mice is reached home and errors number are all less than matched group, wherein, middle and high dosage group compares with matched group, and difference all has significance.
3) Chinese medicine composition of the present invention is on the impact of the remember consolidation disorders of mice-keep away dark test
Keep away dark test: animal is selected, test grouping, dosage, approach, time all same step down test.Continuous gavage starts after 30 days to carry out keeping away dark training, records every Mus and enters darkroom and meet with from putting into bright room shock by electricity required time, i.e. incubation period.Cyclical test after 24 hours, records the errors number in the incubation period of every Mus, 5 minutes and enters the number of animals in darkroom.
Selected Chinese medicine composition is the Chinese medicine composition that the embodiment of the present invention 6 prepares.
Table 2-1 Chinese medicine composition of the present invention consolidates the impact of obstacle on mouse memory
Table 2-2 Chinese medicine composition of the present invention consolidates the impact of obstacle on mouse memory
2-1 is visible for table, and the continuous gavage of pharmaceutical composition of the present invention, after 30 days, is being kept away in dark test, when each dosage group of mice is trained, incubation period compares with matched group, and there are no significant for difference, tests incubation period after 24 hours, each dosage group compares with matched group, and difference all has significance.The visible average error number of times of table 2-2 is lower than matched group, and difference has significance; The wrong reaction rate of middle and high dosage group is lower than matched group, and difference also has significant.
Inventor is in the impact-keep away and secretly test discovery of the remember consolidation disorders of Study Mouse, take the Chinese medicine composition that any one of embodiment 5,7 and 8 prepares, adopt above-mentioned identical method of testing, after 24 hours, test incubation period, each dosage group compares with matched group, and difference all has significance; In addition, average error number of times is lower than matched group, and difference has significance; The wrong reaction rate of middle and high dosage group is lower than matched group, and difference also has significant.
4) Chinese medicine composition of the present invention is to the improvement result-step down test of mouse memory acquired disturbance
Step down test: dosage group gavage every day gives tested material, carries out diving tower training after giving sample 30d continuously.Animal is put into reaction chamber endoadaptation 3min, pass to 36 volts of alternating currents immediately, the normal reaction of animal jumps back on insulated platform.Most animals may skip on copper grid again or repeatedly, is subject to the platform that snaps back again that shocks by electricity.After training once, be placed on by animal on the platform in reaction chamber, the number of times (errors number) that in record 5min, every Mus is shocked by electricity, in this, as school grade.Resurvey after 24h and test, record the errors number in the number of animals shocked by electricity, the incubation period of jumping off platform for the first time and 3min.Experimental result is in Table 3-1 and table 3-2.
Selected Chinese medicine composition is the Chinese medicine composition that the embodiment of the present invention 6 prepares.
Table 3-1 Chinese medicine composition of the present invention is on the impact of mouse memory acquired disturbance
Table 3-2 Chinese medicine composition of the present invention is on the impact of mouse memory acquired disturbance
3-1 is visible for table, and in step down test, during the test of mice each dosage group, incubation period is all longer than matched group with matched group more each dosage group incubation period, and diversity is remarkable.3-2 is visible for table, and in step down test, during the test of mice each dosage group, average error number of times has significant diversity compared with matched group, and wrong reaction rate is lower than matched group, and difference also has significance.
Inventor finds at the improvement result-step down test of Study Mouse memory acquisition disturbance, take the Chinese medicine composition that any one of embodiment 9 ~ 12 prepares, adopt above-mentioned identical method of testing, during the test of mice each dosage group, incubation period is all longer than matched group with matched group more each dosage group incubation period, and diversity is remarkable.In addition, in step down test, during the test of mice each dosage group, average error number of times has significant diversity compared with matched group, and wrong reaction rate is lower than matched group, and difference also has significance.
2, clinical experiment
Experimental subject: select 16 ~ 18 years old age student to be subjects.
Method of administration and the course for the treatment of: each 6g of oral liquid, every day 3 times; Each 4 of capsule, every day 3 times; The each 4.5g of tablet, every day 3 times was a course for the treatment of with one month.
Experimenter of the present invention takes the embodiment of the present invention 1 ~ 12 respectively; Herba Cistanches; Rhizoma Polygonati; Herba Cistanches+Folium Ginkgo (1:1); Folium Ginkgo+Rhizoma Polygonati extract+Flos Rosae Rugosae (1:1:1); Herba Cistanches+Folium Ginkgo+Flos Rosae Rugosae (1:1:1), contrast experimenter takes not containing the blank formulation of Chinese medicine composition of the present invention.
Inventor studies by dividing association's quantity of study table, by the index of experimenter with contrast experimenter's Indexes Comparison, index improve more than 10% for improve.
Therapeutic evaluation:
Table 4 Chinese medicine composition of the present invention affects result to association's quantity of study
| Compositions | Number of cases | Improve | Improvement rate |
| Embodiment 1 | 122 | 106 | 86.9％ |
| Embodiment 2 | 114 | 97 | 85.1％ |
| Embodiment 3 | 106 | 91 | 85.8％ |
| Embodiment 4 | 142 | 121 | 85.2％ |
| Embodiment 5 | 146 | 124 | 84.9％ |
| Embodiment 6 | 138 | 119 | 86.2％ |
| Embodiment 7 | 138 | 122 | 88.4％ |
| Embodiment 8 | 113 | 101 | 89.4％ |
| Embodiment 9 | 160 | 135 | 84.4％ |
| Embodiment 10 | 109 | 95 | 87.2％ |
| Embodiment 11 | 110 | 93 | 84.5％ |
| Embodiment 12 | 124 | 107 | 86.3％ |
| Herba Cistanches | 135 | 76 | 56.3％ |
| Rhizoma Polygonati | 101 | 55 | 54.4％ |
| Herba Cistanches+Folium Ginkgo | 106 | 65 | 61.3％ |
| Folium Ginkgo+Rhizoma Polygonati extract+Flos Rosae Rugosae | 105 | 75 | 71.4％ |
| Herba Cistanches+Folium Ginkgo+Flos Rosae Rugosae | 111 | 77 | 69.4％ |
As can be seen from Table 4, the Chinese medicine composition of technical solution of the present invention has good curative effect to improving sleep quality, and the beneficial effect of this Chinese medicine composition to human body effect be single dose incomparable.
Claims (10)
1. the Chinese medicine composition of an Improving memory power, it is characterized in that: the effective ingredient of this Chinese medicine composition is Herba Cistanches, Folium Ginkgo, Rhizoma Polygonati and Flos Rosae Rugosae, and forms by the raw material of following weight parts: Herba Cistanches 1 ~ 90 part, Folium Ginkgo 1 ~ 90 part, Rhizoma Polygonati 1 ~ 90 part and Flos Rosae Rugosae 1 ~ 90 part.
2. the Chinese medicine composition of Improving memory power according to claim 1, is characterized in that: the parts by weight of Herba Cistanches, Folium Ginkgo, Rhizoma Polygonati and Flos Rosae Rugosae are followed successively by 2 ~ 75 parts, 2 ~ 80 parts, 2 ~ 80 parts and 4 ~ 75 parts.
3. the Chinese medicine composition of Improving memory power according to claim 2, is characterized in that: the parts by weight of Herba Cistanches, Folium Ginkgo, Rhizoma Polygonati and Flos Rosae Rugosae are followed successively by 20 ~ 40 parts, 20 ~ 40 parts, 20 ~ 40 parts and 5 ~ 15 parts.
4. the Chinese medicine composition of Improving memory power according to claim 3, is characterized in that: the parts by weight of Herba Cistanches, Folium Ginkgo, Rhizoma Polygonati and Flos Rosae Rugosae are followed successively by 30 parts, 30 parts, 30 parts and 10 parts.
5. a Chinese medicine composition for the Improving memory power described in any one of claim 1-4, is characterized in that: in Herba Cistanches, Folium Ginkgo, Rhizoma Polygonati and Flos Rosae Rugosae at least one with the form of its extract for effective ingredient.
6. the Chinese medicine composition of Improving memory power according to claim 5, is characterized in that: the extract of organic solvent that Herba Cistanches extract is Herba Cistanches water or dissolves each other with water; The extract of organic solvent that Folium Ginkgo extract is Folium Ginkgo water or dissolves each other with water; The extract of organic solvent that Rhizoma Polygonati extract is Rhizoma Polygonati water or dissolves each other with water; The extract of organic solvent that Flos Rosae Rugosae extract is rose wate or dissolves each other with water; The described organic solvent dissolved each other with water is any one in methanol, ethanol, acetone; Extracting method be decoct in extraction, reflux, extract, soak extraction, supersound extraction or seepage pressure effects any one or a few.
7. the Chinese medicine composition of the Improving memory power according to any one of claim 1-4, is characterized in that: after the effective ingredient mixing of compositions, add the acceptable adjuvant of pharmaceutics, make clinical acceptable dosage form; Described dosage form is the preparation of peroral dosage form, Tabules or capsule formulation.
8. the Chinese medicine composition of Improving memory power according to claim 5, is characterized in that: after the effective ingredient mixing of compositions, add the acceptable adjuvant of pharmaceutics, make clinical acceptable dosage form; Described dosage form is the preparation of peroral dosage form, Tabules or capsule formulation.
9. the Chinese medicine composition described in any one of claim 1-4 is preparing the purposes in Improving memory force health-care medicine.
10. Chinese medicine composition according to claim 5 is preparing the purposes in Improving memory force health-care medicine.
Priority Applications (1)
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106668564A (en) * | 2016-12-15 | 2017-05-17 | 深圳海王医药科技研究院有限公司 | Natural pharmaceutical composition capable of improving memory function |
| CN107625887A (en) * | 2017-09-29 | 2018-01-26 | 甘肃汇勤生物科技有限公司 | Pharmaceutical composition and its application comprising saline cistanche |
| CN109331143A (en) * | 2018-10-30 | 2019-02-15 | 河西学院 | A kind of desert cistanche compound and its preparation method |
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| JP2004075618A (en) * | 2002-08-20 | 2004-03-11 | Yaizu Suisankagaku Industry Co Ltd | Memory learning ability-improving agent |
| CN102488841A (en) * | 2011-12-14 | 2012-06-13 | 浙江省医学科学院 | Capsule or tablet for assisting memory improvement and preparation method thereof |
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| JP2004075618A (en) * | 2002-08-20 | 2004-03-11 | Yaizu Suisankagaku Industry Co Ltd | Memory learning ability-improving agent |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106668564A (en) * | 2016-12-15 | 2017-05-17 | 深圳海王医药科技研究院有限公司 | Natural pharmaceutical composition capable of improving memory function |
| CN107625887A (en) * | 2017-09-29 | 2018-01-26 | 甘肃汇勤生物科技有限公司 | Pharmaceutical composition and its application comprising saline cistanche |
| CN109331143A (en) * | 2018-10-30 | 2019-02-15 | 河西学院 | A kind of desert cistanche compound and its preparation method |
| CN109331143B (en) * | 2018-10-30 | 2022-07-08 | 河西学院 | A herba cistanches Deserticolae composition and its preparation method |
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