CN102482244B - 细菌群体感应的共价抑制 - Google Patents

细菌群体感应的共价抑制 Download PDF

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CN102482244B
CN102482244B CN201080038367.2A CN201080038367A CN102482244B CN 102482244 B CN102482244 B CN 102482244B CN 201080038367 A CN201080038367 A CN 201080038367A CN 102482244 B CN102482244 B CN 102482244B
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CN102482244A (zh
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迈克尔·M·梅杰勒
内里·阿马拉
何塞普·拉约
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National Institute for Biotechnology in the Negev Ltd
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National Institute for Biotechnology in the Negev Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
    • A01N43/08—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dental Preparations (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201080038367.2A 2009-07-03 2010-07-04 细菌群体感应的共价抑制 Expired - Fee Related CN102482244B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22294409P 2009-07-03 2009-07-03
US61/222,944 2009-07-03
PCT/IB2010/053061 WO2011001419A1 (en) 2009-07-03 2010-07-04 Covalent inhibition of bacterial quorum sensing

Publications (2)

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CN102482244A CN102482244A (zh) 2012-05-30
CN102482244B true CN102482244B (zh) 2015-09-09

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CN201080038367.2A Expired - Fee Related CN102482244B (zh) 2009-07-03 2010-07-04 细菌群体感应的共价抑制

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US (2) US8501969B2 (enExample)
EP (1) EP2448930B1 (enExample)
JP (1) JP5816618B2 (enExample)
CN (1) CN102482244B (enExample)
AU (1) AU2010267596A1 (enExample)
CA (1) CA2767183C (enExample)
IN (1) IN2012DN00939A (enExample)
WO (1) WO2011001419A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2463181B (en) 2007-05-14 2013-03-27 Univ New York State Res Found Induction of a physiological dispersion response in bacterial cells in a biofilm
US10647668B2 (en) * 2011-01-03 2020-05-12 The William M. Yarbrough Foundation Isothiocyanate functional surfactant and associated method of use
US10273205B2 (en) * 2011-01-03 2019-04-30 The William M. Yarbrough Foundation Isothiocyanate functional surfactants, formulations incorporating isothiocyanate functional surfactants and associated methods for treating biofilms
US9962361B2 (en) * 2011-01-03 2018-05-08 The William M. Yarbrough Foundation Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use
US8933119B2 (en) * 2011-01-03 2015-01-13 The William M. Yarbrough Foundation Method for treating phytophotodermatitis
CN102219753B (zh) * 2011-04-21 2012-10-31 山东大学 一种三氮唑类化合物及其制备方法与应用
EP2753177A1 (en) * 2011-09-09 2014-07-16 Bayer Intellectual Property GmbH Acyl-homoserine lactone derivatives for improving plant yield
CN103980219B (zh) * 2013-02-08 2016-12-28 中国人民解放军军事医学科学院毒物药物研究所 一种新型细菌群体感应调节剂及其医疗用途
US9604950B2 (en) 2013-03-19 2017-03-28 The Scripps Research Institute Trail enhancers for the selective killing of cancer cells
WO2015042363A1 (en) * 2013-09-20 2015-03-26 The Trustees Of Princeton University Molecules and compositions that inhibit gram negative bacteria and their uses
CA2966489A1 (en) * 2014-11-03 2016-05-12 Nicolai Vladimirovich Bovin Antimicrobial surface treatment
JP6842089B2 (ja) * 2015-04-23 2021-03-17 ディブロフ，パベル 抗生物質として有用なコロルマイシン誘導体
CN104909450B (zh) * 2015-06-01 2017-03-08 东北电力大学 一种膜生物反应器膜污染抑制剂的制备及其应用方法
CN106635446B (zh) * 2016-09-26 2019-08-13 浙江工商大学 一种生物膜清洁剂及其制备和应用
CN108130358A (zh) * 2017-12-21 2018-06-08 广西医科大学 对铜绿假单胞菌-烟曲霉菌混合生物被膜抑制作用的研究方法
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
CN109608292B (zh) * 2018-12-27 2021-11-30 中国科学院生态环境研究中心 一种氮肥组合物及其用途
FR3112343B1 (fr) * 2020-07-10 2022-12-23 Arkema France Procédé de fabrication d’acides et esters Ω-bromoalcanoïques
WO2023042009A1 (en) * 2021-09-20 2023-03-23 3M Innovative Properties Company Thiol-based beta-diketone primers for adhesion to metal

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001074801A1 (en) * 2000-03-30 2001-10-11 University Of Nottingham Immunosuppressant n-acyles homoserine lactones
WO2003022828A1 (en) * 2001-09-12 2003-03-20 The University Of Nottingham Use of n-acyl homoserine lactones for the treatment of insulitis
WO2003026641A2 (en) * 2001-09-22 2003-04-03 University Of Nottingham Modulation of stat activity
CN1839204A (zh) * 2002-08-15 2006-09-27 纽约州州立大学研究基金会 自诱导剂类似物的组合库,自诱导剂激动剂和拮抗剂,以及它们的使用方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6703513B1 (en) * 2000-06-02 2004-03-09 K-Quay Enterprises Llc Production and use of derivatized homoserine lactones
GB0116312D0 (en) * 2001-07-04 2001-08-29 Univ Nottingham "Compositions containing N-acyl homoserine lactones"
WO2006084056A2 (en) * 2005-02-04 2006-08-10 Wisconsin Alumni Research Foundation Compounds and methods for modulating communication and virulence in quorum sensing bacteria

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001074801A1 (en) * 2000-03-30 2001-10-11 University Of Nottingham Immunosuppressant n-acyles homoserine lactones
WO2003022828A1 (en) * 2001-09-12 2003-03-20 The University Of Nottingham Use of n-acyl homoserine lactones for the treatment of insulitis
WO2003026641A2 (en) * 2001-09-22 2003-04-03 University Of Nottingham Modulation of stat activity
CN1839204A (zh) * 2002-08-15 2006-09-27 纽约州州立大学研究基金会 自诱导剂类似物的组合库,自诱导剂激动剂和拮抗剂,以及它们的使用方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Covalent Inhibition of Bacterial Quorum Sensing;Neri Amara et al.;《J. Am. Chem. Soc.》;20090708;第131卷(第30期);10610–10619 *
Synthesis of Pseudomonas quorum-sensing autoinducer analogs and structural entities required for induction of apoptosis in macrophages;Manabu Horikawa et al.;《Bioorg. Med. Chem. Lett.》;20060207;第16卷(第8期);2130–2133 *
Synthetic Analogues of the Bacterial Signal (Quorum Sensing) Molecule N-(3-Oxododecanoyl)-L-homoserine Lactone as Immune Modulators;Siri Ram Chhabra et al.;《J. Med. Chem.》;20021128;第46卷(第1期);97-104 *

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JP2012532095A (ja) 2012-12-13
JP5816618B2 (ja) 2015-11-18
US20120135925A1 (en) 2012-05-31
EP2448930A1 (en) 2012-05-09
IN2012DN00939A (enExample) 2015-04-03
CN102482244A (zh) 2012-05-30
CA2767183A1 (en) 2011-01-06
EP2448930B1 (en) 2017-02-15
WO2011001419A1 (en) 2011-01-06
US8501969B2 (en) 2013-08-06
US9242951B2 (en) 2016-01-26
CA2767183C (en) 2018-03-13
US20140073690A1 (en) 2014-03-13
AU2010267596A1 (en) 2012-02-02

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