CN102475770A - Soft capsule possessing effects of tranquilizing and allaying excitement and its preparation method - Google Patents
Soft capsule possessing effects of tranquilizing and allaying excitement and its preparation method Download PDFInfo
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- CN102475770A CN102475770A CN2010105654916A CN201010565491A CN102475770A CN 102475770 A CN102475770 A CN 102475770A CN 2010105654916 A CN2010105654916 A CN 2010105654916A CN 201010565491 A CN201010565491 A CN 201010565491A CN 102475770 A CN102475770 A CN 102475770A
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Abstract
The invention relates to the traditional Chinese medicine preparation technical field, concretely relates to a soft capsule possessing effects of tranquilizing and allaying excitement and its preparation method. The current western medicines for treating insomnia have large side-effect on human body and influence the health. The soft capsule possessing effects of tranquilizing and allaying excitement comprises the following bulk drugs by weight part: 100-200 parts of panax notoginseng saponins, 50-90 parts of haw extract, 10-30 parts of soybean oil, 0.1-0.3 parts of vitamin E, 0.95-1.05 parts of gelatin and 0.6-0.8 parts of glycerin. The invention has the advantages that the composition is reasonable, the compatibility is simple, the medication is simple, the employed various traditional Chinese medicines are usual medicines, the cost is low, no toxic or side-effect is generated, and the soft capsule is suitable for long-term administration.
Description
Technical field
The present invention relates to the Chinese drug preparation technique field, refer to a kind of Chinese medicine composition and preparation thereof, specifically refer to a kind of soft capsule and preparation method thereof with tranquilizing effect.
Background technology
Along with the people in modern growth in the living standard, the increase of operating pressure, life stress often causes to fall asleep its night and maybe can't keep sleep state, causes not having enough sleep.The insomnia refers to dyskoimesis, is modal sleep disorder, symptom as feel fatigue, agitation, emotional maladjustment, absent minded and poor memory etc., usually show as and can not fall asleep, the shakiness of sleeping, early awakening and the rear portion of wakeing up can refresh.Insomnia's the cause of disease is varied, can be caused by spirit, psychology and body illness, and difficulty falling asleep or initial aypnia are past habitually in the past with dysthymic disorders such as anxiety, fear or depressions.Insomnia makes troubles for people's life for a long time, even causes the neurasthenia, for eliminating this kind disease; People can suitably take hypnotic; Be the successful methods that solves the insomnia problem, still, existing this kind Western medicine prepn often between the use meeting human body is had side effects; Like triazolam diazepam and other benzodiazepine, the common side effect of continuous use is drowsiness, dizzy, weak etc.; Heavy dose of idol of using causes ataxia, and abuse or heavy dose are taken diazepam for a long time and can be produced toleration, habituation and addiction property, makes people's absentminded easily, has a dizzy spell, astasia, obnubilation, hypomnesis etc.
In sum, existing medicine is bigger to the side effect of human body, and is unhealthful.
Summary of the invention
The technical problem that the present invention will solve provides a kind of soft capsule with tranquilizing effect and preparation method thereof, to solve the existing Western medicine problem big to the human body side effect.
For solving the problems of the technologies described above; The technical scheme that the present invention adopts is: a kind of soft capsule with tranquilizing effect; It is to be made up of capsulation solution and softgel shell two parts; Wherein capsulation solution is made up of following raw medicaments in portion by weight: Radix Notoginseng total saponin from leaves 100-200 part, Fructus Crataegi extract 50-90 part, soybean oil 10-30 part; Vitamin E 0.1-0.3 part; Softgel shell is to be processed by the raw material of following weight parts: gelatin 0.95-1.05 part, glycerol 0.6-0.8, water 1-3 part
Above-mentioned a kind of soft capsule and preparation method thereof with tranquilizing effect, wherein capsulation solution is made up of following raw medicaments in portion by weight: 150 parts of Radix Notoginseng total saponin from leaves, 70 parts of Fructus Crataegi extracts, 20 parts of soybean oils, 0.2 part of vitamin E; Softgel shell is to be processed by the raw material of following weight parts: 1 part in gelatin, 0.7 part of glycerol, 2 parts in water.
Above-mentioned preparation of soft capsule method with tranquilizing effect is; It is even to pour said Radix Notoginseng total saponin from leaves, Fructus Crataegi extract and said soybean oil into the mill that circulates in the colloid mill by said weight portion; The medicinal liquid that mill is good is poured in the dispensing canister of cleaning; Vitamin E is joined in the said dispensing canister, stir into uniform suspension, both got the capsule medicinal liquid; Get gelatin, glycerol, water, put vessel in heating to 80 ℃ dissolving, filter, filtrating adds antiseptic, and mixing in 65 ℃ of insulations, gets rubber solution; Get foregoing thing and rubber solution,, get final product after the drying with the compression moulding of soft capsule production equipment.
The present invention has following advantage and effect with respect to prior art:
1, reasonable recipe, compatibility is simple, and the medicine of employing is common medicine, is easy to compatible combination, and cost is low and have no side effect, and no Drug resistance and drug resistance have the effect of calming the nerves, and the old and the young are used in combination.
2, the dosage form that adopts is taken more convenient, and is beneficial to absorption, and curative effect is more obvious.
The specific embodiment:
Theory of Chinese medical science research, Folium Notoginseng total arasaponins are a kind of Chinese herbal medicine, have the shortening time for falling asleep, prolong the length of one's sleep, reduce the awakening number of times, improve headache, dizziness, cardiopalmus, weak, treat neurasthenic effect; Fructus Crataegi has promoting digestion and invigorating the stomach, and the effect of circulation of qi promoting dissipating blood stasis is so think assistant.
The three flavor herbal natures that the present invention adopts are following:
1, Folium Notoginseng total arasaponins;
Pharmacological action: except the special efficacy of treatment traumatic injury, Radix Notoginseng also has the effect of strengthening by means of tonics.Modern pharmacology research shows that Radix Notoginseng has tangible prevention and therapeutical effect to hyperlipemia, high blood viscosity, hypertension, arrhythmia etc.Saponin of Radix Notoginseng leaf prolongs the length of one's sleep to shortening time for falling asleep, reduces the awakening number of times, improves headache, dizziness, cardiopalmus, weak all better.Treatment neurasthenia total effective rate is apparently higher than the gastrodine matched group.
2, Fructus Crataegi;
Pharmacological action: Fructus Crataegi has effects such as removing food stagnancyization stagnates, convergence dysentery relieving, activating blood circulation to dissipate blood stasis.Cure mainly diseases such as eating accumulation, chest and diaphragm feeling of fullness, the amenorrhea of hernia blood stasis.Contain ingredients such as mountain terpenoid and flavonoid in the Fructus Crataegi, have significant blood vessel dilating and hypotensive effect, the function that strengthens cardiac muscle, arrhythmia, blood lipid regulation and cholesterol level is arranged.
Embodiment 1
Getting 10 parts of 100 parts of Radix Notoginseng total saponin from leaves, 50 parts of Fructus Crataegi extracts and soybean oils, to pour in the colloid mill circulation mill into even; The medicinal liquid that mill is good is poured in the dispensing canister of cleaning; Vitamin E is joined in the said dispensing canister for 0.1 part, stir into uniform suspension, both got the capsule medicinal liquid; Get 0.95 part in gelatin, 0.6 part of glycerol, 1 part in water, put vessel in heating to 80 ℃ dissolving, filter, filtrating adds antiseptic, and mixing in 65 ℃ of insulations, gets rubber solution; Get foregoing thing and rubber solution,, get final product after the drying with the compression moulding of soft capsule production equipment.
Embodiment 2
Getting 30 parts of 200 parts of Radix Notoginseng total saponin from leaves, 90 parts of Fructus Crataegi extracts and soybean oils, to pour in the colloid mill circulation mill into even; The medicinal liquid that mill is good is poured in the dispensing canister of cleaning; Vitamin E is joined in the said dispensing canister for 0.3 part, stir into uniform suspension, both got the capsule medicinal liquid; Get 1.05 parts in gelatin, 0.8 part of glycerol, 3 parts in water, put vessel in heating to 80 ℃ dissolving, filter, filtrating adds antiseptic, and mixing in 65 ℃ of insulations, gets rubber solution; Get foregoing thing and rubber solution,, get final product after the drying with the compression moulding of soft capsule production equipment.
Embodiment 3
Getting 15 parts of 120 parts of Radix Notoginseng total saponin from leaves, 60 parts of Fructus Crataegi extracts and soybean oils, to pour in the colloid mill circulation mill into even; The medicinal liquid that mill is good is poured in the dispensing canister of cleaning; Vitamin E is joined in the said dispensing canister for 0.15 part, stir into uniform suspension, both got the capsule medicinal liquid; Get 0.96 part in gelatin, 0.65 part of glycerol, 1.5 parts in water, put vessel in heating to 80 ℃ dissolving, filter, filtrating adds antiseptic, and mixing in 65 ℃ of insulations, gets rubber solution; Get foregoing thing and rubber solution,, get final product after the drying with the compression moulding of soft capsule production equipment.
Embodiment 4
Getting 20 parts of 150 parts of Radix Notoginseng total saponin from leaves, 70 parts of Fructus Crataegi extracts and soybean oils, to pour in the colloid mill circulation mill into even; The medicinal liquid that mill is good is poured in the dispensing canister of cleaning; Vitamin E is joined in the said dispensing canister for 0.2 part, stir into uniform suspension, both got the capsule medicinal liquid; Get 1 part in gelatin, 0.7 part of glycerol, 2 parts in water, put vessel in heating to 80 ℃ dissolving, filter, filtrating adds antiseptic, and mixing in 65 ℃ of insulations, gets rubber solution; Get foregoing thing and rubber solution,, get final product after the drying with the compression moulding of soft capsule production equipment.
Claims (3)
1. one kind has soft capsule of tranquilizing effect and preparation method thereof, it is characterized in that: it is by being made up of capsulation solution and softgel shell two parts,
Wherein capsulation solution is made up of following raw medicaments in portion by weight:
Radix Notoginseng total saponin from leaves 100-200 part, Fructus Crataegi extract 50-90 part, soybean oil 10-30 part; Vitamin E 0.1-0.3 part;
Softgel shell is to be processed by the raw material of following weight parts:
Gelatin 0.95-1.05 part, glycerol 0.6-0.8, water 1-3 part.
2. a kind of Chinese medicine composition according to claim 1 with heart-nourishing brain-nourishing effect, it is characterized in that: wherein capsulation solution is made up of following raw medicaments in portion by weight:
150 parts of Radix Notoginseng total saponin from leaves, 70 parts of Fructus Crataegi extracts, 20 parts of soybean oils, 0.2 part of vitamin E;
Softgel shell is to be processed by the raw material of following weight parts:
1 part in gelatin, 0.7 part of glycerol, 2 parts in water.
3. according to according to claim 1 or claim 2 a kind of soft capsule and preparation method thereof, it is characterized in that: comprise the steps: with tranquilizing effect
(1) it is even to pour said Radix Notoginseng total saponin from leaves, Fructus Crataegi extract and said soybean oil into the mill that circulates in the colloid mill by said weight portion; The medicinal liquid that mill is good is poured in the dispensing canister of cleaning; Vitamin E is joined in the said dispensing canister, stir into uniform suspension, both got the capsule medicinal liquid;
(2) get gelatin, glycerol, water, put vessel in heating to 80 and dissolve, filter, filtrating adds antiseptic, and mixing in 65 insulations, gets rubber solution;
(3) get foregoing thing and rubber solution,, get final product after the drying with the compression moulding of soft capsule production equipment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105654916A CN102475770A (en) | 2010-11-30 | 2010-11-30 | Soft capsule possessing effects of tranquilizing and allaying excitement and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105654916A CN102475770A (en) | 2010-11-30 | 2010-11-30 | Soft capsule possessing effects of tranquilizing and allaying excitement and its preparation method |
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| CN102475770A true CN102475770A (en) | 2012-05-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010105654916A Pending CN102475770A (en) | 2010-11-30 | 2010-11-30 | Soft capsule possessing effects of tranquilizing and allaying excitement and its preparation method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716103A (en) * | 2012-07-02 | 2012-10-10 | 西安力邦制药有限公司 | 2, 2', 6, 6'-tetraisopropyl-4, 4'-2-biphenol soft capsule and method for preparing same |
-
2010
- 2010-11-30 CN CN2010105654916A patent/CN102475770A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716103A (en) * | 2012-07-02 | 2012-10-10 | 西安力邦制药有限公司 | 2, 2', 6, 6'-tetraisopropyl-4, 4'-2-biphenol soft capsule and method for preparing same |
| CN102716103B (en) * | 2012-07-02 | 2013-12-18 | 西安力邦制药有限公司 | 2, 2', 6, 6'-tetraisopropyl-4, 4'-2-biphenol soft capsule and method for preparing same |
| WO2014005363A1 (en) * | 2012-07-02 | 2014-01-09 | 西安力邦制药有限公司 | 2,2',6,6'-tetraisopropyl-4,4'-2-biphenol soft capsule and method for preparing same |
| US9693963B2 (en) | 2012-07-02 | 2017-07-04 | Xi'an Libang Pharmaceutical Co., Ltd. | 2,2′,6,6′-tetraisopropyl-4,4′-2-biphenol soft capsule and method for preparing same |
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Application publication date: 20120530 |