CN102471773A - 发酵方法 - Google Patents

发酵方法 Download PDF

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Publication number
CN102471773A
CN102471773A CN2010800353751A CN201080035375A CN102471773A CN 102471773 A CN102471773 A CN 102471773A CN 2010800353751 A CN2010800353751 A CN 2010800353751A CN 201080035375 A CN201080035375 A CN 201080035375A CN 102471773 A CN102471773 A CN 102471773A
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CN
China
Prior art keywords
nucleic acid
inducer
mannose
host cell
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800353751A
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English (en)
Chinese (zh)
Inventor
M·文泽尔
J·埃尔滕布克纳
C·基茨亚克
M·西曼赫茨伯格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Publication of CN102471773A publication Critical patent/CN102471773A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN2010800353751A 2009-08-10 2010-08-02 发酵方法 Pending CN102471773A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09010287A EP2292769A1 (en) 2009-08-10 2009-08-10 Fermentation process
EP09010287.2 2009-08-10
PCT/EP2010/061195 WO2011018377A1 (en) 2009-08-10 2010-08-02 Fermentation process

Publications (1)

Publication Number Publication Date
CN102471773A true CN102471773A (zh) 2012-05-23

Family

ID=41435285

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800353751A Pending CN102471773A (zh) 2009-08-10 2010-08-02 发酵方法

Country Status (11)

Country Link
US (1) US20120196323A1 (enExample)
EP (2) EP2292769A1 (enExample)
JP (1) JP2013501511A (enExample)
CN (1) CN102471773A (enExample)
AU (1) AU2010283808A1 (enExample)
CA (1) CA2770605A1 (enExample)
IL (1) IL218026A0 (enExample)
SG (1) SG178293A1 (enExample)
TW (1) TW201111505A (enExample)
WO (1) WO2011018377A1 (enExample)
ZA (1) ZA201200628B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113788884A (zh) * 2011-10-07 2021-12-14 隆扎有限公司 可调控启动子

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2394668T3 (es) * 2009-08-10 2013-02-04 Lonza Ag Vector que comprende promotor de manosa y promotor de manosa
PL2722390T3 (pl) * 2010-07-29 2017-12-29 Lonza Ltd Regulacja indukowalnych promotorów
US20230287379A1 (en) * 2020-07-28 2023-09-14 Basf Se Industrial fermentation process for bacillus using feed rate shift
CN114480359B (zh) * 2022-03-22 2023-04-07 河南中大恒源生物科技股份有限公司 一种高密度发酵生产阿洛酮糖3-差向异构酶的方法
CN120015152B (zh) * 2025-04-21 2025-08-12 苏州工业园区旭太生物工程有限公司 一种多肽诱导型生物发酵培养基优化方法及系统

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004033633A2 (en) * 2002-10-04 2004-04-22 Embiosis Pharmaceuticals Compatible host/vector systems for expression of dna
CN101193906A (zh) * 2005-06-06 2008-06-04 陶氏环球技术公司 细菌宿主细胞中甘露糖醇诱导的启动子系统

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2394668T3 (es) * 2009-08-10 2013-02-04 Lonza Ag Vector que comprende promotor de manosa y promotor de manosa

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004033633A2 (en) * 2002-10-04 2004-04-22 Embiosis Pharmaceuticals Compatible host/vector systems for expression of dna
CN101193906A (zh) * 2005-06-06 2008-06-04 陶氏环球技术公司 细菌宿主细胞中甘露糖醇诱导的启动子系统

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
F. KUNST等: "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis", 《NATURE》 *
JONATHAN REIZER等: "Novel phosphotransferase system genes revealed by genome analysis - the complete complement of PTS proteins encoded within the genome of Bacillus subtilis", 《MICROBIOLOGY》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113788884A (zh) * 2011-10-07 2021-12-14 隆扎有限公司 可调控启动子
US11976284B2 (en) 2011-10-07 2024-05-07 Lonza Ltd Promoter variants for protein production
CN113788884B (zh) * 2011-10-07 2024-07-23 隆扎有限公司 可调控启动子

Also Published As

Publication number Publication date
WO2011018377A1 (en) 2011-02-17
JP2013501511A (ja) 2013-01-17
TW201111505A (en) 2011-04-01
AU2010283808A1 (en) 2012-07-12
IL218026A0 (en) 2012-04-30
SG178293A1 (en) 2012-03-29
ZA201200628B (en) 2012-09-26
CA2770605A1 (en) 2011-02-17
US20120196323A1 (en) 2012-08-02
EP2292769A1 (en) 2011-03-09
EP2464732A1 (en) 2012-06-20

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