CN102471279A - 吡唑的烷基化方法 - Google Patents

吡唑的烷基化方法 Download PDF

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Publication number
CN102471279A
CN102471279A CN2010800339701A CN201080033970A CN102471279A CN 102471279 A CN102471279 A CN 102471279A CN 2010800339701 A CN2010800339701 A CN 2010800339701A CN 201080033970 A CN201080033970 A CN 201080033970A CN 102471279 A CN102471279 A CN 102471279A
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CN
China
Prior art keywords
formula
compound
optionally substituted
alkyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800339701A
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English (en)
Chinese (zh)
Inventor
王林华
J·T·艾伯特
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Syngenta Participations AG
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Syngenta Participations AG
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Publication date
Application filed by Syngenta Participations AG filed Critical Syngenta Participations AG
Publication of CN102471279A publication Critical patent/CN102471279A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
CN2010800339701A 2009-07-31 2010-07-27 吡唑的烷基化方法 Pending CN102471279A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US23013409P 2009-07-31 2009-07-31
US61/230,134 2009-07-31
US36157010P 2010-07-06 2010-07-06
US61/361,570 2010-07-06
PCT/EP2010/060884 WO2011012620A2 (en) 2009-07-31 2010-07-27 Processes for the alkylation of pyrazoles

Publications (1)

Publication Number Publication Date
CN102471279A true CN102471279A (zh) 2012-05-23

Family

ID=42782270

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800339701A Pending CN102471279A (zh) 2009-07-31 2010-07-27 吡唑的烷基化方法

Country Status (12)

Country Link
US (1) US8563747B2 (https=)
EP (1) EP2459538B1 (https=)
JP (1) JP5956334B2 (https=)
CN (1) CN102471279A (https=)
AR (1) AR077332A1 (https=)
BR (1) BR112012008128B8 (https=)
DK (1) DK2459538T3 (https=)
ES (1) ES2525489T3 (https=)
IL (1) IL217387A (https=)
MX (1) MX2012001067A (https=)
TW (1) TW201107296A (https=)
WO (1) WO2011012620A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103842345A (zh) * 2012-09-05 2014-06-04 撻马化学工业株式会社 1-取代-3-氟烷基吡唑-4-羧酸酯的制造方法
CN119823045A (zh) * 2024-12-18 2025-04-15 湖南化工研究院有限公司 一种3-二氟甲基-1-甲基吡唑-4-甲酸乙酯的合成方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102471278B (zh) 2009-07-28 2015-04-01 先正达参股股份有限公司 关于吡唑的烷基化方法
JP5869570B2 (ja) * 2010-08-10 2016-02-24 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト ３−ハロアルキルピラゾールの調製方法
ES2750353T3 (es) 2014-08-19 2020-03-25 Bayer Animal Health Gmbh Procedimiento de preparación de 5-fluoro-1H-pirazoles partiendo de hexafluoropropeno
WO2024014780A1 (ko) * 2022-07-11 2024-01-18 주식회사 엘지에너지솔루션 리튬 이차전지용 비수 전해액 및 이를 포함하는 리튬 이차전지

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995025099A1 (en) * 1994-03-17 1995-09-21 Rhone-Poulenc Agriculture Ltd. 2-cyano-1,3-dione derivatives useful as herbicides
JP2000044541A (ja) * 1998-08-03 2000-02-15 Mitsui Chemicals Inc １，３−ジアルキルピラゾール−４−カルボン酸エステルの製造法
WO2006045504A1 (en) * 2004-10-21 2006-05-04 Syngenta Participations Ag Process for the preparation of pyrazoles
CN1968934A (zh) * 2004-06-18 2007-05-23 巴斯福股份公司 N－(邻苯基)－1－甲基－3－二氟甲基吡唑－4－甲酰苯胺及其作为杀真菌剂的用途
WO2008053044A2 (de) * 2006-11-03 2008-05-08 Basf Se Hetarylcarbonsäure-n-(biphen-2-yl)amid-verbindungen
CN101296913A (zh) * 2005-10-25 2008-10-29 先正达参股股份有限公司 用作杀微生物剂的杂环酰胺衍生物
WO2008141020A1 (en) * 2007-05-11 2008-11-20 Eli Lilly And Company 2-[4-(pyrazol-4-ylalkyl)piperazin-1-yl]-3-phenyl pyrazines and pyridines and 3-[4-(pyrazol-4-ylalkyl)piperazin-1-yl]-2-phenyl pyridines as 5-ht7 receptor antagonists

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0759560B2 (ja) * 1987-10-19 1995-06-28 三井東圧化学株式会社 １，３−ジアルキルピラゾール−４−カルボン酸エステルの製造法
US5498624A (en) * 1995-05-03 1996-03-12 Monsanto Company Selected pyrazolyl derivatives
JP4568404B2 (ja) 2000-05-17 2010-10-27 三井化学アグロ株式会社 ピラゾールカルボン酸エステル誘導体の製造法
MXPA04008314A (es) 2002-03-05 2004-11-26 Syngenta Participations Ag O-ciclopropil-carboxaniluros y su uso como funguicidas.
GB0224316D0 (en) 2002-10-18 2002-11-27 Syngenta Participations Ag Chemical compounds
US7863460B2 (en) * 2005-02-25 2011-01-04 Sagami Chemical Research Center Process for producing 1-substituted-3-fluoroalkylpyrazole-4-carboxylate
GB0526044D0 (en) * 2005-12-21 2006-02-01 Syngenta Ltd Novel herbicides
BRPI0808927B1 (pt) 2007-03-16 2023-09-26 Syngenta Participations Ag Modificação c cristalográfica (9-isopropil-1,2,3,4- tetra-hidro-1,4- metano-naftalen-5-il)-amida racêmica syn do ácido 3-difluorometil-1-metil-1hpirazol-4- carboxílico e composição a compreendendo, bem como método para controlar doenças em plantas úteis ou no material de propagação das mesmas, causadas por agentes fitopatogênicos
KR20100017431A (ko) 2007-05-31 2010-02-16 신젠타 파티서페이션즈 아게 피라졸의 제조 방법
WO2009135860A1 (de) 2008-05-08 2009-11-12 Basf Se Verfahren zur herstellung von arylcarboxamiden
GB0812028D0 (en) 2008-07-01 2008-08-06 Syngenta Participations Ag Fungicidal compositions

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995025099A1 (en) * 1994-03-17 1995-09-21 Rhone-Poulenc Agriculture Ltd. 2-cyano-1,3-dione derivatives useful as herbicides
JP2000044541A (ja) * 1998-08-03 2000-02-15 Mitsui Chemicals Inc １，３−ジアルキルピラゾール−４−カルボン酸エステルの製造法
CN1968934A (zh) * 2004-06-18 2007-05-23 巴斯福股份公司 N－(邻苯基)－1－甲基－3－二氟甲基吡唑－4－甲酰苯胺及其作为杀真菌剂的用途
WO2006045504A1 (en) * 2004-10-21 2006-05-04 Syngenta Participations Ag Process for the preparation of pyrazoles
CN101296913A (zh) * 2005-10-25 2008-10-29 先正达参股股份有限公司 用作杀微生物剂的杂环酰胺衍生物
WO2008053044A2 (de) * 2006-11-03 2008-05-08 Basf Se Hetarylcarbonsäure-n-(biphen-2-yl)amid-verbindungen
WO2008141020A1 (en) * 2007-05-11 2008-11-20 Eli Lilly And Company 2-[4-(pyrazol-4-ylalkyl)piperazin-1-yl]-3-phenyl pyrazines and pyridines and 3-[4-(pyrazol-4-ylalkyl)piperazin-1-yl]-2-phenyl pyridines as 5-ht7 receptor antagonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KIYOSHI YAMAUCHI，等: "Esters of Phosphorus Oxy-acids as Alkylating Agents. Part 11.l N-Alkylation of lmidazole and Related Heterocyclic Compounds with Trialkyl Phosphates", 《J.C.S.PERKIN I》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103842345A (zh) * 2012-09-05 2014-06-04 撻马化学工业株式会社 1-取代-3-氟烷基吡唑-4-羧酸酯的制造方法
CN103842345B (zh) * 2012-09-05 2016-01-20 撻马化学工业株式会社 1-取代-3-氟烷基吡唑-4-羧酸酯的制造方法
CN119823045A (zh) * 2024-12-18 2025-04-15 湖南化工研究院有限公司 一种3-二氟甲基-1-甲基吡唑-4-甲酸乙酯的合成方法
CN119823045B (zh) * 2024-12-18 2025-10-17 湖南化工研究院有限公司 一种3-二氟甲基-1-甲基吡唑-4-甲酸乙酯的合成方法

Also Published As

Publication number Publication date
IL217387A0 (en) 2012-02-29
EP2459538B1 (en) 2014-10-15
US8563747B2 (en) 2013-10-22
MX2012001067A (es) 2012-03-16
DK2459538T3 (en) 2015-01-05
BR112012008128B1 (pt) 2017-10-31
WO2011012620A3 (en) 2011-06-09
TW201107296A (en) 2011-03-01
IL217387A (en) 2016-02-29
BR112012008128A2 (pt) 2015-09-22
ES2525489T3 (es) 2014-12-23
EP2459538A2 (en) 2012-06-06
JP2013500945A (ja) 2013-01-10
JP5956334B2 (ja) 2016-07-27
WO2011012620A2 (en) 2011-02-03
AR077332A1 (es) 2011-08-17
US20120130085A1 (en) 2012-05-24
BR112012008128B8 (pt) 2019-07-16

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Application publication date: 20120523