CN102459598B - 用于代谢紊乱的靶向微小rna - Google Patents

用于代谢紊乱的靶向微小rna Download PDF

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CN102459598B
CN102459598B CN201080032062.0A CN201080032062A CN102459598B CN 102459598 B CN102459598 B CN 102459598B CN 201080032062 A CN201080032062 A CN 201080032062A CN 102459598 B CN102459598 B CN 102459598B
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certain embodiments
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mir
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oligonucleotide
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CN102459598A (zh
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M·斯托夫
M·塔可夫斯基
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Eidgenoessische Technische Hochschule Zurich ETHZ
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Eidgenoessische Technische Hochschule Zurich ETHZ
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    • A—HUMAN NECESSITIES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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CN201080032062.0A 2009-05-20 2010-05-19 用于代谢紊乱的靶向微小rna Expired - Fee Related CN102459598B (zh)

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US18002409P 2009-05-20 2009-05-20
US61/180,024 2009-05-20
US32287810P 2010-04-11 2010-04-11
US61/322,878 2010-04-11
PCT/IB2010/001384 WO2010133970A1 (en) 2009-05-20 2010-05-19 Targeting micrornas for metabolic disorders

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US (6) US8592388B2 (enExample)
EP (1) EP2432880A1 (enExample)
JP (2) JP2012527444A (enExample)
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AU (2) AU2010250838B2 (enExample)
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RU2017105342A (ru) * 2014-08-07 2018-09-13 Регулус Терапьютикс Инк. НАЦЕЛИВАНИЕ НА микроРНК ПРИ РАССТРОЙСТВАХ ОБМЕНА ВЕЩЕСТВ
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CN105457028B (zh) * 2014-09-04 2019-08-20 中国科学院上海生命科学研究院 在骨形成中发挥调控作用的应力敏感性microRNA
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CN112635018B (zh) * 2020-12-24 2025-04-18 江苏精策医疗科技有限公司 一种提高无创血糖代谢热整合法检测的准确性的方法

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AU2016202224B2 (en) 2018-03-08
AU2016202224A1 (en) 2016-05-05
US8592388B2 (en) 2013-11-26
CN105935365B (zh) 2018-12-21
CN102459598A (zh) 2012-05-16
US9932595B2 (en) 2018-04-03
CA2763016C (en) 2018-04-17
CN105935365A (zh) 2016-09-14
EP2432880A1 (en) 2012-03-28
AU2010250838B2 (en) 2016-01-21
US20170218368A1 (en) 2017-08-03
CA2763016A1 (en) 2010-11-25
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US20140113953A1 (en) 2014-04-24
JP6300775B2 (ja) 2018-03-28
US20150038550A1 (en) 2015-02-05
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US9243249B2 (en) 2016-01-26
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US8877730B2 (en) 2014-11-04
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US9550996B2 (en) 2017-01-24

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