CN102459225B - Ccr2的4-氮杂环丁烷基-1-杂芳基-环己烷拮抗剂 - Google Patents

Ccr2的4-氮杂环丁烷基-1-杂芳基-环己烷拮抗剂 Download PDF

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CN102459225B
CN102459225B CN201080027215.2A CN201080027215A CN102459225B CN 102459225 B CN102459225 B CN 102459225B CN 201080027215 A CN201080027215 A CN 201080027215A CN 102459225 B CN102459225 B CN 102459225B
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alkyl
pyridin
compound
methyl
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CN102459225A (zh
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张旭庆
H·R·赫夫奈格尔
蔡潮钟
J·兰特
T·P·马科坦
隋治华
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Janssen Pharmaceutica NV
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201080027215.2A 2009-04-16 2010-04-15 Ccr2的4-氮杂环丁烷基-1-杂芳基-环己烷拮抗剂 Expired - Fee Related CN102459225B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16987609P 2009-04-16 2009-04-16
US61/169876 2009-04-16
PCT/US2010/031212 WO2010121011A1 (en) 2009-04-16 2010-04-15 4-azetidinyl-1-heteroaryl-cyclohexane antagonists of ccr2

Publications (2)

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CN102459225A CN102459225A (zh) 2012-05-16
CN102459225B true CN102459225B (zh) 2014-08-20

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US (1) US8269015B2 (enExample)
EP (1) EP2419417B1 (enExample)
JP (1) JP5685580B2 (enExample)
KR (1) KR20120061060A (enExample)
CN (1) CN102459225B (enExample)
AR (1) AR076310A1 (enExample)
AU (1) AU2010236393B2 (enExample)
BR (1) BRPI1016207A2 (enExample)
CA (1) CA2758918A1 (enExample)
ES (1) ES2539161T3 (enExample)
MX (1) MX2011010919A (enExample)
NZ (1) NZ595431A (enExample)
TW (1) TW201105649A (enExample)
WO (1) WO2010121011A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2745969C (en) * 2008-12-10 2017-04-25 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of ccr2
ES2528625T3 (es) * 2009-04-17 2015-02-11 Janssen Pharmaceutica Nv Antagonistas de 4-azetidinil-1-fenil-ciclohexano de CCR2
CA2758929A1 (en) 2009-04-17 2010-10-21 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2
TW201211027A (en) * 2010-06-09 2012-03-16 Janssen Pharmaceutica Nv Cyclohexyl-azetidinyl antagonists of CCR2
WO2011159854A1 (en) 2010-06-17 2011-12-22 Janssen Pharmaceutica Nv Cyclohexyl-azetidinyl antagonists of ccr2
CA2852160A1 (en) 2011-10-28 2013-05-02 Galderma Research & Development New leukocyte infiltrate markers for rosacea and uses thereof
RU2726206C2 (ru) 2015-05-21 2020-07-09 Кемосентрикс, Инк. Модуляторы ccr2
EP3687525B1 (en) 2017-09-25 2025-10-29 ChemoCentryx, Inc. Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor
CN112105353B (zh) 2018-01-08 2024-04-19 凯莫森特里克斯股份有限公司 Ccr2拮抗剂治疗实体瘤的方法
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists

Citations (2)

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US20030004151A1 (en) * 2000-12-20 2003-01-02 Robert Cherney Cyclic derivatives as modulators of chemokine receptor activity
CN1741994A (zh) * 2002-11-27 2006-03-01 因塞特公司 作为趋化因子受体调节剂的3－氨基吡咯烷衍生物

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US6037354A (en) 1997-06-18 2000-03-14 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
CA2378499A1 (en) 1999-08-04 2001-02-15 Teijin Limited Cyclic amine ccr3 antagonists
US6245799B1 (en) 1999-11-08 2001-06-12 American Home Products Corp [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders
WO2004050024A2 (en) * 2002-11-27 2004-06-17 Incyte Corporation 3-aminopyrrolidine derivatives as modulators of chemokine receptors
GB0417801D0 (en) * 2004-08-10 2004-09-15 Novartis Ag Organic compounds
KR20070063562A (ko) 2004-09-28 2007-06-19 얀센 파마슈티카 엔.브이. 치환 디피페리딘 ｃｃｒ２ 길항제
PA8653301A1 (es) 2004-11-22 2006-11-09 Incyte Corp Incyte Corp Sales de la n-[2-({(3r)-1-[trans-4-hidroxi-4-(6-metoxipiridin-3-il) ciclohexil)pirrolidin
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US20070197590A1 (en) 2006-01-31 2007-08-23 Demong Duane E Substituted dipiperidine ccr2 antagonists
AU2008335135A1 (en) * 2007-12-11 2009-06-18 Cytopathfinder, Inc. Carboxamide compounds and their use as chemokine receptor agonists
CA2745969C (en) * 2008-12-10 2017-04-25 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of ccr2
CA2758929A1 (en) 2009-04-17 2010-10-21 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2
ES2528625T3 (es) 2009-04-17 2015-02-11 Janssen Pharmaceutica Nv Antagonistas de 4-azetidinil-1-fenil-ciclohexano de CCR2

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030004151A1 (en) * 2000-12-20 2003-01-02 Robert Cherney Cyclic derivatives as modulators of chemokine receptor activity
CN1741994A (zh) * 2002-11-27 2006-03-01 因塞特公司 作为趋化因子受体调节剂的3－氨基吡咯烷衍生物

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Publication number Publication date
US8269015B2 (en) 2012-09-18
JP2012524107A (ja) 2012-10-11
JP5685580B2 (ja) 2015-03-18
TW201105649A (en) 2011-02-16
ES2539161T3 (es) 2015-06-26
CN102459225A (zh) 2012-05-16
MX2011010919A (es) 2011-11-02
WO2010121011A1 (en) 2010-10-21
CA2758918A1 (en) 2010-10-21
NZ595431A (en) 2013-12-20
AU2010236393A1 (en) 2011-11-03
EP2419417B1 (en) 2015-03-25
KR20120061060A (ko) 2012-06-12
US20100267688A1 (en) 2010-10-21
EP2419417A1 (en) 2012-02-22
AR076310A1 (es) 2011-06-01
AU2010236393B2 (en) 2014-11-13
BRPI1016207A2 (pt) 2016-04-26

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