CN102459225B - Ccr2的4-氮杂环丁烷基-1-杂芳基-环己烷拮抗剂 - Google Patents

Ccr2的4-氮杂环丁烷基-1-杂芳基-环己烷拮抗剂 Download PDF

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CN102459225B
CN102459225B CN201080027215.2A CN201080027215A CN102459225B CN 102459225 B CN102459225 B CN 102459225B CN 201080027215 A CN201080027215 A CN 201080027215A CN 102459225 B CN102459225 B CN 102459225B
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alkyl
pyridin
group
methyl
compound
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CN102459225A (zh
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张旭庆
H·R·赫夫奈格尔
蔡潮钟
J·兰特
T·P·马科坦
隋治华
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Janssen Pharmaceutica NV
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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CN201080027215.2A 2009-04-16 2010-04-15 Ccr2的4-氮杂环丁烷基-1-杂芳基-环己烷拮抗剂 Expired - Fee Related CN102459225B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16987609P 2009-04-16 2009-04-16
US61/169876 2009-04-16
PCT/US2010/031212 WO2010121011A1 (en) 2009-04-16 2010-04-15 4-azetidinyl-1-heteroaryl-cyclohexane antagonists of ccr2

Publications (2)

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CN102459225A CN102459225A (zh) 2012-05-16
CN102459225B true CN102459225B (zh) 2014-08-20

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US (1) US8269015B2 (enExample)
EP (1) EP2419417B1 (enExample)
JP (1) JP5685580B2 (enExample)
KR (1) KR20120061060A (enExample)
CN (1) CN102459225B (enExample)
AR (1) AR076310A1 (enExample)
AU (1) AU2010236393B2 (enExample)
BR (1) BRPI1016207A2 (enExample)
CA (1) CA2758918A1 (enExample)
ES (1) ES2539161T3 (enExample)
MX (1) MX2011010919A (enExample)
NZ (1) NZ595431A (enExample)
TW (1) TW201105649A (enExample)
WO (1) WO2010121011A1 (enExample)

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Publication number Priority date Publication date Assignee Title
EP2376475B1 (en) * 2008-12-10 2015-09-02 Janssen Pharmaceutica NV 4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of ccr2
WO2010121036A1 (en) * 2009-04-17 2010-10-21 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2
NZ595432A (en) * 2009-04-17 2013-12-20 Janssen Pharmaceutica Nv 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2
TW201211027A (en) * 2010-06-09 2012-03-16 Janssen Pharmaceutica Nv Cyclohexyl-azetidinyl antagonists of CCR2
KR101743280B1 (ko) 2010-06-17 2017-06-02 얀센 파마슈티카 엔.브이. Ccr2의 사이클로헥실-아제티디닐 길항제
US20140329809A1 (en) 2011-10-28 2014-11-06 Galderma Research & Development New leukocyte infiltrate markers for rosacea and uses thereof
KR102622891B1 (ko) 2015-05-21 2024-01-08 케모센트릭스, 인크. Ccr2 조절제
KR102677442B1 (ko) 2017-09-25 2024-06-20 케모센트릭스, 인크. 케모카인 수용체 2(ccr2) 길항제 및 pd-1/pd-l1 억제제를 사용하는 병용 요법
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
ES2991280T3 (es) 2018-01-08 2024-12-03 Chemocentryx Inc Antagonistas de CCR2 para el tratamiento del linfoma cutáneo de linfocitos T

Citations (2)

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US20030004151A1 (en) * 2000-12-20 2003-01-02 Robert Cherney Cyclic derivatives as modulators of chemokine receptor activity
CN1741994A (zh) * 2002-11-27 2006-03-01 因塞特公司 作为趋化因子受体调节剂的3－氨基吡咯烷衍生物

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EP1201239A4 (en) 1999-08-04 2004-12-08 Teijin Ltd CCR3 CYCLIC AMINE ANTAGONISTS
US6245799B1 (en) * 1999-11-08 2001-06-12 American Home Products Corp [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders
ATE555087T1 (de) 2002-11-27 2012-05-15 Incyte Corp 3-aminopyrrolidinderivate als modulatoren von chemokinrezeptoren
GB0417801D0 (en) * 2004-08-10 2004-09-15 Novartis Ag Organic compounds
JP2008514700A (ja) * 2004-09-28 2008-05-08 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 置換されたジピペリジンｃｃｒ２アンタゴニスト
UY29219A1 (es) 2004-11-22 2006-04-28 Incyte Corp Sales de la n-(2- (((3r)-1-(trans-4-hidroxi-4-(6-metoxipiridin-3-il)-cilohexil) pirrolidin-3-il)amino)-2-oxoetil)-3- (trifluorometil) benzamida
WO2007053498A1 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
US20070197590A1 (en) 2006-01-31 2007-08-23 Demong Duane E Substituted dipiperidine ccr2 antagonists
CA2708364A1 (en) * 2007-12-11 2009-06-18 Efrat Ben-Zeev Carboxamide compounds and their use as chemokine receptor agonists
EP2376475B1 (en) * 2008-12-10 2015-09-02 Janssen Pharmaceutica NV 4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of ccr2
WO2010121036A1 (en) * 2009-04-17 2010-10-21 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2
NZ595432A (en) * 2009-04-17 2013-12-20 Janssen Pharmaceutica Nv 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030004151A1 (en) * 2000-12-20 2003-01-02 Robert Cherney Cyclic derivatives as modulators of chemokine receptor activity
CN1741994A (zh) * 2002-11-27 2006-03-01 因塞特公司 作为趋化因子受体调节剂的3－氨基吡咯烷衍生物

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Publication number Publication date
US20100267688A1 (en) 2010-10-21
WO2010121011A1 (en) 2010-10-21
BRPI1016207A2 (pt) 2016-04-26
NZ595431A (en) 2013-12-20
KR20120061060A (ko) 2012-06-12
JP5685580B2 (ja) 2015-03-18
EP2419417A1 (en) 2012-02-22
TW201105649A (en) 2011-02-16
MX2011010919A (es) 2011-11-02
AU2010236393B2 (en) 2014-11-13
CN102459225A (zh) 2012-05-16
ES2539161T3 (es) 2015-06-26
AR076310A1 (es) 2011-06-01
JP2012524107A (ja) 2012-10-11
US8269015B2 (en) 2012-09-18
AU2010236393A1 (en) 2011-11-03
EP2419417B1 (en) 2015-03-25
CA2758918A1 (en) 2010-10-21

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