CN102458476B - 用于治疗多发性硬化症的组合物及方法 - Google Patents

用于治疗多发性硬化症的组合物及方法 Download PDF

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Publication number
CN102458476B
CN102458476B CN201080026791.5A CN201080026791A CN102458476B CN 102458476 B CN102458476 B CN 102458476B CN 201080026791 A CN201080026791 A CN 201080026791A CN 102458476 B CN102458476 B CN 102458476B
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CN
China
Prior art keywords
multiple sclerosis
medicament
administered
treatment
mis416
Prior art date
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Expired - Fee Related
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CN201080026791.5A
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English (en)
Chinese (zh)
Other versions
CN102458476A (zh
Inventor
弗朗克·B·戈尔德
吉利安·爱力森·韦伯斯特
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Innate Therapeutics Ltd
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Innate Therapeutics Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Photographic Developing Apparatuses (AREA)
CN201080026791.5A 2009-06-16 2010-01-16 用于治疗多发性硬化症的组合物及方法 Expired - Fee Related CN102458476B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NZ5777731 2009-06-16
NZ577731A NZ577731A (en) 2009-06-16 2009-06-16 Compositions and methods for treatment of multiple sclerosis
PCT/NZ2010/000112 WO2010147484A1 (en) 2009-06-16 2010-06-16 Compositions and methods for treatment of multiple sclerosis

Publications (2)

Publication Number Publication Date
CN102458476A CN102458476A (zh) 2012-05-16
CN102458476B true CN102458476B (zh) 2014-08-20

Family

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Family Applications (1)

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CN201080026791.5A Expired - Fee Related CN102458476B (zh) 2009-06-16 2010-01-16 用于治疗多发性硬化症的组合物及方法

Country Status (20)

Country Link
US (1) US8389479B2 (https=)
EP (1) EP2442832B1 (https=)
JP (1) JP5646617B2 (https=)
CN (1) CN102458476B (https=)
AU (1) AU2010260585B2 (https=)
BR (1) BRPI1009606A2 (https=)
CA (1) CA2688766C (https=)
CY (1) CY1115714T1 (https=)
DK (1) DK2442832T3 (https=)
ES (1) ES2521565T3 (https=)
HR (1) HRP20141035T1 (https=)
IL (1) IL216993A (https=)
IN (1) IN2012DN00167A (https=)
MX (1) MX2011013661A (https=)
NZ (1) NZ577731A (https=)
PL (1) PL2442832T3 (https=)
PT (1) PT2442832E (https=)
SI (1) SI2442832T1 (https=)
SM (1) SMT201400165B (https=)
WO (1) WO2010147484A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009123480A1 (en) * 2008-04-01 2009-10-08 Virionyx Corporation Ltd Anti-infective agents and uses thereof
HUE050713T2 (hu) * 2010-10-25 2020-12-28 Biogen Ma Inc Módszerek az ALFA-4 integrin aktivitás eltéréseinek meghatározásához, a sVCAM ÉS/VAGY sMAdCAM szintek egymáshoz viszonyításával
UY35790A (es) * 2013-10-21 2015-05-29 Teva Pharma Marcadores genéticos que predicen la respuesta al acetato de glatiramer
WO2017059486A1 (en) * 2015-10-06 2017-04-13 Innate Immunotherapeutics Limited Compositions and methods for the treatment of epilepsy
CA2926507A1 (en) * 2015-10-06 2017-04-06 Innate Immunotherapeutics Limited Compositions and methods for protection and/or repair of the nervous system
WO2017070731A1 (en) * 2015-10-28 2017-05-04 Innate Immunotherapeutics Limited Compositions and methods for the treatment of alzheimer's disease
US12097292B2 (en) 2016-08-28 2024-09-24 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
HUE071047T2 (hu) 2016-08-31 2025-07-28 Mapi Pharma Ltd Glatiramer-acetátot tartalmazó depórendszerek
CN110382052A (zh) 2017-03-26 2019-10-25 Mapi医药公司 用于治疗进展型形式的多发性硬化症的格拉替雷储库系统
CA3099946A1 (en) * 2018-05-18 2019-11-21 Universite Laval Use of nod2 agonist for the treatment, prophylaxis and/or delay of the onset of multiple sclerosis and alzheimer's disease
WO2020010221A1 (en) * 2018-07-03 2020-01-09 University Of Florida Research Foundation, Inc. Microparticle systems and their use for the treatment of multiple sclerosis
US20230190570A1 (en) * 2020-06-22 2023-06-22 Otivio As Methods for treating spasticity using anti-spasmodic compositions and negative pressure therapy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008070564A1 (en) * 2006-12-01 2008-06-12 The Government Of The U.S.A, As Represented By The Secretary, Departmentof Health And Human Services Uses of muramyl dipeptide (mdp) for treating inflammation
WO2008150181A1 (en) * 2007-06-05 2008-12-11 Innate Therapeutics Limited Compositions and methods for treating anthrax exposure associated conditions
WO2008150182A1 (en) * 2007-06-05 2008-12-11 Innate Therapeutics Limited Compositions and methods for treatment of anthrax

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1327896C (zh) * 1996-10-10 2007-07-25 探针国际公司 治疗病毒感染的组合物及方法
JP2008505130A (ja) * 2004-07-01 2008-02-21 ケベンハウンス・ウニヴェルジテート レプトスピラ属感染の治療による多発性硬化症の治療及び予防方法
JP2008251608A (ja) 2007-03-29 2008-10-16 Casio Comput Co Ltd 半導体装置およびその製造方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008070564A1 (en) * 2006-12-01 2008-06-12 The Government Of The U.S.A, As Represented By The Secretary, Departmentof Health And Human Services Uses of muramyl dipeptide (mdp) for treating inflammation
WO2008150181A1 (en) * 2007-06-05 2008-12-11 Innate Therapeutics Limited Compositions and methods for treating anthrax exposure associated conditions
WO2008150182A1 (en) * 2007-06-05 2008-12-11 Innate Therapeutics Limited Compositions and methods for treatment of anthrax

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Clinical Suppression of Experimental Allergic Encephalomyelitis by Muramyl Dipeptide "Adjuvant";Root-Bernstein,R.S. et al;《Brain Research Bulletin》;19861231;第17卷(第4期);473-476 *
Macrophage activation through phagocytosis of muramyl dipeptide encapsulated in gelatin microspheres;Tabata,Y,et al;《Journal of Pharmacy and Pharmacology》;19871231;第39卷(第9期);698-704 *

Also Published As

Publication number Publication date
EP2442832A4 (en) 2013-07-03
IN2012DN00167A (https=) 2015-04-17
US20100317589A1 (en) 2010-12-16
BRPI1009606A2 (pt) 2016-10-11
HK1167101A1 (en) 2013-02-01
CY1115714T1 (el) 2017-01-25
CA2688766C (en) 2015-06-30
MX2011013661A (es) 2012-05-22
AU2010260585B2 (en) 2013-02-21
PT2442832E (pt) 2014-11-11
PL2442832T3 (pl) 2015-01-30
WO2010147484A8 (en) 2012-07-19
JP2012530132A (ja) 2012-11-29
AU2010260585A1 (en) 2012-01-19
SMT201400165B (it) 2015-01-15
CA2688766A1 (en) 2010-12-16
DK2442832T3 (da) 2014-11-10
ES2521565T3 (es) 2014-11-12
HRP20141035T1 (hr) 2014-12-19
EP2442832A1 (en) 2012-04-25
NZ577731A (en) 2010-08-27
EP2442832B1 (en) 2014-08-06
AU2010260585A8 (en) 2012-06-14
JP5646617B2 (ja) 2014-12-24
WO2010147484A1 (en) 2010-12-23
IL216993A (en) 2016-03-31
CN102458476A (zh) 2012-05-16
IL216993A0 (en) 2012-02-29
SI2442832T1 (sl) 2014-12-31
US8389479B2 (en) 2013-03-05

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Number: 34

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Granted publication date: 20140820

Termination date: 20180616