CN102458441A - 用于治疗神经疾病的模型系统和治疗方案 - Google Patents

用于治疗神经疾病的模型系统和治疗方案 Download PDF

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Publication number
CN102458441A
CN102458441A CN2010800352462A CN201080035246A CN102458441A CN 102458441 A CN102458441 A CN 102458441A CN 2010800352462 A CN2010800352462 A CN 2010800352462A CN 201080035246 A CN201080035246 A CN 201080035246A CN 102458441 A CN102458441 A CN 102458441A
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medicament
peptide
blood vessel
experimenter
dosage
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Chinese (zh)
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M·蒂米安斯基
J·D·加曼
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NoNO Inc
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NoNO Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
CN2010800352462A 2009-06-10 2010-06-10 用于治疗神经疾病的模型系统和治疗方案 Pending CN102458441A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18598909P 2009-06-10 2009-06-10
US61/185,989 2009-06-10
PCT/US2010/038200 WO2010144721A2 (en) 2009-06-10 2010-06-10 Model systems and treatment regimes for treatment of neurological disease

Publications (1)

Publication Number Publication Date
CN102458441A true CN102458441A (zh) 2012-05-16

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CN2010800352462A Pending CN102458441A (zh) 2009-06-10 2010-06-10 用于治疗神经疾病的模型系统和治疗方案

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Country Link
US (2) US8940699B2 (enExample)
EP (2) EP2440230B1 (enExample)
JP (2) JP6005514B2 (enExample)
CN (1) CN102458441A (enExample)
AU (1) AU2010258664B2 (enExample)
BR (1) BRPI1010718A2 (enExample)
CA (1) CA2765169C (enExample)
DK (1) DK2440230T3 (enExample)
ES (1) ES2847293T3 (enExample)
HR (1) HRP20210112T1 (enExample)
HU (1) HUE053131T2 (enExample)
PL (1) PL2440230T3 (enExample)
PT (1) PT2440230T (enExample)
WO (1) WO2010144721A2 (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106661126A (zh) * 2014-05-28 2017-05-10 诺诺公司 TAT‑NR2B9c的氯盐
WO2018103038A1 (zh) * 2016-12-08 2018-06-14 拜西欧斯(北京)生物技术有限公司 一种缀合物及其应用
CN109106941A (zh) * 2012-11-28 2019-01-01 诺诺公司 Tat-nr2b9c的冻干制剂
WO2019006692A1 (zh) * 2017-07-05 2019-01-10 拜西欧斯(北京)生物技术有限公司 用于治疗、改善或预防神经系统相关病症的化合物及其用途
CN113735938A (zh) * 2021-07-30 2021-12-03 英纳氏(珠海)药业有限公司 一种神经保护多肽化合物及其应用
CN114469084A (zh) * 2022-04-02 2022-05-13 剑博微电子(深圳)有限公司 一种基于高精度adc的血氧监测系统
CN114642402A (zh) * 2022-03-07 2022-06-21 翰博瑞强(上海)医药科技有限公司 一种用于预测药物对心脏毒性影响的方法及心电图设备

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US7510824B2 (en) * 1999-06-02 2009-03-31 Nono Inc. Method of screening peptides useful in treating traumatic injury to the brain or spinal cord
BRPI1010718A2 (pt) 2009-06-10 2016-03-15 Nono Inc sistemas modelo e regimes de tratamento para tratar doença neurológica.
EP2616094B1 (en) 2010-08-12 2017-11-08 NoNO Inc. Treatment of penetrative injury to the brain
KR102022116B1 (ko) 2011-06-24 2019-09-18 노노 인코포레이티드 허혈에 대한 psd-95 억제제와의 조합 요법
KR102114490B1 (ko) * 2011-12-13 2020-05-25 노노 인코포레이티드 지주막하 출혈 및 허혈에 대한 치료법
US9241970B2 (en) 2011-12-13 2016-01-26 Nono Inc. Therapy for subarachnoid hemorrhage and ischemia
AU2013204309A1 (en) * 2012-11-13 2014-05-29 Biodiem Limited Therapeutic Compounds and Uses Thereof
US10251935B2 (en) 2012-11-28 2019-04-09 Nono Inc. Lyophilized formulation comprising tat-NR2B9C, histidine and trehalose
KR20180135493A (ko) * 2016-04-27 2018-12-20 바이오셀즈(베이징) 바이오테크 코., 엘티디. 흥분성 신경독성 관련 손상의 치료 방법
ES2869300T3 (es) * 2016-04-27 2021-10-25 Biocells Beijing Biotech Co Ltd Péptido terapéutico para las lesiones relacionadas con la neurotoxicidad excitadora
EA039314B1 (ru) * 2017-07-05 2022-01-12 Биоселз (Бейдзин) Биотек Ко., Лтд. Фармацевтически приемлемые соли полипептидов и их применение
WO2019061395A1 (zh) 2017-09-30 2019-04-04 拜西欧斯(北京)生物技术有限公司 兴奋性神经毒性相关损伤的治疗肽组合物
CN113150065B (zh) 2021-03-11 2022-07-08 武汉英纳氏药业有限公司 一种合成肽及其应用
CN113121641B (zh) 2021-03-11 2022-11-01 武汉英纳氏药业有限公司 一类多功能多肽及其在医药领域的应用

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US20060148711A1 (en) 1999-05-14 2006-07-06 Arbor Vita Corporation Molecular interactions in neurons
US7510824B2 (en) * 1999-06-02 2009-03-31 Nono Inc. Method of screening peptides useful in treating traumatic injury to the brain or spinal cord
GB0025473D0 (en) 2000-10-17 2000-11-29 Pfizer Ltd Pharmaceutical combinations
WO2004045535A2 (en) * 2002-11-14 2004-06-03 Arbor Vita Corporation Molecular interactions in neurons
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PL1622639T3 (pl) 2003-05-02 2013-06-28 Lundbeck H As Dożylne wstrzyknięcie nieneurotoksycznych aktywatorów plazminogenu do leczenia udaru mózgu
ES2804424T3 (es) * 2006-07-11 2021-02-08 Nono Inc Péptido y composición del mismo para usar en el tratamiento del accidente cerebrovascular con fiebre
EP1884521A1 (en) * 2006-07-31 2008-02-06 Xigen S.A. Fusion peptide for inhibiting interaction of neuronal NMDA receptor (NMDAR) and NMDAR interacting proteins
EP2120987B1 (en) * 2007-03-02 2014-01-15 NoNO Inc. Treating stroke and other diseases without inhibiting n-type calcium channels
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US8080518B2 (en) 2007-12-05 2011-12-20 Arbor Vita Corporation Co-administration of an agent linked to an internalization peptide with an anti-inflammatory
PL2320927T3 (pl) 2008-07-09 2016-02-29 Univ Copenhagen Modyfikowane peptydy jako potencjalne inhibitory w reakcjach receptorów PSD 95 i NMD
BRPI1010718A2 (pt) 2009-06-10 2016-03-15 Nono Inc sistemas modelo e regimes de tratamento para tratar doença neurológica.
KR102022116B1 (ko) 2011-06-24 2019-09-18 노노 인코포레이티드 허혈에 대한 psd-95 억제제와의 조합 요법
KR102114490B1 (ko) 2011-12-13 2020-05-25 노노 인코포레이티드 지주막하 출혈 및 허혈에 대한 치료법
US9241970B2 (en) 2011-12-13 2016-01-26 Nono Inc. Therapy for subarachnoid hemorrhage and ischemia

Non-Patent Citations (3)

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CUI ,H.等: "PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors", 《J.NEUROSCI》 *
HONG-SHUO SUN等: "Effectiveness of PSD95 Inhibitors in Permanent and Transient Focal Ischemia in the Rat", 《STROKE》 *
MARTEL,M.A.等: "Inhibiting pro-death NMDA receptor signaling dependent on the NR2 PDZ ligand may not affect synaptic function or synaptic NMDA receptor signaling to gene expression", 《CHANNELS (AUSTIN)》 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109106941A (zh) * 2012-11-28 2019-01-01 诺诺公司 Tat-nr2b9c的冻干制剂
CN106661126A (zh) * 2014-05-28 2017-05-10 诺诺公司 TAT‑NR2B9c的氯盐
CN106661126B (zh) * 2014-05-28 2021-12-10 诺诺公司 TAT-NR2B9c的氯盐
WO2018103038A1 (zh) * 2016-12-08 2018-06-14 拜西欧斯(北京)生物技术有限公司 一种缀合物及其应用
WO2019006692A1 (zh) * 2017-07-05 2019-01-10 拜西欧斯(北京)生物技术有限公司 用于治疗、改善或预防神经系统相关病症的化合物及其用途
CN113735938A (zh) * 2021-07-30 2021-12-03 英纳氏(珠海)药业有限公司 一种神经保护多肽化合物及其应用
CN113735938B (zh) * 2021-07-30 2024-11-08 英纳氏(珠海)药业有限公司 一种神经保护多肽化合物及其应用
CN114642402A (zh) * 2022-03-07 2022-06-21 翰博瑞强(上海)医药科技有限公司 一种用于预测药物对心脏毒性影响的方法及心电图设备
CN114469084A (zh) * 2022-04-02 2022-05-13 剑博微电子(深圳)有限公司 一种基于高精度adc的血氧监测系统

Also Published As

Publication number Publication date
US8940699B2 (en) 2015-01-27
AU2010258664A1 (en) 2012-01-12
CA2765169A1 (en) 2010-12-16
EP2440230B1 (en) 2020-11-11
AU2010258664B2 (en) 2015-05-28
US20120269733A1 (en) 2012-10-25
WO2010144721A3 (en) 2011-04-21
JP2012530057A (ja) 2012-11-29
JP6220371B2 (ja) 2017-10-25
ES2847293T3 (es) 2021-08-02
BRPI1010718A2 (pt) 2016-03-15
JP6005514B2 (ja) 2016-10-12
DK2440230T3 (da) 2021-01-18
PT2440230T (pt) 2021-02-03
EP2440230A2 (en) 2012-04-18
HRP20210112T1 (hr) 2021-04-16
CA2765169C (en) 2019-06-18
US20150202253A1 (en) 2015-07-23
US9610323B2 (en) 2017-04-04
JP2016041731A (ja) 2016-03-31
WO2010144721A2 (en) 2010-12-16
EP3808366A1 (en) 2021-04-21
PL2440230T3 (pl) 2021-06-14
EP2440230A4 (en) 2014-05-28
HUE053131T2 (hu) 2021-06-28

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