AU2010258664B2 - Model systems and treatment regimes for treatment of neurological disease - Google Patents

Model systems and treatment regimes for treatment of neurological disease Download PDF

Info

Publication number
AU2010258664B2
AU2010258664B2 AU2010258664A AU2010258664A AU2010258664B2 AU 2010258664 B2 AU2010258664 B2 AU 2010258664B2 AU 2010258664 A AU2010258664 A AU 2010258664A AU 2010258664 A AU2010258664 A AU 2010258664A AU 2010258664 B2 AU2010258664 B2 AU 2010258664B2
Authority
AU
Australia
Prior art keywords
agent
seq
peptide
aneurysm
endovascular surgery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010258664A
Other languages
English (en)
Other versions
AU2010258664A1 (en
Inventor
Jonathan David Garman
Michael Tymianski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NoNO Inc
Original Assignee
NoNO Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NoNO Inc filed Critical NoNO Inc
Publication of AU2010258664A1 publication Critical patent/AU2010258664A1/en
Assigned to NONO INC. reassignment NONO INC. Amend patent request/document other than specification (104) Assignors: NONO, INC.
Application granted granted Critical
Publication of AU2010258664B2 publication Critical patent/AU2010258664B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
AU2010258664A 2009-06-10 2010-06-10 Model systems and treatment regimes for treatment of neurological disease Ceased AU2010258664B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18598909P 2009-06-10 2009-06-10
US61/185,989 2009-06-10
PCT/US2010/038200 WO2010144721A2 (en) 2009-06-10 2010-06-10 Model systems and treatment regimes for treatment of neurological disease

Publications (2)

Publication Number Publication Date
AU2010258664A1 AU2010258664A1 (en) 2012-01-12
AU2010258664B2 true AU2010258664B2 (en) 2015-05-28

Family

ID=43309469

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010258664A Ceased AU2010258664B2 (en) 2009-06-10 2010-06-10 Model systems and treatment regimes for treatment of neurological disease

Country Status (14)

Country Link
US (2) US8940699B2 (enExample)
EP (2) EP2440230B1 (enExample)
JP (2) JP6005514B2 (enExample)
CN (1) CN102458441A (enExample)
AU (1) AU2010258664B2 (enExample)
BR (1) BRPI1010718A2 (enExample)
CA (1) CA2765169C (enExample)
DK (1) DK2440230T3 (enExample)
ES (1) ES2847293T3 (enExample)
HR (1) HRP20210112T1 (enExample)
HU (1) HUE053131T2 (enExample)
PL (1) PL2440230T3 (enExample)
PT (1) PT2440230T (enExample)
WO (1) WO2010144721A2 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7510824B2 (en) * 1999-06-02 2009-03-31 Nono Inc. Method of screening peptides useful in treating traumatic injury to the brain or spinal cord
BRPI1010718A2 (pt) 2009-06-10 2016-03-15 Nono Inc sistemas modelo e regimes de tratamento para tratar doença neurológica.
EP2616094B1 (en) 2010-08-12 2017-11-08 NoNO Inc. Treatment of penetrative injury to the brain
KR102022116B1 (ko) 2011-06-24 2019-09-18 노노 인코포레이티드 허혈에 대한 psd-95 억제제와의 조합 요법
KR102114490B1 (ko) * 2011-12-13 2020-05-25 노노 인코포레이티드 지주막하 출혈 및 허혈에 대한 치료법
US9241970B2 (en) 2011-12-13 2016-01-26 Nono Inc. Therapy for subarachnoid hemorrhage and ischemia
AU2013204309A1 (en) * 2012-11-13 2014-05-29 Biodiem Limited Therapeutic Compounds and Uses Thereof
US10251935B2 (en) 2012-11-28 2019-04-09 Nono Inc. Lyophilized formulation comprising tat-NR2B9C, histidine and trehalose
HUE043820T2 (hu) * 2012-11-28 2019-09-30 Nono Inc Liofilizált TAT-NR2B9c készítmény
KR102605540B1 (ko) * 2014-05-28 2023-11-22 노노 인코포레이티드 Tat-nr2b9c의 클로라이드 염
KR20180135493A (ko) * 2016-04-27 2018-12-20 바이오셀즈(베이징) 바이오테크 코., 엘티디. 흥분성 신경독성 관련 손상의 치료 방법
ES2869300T3 (es) * 2016-04-27 2021-10-25 Biocells Beijing Biotech Co Ltd Péptido terapéutico para las lesiones relacionadas con la neurotoxicidad excitadora
WO2018103038A1 (zh) * 2016-12-08 2018-06-14 拜西欧斯(北京)生物技术有限公司 一种缀合物及其应用
WO2019006692A1 (zh) * 2017-07-05 2019-01-10 拜西欧斯(北京)生物技术有限公司 用于治疗、改善或预防神经系统相关病症的化合物及其用途
EA039314B1 (ru) * 2017-07-05 2022-01-12 Биоселз (Бейдзин) Биотек Ко., Лтд. Фармацевтически приемлемые соли полипептидов и их применение
WO2019061395A1 (zh) 2017-09-30 2019-04-04 拜西欧斯(北京)生物技术有限公司 兴奋性神经毒性相关损伤的治疗肽组合物
CN113150065B (zh) 2021-03-11 2022-07-08 武汉英纳氏药业有限公司 一种合成肽及其应用
CN113121641B (zh) 2021-03-11 2022-11-01 武汉英纳氏药业有限公司 一类多功能多肽及其在医药领域的应用
CN113735938B (zh) 2021-07-30 2024-11-08 英纳氏(珠海)药业有限公司 一种神经保护多肽化合物及其应用
CN114642402A (zh) * 2022-03-07 2022-06-21 翰博瑞强(上海)医药科技有限公司 一种用于预测药物对心脏毒性影响的方法及心电图设备
CN114469084B (zh) * 2022-04-02 2022-06-24 剑博微电子(深圳)有限公司 一种基于高精度adc的血氧监测系统

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050059597A1 (en) * 1999-06-02 2005-03-17 Michael Tymianski Method of reducing injury to mammalian cells
WO2008008348A2 (en) * 2006-07-11 2008-01-17 Arbor Vita Corporation Method and compositions for treating stroke with fever
WO2008014917A1 (en) * 2006-07-31 2008-02-07 Xigen S.A. Fusion peptide for inhibiting interaction of neuronal nmda receptor (nmdar) and nmdar interacting proteins
WO2008109010A1 (en) * 2007-03-02 2008-09-12 Arbor Vita Corporation Treating stroke and other diseases without inhibiting n-type calcium channels

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060148711A1 (en) 1999-05-14 2006-07-06 Arbor Vita Corporation Molecular interactions in neurons
GB0025473D0 (en) 2000-10-17 2000-11-29 Pfizer Ltd Pharmaceutical combinations
WO2004045535A2 (en) * 2002-11-14 2004-06-03 Arbor Vita Corporation Molecular interactions in neurons
US20060276455A1 (en) 2003-02-13 2006-12-07 Lindsberg Perttu J Use of a mast cell activation or degranulation blocking agent in the manufacture of a medicament for the treatment of cerebral ischemia
PL1622639T3 (pl) 2003-05-02 2013-06-28 Lundbeck H As Dożylne wstrzyknięcie nieneurotoksycznych aktywatorów plazminogenu do leczenia udaru mózgu
WO2009006611A1 (en) 2007-07-03 2009-01-08 Arbor Vita Corporation Small molecule inhibitors of pdz interactions
US8080518B2 (en) 2007-12-05 2011-12-20 Arbor Vita Corporation Co-administration of an agent linked to an internalization peptide with an anti-inflammatory
PL2320927T3 (pl) 2008-07-09 2016-02-29 Univ Copenhagen Modyfikowane peptydy jako potencjalne inhibitory w reakcjach receptorów PSD 95 i NMD
BRPI1010718A2 (pt) 2009-06-10 2016-03-15 Nono Inc sistemas modelo e regimes de tratamento para tratar doença neurológica.
KR102022116B1 (ko) 2011-06-24 2019-09-18 노노 인코포레이티드 허혈에 대한 psd-95 억제제와의 조합 요법
KR102114490B1 (ko) 2011-12-13 2020-05-25 노노 인코포레이티드 지주막하 출혈 및 허혈에 대한 치료법
US9241970B2 (en) 2011-12-13 2016-01-26 Nono Inc. Therapy for subarachnoid hemorrhage and ischemia

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050059597A1 (en) * 1999-06-02 2005-03-17 Michael Tymianski Method of reducing injury to mammalian cells
WO2008008348A2 (en) * 2006-07-11 2008-01-17 Arbor Vita Corporation Method and compositions for treating stroke with fever
WO2008014917A1 (en) * 2006-07-31 2008-02-07 Xigen S.A. Fusion peptide for inhibiting interaction of neuronal nmda receptor (nmdar) and nmdar interacting proteins
WO2008109010A1 (en) * 2007-03-02 2008-09-12 Arbor Vita Corporation Treating stroke and other diseases without inhibiting n-type calcium channels

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AARTS M., et al, Science, 2002, vol 298, pages 846-850 *
SUN H-S., et al, Stroke, 2008, vol 39, pages 2544-2553 *

Also Published As

Publication number Publication date
US8940699B2 (en) 2015-01-27
AU2010258664A1 (en) 2012-01-12
CA2765169A1 (en) 2010-12-16
EP2440230B1 (en) 2020-11-11
US20120269733A1 (en) 2012-10-25
WO2010144721A3 (en) 2011-04-21
JP2012530057A (ja) 2012-11-29
JP6220371B2 (ja) 2017-10-25
ES2847293T3 (es) 2021-08-02
BRPI1010718A2 (pt) 2016-03-15
JP6005514B2 (ja) 2016-10-12
DK2440230T3 (da) 2021-01-18
PT2440230T (pt) 2021-02-03
EP2440230A2 (en) 2012-04-18
HRP20210112T1 (hr) 2021-04-16
CA2765169C (en) 2019-06-18
US20150202253A1 (en) 2015-07-23
US9610323B2 (en) 2017-04-04
CN102458441A (zh) 2012-05-16
JP2016041731A (ja) 2016-03-31
WO2010144721A2 (en) 2010-12-16
EP3808366A1 (en) 2021-04-21
PL2440230T3 (pl) 2021-06-14
EP2440230A4 (en) 2014-05-28
HUE053131T2 (hu) 2021-06-28

Similar Documents

Publication Publication Date Title
AU2010258664B2 (en) Model systems and treatment regimes for treatment of neurological disease
US11878044B2 (en) Combination therapy for ischemia
JP6427104B2 (ja) Tat−NR2B9cの凍結乾燥製剤
AU2015265487A1 (en) Chloride salt of TAT-NR2B9c
AU2012354072A1 (en) Therapy for subarachnoid hemorrhage and ischemia
AU2022206444A1 (en) Plasmin-resistant peptides for improved therapeutic index
US20230055441A1 (en) Plasmin-resistant peptides for treating stroke and related conditions
HK40050639A (en) Treatment regimes for treatment of neurological disease
US20230285504A1 (en) Inhibition of reperfusion injury with a psd-95 inhibitor
HK40003366A (en) Combination therapy for ischemia
HK1215793B (en) Lyophilized formulation of tat-nr2b9c

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired