CN102438659A - 光学成像剂 - Google Patents

光学成像剂 Download PDF

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Publication number
CN102438659A
CN102438659A CN2010800225217A CN201080022521A CN102438659A CN 102438659 A CN102438659 A CN 102438659A CN 2010800225217 A CN2010800225217 A CN 2010800225217A CN 201080022521 A CN201080022521 A CN 201080022521A CN 102438659 A CN102438659 A CN 102438659A
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CN
China
Prior art keywords
tissue
tumor
polymer
opt
conjugate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800225217A
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English (en)
Chinese (zh)
Inventor
R·L·卡特
J·W·卡斯尔
K·M·费希
A·苏德
N·A·斯塔普尔斯
B·D·李
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General Electric Co
Original Assignee
General Electric Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by General Electric Co filed Critical General Electric Co
Publication of CN102438659A publication Critical patent/CN102438659A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
CN2010800225217A 2009-03-19 2010-03-19 光学成像剂 Pending CN102438659A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16153509P 2009-03-19 2009-03-19
US61/161535 2009-03-19
PCT/EP2010/053619 WO2010106169A1 (en) 2009-03-19 2010-03-19 Optical imaging agents

Publications (1)

Publication Number Publication Date
CN102438659A true CN102438659A (zh) 2012-05-02

Family

ID=42331047

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800225217A Pending CN102438659A (zh) 2009-03-19 2010-03-19 光学成像剂

Country Status (11)

Country Link
US (1) US20120114563A1 (cg-RX-API-DMAC10.html)
EP (1) EP2413976A1 (cg-RX-API-DMAC10.html)
JP (1) JP2012520856A (cg-RX-API-DMAC10.html)
KR (1) KR20110138246A (cg-RX-API-DMAC10.html)
CN (1) CN102438659A (cg-RX-API-DMAC10.html)
AU (1) AU2010224789A1 (cg-RX-API-DMAC10.html)
BR (1) BRPI1009346A2 (cg-RX-API-DMAC10.html)
CA (1) CA2755770A1 (cg-RX-API-DMAC10.html)
MX (1) MX2011009808A (cg-RX-API-DMAC10.html)
RU (1) RU2011138096A (cg-RX-API-DMAC10.html)
WO (1) WO2010106169A1 (cg-RX-API-DMAC10.html)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104470546A (zh) * 2012-07-20 2015-03-25 佳能株式会社 化合物和含有所述化合物的光声成像造影剂
CN105102484A (zh) * 2013-01-30 2015-11-25 艾维拉斯生物科学公司 选择性递送分子及使用方法
CN105688230A (zh) * 2016-02-02 2016-06-22 史春梦 七甲川吲哚花菁染料-聚乙二醇-叶酸复合物及制备方法和应用
CN106243013A (zh) * 2015-06-12 2016-12-21 佳能株式会社 化合物或其盐以及含有该化合物或其盐的光声成像造影剂
US20180057536A1 (en) 2011-07-29 2018-03-01 Avelas Biosciences, Inc. Selective delivery molecules and methods of use
CN109054013A (zh) * 2018-08-22 2018-12-21 东北大学 一种经修饰的吲哚菁绿及其制备方法
CN109738387A (zh) * 2018-12-29 2019-05-10 佛山科学技术学院 一种基于吲哚箐绿的光学相干层析成像方法和装置

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GB201015806D0 (en) 2010-09-21 2010-10-27 Ge Healthcare As Vascular imaging agents
US10053447B2 (en) 2010-12-21 2018-08-21 Pierce Biotechnology, Inc Fluorescent compounds
US8889884B1 (en) 2011-07-14 2014-11-18 Pierce Biotechnology, Inc. Phosphine derivatives of fluorescent compounds
US9249307B2 (en) 2011-08-16 2016-02-02 Pierce Biotechnology, Inc. Benzocyanine compounds
GB201116733D0 (en) 2011-09-28 2011-11-09 Ge Healthcare As Peptide margin imaging agents
US9751868B2 (en) 2012-02-28 2017-09-05 Pierce Biotechnology, Inc. Benzocyanine compounds
CN104395306B (zh) 2012-03-02 2019-04-23 皮尔斯生物科技有限公司 作为生物分子的标记染料的吲哚衍生物
JP6288970B2 (ja) * 2012-07-20 2018-03-07 キヤノン株式会社 化合物、および、前記化合物を有する光音響イメージング用造影剤
US9676787B2 (en) 2012-08-28 2017-06-13 Pierce Biotechnology, Inc. Benzopyrylium compounds
WO2014055253A1 (en) * 2012-10-04 2014-04-10 The General Hospital Corporation Methods of synthesizing and using peg-like fluorochromes
JP6325461B2 (ja) * 2013-01-28 2018-05-16 国立研究開発法人科学技術振興機構 組織透明化方法、組織透明化試薬及び組織観察方法
FR3001463B1 (fr) * 2013-01-31 2015-02-20 Commissariat Energie Atomique Particules luminescentes de carbone, procede de preparation et utilisation
EP3052136A4 (en) * 2013-10-02 2017-06-21 University of Massachusetts Surface functionalized, host-guest polymer nano-assemblies and methods thereof
US9416276B2 (en) 2013-11-07 2016-08-16 Canon Kabushiki Kaisha Method for producing contrast agent
US10245329B2 (en) 2014-09-08 2019-04-02 Canon Kabushiki Kaisha Composition having dye and conjugate of polyethyleneglycol and additive and contrast agent for photoacoustic imaging having the same
WO2016060277A1 (en) 2014-10-16 2016-04-21 Canon Kabushiki Kaisha Polymer, and contrast agent for photoacoustic imaging, including the polymer
JP6736278B2 (ja) 2014-10-24 2020-08-05 キヤノン株式会社 重合体、前記重合体を有する光音響イメージング用造影剤
JP6700750B2 (ja) 2014-12-09 2020-05-27 キヤノン株式会社 化合物、および、前記化合物を有する光学イメージング用造影剤
JP6793122B2 (ja) * 2014-12-19 2020-12-02 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． 術中イメージング
US10383957B2 (en) 2015-01-06 2019-08-20 Anthony H. de Haas Near-infrared fluorescent surgical dye markers
JP6789636B2 (ja) 2015-09-30 2020-11-25 キヤノン株式会社 重合体、前記重合体を有する光音響イメージング用造影剤
WO2017057653A1 (en) 2015-09-30 2017-04-06 Canon Kabushiki Kaisha Conjugate of polysarcosine and nir contrast agent for photoacoustic imaging
WO2025197935A1 (ja) * 2024-03-19 2025-09-25 国立大学法人 東京大学 薬物－ポリマー複合体、医薬組成物、および薬物送達用ポリマー

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GB2337523A (en) * 1998-04-29 1999-11-24 Nycomed Imaging As Light imaging contrast agents

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US5622685A (en) 1990-05-30 1997-04-22 Deutches Krebsforchunszentrum Stiftung Des Offentlichen Rechts Polyether-substituted porphyrin anti-tumor agents
DE4445065A1 (de) 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
DE69820867T2 (de) 1997-04-29 2004-11-18 Amersham Health As Lichtbilderzeugungskontrastmitteln
US20100143258A1 (en) * 2008-12-05 2010-06-10 General Electric Company Tumor margin imaging agents

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GB2337523A (en) * 1998-04-29 1999-11-24 Nycomed Imaging As Light imaging contrast agents

Non-Patent Citations (2)

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Title
BJÖRN RIEFKE, ET AL.: "Tumor Detection with Cyanine Dye-Poly(ethylene Glycol) Conjugates as Contrast Agents for Near-Infrared Imaging", 《SPIE》 *
KAI LICHA, ET AL.: "Synthesis and Characterization of Cyanine Dye-Poly(ethylene Glycol) Conjugates as Contrast Agents for In Vivo Fluorescence Imaging", 《SPIE》 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10239919B2 (en) 2011-07-29 2019-03-26 Avelas Biosciences, Inc. Selective delivery molecules and methods of use
US20180057536A1 (en) 2011-07-29 2018-03-01 Avelas Biosciences, Inc. Selective delivery molecules and methods of use
US10570178B2 (en) 2011-07-29 2020-02-25 Avelas Biosciences, Inc. Selective delivery molecules and methods of use
CN104470546A (zh) * 2012-07-20 2015-03-25 佳能株式会社 化合物和含有所述化合物的光声成像造影剂
US9592307B2 (en) 2012-07-20 2017-03-14 Canon Kabushiki Kaisha Compound and photoacoustic imaging contrast medium containing the compound
CN105102484A (zh) * 2013-01-30 2015-11-25 艾维拉斯生物科学公司 选择性递送分子及使用方法
US11052160B2 (en) 2013-01-30 2021-07-06 Avelas Biosciences, Inc. Selective delivery molecules and methods of use
CN105102484B (zh) * 2013-01-30 2020-03-10 艾维拉斯生物科学公司 选择性递送分子及使用方法
US10226539B2 (en) 2013-01-30 2019-03-12 Avelas Biosciences, Inc. Selective delivery molecules and methods of use
CN106243013A (zh) * 2015-06-12 2016-12-21 佳能株式会社 化合物或其盐以及含有该化合物或其盐的光声成像造影剂
CN105688230B (zh) * 2016-02-02 2018-12-11 史春梦 七甲川吲哚花菁染料-聚乙二醇-叶酸复合物及制备方法和应用
CN105688230A (zh) * 2016-02-02 2016-06-22 史春梦 七甲川吲哚花菁染料-聚乙二醇-叶酸复合物及制备方法和应用
CN109054013A (zh) * 2018-08-22 2018-12-21 东北大学 一种经修饰的吲哚菁绿及其制备方法
CN109738387A (zh) * 2018-12-29 2019-05-10 佛山科学技术学院 一种基于吲哚箐绿的光学相干层析成像方法和装置

Also Published As

Publication number Publication date
US20120114563A1 (en) 2012-05-10
RU2011138096A (ru) 2013-04-27
KR20110138246A (ko) 2011-12-26
MX2011009808A (es) 2011-09-30
AU2010224789A1 (en) 2011-10-06
CA2755770A1 (en) 2010-09-23
EP2413976A1 (en) 2012-02-08
WO2010106169A1 (en) 2010-09-23
BRPI1009346A2 (pt) 2017-05-30
JP2012520856A (ja) 2012-09-10

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Application publication date: 20120502