CN102432604A - 一种苯并咪唑基取代苯基噻唑啉酮类衍生物及其合成方法 - Google Patents
一种苯并咪唑基取代苯基噻唑啉酮类衍生物及其合成方法 Download PDFInfo
- Publication number
- CN102432604A CN102432604A CN2011103574254A CN201110357425A CN102432604A CN 102432604 A CN102432604 A CN 102432604A CN 2011103574254 A CN2011103574254 A CN 2011103574254A CN 201110357425 A CN201110357425 A CN 201110357425A CN 102432604 A CN102432604 A CN 102432604A
- Authority
- CN
- China
- Prior art keywords
- benzimidazolyl
- phenyl
- thiazolinone
- substituted
- nitro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- NDZFORWVONADMI-UHFFFAOYSA-N 4-phenyl-5h-1,3-thiazol-2-one Chemical class O=C1SCC(C=2C=CC=CC=2)=N1 NDZFORWVONADMI-UHFFFAOYSA-N 0.000 title abstract 3
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 title abstract 3
- 238000001308 synthesis method Methods 0.000 title abstract 3
- -1 N-benzimidazolyl Chemical group 0.000 claims abstract description 22
- 238000000034 method Methods 0.000 claims abstract description 12
- 238000006243 chemical reaction Methods 0.000 claims abstract description 11
- 239000003960 organic solvent Substances 0.000 claims abstract description 9
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 claims abstract description 8
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 5
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 5
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 5
- 150000002367 halogens Chemical class 0.000 claims abstract description 5
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 5
- 239000001257 hydrogen Substances 0.000 claims abstract description 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 5
- 238000005406 washing Methods 0.000 claims abstract description 5
- 238000010438 heat treatment Methods 0.000 claims abstract description 3
- 230000005855 radiation Effects 0.000 claims abstract description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Natural products CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 25
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 21
- 238000001953 recrystallisation Methods 0.000 claims description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- 229910052801 chlorine Inorganic materials 0.000 claims description 4
- 239000000460 chlorine Substances 0.000 claims description 4
- 229910052731 fluorine Inorganic materials 0.000 claims description 4
- 239000011737 fluorine Substances 0.000 claims description 4
- 238000004090 dissolution Methods 0.000 claims description 2
- 125000003944 tolyl group Chemical group 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 abstract description 11
- 230000035484 reaction time Effects 0.000 abstract description 2
- 238000001816 cooling Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 9
- 235000019441 ethanol Nutrition 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 5
- 241000295146 Gallionellaceae Species 0.000 description 5
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 230000000855 fungicidal effect Effects 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 230000001954 sterilising effect Effects 0.000 description 5
- 229910021653 sulphate ion Inorganic materials 0.000 description 5
- 230000002194 synthesizing effect Effects 0.000 description 5
- 230000004071 biological effect Effects 0.000 description 4
- 150000002391 heterocyclic compounds Chemical class 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002141 anti-parasite Effects 0.000 description 1
- 239000003096 antiparasitic agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000001207 fluorophenyl group Chemical group 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 239000005648 plant growth regulator Substances 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Landscapes
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011103574254A CN102432604A (zh) | 2011-11-11 | 2011-11-11 | 一种苯并咪唑基取代苯基噻唑啉酮类衍生物及其合成方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011103574254A CN102432604A (zh) | 2011-11-11 | 2011-11-11 | 一种苯并咪唑基取代苯基噻唑啉酮类衍生物及其合成方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN102432604A true CN102432604A (zh) | 2012-05-02 |
Family
ID=45980992
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2011103574254A Pending CN102432604A (zh) | 2011-11-11 | 2011-11-11 | 一种苯并咪唑基取代苯基噻唑啉酮类衍生物及其合成方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102432604A (zh) |
-
2011
- 2011-11-11 CN CN2011103574254A patent/CN102432604A/zh active Pending
Non-Patent Citations (4)
Title |
---|
《Indian Journal of Chemistry》 20060731 Ketan Mistry, et al. "Microwave assisted rapid and efficient synthesis of nitrogen and sulphur containing heterocyclic compounds and their pharmacological evaluation" 1762-1766 3-6 第45B卷, * |
《Pharmazie》 19831231 A.E.Abdel-Rahman, et al. "Synthesis and Biological Activity of Some New Benzimidazolyl-azetidin-2-ones and thiazolidin-4-ones" 589-590 1-2 第38卷, * |
A.E.ABDEL-RAHMAN, ET AL.: ""Synthesis and Biological Activity of Some New Benzimidazolyl-azetidin-2-ones and thiazolidin-4-ones"", 《PHARMAZIE》 * |
KETAN MISTRY, ET AL.: ""Microwave assisted rapid and efficient synthesis of nitrogen and sulphur containing heterocyclic compounds and their pharmacological evaluation"", 《INDIAN JOURNAL OF CHEMISTRY》 * |
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SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent of invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Wan Rong Inventor after: Xu Yanhua Inventor after: Hu Jun Inventor after: Yu Peng Inventor after: Zhou Taoyu Inventor before: Xu Yanhua Inventor before: Hu Jun Inventor before: Yu Peng Inventor before: Zhou Taoyu |
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COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: XU YANHUA HU JUN YU PENG ZHOU TAOYU TO: WAN RONG XU YANHUA HU JUN YU PENG ZHOU TAOYU |
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C12 | Rejection of a patent application after its publication | ||
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Application publication date: 20120502 |