CN102428934A - Novel germicide composition containing probenazole - Google Patents
Novel germicide composition containing probenazole Download PDFInfo
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- CN102428934A CN102428934A CN2011104554525A CN201110455452A CN102428934A CN 102428934 A CN102428934 A CN 102428934A CN 2011104554525 A CN2011104554525 A CN 2011104554525A CN 201110455452 A CN201110455452 A CN 201110455452A CN 102428934 A CN102428934 A CN 102428934A
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- probenazole
- thifluzamide
- isoprothiolane
- kasugarnycin
- jinggangmeisu
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Abstract
The invention discloses a novel germicide composition containing probenazole. The composition is mainly characterized by containing an active ingredient A, an active ingredient B and the balance of auxiliaries, wherein the active ingredient A is probenazole; the active ingredient B is any one of kasugamycin, validamycin, thifluzamide and isoprothiolane; and the weight ratio of the active ingredient A to the active ingredient B is (80:1)-(1:80). The composition can be prepared into wettable powder, water dispersible granules, emulsifiable solution, suspensions, suspoemulsion, emulsion in water, microemulsion, microcapsule suspensions and microcapsule-microcapsule suspensions. The composition can be used for controlling various diseases, has obvious synergistic effect, expands the germicidal spectrum, has higher activity against the diseases of rice, cruciferous vegetables, fruit trees and cotton, has slow release effect, reduces the pesticide application quantity, is harmless to people and livestock, has no phytotoxicity and has good environmental compatibility. The preparations have the advantages of enhanced adhesive forces, rain wash resistance, long duration of efficacy and the like.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of disinfecting composition that contains probenazole.
Background technology
Probenazole (probenazole), chemical name: 3-allyloxy-1,2-benzisothiazole-1,1-dioxide, chemical molecular formula: C
10H
9NO
3S.Can extensively protect and eradicate field crop, fruit tree, grassland, vegetables germ.Antimicrobial acivity is arranged in the isolated test slightly; Handle paddy rice, promote root system to absorb, cover crop does not receive infecting of Pyricularia oryzae and rice bacterial leaf spot pathogenic bacteria.
Bactericide such as kasugarnycin, jinggangmeisu, thifluzamide, Isoprothiolane have excellent preventive effect and therapeutic action to rice blast, banded sclerotial blight, false smut.
Yet in the real process of agricultural production, preventing and treating the problem that disease is easy to generate most is the generation of disease drug resistance.The different cultivars composition carries out composite, is to prevent and treat the very common method of resistance disease.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of agricultural chemicals all is an additive effect, and the seldom composite of synergistic effect really arranged, especially synergistic effect very obviously, co-toxicity coefficient very high composite just still less.Test discovery in a large number through the inventor, after probenazole and kasugarnycin, jinggangmeisu, thifluzamide, Isoprothiolane were composite, synergistic effect was remarkable, and Environmental compatibility is fabulous, has greatly reduced the agricultural chemicals dosage.
Summary of the invention
The Pesticidal combination that the present invention proposes contains in probenazole and kasugarnycin, jinggangmeisu, thifluzamide, the Isoprothiolane any one two kinds of active components, and an amount of surfactant and carrier.
A kind of disinfecting composition that contains probenazole comprises active components A, active component B, the auxiliary agent surplus.It is characterized in that: active components A is a probenazole, and active component B is a kind of arbitrarily in kasugarnycin, jinggangmeisu, thifluzamide, the Isoprothiolane, and the weight ratio of active components A and active component B is 80: 1～1: 80.
The described disinfecting composition that contains probenazole is characterized in that: the weight ratio of active components A and active component B is 60: 1～1: 40.
The described disinfecting composition that contains probenazole is characterized in that: the weight ratio of active components A and kasugarnycin is 45: 1～5: 1.
The described disinfecting composition that contains probenazole is characterized in that: the weight ratio of active components A and jinggangmeisu is 36: 1～1: 1.
The described disinfecting composition that contains probenazole is characterized in that: the weight ratio of active components A and thifluzamide is 35: 1～1: 1.
The described disinfecting composition that contains probenazole is characterized in that: the weight ratio of active components A and Isoprothiolane is 18: 1～1: 3.
The described disinfecting composition that contains probenazole, it is characterized in that: composition is processed wetting powder, water dispersible granules, missible oil, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent, micro-capsule-microcapsule suspending agent.
The described disinfecting composition that contains probenazole is used to prevent and treat the application of disease on paddy rice, brassicaceous vegetable, fruit tree, the cotton.
Described application prevents and treats disease and comprises: rice blast, banded sclerotial blight, false smut, damping off, bacterial leaf-blight, powdery mildew, gray mold, downy mildew, leaf spot, anthracnose, fusarium wilt, rust, early blight, late blight, bacillary angle spot, shot hole, shothole disease, culm rot.
At least contain a kind of surfactant in the Pesticidal combination of the present invention, the dispersion of active component in water when being beneficial to use.Surface-active contents is 5%～30% of a total formulation weight amount, and surplus is solid or liquid diluent.The surfactant that Pesticidal combination of the present invention is selected for use is known in those skilled in the art: can be selected from dispersant, wetting agent, emulsifier or the antifoaming agent one or more.
The said disinfecting composition that contains probenazole is characterized in that: comprise following constituent content when processing wetting powder: active components A 0.1%～80%, active component B0.1%～80%, dispersant 5%～10%, wetting agent 2%～10%, filler 8%～92.8%.
Active components A, active component B, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, promptly can be made into probenazole kasugarnycin wetting powder product.
The said disinfecting composition that contains probenazole is characterized in that: comprise following constituent content when composition is processed water dispersible granules: active components A 0.1%～80%, active component B 0.1%～80%, dispersant 3%～12%, wetting agent 1%～8%, disintegrant 1%～10%, filler 10%～94.8%.
Active components A, active component B, dispersant, wetting agent, disintegrant, filler etc. are obtained the particle diameter that needs through comminution by gas stream together, obtain the materials of granulating.It is interior through after granulation and the drying to expect that article are quantitatively sent the fluidized bed granulation dryer to, makes probenazole kasugamycin water-dispersion granule product.
The said disinfecting composition that contains probenazole; It is characterized in that: comprise following constituent content when composition is processed suspending agent: active components A 0.1%～50%, active component B0.1%～50%, dispersant 2～10%, wetting agent 2～10%, antifoaming agent 0.1～1%, thickener 0.1～2%, antifreeze 0.1～8%, emulsifier 0.5%～5%, water adds to 100%.
Dispersant, wetting agent, antifoaming agent, thickener, antifreeze, emulsifier in the above-mentioned formulation material are mixed through high speed shear; Add probenazole, kasugarnycin ball milling 2～3 hours in ball mill; Make diameter of particle all below 5 μ m, make suspending agent product of the present invention.
The said disinfecting composition that contains probenazole; It is characterized in that: comprise following constituent content when composition is processed suspension emulsion: active components A 0.1%～50%, active component B0.1%～50%, emulsifier 2%～12%, dispersant 2%～10%, antifoaming agent 0.1%～2%, thickener 0.1%～2%, antifreeze 0.1%～8%, stabilizing agent 0.05%～3%, deionized water add to 100%.
Dispersant, antifoaming agent, thickener, antifreeze, stabilizing agent in the above-mentioned formulation material are mixed through high speed shear; Add the former medicine of probenazole; Ball milling is 2～3 hours in ball mill, makes diameter of particle all below 5 μ m, makes the probenazole suspending agent; Then with the former medicine of active component B, emulsifier and various auxiliary agent with the direct emulsification of high speed agitator in suspending agent, make suspension emulsion product of the present invention.
Comprise following constituent content when composition is processed aqueous emulsion: active components A 0.1%～50%, active component B 0.1%～50%, solvent 0%～30%, emulsifier 1%～15%, co-emulsifier 0%～8%, antifreeze 0%～10%, thickener 0.1%～2%, antifoaming agent 0.01%～2%, deionized water are supplied surplus.
Above-mentioned prescription is mixed, active ingredient, solvent, emulsifier, co-emulsifier are added together, make and be dissolved into even oil phase; Water, antifreeze, thickener, antifoaming agent are mixed, become the homogeneous water.Under high-speed stirred, water is added oil phase, make aqueous emulsion product of the present invention.
Comprise following constituent content when composition is processed microemulsion: active components A 0.1%～50%, active component B 0.1%～50%, solvent 0%～30%, emulsifier 3%～20%, co-emulsifier 0%～12%, antifreeze 0%～10%, thickener 0.1%～2%, antifoaming agent 0.01%～2%, stabilizing agent 0%～4%, deionized water is supplied surplus.
Probenazole and the former medicine of active component B are dissolved in the homogenizer that solvent and cosolvent are housed; Give intense mixing and homogenize after joining emulsifier, stabilizing agent and antifreeze, water in the homogenizer that above-mentioned solution is housed, obtain the as clear as crystal microemulsion product of the present invention of outward appearance at last.
The formulation technology that composition is processed missible oil, microcapsule suspending agent, micro-capsule-microcapsule suspending agent is technical matters conventionally known to one of skill in the art.
Described dispersant is selected from alkylnaphthalene sulfonate; Two (alkyl) naphthalenesulfonate formaldehyde condensation compound; Naphthalene sulfonic acid-formaldehyde condensation product; Aryl phenol polyoxyethylene succinate sulfonate; Octylphenol polyethylene oxyethylene group ether sulfate; Polycarboxylate; Lignosulfonates; The phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy; Alkyl benzene sulfonate calcium salt; The naphthalene sulfonic acid-formaldehyde condensation product sodium salt; Alkylphenol-polyethenoxy is phonetic; Aliphatic amine polyoxyethylene is phonetic; Polyoxyethylene carboxylate; During the ester polyoxyethylene is phonetic one or more.
Described wetting agent is selected from: lauryl sodium sulfate, neopelex, Nekal BX, washing powder, farming breast 2000
#Series, sldium lauryl sulfate, wetting and penetrating agent F, wetting agent T, spaonin powder, tea are withered, in the silkworm excrement, soapberry powder one or more.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, the glucose.
Described emulsifier is selected from: farming breast 500
#(alkyl benzene calcium sulfonate), OP series phosphate (NPE phosphate), 600
#Phosphate (phenyl phenol polyoxy ethyl ether phosphate), styrene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, farming breast 400
#(benzyl dimethyl phenol polyoxy ethyl ether), farming breast 600
#(phenyl phenol polyoxy ethyl ether), Nongru-700
#(alkylphenol-formaldehyde resin polyoxy ethyl ether), farming breast 36
#(phenethyl fluosite polyoxy ethyl ether), farming breast 1600
#(phenethyl phenol polyoxy ethyl polypropylene-base ether), ethylene oxide-propylene oxide block copolymer, OP series (NPE), By series (castor oil polyoxyethylene ether), farming breast 33
#(alkylaryl polyoxyethylene polyoxypropylene ether), farming breast 34
#In (alkylaryl polyoxyethylene poly-oxygen propylene aether), sapn series (sorbitan monostearate), tween series (sorbitan fatty acid ester APEO), the EO series (the pure APEO of fat) one or more.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, the polyethylene glycol.
Described antifoaming agent is selected from: silicone, C
8～10Aliphatic alcohols, C
10～20In saturated fat acids (like capric acid) and acid amides, silicone oil, the silicone compound one or more.
Described thickener is selected from: one or more in xanthans, CMC, hydroxyethylcellulose, methylcellulose, Magnesiumaluminumsilicate, the polyvinyl alcohol.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, precipitated calcium carbonate, the vegetable oil.
Described macromolecule cyst material: PIC, polyfunctional group acyl halide polyamines, polyfunctional group acyl halide dihydroxylic alcohols.
Wetting powder the key technical indexes of the present invention:
Water dispersible granules the key technical indexes of the present invention:
Suspending agent the key technical indexes of the present invention:
Suspension emulsion the key technical indexes of the present invention:
Aqueous emulsion the key technical indexes of the present invention:
Microemulsion the key technical indexes of the present invention:
Missible oil the key technical indexes of the present invention:
Microcapsule suspending agent the key technical indexes of the present invention:
Microcapsule suspension of the present invention-suspending agent the key technical indexes:
The invention has the advantages that:
(1) probenazole and kasugarnycin, jinggangmeisu, thifluzamide, Isoprothiolane composite after, have notable synergistic and lasting effect;
(2) enlarged fungicidal spectrum, the rice blast of paddy rice, brassicaceous vegetable, fruit tree, cotton, banded sclerotial blight, false smut, damping off, bacterial leaf-blight, bacillary angle spot, shot hole, shothole disease, culm rot etc. have all been had greater activity;
(3) reduce the dosage of agricultural chemicals, reduced the residual quantity of agricultural chemicals on crop, alleviated environmental pollution;
(4) to the person poultry safety, Environmental compatibility is good, and disease is difficult for developing immunity to drugs.
Embodiment
The present invention is explained further that the percentage among the embodiment is weight ratio below in conjunction with embodiment, but the present invention is not limited thereto.
Application implementation example one
Embodiment 1 62% probenazole kasugarnycin wetting powder
Probenazole 60%, kasugarnycin 2%, polyoxyethylene carboxylate 5.8%, wetting and penetrating agent F 6.5%, bentonite add to 100%, and mixture carries out comminution by gas stream, make 62% probenazole kasugarnycin wetting powder.
Embodiment 2 81% probenazole kasugarnycin wetting powders
Probenazole 80%, kasugarnycin 1%, aliphatic amine polyoxyethylene are phonetic 5.5%, expoxy propane condensation product 5%, white carbon 6.5%, and kaolin adds to 100%, and mixture carries out comminution by gas stream, makes 81% probenazole kasugarnycin wetting powder.
Embodiment 3 60% probenazole jinggangmeisu wetting powders
The phonetic formaldehyde condensation products sulphate of probenazole 55%, jinggangmeisu 5%, alkylphenol-polyethenoxy 5.5%, soapberry powder 5.5%, bentonite add to 100%, and mixture carries out comminution by gas stream, makes 60% probenazole jinggangmeisu wetting powder.
Embodiment 4 75% probenazole jinggangmeisu wetting powders
Probenazole 72%, jinggangmeisu 3%, aryl phenol polyoxyethylene succinate sulfonate 4.5%, neopelex 5.5%, spaonin powder 2.5%, kaolin add to 100%; Mixture carries out comminution by gas stream, makes 75% probenazole jinggangmeisu wetting powder.
Embodiment 5 66% probenazole thifluzamide wetting powders
Probenazole 64%, thifluzamide 2%, aliphatic amine polyoxyethylene are phonetic 5.5%, soapberry powder 5.5%, white carbon 6.5%, and kaolin adds to 100%, and mixture carries out comminution by gas stream, makes 66% probenazole thifluzamide wetting powder.
Embodiment 6 81% probenazole thifluzamide wetting powders
Probenazole 80%, thifluzamide 1%, ester polyoxyethylene are phonetic 6.5%, silkworm excrement 3.5%, bentonite add to 100%, and mixture carries out comminution by gas stream, makes 81% probenazole thifluzamide wetting powder.
Embodiment 7 72% probenazole Isoprothiolane wetting powders
Probenazole 70%, Isoprothiolane 2%, aliphatic amine polyoxyethylene are phonetic 5%, expoxy propane condensation product 5%, white carbon 6.5%, and kaolin adds to 100%, and mixture carries out comminution by gas stream, makes 72% probenazole Isoprothiolane wetting powder.
Embodiment 8 81% probenazole Isoprothiolane wetting powders
Probenazole 1%, Isoprothiolane 80%, polyoxyethylene carboxylate 5.5%, wetting and penetrating agent F 5.5%, bentonite add to 100%, and mixture carries out comminution by gas stream, make 81% probenazole Isoprothiolane wetting powder.
Embodiment 9 55% probenazole kasugamycin water-dispersion granules
Probenazole 50%, kasugarnycin 5%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 5.5%, expoxy propane condensation product 5.5%, kaolin add to 100%, the mixed 55% probenazole kasugamycin water-dispersion granule that gets.
Embodiment 10 82% probenazole kasugamycin water-dispersion granules
Probenazole 80%, kasugarnycin 2%, wetting agent T6.5%, naphthalene sulfonic acid-formaldehyde condensation product 4.5%, polyvinylpyrrolidone 3%, white carbon 5%, bentonite add to 100%, the mixed 82% probenazole kasugamycin water-dispersion granule that gets.
Embodiment 11 64% probenazole jinggangmeisu water dispersible granules
Probenazole 60%, jinggangmeisu 4%, polyoxyethylene carboxylate 5.5%, soapberry powder 5%, aluminium chloride 3.5%, kaolin add to 100%, the mixed 64% probenazole jinggangmeisu water dispersible granules that gets.
Embodiment 12 80% probenazole jinggangmeisu water dispersible granules
Probenazole 72%, jinggangmeisu 8%, polycarboxylate 5.5%, wetting and penetrating agent F 4.5%, sodium bicarbonate 2%, gum Arabic 2.5%, bentonite add to 100%, the mixed 80% probenazole jinggangmeisu water dispersible granules that gets.
Embodiment 13 68% probenazole thifluzamide water dispersible granules
Probenazole 64%, thifluzamide 4%, wetting agent T6%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 5%, polyvinylpyrrolidone 3%, white carbon 5%, bentonite add to 100%, the mixed 68% probenazole thifluzamide water dispersible granules that gets.
Embodiment 14 78% probenazole thifluzamide water dispersible granules
Probenazole 76%, thifluzamide 2%, octylphenol polyethylene oxyethylene group ether sulfate 5%, Nekal BX 4%, sodium bicarbonate 4%, white dextrin 2%, bentonite add to 100%, the mixed 78% probenazole thifluzamide water dispersible granules that gets.
Embodiment 15 60% probenazole 'Daowenling ' water dispersible granules
Probenazole 50%, Isoprothiolane 10%, wetting agent T 4.5%, naphthalene sulfonic acid-formaldehyde condensation product 6%, polyvinylpyrrolidone 4%, white carbon 5%, bentonite add to 100%, the mixed 60% probenazole 'Daowenling ' water dispersible granule that gets.
Embodiment 16 85% probenazole 'Daowenling ' water dispersible granules
Probenazole 80%, Isoprothiolane 5%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 6%, expoxy propane condensation product 4%, kaolin add to 100%, the mixed 85% probenazole 'Daowenling ' water dispersible granule that gets.
Embodiment 17 36% probenazole kasugarnycin suspending agents
Probenazole 32%, kasugarnycin 4%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 6%, amide-type antifoaming agent 4%, aluminium-magnesium silicate 3%, OP series 6%, deionized water add to 100%, the mixed 36% probenazole kasugarnycin suspending agent that gets.
Embodiment 18 48% probenazole kasugarnycin suspending agents
Probenazole 45%, kasugarnycin 3%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 6%, wetting agent T 5%, C
8～10Aliphatic alcohols 3%, polyvinyl alcohol 3%, deionized water add to 100%, the mixed 48% probenazole kasugarnycin suspending agent that gets.
Embodiment 19 35% probenazole jinggangmeisu suspending agents
Probenazole 30%, jinggangmeisu 5%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 6%, spaonin powder 2%, PAA 5%, silicone oil 2%, deionized water add to 100%, the mixed 35% probenazole jinggangmeisu suspending agent that gets.
Embodiment 20 44% probenazole jinggangmeisu suspending agents
The phonetic formaldehyde condensation products sulphate of probenazole 40%, jinggangmeisu 4%, polycarboxylate 5%, alkylphenol-polyethenoxy 4%, silicone antifoaming agent 2%, aluminium-magnesium silicate 2%, phenyl phenol polyoxy ethyl ether phosphate 5%, deionized water add to 100%, mixed 44% probenazole jinggangmeisu suspending agent.
Embodiment 21 36% probenazole thifluzamide suspending agents
Probenazole 33%, thifluzamide 3%, polyoxyethylene carboxylate 6.5%, silicone antifoaming agent 2%, aluminium-magnesium silicate 3%, OP series 6%, deionized water add to 100%, the mixed 36% probenazole thifluzamide suspending agent that gets.
Embodiment 22 42% probenazole thifluzamide suspending agents
Probenazole 40%, thifluzamide 2%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 7%, soapberry powder 3%, PAA 5%, silicone oil 2%, deionized water add to 100%, the mixed 42% probenazole thifluzamide suspending agent that gets.
Embodiment 23 30% probenazole Isoprothiolane suspending agents
Probenazole 20%, Isoprothiolane 10%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 6%, amide-type antifoaming agent 4%, aluminium-magnesium silicate 3%, OP series 6%, deionized water add to 100%, the mixed 30% probenazole Isoprothiolane suspending agent that gets.
Embodiment 24 50% probenazole Isoprothiolane suspending agents
Probenazole 25%, Isoprothiolane 25%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 6%, wetting agent T 5%, C
8～10Aliphatic alcohols 3%, polyvinyl alcohol 3%, deionized water add to 100%, the mixed 50% probenazole Isoprothiolane suspending agent that gets.
Embodiment 25 42% probenazole kasugarnycin suspension emulsions
Probenazole 40%, kasugarnycin 2%, lignosulfonates 6%, Nekal BX 6%, 600# phosphate 6%, PVPP 3%, glycerine 2%, deionized water add to 100%, the mixed 42% probenazole kasugarnycin suspension emulsion that gets.
Embodiment 26 40.5% probenazole kasugarnycin suspension emulsions
Probenazole 0.5%, kasugarnycin 40%, ester polyoxyethylene are phonetic 6%, spaonin powder 5%, sodium alginate 3%, Nongru-700 #6%, triethylene glycol 3%, silicone oil 2%, deionized water add to 100%, through mixed 40.5% probenazole kasugarnycin suspension emulsion.
Embodiment 27 39% probenazole jinggangmeisu suspension emulsions
Probenazole 36%, jinggangmeisu 3%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 6%, tea are withered 4%, polyvinylpyrrolidone 2%, agricultural newborn 36#6%, glycerine 3%, silicone 2%, deionized water add to 100%, through mixed 39% probenazole jinggangmeisu suspension emulsion.
Embodiment 28 40.5% probenazole jinggangmeisu suspension emulsions
Probenazole 40%, jinggangmeisu 0.5%, triethanolamine salt 6%, agricultural newborn 33#6%, silicone compound 3%, polyethylene glycol 2%, propane diols 2%, deionized water add to 100%, the mixed 40.5% probenazole jinggangmeisu suspension emulsion that gets.
Embodiment 29 32% probenazole thifluzamide suspension emulsions
Probenazole 30%, thifluzamide 2%, lignosulfonates 6%, Nekal BX 5%, agricultural newborn 1600#6%, carboxymethyl cellulose 3%, glycerine 2%, deionized water add to 100%, the mixed 32% probenazole thifluzamide suspension emulsion that gets.
Embodiment 30 40.5% probenazole thifluzamide suspension emulsions
Probenazole 0.5%, thifluzamide 40%, ester polyoxyethylene are phonetic 7%, spaonin powder 3%, polyvinylpyrrolidone 4%, agricultural newborn 1600#5%, glycerine 3%, C
8～10Aliphatic alcohols 2%, deionized water add to 100%, through the mixed 40.5% probenazole thifluzamide suspension emulsion that gets.
Embodiment 31 40% probenazole Isoprothiolane suspension emulsions
Probenazole 10%, Isoprothiolane 30%, ester polyoxyethylene are phonetic 6.5%, spaonin powder 4%, sodium alginate 2%, Nongru-700 #5.5%, triethylene glycol 2%, silicone oil 2%, deionized water add to 100%, through mixed 40% probenazole Isoprothiolane suspension emulsion.
Embodiment 32 44% probenazole Isoprothiolane suspension emulsions
Probenazole 40%, Isoprothiolane 4%, lignosulfonates 6%, Nekal BX 3%, 600# phosphate 5%, PVPP 3%, glycerine 2%, deionized water add to 100%, the mixed 44% probenazole Isoprothiolane suspension emulsion that gets.
Embodiment 33 65% probenazole kasugarnycin missible oil
Probenazole 62.5%, kasugarnycin 2.5%, ethanol 5%, OP series 6%, polyethylene glycol 5%, toluene add to 100%, through the mixed 65% probenazole kasugarnycin missible oil that gets.
Embodiment 34 63% probenazole jinggangmeisu missible oil
Probenazole 60%, jinggangmeisu 3%, triethanolamine salt 6%, agricultural newborn 33#6%, polyethylene glycol 6%, propane diols 5%, xylol add to 100%, the mixed 63% probenazole jinggangmeisu missible oil that gets.
Embodiment 35 65% probenazole thifluzamide missible oil
Probenazole 60%, thifluzamide 5%, styrene polyoxyethylene ether ammonium sulfate salt 6%, agricultural newborn 600#5%, diethylene glycol (DEG) 6%, propane diols 3%, acetone add to 100%, the mixed 65% probenazole thifluzamide missible oil that gets.
Embodiment 36 80% probenazole Isoprothiolane missible oil
Probenazole 60%, Isoprothiolane 20%, triethanolamine salt 6%, agricultural newborn 33#6%, polyethylene glycol 7%, propane diols 4%, xylol add to 100%, the mixed 80% probenazole Isoprothiolane missible oil that gets.
Embodiment 37 30% probenazole kasugarnycin microemulsions
The phonetic formaldehyde condensation products sulphate of probenazole 24%, kasugarnycin 6%, ethylene oxide-propylene oxide block copolymer 5%, alkylphenol-polyethenoxy 5%, propane diols 3%, butyl ether 3%; Deionized water supplies 100%, the mixed 30% probenazole kasugarnycin microemulsion that gets.
Embodiment 38 50% probenazole kasugarnycin microemulsions
Probenazole 48%, kasugarnycin 2%, sapn series 6%, methyl alcohol 5%, aliphatic alcohol polyoxyvinethene phosphate 6%, propane diols 2%, gelatin 2%, deionized water supplies 100%, the mixed 50% probenazole kasugarnycin microemulsion that gets.
Embodiment 39 24.3% probenazole jinggangmeisu microemulsions
Probenazole 0.3%, jinggangmeisu 24%, AEO series 6%, methyl alcohol 4%, aliphatic alcohol polyoxyvinethene phosphate 5%, propane diols 2%, gelatin 2%, deionized water supplies 100%, the mixed 24.3% probenazole jinggangmeisu microemulsion that gets.
Embodiment 40 32% probenazole jinggangmeisu microemulsions
Probenazole 28%, jinggangmeisu 4%, By series 6%, ethyl acetate 6%, polyethylene glycol 6%, C
10～20Saturated fat acids 2%, deionized water adds to 100%, through the mixed 32% probenazole jinggangmeisu microemulsion that gets.
Embodiment 41 27% probenazole thifluzamide microemulsions
The phonetic formaldehyde condensation products sulphate of probenazole 24%, thifluzamide 3%, By series 6%, alkylphenol-polyethenoxy 5%, propane diols 3%, butyl ether 2%, deionized water supplies 100%, mixed 27% probenazole thifluzamide microemulsion.
Embodiment 42 41% probenazole thifluzamide microemulsions
Probenazole 1%, thifluzamide 40%, ethylene oxide-propylene oxide block copolymer 6%, methyl alcohol 4%, aliphatic alcohol polyoxyvinethene phosphate 6%, propane diols 2%, gelatin 2%; Deionized water supplies 100%, the mixed 41% probenazole thifluzamide microemulsion that gets.
Embodiment 43 40.5% probenazole Isoprothiolane microemulsions
The phonetic formaldehyde condensation products sulphate of probenazole 40%, Isoprothiolane 0.5%, ethylene oxide-propylene oxide block copolymer 6%, alkylphenol-polyethenoxy 6%, propane diols 3%, butyl ether 2%; Deionized water supplies 100%, the mixed 40.5% probenazole Isoprothiolane microemulsion that gets.
Embodiment 44 50% probenazole Isoprothiolane microemulsions
Probenazole 40%, Isoprothiolane 10%, sapn series 7%, methyl alcohol 5%, aliphatic alcohol polyoxyvinethene phosphate 5%, propane diols 2%, gelatin 2%, deionized water supplies 100%, the mixed 50% probenazole Isoprothiolane microemulsion that gets.
Embodiment 45 20.5% probenazole kasugarnycin aqueous emulsions
Probenazole 0.5, kasugarnycin 20%, OP series phosphate 8%, butanols 5%, ethylene glycol 5%, silicone compound 2%, deionized water adds to 100%, makes 20.5% probenazole kasugarnycin aqueous emulsion.
Embodiment 46 34% probenazole kasugarnycin aqueous emulsions
Probenazole 32%, kasugarnycin 2%, aryl phenol polyoxyethylene succinate sulfonate 7%, agricultural newborn 1600#7%, glycerine 3%, gum Arabic 2%, silicone oil 2%, deionized water supplies 100%, makes 34% probenazole kasugarnycin aqueous emulsion.
Embodiment 47 24% probenazole jinggangmeisu aqueous emulsions
The phonetic formaldehyde condensation products sulphate of probenazole 20%, jinggangmeisu 4%, alkylphenol-polyethenoxy 7%, agricultural newborn 33#6%, gelatin 3%, glycerine 3%, sodium chloride 2%, C
10～20Saturated fat acids 2%, deionized water supplies 100%, makes 24% probenazole jinggangmeisu aqueous emulsion.
Embodiment 48 31% probenazole jinggangmeisu aqueous emulsions
Probenazole 1%, jinggangmeisu 30%, phenethyl phenol polyethenoxy ether 8%, alkylbenzenesulfonate 3%, agricultural newborn 36#6%, glycerine 3%, gum Arabic 3%, silicone oil 2%; Deionized water supplies 100%, makes 31% probenazole jinggangmeisu aqueous emulsion.
Embodiment 49 38% probenazole thifluzamide aqueous emulsions
Probenazole 36%, thifluzamide 2%, aryl phenol polyoxyethylene succinate sulfonate 6%, OP series 6%, glycerine 2%, gum Arabic 3%, silicone oil 2%, deionized water supplies 100%, makes 38% probenazole thifluzamide aqueous emulsion.
Embodiment 50 44% probenazole thifluzamide aqueous emulsions
The phonetic formaldehyde condensation products sulphate of probenazole 40%, thifluzamide 4%, alkylphenol-polyethenoxy 7%, OP series 7%, gelatin 3%, glycerine 3%, sodium chloride 2%, C
10～20Saturated fat acids 2%, deionized water supplies 100%, makes 44% probenazole thifluzamide aqueous emulsion.
Embodiment 51 36% probenazole Isoprothiolane aqueous emulsions
Probenazole 32%, Isoprothiolane 4%, aryl phenol polyoxyethylene succinate sulfonate 7%, agricultural newborn 1600#7%, glycerine 2%, gum Arabic 2%, silicone oil 2%, deionized water supplies 100%, makes 36% probenazole Isoprothiolane aqueous emulsion.
Embodiment 52 45% probenazole Isoprothiolane aqueous emulsions
Probenazole 30%, Isoprothiolane 15%, OP series phosphate 8%, butanols 5%, ethylene glycol 4%, silicone compound 2%, deionized water adds to 100%, makes 45% probenazole Isoprothiolane aqueous emulsion.
Embodiment 53 40.5% probenazole active component B microcapsule suspending agents
Probenazole 0.5%, active component B 40%, gamma cyhalothrin 7%, PIC 4.5%, octylphenol polyethylene oxyethylene group ether sulfate 4%, cyclohexanone 2.5%, ethylene oxide-propylene oxide block copolymer 3.5%; Deionized water adds to 100% weight portion, makes 40.5% probenazole active component B microcapsule suspending agent.
Embodiment 54 40.5% probenazole active component B micro-capsule-microcapsule suspending agents
The phonetic formaldehyde condensation products sulphate of probenazole 40%, active component B 0.5%, polyfunctional group acyl halide dihydroxylic alcohols 3.5%, alkylphenol-polyethenoxy 5.5%, cyclohexanone 3.5%; By series 6.5%; Deionized water adds to 100% weight portion, makes 40.5% probenazole active component B micro-capsule-microcapsule suspending agent.
The foregoing description 53, embodiment 54 described active component B are a kind of arbitrarily in kasugarnycin, jinggangmeisu, thifluzamide, the Isoprothiolane, and the weight ratio of probenazole and active component B is 1～80: any ratio between 80～1.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.Pass through Toxicity Determination earlier, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect, on this basis, carry out field trial again.
Probenazole and active component B (B is selected from kasugarnycin, jinggangmeisu, thifluzamide, the Isoprothiolane a kind of arbitrarily) are composite to the crop pest Toxicity Determination.
After the effective inhibition concentration scope of each medicament was confirmed in prerun, each medicament was established 5 dosage respectively by active constituent content and is handled, and established the clear water contrast.Carry out with reference to " agricultural chemicals indoor bioassay test rule bactericide ", adopt the mycelial growth rate method to measure the virulence of medicament the crop germ.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively handle clean amount of growth, mycelial growth inhibition rate.
Clean amount of growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates the EC of every kind of medicament thus
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is following:
Wherein: a, b are respectively active component probenazole and active component B (kasugarnycin, jinggangmeisu, thifluzamide, Isoprothiolane) shared ratio in combination;
A is a probenazole;
B is a kind of arbitrarily in kasugarnycin, jinggangmeisu, thifluzamide, the Isoprothiolane.
Application implementation example two:
Supply the examination disease: rice blast.
Experimental scheme: effective lethal concentration scope of confirming probenazole, the former medicine of kasugarnycin and the two different proportioning mixture through preliminary experiment.
Toxicity test result one
The different proportionings with kasugarnycin of table 1 probenazole are to the toxicity test of rice blast
Can know that by table 1 probenazole and kasugarnycin are to the EC of rice blast
50Be respectively 12.45mg/L and 0.59mg/L.Probenazole and kasugarnycin proportioning were at 80: 1 to 1: 80 o'clock; Synergy ratio SR is all greater than 1.5; Explaining that probenazole and kasugarnycin were mixed in the scope at 80: 1 to 1: 80 all shows synergistic effect, and especially when the two proportioning during at 35: 1 to 1: 1, synergistic effect is more obviously outstanding; Find through the test people; Probenazole and kasugarnycin are composite better to the spot synergistic effect of bacillary angle, and wherein synergy ratio SR is maximum when probenazole and kasugarnycin percentage by weight are 15: 1, and synergistic effect is the most obvious.
Application implementation example three:
Supply the examination disease: banded sclerotial blight.
Experimental scheme: effective lethal concentration scope of confirming probenazole, the former medicine of jinggangmeisu and the two different proportioning mixture through preliminary experiment.
Toxicity test result two
The toxicity test of the different proportioning banded sclerotial blights of table 2 probenazole with jinggangmeisu
Can know that by table 2 probenazole and jinggangmeisu are to the EC of banded sclerotial blight
50Be respectively 11.68mg/L and 1.35mg/L.Probenazole and jinggangmeisu proportioning were at 80: 1 to 1: 80 o'clock; Synergy ratio SR is all greater than 1.5; Explaining that probenazole and jinggangmeisu were mixed in the scope at 80: 1 to 1: 80 all shows synergistic effect, and especially when the two proportioning during at 36: 1 to 1: 1, synergistic effect is more obviously outstanding; Find through the test people; Probenazole and composite jinggangmycin are better to the damping off synergistic effect, and wherein synergy ratio SR is maximum when probenazole and jinggangmeisu percentage by weight are 9: 1, and synergistic effect is the most obvious.
Application implementation example four:
Supply the examination disease: banded sclerotial blight.
Experimental scheme: effective lethal concentration scope of confirming probenazole, the former medicine of thifluzamide and the two different proportioning mixture through preliminary experiment.
Toxicity test result three
The different proportionings with thifluzamide of table 3 probenazole are to the toxicity test of banded sclerotial blight
Can know that by table 3 probenazole and thifluzamide are to the EC of banded sclerotial blight
50Be respectively 11.69mg/L and 0.82mg/L.Probenazole and thifluzamide proportioning were at 80: 1 to 1: 80 o'clock; Synergy ratio SR is all greater than 1.5; Explaining that probenazole and thifluzamide were mixed in the scope at 80: 1 to 1: 80 all shows synergistic effect, and especially when the two proportioning during at 35: 1 to 1: 1, synergistic effect is more obviously outstanding; Find through the test people; Probenazole and thifluzamide are composite better to the bacterial leaf-blight synergistic effect, and wherein synergy ratio SR is maximum when probenazole and thifluzamide percentage by weight are 15: 1, and synergistic effect is the most obvious.
Application implementation example five:
Supply the examination disease: rice blast.
Experimental scheme: effective lethal concentration scope of confirming probenazole, the former medicine of Isoprothiolane and the two different proportioning mixture through preliminary experiment.
Toxicity test result four
The different proportionings with Isoprothiolane of table 4 probenazole are to the toxicity test of rice blast
Can know that by table 4 probenazole and Isoprothiolane are to the EC of rice blast
50Be respectively 12.05mg/L and 3.95mg/L.Probenazole and Isoprothiolane proportioning were at 80: 1 to 1: 80 o'clock; Synergy ratio SR is all greater than 1.5; Explaining that probenazole and Isoprothiolane were mixed in the scope at 80: 1 to 1: 80 all shows synergistic effect, and especially when the two proportioning during at 18: 1 to 1: 3, synergistic effect is more obviously outstanding; Find through the test people; Probenazole and Isoprothiolane are composite better to the culm rot synergistic effect, and wherein synergy ratio SR is maximum when probenazole and Isoprothiolane percentage by weight are 3: 1, and synergistic effect is the most obvious.
Application implementation example six probenazoles and the kasugarnycin and the composite control rice blast test of pesticide effectiveness thereof
This test medicine is provided by the individual, contrast medicament 8% probenazole granule (commercial), 6% kasugarnycin wetting powder (commercial).
The investigation rice blast state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated disease index respectively and calculated preventive effect in 3 days, 14 days, 30 days after the dispenser for the second time.Experimental result is as follows:
Table 5 probenazole, kasugarnycin and the composite control rice blast test of pesticide effectiveness thereof
Can find out by table 5; Can effectively prevent and treat rice blast after probenazole and kasugarnycin are composite; Find that through the test people probenazole and kasugarnycin are composite all to have favorable effect to control shot hole, shothole disease, culm rot etc., 30 days preventive effects are up to more than 95% behind the medicine; Control efficiency all is superior to the preventive effect of single agent, and the preventive effect time is long.In the test scope of medication, the target crop is had no adverse effects.
Application implementation example seven probenazoles and the jinggangmeisu and the composite false smut test of pesticide effectiveness of preventing and treating thereof
This test medicine is provided by the individual, contrast medicament 8% probenazole granule (commercial), the solvable pulvis of 20% jinggangmeisu (commercial).
The investigation false smut state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated disease index respectively and calculated preventive effect in 3 days, 14 days, 30 days after the dispenser for the second time.Experimental result is as follows:
Table 6 probenazole, jinggangmeisu and the composite false smut test of pesticide effectiveness of preventing and treating thereof
Can find out by table 6; Can effectively prevent and treat false smut behind probenazole and the composite jinggangmycin; Find that through the applicant also better to preventive effects such as damping off, bacterial leaf-blight, bacillary angle spots behind probenazole and the composite jinggangmycin, 30 days preventive effects reach more than 95% behind the medicine; Control efficiency all is superior to the preventive effect of single agent, and the preventive effect time is long.In the test scope of medication, the target crop is had no adverse effects.
Application implementation example eight probenazoles and the thifluzamide and the composite banded sclerotial blight test of pesticide effectiveness of preventing and treating thereof
This test medicine is provided by the individual, contrast medicament 8% probenazole granule (commercial), 240 grams per liter thifluzamide suspending agents (commercial).
The investigation banded sclerotial blight state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated disease index respectively and calculated preventive effect in 3 days, 14 days, 30 days after the dispenser for the second time.Experimental result is as follows:
Table 7 probenazole, thifluzamide and the composite banded sclerotial blight test of pesticide effectiveness of preventing and treating thereof
Can find out by table 7; Can effectively prevent and treat banded sclerotial blight after probenazole and thifluzamide are composite; Find that through the applicant the composite back of probenazole and thifluzamide is also better to preventive effects such as false smut, damping off, bacterial leaf-blights, 30 days preventive effects reach more than 95% behind the medicine; Control efficiency all is superior to the preventive effect of single agent, and the preventive effect time is long.In the test scope of medication, the target crop is had no adverse effects.
Application implementation example nine probenazoles and the Isoprothiolane and the composite control rice blast test of pesticide effectiveness thereof
This test medicine is provided by the individual, contrast medicament 8% probenazole granule (commercial), 40% Isoprothiolane missible oil (commercial).
The investigation rice blast state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated disease index respectively and calculated preventive effect in 3 days, 14 days, 30 days after the dispenser for the second time.Experimental result is as follows:
Table 8 probenazole, Isoprothiolane and the composite control rice blast test of pesticide effectiveness thereof
Can find out by table 8; Can effectively prevent and treat rice blast after probenazole and Isoprothiolane are composite; Find that through the applicant the composite back of probenazole and Isoprothiolane is also better to preventive effects such as rice blast, banded sclerotial blight, false smut, 30 days preventive effects reach more than 95% behind the medicine; Control efficiency all is superior to the preventive effect of single agent, and the preventive effect time is long.In the test scope of medication, the target crop is had no adverse effects.
Claims (8)
1. a disinfecting composition that contains probenazole comprises active components A, active component B, the auxiliary agent surplus.It is characterized in that: active components A is a probenazole, and active component B is a kind of arbitrarily in kasugarnycin, jinggangmeisu, thifluzamide, the Isoprothiolane, and the weight ratio of active components A and active component B is 80: 1～1: 80.
2. the disinfecting composition that contains probenazole according to claim 1 is characterized in that: the weight ratio of active components A and active component B is 60: 1～1: 40.
3. the disinfecting composition that contains probenazole according to claim 2 is characterized in that: the weight ratio of active components A and kasugarnycin is 45: 1～5: 1.
4. the disinfecting composition that contains probenazole according to claim 2 is characterized in that: the weight ratio of active components A and jinggangmeisu is 36: 1～1: 1.
5. the disinfecting composition that contains probenazole according to claim 2 is characterized in that: the weight ratio of active components A and thifluzamide is 35: 1～1: 1.
6. the disinfecting composition that contains probenazole according to claim 2 is characterized in that: the weight ratio of active components A and Isoprothiolane is 18: 1～1: 3.
7. according to any described disinfecting composition that contains probenazole in the claim 1～6, it is characterized in that: composition is processed wetting powder, water dispersible granules, missible oil, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent, micro-capsule-microcapsule suspending agent.
8. the disinfecting composition that contains probenazole according to claim 7 is used to prevent and treat the application of disease on paddy rice, brassicaceous vegetable, fruit tree, the cotton.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103918668A (en) * | 2014-04-24 | 2014-07-16 | 深圳诺普信农化股份有限公司 | Bactericidal composition |
| CN106538585A (en) * | 2016-09-30 | 2017-03-29 | 江苏新农化工有限公司 | Composition containing MTI-446, thifluzamide and probenazole and its preparation and application |
| CN107242239A (en) * | 2017-06-30 | 2017-10-13 | 江苏省绿盾植保农药实验有限公司 | A kind of composite bactericide containing probenazole and Isoprothiolane and its application |
| CN107711831A (en) * | 2017-03-01 | 2018-02-23 | 南京高正农用化工有限公司 | A kind of bactericidal composition and its application process comprising probenazole |
| CN114304168A (en) * | 2020-10-09 | 2022-04-12 | 陕西西大华特科技实业有限公司 | Bactericidal composition containing benziothiazolinone and isoprothiolane and application thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103918668A (en) * | 2014-04-24 | 2014-07-16 | 深圳诺普信农化股份有限公司 | Bactericidal composition |
| CN106538585A (en) * | 2016-09-30 | 2017-03-29 | 江苏新农化工有限公司 | Composition containing MTI-446, thifluzamide and probenazole and its preparation and application |
| CN107711831A (en) * | 2017-03-01 | 2018-02-23 | 南京高正农用化工有限公司 | A kind of bactericidal composition and its application process comprising probenazole |
| CN107242239A (en) * | 2017-06-30 | 2017-10-13 | 江苏省绿盾植保农药实验有限公司 | A kind of composite bactericide containing probenazole and Isoprothiolane and its application |
| CN114304168A (en) * | 2020-10-09 | 2022-04-12 | 陕西西大华特科技实业有限公司 | Bactericidal composition containing benziothiazolinone and isoprothiolane and application thereof |
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