CN102423382A - Chinese medicine composition for treating dyslipidemia and application thereof - Google Patents
Chinese medicine composition for treating dyslipidemia and application thereof Download PDFInfo
- Publication number
- CN102423382A CN102423382A CN2011103721304A CN201110372130A CN102423382A CN 102423382 A CN102423382 A CN 102423382A CN 2011103721304 A CN2011103721304 A CN 2011103721304A CN 201110372130 A CN201110372130 A CN 201110372130A CN 102423382 A CN102423382 A CN 102423382A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- medicine composition
- parts
- fab
- rhizoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a Chinese medicine composition which can regulate dyslipidemia. The Chinese medicine composition is prepared from 3-24 parts of pinellia tuber, 5-30 parts of trichosanthes, 3-60 parts of rhizoma coptidis, 5-45 parts of maggot and 10-80 parts of raw hawthorn. Furthermore, the Chinese medicine composition provided by the invention can also comprises 1-20 parts of red yeast rice. The formulation of the Chinese medicine composition has the effects of heat-clearing, phlegm-eliminating, turbidity-dissolving and lipid-reducing, and thus, the Chinese medicine composition is an effective composition for clinically treating hyperlipaemia.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and application thereof, especially relate to the Chinese medicine composition and the application thereof of treating dyslipidemia.
Background technology
Lipid metabolism or running make one or more lipids of blood plasma be higher than normally to be called hyperlipidemia unusually.Hyperlipidemia is a kind of systemic disease, is meant that blood cholesterol (TC) and/or triglyceride (TG) are too high or HDL-C (HDL-C) is low excessively, and modern medicine is referred to as dyslipidemia.Lipid is insoluble or be slightly soluble in water, must exist with the lipoprotein form with protein bound, and therefore, hyperlipidemia is generally hyperlipoproteinemia, and promptly serum lipoprotein concentration raises.Generally acknowledge hyperlipidemia at present, comprised hypercholesterolemia, hypertriglyceridemia and the plyability hyperlipidemia that the two is all high.
This disease to the infringement of health be concealment, gradually, carrying out property and general.Its direct infringement is to quicken systemic atherosclerosis, because the vitals of whole body all will rely on tremulous pulse blood supply, oxygen supply, in case tremulous pulse is stopped up by atheromatous plaque, will cause serious consequence.A large amount of research datas show that hyperlipidemia is apoplexy, coronary heart disease, myocardial infarction, cardiac sudden death is independent and important risk.Hyperlipidemia also is an important risk factor that promotes hypertension, impaired glucose tolerance, diabetes.Hyperlipidemia also can cause fatty liver, liver cirrhosis, cholelithiasis, pancreatitis, retinal hemorrhage, blind, peripheral vascular disease, limping, hyperuricemia.
The Chinese medicine dyslipidemia is very characteristic.The traditional Chinese medical science think dyslipidemia main diseases because: 1. dietary factor: addiction to greasy and sweet foods, rich and fatty diet, it is immoderate to be addicted to drink, impairing the spleen and stomach, dysfunction of the spleen in transportation, indigestion, give birth to expectorant give birth to wet, stagnation of phlegm-damp in middle-JIAO, cereal nutrient is failed cloth mistake department, makes to be primary disease.2. feelings will factor: long-term feelings will is unsuccessful, and liver is lost bar and reaches, and catharsis is not normal, and QI-blood circulation is not smooth, and cream fat cloth mistake degree, or excessive thinking injure taste, and interior living phlegm-damp can cause primary disease.3. physical factors: the fat or plain body deficiency of YIN of plain body, " fertile people's excessive phlegm ", expectorant be disease, of a specified duration and heat-transformation; Stagnation of turbid phlegm in middle-JIAO or accumulation of phlegm-heat in the interior can cause primary disease, the many deficiency of the liver and kindey of deficiency of YIN person, and the hepatic and renal YIN deficiency, liver-yang is high partially; The prosperous gram soil of wood, imapirment of the spleen and stomach is given birth to expectorant, or labor is desired excessively; It is dirty more to be impairment of the kidney, and causes Metabolic disorder because of life motive power lacks, and sends out to be primary disease.
Many natural Chinese crude drugs have effect for reducing blood fat preferably, like Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, the Radix Polygoni Multiflori, Semen Cassiae, Rhizoma Polygonati, Radix Puerariae, Pollen Typhae, Folium Nelumbinis, Folium Ginkgo etc.These medicines can be fried in shallow oil water by single, for tea-drinking usefulness, effect for reducing fat are preferably arranged.In order to improve lipid-lowering effect, a lot of commercially available Chinese patent medicine products have also appearred, and these products all have certain effect for reducing fat, but not good for the effect of serious symptom dyslipidemia.
For treating increasing hyperlipemia better, excavating me and cross the Chinese medicine resource, a kind of efficient, safety need be provided, dyslipidemia be had the Chinese medicine composition of definite curative effect.
Summary of the invention
The object of the present invention is to provide a kind of efficient, safety, dyslipidemia had the Chinese medicine composition of definite curative effect.
Another object of the present invention is to provide the application of this Chinese medicine composition.
In order to realize an above-mentioned at least goal of the invention, the invention provides the unusual Chinese medicine composition of a kind of ability blood lipid regulation, its composition comprises Rhizoma Pinelliae 3-24 part, Fructus Trichosanthis 5-30 part, Rhizoma Coptidis 3-60 part, Chrysomyiame gacephala (Fab.) 5-45 part, Fructus Crataegi 10-80 part.In this article, if do not offer some clarification on, employed term " part " refers to weight fraction.
Fructus Trichosanthis is a monarch drug in the side, removing heat-phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens.The Rhizoma Pinelliae, Rhizoma Coptidis are ministerial drug, the relieving accumulation of pathogens that reduces phlegm, and two medicines share, pungent drugs can disperse and bitter drugs can descend, the kind retention of phlegm-heat in the interior of controlling.The monarch and his subjects' compatibility, three medicines (Fructus Trichosanthis, the Rhizoma Pinelliae, Rhizoma Coptidis) are played removing heat-phlegm, the merit of relieving stuffiness of the chest by dispersing aggregation of pathogens altogether.Chrysomyiame gacephala (Fab.), Fructus Crataegi are adjuvant, play removing heat-phlegm, and removing food stagnancy stagnates, and changes turbid effect.Full side plays removing heat-phlegm altogether, changes the merit of turbid blood fat reducing.
One of according to the embodiment of the present invention, the proportion of composing of said Chinese medicine composition is: Rhizoma Pinelliae 6-12 part, Fructus Trichosanthis 10-15 part, Rhizoma Coptidis 6-30 part, Chrysomyiame gacephala (Fab.) 10-40 part, Fructus Crataegi 20-40 part.
According to another embodiment of the present invention, the proportion of composing of said Chinese medicine composition is: 8 parts of the Rhizoma Pinelliaes, 12 parts of Fructus Trichosanthis, 5 parts of Rhizoma Coptidis, 10 parts of Chrysomyiame gacephala (Fab.), 25 parts of Fructus Crataegi.
In order to realize goal of the invention of the present invention, can also further contain Monas cuspurpureus Went 1-20 part in the above-mentioned Chinese medicine composition.The adding of Monas cuspurpureus Went can further be strengthened removing heat-phlegm, removing food stagnancy and stagnate, and changes turbid effect.
Preferably, the addition of Monas cuspurpureus Went is 3～10 parts.More preferably, the content of Monas cuspurpureus Went is 5 parts.
The present invention also provides the application of this Chinese medicine composition, and this Chinese medicine composition can be used as the oral formulations form of treating dyslipidemia clinically.
One of according to the embodiment of the present invention, wherein the oral formulations form includes, but are not limited to the form of preparations such as capsule, tablet, pill, electuary, powder, Emulsion, syrup, oral liquid.
Additional aspect of the present invention and advantage part in the following description provide, and part will become obviously from the following description, or recognize through practice of the present invention.
The specific embodiment
Describe embodiments of the invention below in detail, following embodiment is exemplary, only is used to explain the present invention, and can not be interpreted as limitation of the present invention.
Embodiment 1
Rhizoma Pinelliae 8g, Fructus Trichosanthis 12g, Rhizoma Coptidis 5g, Chrysomyiame gacephala (Fab.) 10g, Fructus Crataegi 25g, Monas cuspurpureus Went 5g adds water 500ml, soaks 30 minutes, and moderate heat was fried in shallow oil 1 hour, and inclining supernatant, adds water 500ml again, and moderate heat decocted 40 minutes, and inclining supernatant.Merge supernatant twice.
Embodiment 2
Rhizoma Pinelliae 8g, Fructus Trichosanthis 12g, Rhizoma Coptidis 5g, Chrysomyiame gacephala (Fab.) 10g, Fructus Crataegi 25g adds water 500ml, soaks 30 minutes, and moderate heat was fried in shallow oil 1 hour, and inclining supernatant, adds water 500ml again, and moderate heat decocted 40 minutes, and inclining supernatant.Merge supernatant twice.
Embodiment 3
Rhizoma Pinelliae 6g, Fructus Trichosanthis 10g, Rhizoma Coptidis 6g, Chrysomyiame gacephala (Fab.) 10g, Fructus Crataegi 20g, Monas cuspurpureus Went 3g adds water 500ml, soaks 30 minutes, and moderate heat was fried in shallow oil 1 hour, and inclining supernatant, adds water 500ml again, and moderate heat decocted 40 minutes, and inclining supernatant.Merge supernatant twice.
Embodiment 4
Rhizoma Pinelliae 3g, Fructus Trichosanthis 10g, Rhizoma Coptidis 3g, Chrysomyiame gacephala (Fab.) 8g, Fructus Crataegi 15g adds water 500ml, soaks 30 minutes, and moderate heat was fried in shallow oil 1 hour, and inclining supernatant, adds water 500ml again, and moderate heat decocted 20 minutes, and inclining supernatant.Merge supernatant twice.
Embodiment 5
Rhizoma Pinelliae 20g, Fructus Trichosanthis 25g, Rhizoma Coptidis 10g, Chrysomyiame gacephala (Fab.) 25g, Fructus Crataegi 40g adds water 500ml, soaks 30 minutes, and moderate heat was fried in shallow oil 1 hour, and inclining supernatant, adds water 500ml again, and moderate heat decocted 40 minutes, and inclining supernatant.Merge supernatant twice.
Embodiment 6
Rhizoma Pinelliae 10g, Fructus Trichosanthis 13g, Rhizoma Coptidis 15g, Chrysomyiame gacephala (Fab.) 15g, Fructus Crataegi 30g, Monas cuspurpureus Went 5g adds water 500ml, soaks 30 minutes, and moderate heat was fried in shallow oil 1 hour, and inclining supernatant, adds water 500ml again, and moderate heat decocted 40 minutes, and inclining supernatant.Merge supernatant twice.
Embodiment 7
Rhizoma Pinelliae 20g, Fructus Trichosanthis 30g, Rhizoma Coptidis 30g, Chrysomyiame gacephala (Fab.) 30g, Fructus Crataegi 30g, Monas cuspurpureus Went 6g adds water 500ml, soaks 30 minutes, and moderate heat was fried in shallow oil 1 hour, and inclining supernatant, adds water 500ml again, and moderate heat decocted 40 minutes, and inclining supernatant.Merge supernatant twice.
Embodiment 8
Rhizoma Pinelliae 12g, Fructus Trichosanthis 15g, Rhizoma Coptidis 20g, Chrysomyiame gacephala (Fab.) 30g, Fructus Crataegi 35g adds water 500ml, soaks 30 minutes, and moderate heat was fried in shallow oil 1 hour, and inclining supernatant, adds water 500ml again, and moderate heat decocted 40 minutes, and inclining supernatant.Merge supernatant twice.
Embodiment 9
Rhizoma Pinelliae 10g, Fructus Trichosanthis 13g, Rhizoma Coptidis 30g, Chrysomyiame gacephala (Fab.) 40g, Fructus Crataegi 40g, Monas cuspurpureus Went 10g adds water 500ml, soaks 30 minutes, and moderate heat was fried in shallow oil 1 hour, and inclining supernatant, adds water 500ml again, and moderate heat decocted 40 minutes, and inclining supernatant.Merge supernatant twice.
Embodiment 10
Rhizoma Pinelliae 18g, Fructus Trichosanthis 20g, Rhizoma Coptidis 20g, Chrysomyiame gacephala (Fab.) 20g, Fructus Crataegi 50g, Monas cuspurpureus Went 15g adds water 500ml, soaks 30 minutes, and moderate heat was fried in shallow oil 1 hour, and inclining supernatant, adds water 500ml again, and moderate heat decocted 40 minutes, and inclining supernatant.Merge supernatant twice.
Embodiment 11
The material raw material Rhizoma Pinelliae 6g that gets it filled, Fructus Trichosanthis 10g, Rhizoma Coptidis 6g, Chrysomyiame gacephala (Fab.) 10g, Fructus Crataegi 20g, Monas cuspurpureus Went 3g adds water reflux, extract, twice, merge extractive liquid, concentrates, and adds ethanol precipitation, filters, concentrate to reclaim ethanol, medical material extractum; Behind extractum and adjuvant Polyethylene Glycol mix homogeneously, add the transconversion into heat material, the weight ratio of extractum and adjuvant is 1: 2; The extractum that mixes adjuvant is moved into the dropping-pill machine jar, splash in the cryogenic liquid paraffin, remove liquid paraffin, select ball, promptly get the oral drip-ball preparation of treating dyslipidemia.
Embodiment 12
The material raw material Rhizoma Pinelliae 24g that gets it filled, Fructus Trichosanthis 30g, Rhizoma Coptidis 60g, Chrysomyiame gacephala (Fab.) 45g, Fructus Crataegi 80g, Monas cuspurpureus Went 20g; After the pulverizing, add 4 times of amount ethanol of 80%, 65 ℃ of reflux, extract, 3 times, each 1.5 hours, merge extractive liquid,, 70 ℃ of decompression recycling ethanols, 80 ℃ of vacuum dryings were pulverized 80 mesh sieves, drug extract; Add lactose and process capsule.
Embodiment 13
The material raw material Rhizoma Pinelliae 12g that gets it filled, Fructus Trichosanthis 15g, Rhizoma Coptidis 30g, Chrysomyiame gacephala (Fab.) 40g, Fructus Crataegi 40g, Monas cuspurpureus Went 20g; Add 4 times of amount ethanol of 77%, 63 ℃ of reflux, extract, 3 times, each 1.5 hours, merge extractive liquid,, 66 ℃ of decompression recycling ethanols, 80 ℃ of vacuum dryings were pulverized 80 mesh sieves, drug extract; Add dextrin and process tablet.
Embodiment 14
The material raw material Rhizoma Pinelliae 8g that gets it filled, Fructus Trichosanthis 12g, Rhizoma Coptidis 5g, Chrysomyiame gacephala (Fab.) 10g, Fructus Crataegi 25g, Monas cuspurpureus Went 5g; Add 4 times of amount ethanol of 80%, 65 ℃ of reflux, extract, 3 times, each 1.5 hours, merge extractive liquid,, 70 ℃ of decompression recycling ethanols, 80 ℃ of vacuum dryings were pulverized 80 mesh sieves, drug extract; Add the lactose fluidized bed granulation, process granule.
The clinical observation on the therapeutic effect that experimental example 1 Chinese medicine composition is sick to dyslipidemia
One, clinical data
Select 120 routine dyslipidemia patients, the PROC PLAN program through SAS6.12 software produces the random assortment in 1: 1 that the experimenter accepts processing (treatment group and matched group), and 60 examples are organized in treatment, male 32 examples, women 28 examples; Year at age (53.1 ± 11.6), Body Mass Index (24.6 ± 2.8); Matched group 60 examples, male 35 examples, women 25 examples; Year at age (55.6 ± 15.2), Body Mass Index (24.4 ± 2.3).2 groups of patient ages, sex, Body Mass Index, dyslipidemia parameter etc. have comparability through statistical analysis difference not statistically significant (P＞0.05).
The hyperlipemia diagnostic criteria is with reference to the standard of Chinese cardiovascular diseases's magazine editorial board's dyslipidemia Preventing Countermeasures special topic group " dyslipidemia control suggestion ".Anemia of pregnant woman or women breast-feeding their children, indulge in excessive drinking or have drug dependence history, hypothyroidism, nephrotic syndrome, familial hyperlipidemia patient etc. all to discharge outside clinical trial at the bad diabetes of serious hepatic and renal function injure, organic heart disease, control (need with insulin or hypoglycemia arranged).
Two, Therapeutic Method
The treatment group is taken decoction 200ml/ bag, and is each 1 bag sooner or later, oral.Decoction is formed by the following medical herbs decocting of forming: Rhizoma Pinelliae 6-12g, Fructus Trichosanthis 10-15g, Rhizoma Coptidis 6-30g, Chrysomyiame gacephala (Fab.) 10-40g, Fructus Crataegi 20-40g, Monas cuspurpureus Went 3-10g (drug dose is suitably adjusted according to patient's situation in above-mentioned scope).
Matched group is with pravastatin (Sino-U.S. executes in Shanghai expensive precious pharmaceutical Co. Ltd and produces) 20mg, and is 1 time every night, oral.
2 groups of lipid-regulation medicine, Chinese medicine and immunosuppressant etc. of all in process of the test, not using any other kind, 8 all post-evaluation curative effects.
Three, observation index and statistical method
Mainly measure patients serum TC before and after the treatment, TG, LDL-C, HDL-C, 24h alcohol prohibition and high fat diet do not take vigorous exercise before the blood drawing, extracting vein blood behind the empty stomach 12h, instant separation of serum is measured each index concentration of blood fat.
Adopt SAS.6.12 version statistical software to analyze.Measurement data is represented with mean scholar standard deviation.The ranked data data relatively adopts CMH X
2The t check of paired t-test and design is in groups relatively adopted in check, measurement data.
Four, criterion of therapeutical effect
" new Chinese medicine clinical research guideline (the trying) " evaluation in 2002 of therapeutic evaluation standard reference.Produce effects: reach following wantonly 1 person, TC descends >=20%, and TG descends >=40%, HDL-C rising >=0.26mmol/L.Effectively: TC descends 10%～19%, and TG descends 20%～39%, the HDL-C 0.10～0.25mmol/L that rises.Invalid: as not reach effective standard person.
Five, result
1. ordinary circumstance
The treatment group withdraws from test because of oral other lipid lowerers of 1 routine patient.Test group has the 2 routine patients other places of going on business, and can't follow up a case by regular visits to and withdraws from this test.
2. the comparison of two groups of blood fat
Table 1 liang group blood fat is
mmol/L relatively
Annotate: relatively preceding with treatment,
*P＜0.05,
*P＜0.01; With comparison after the treatment of control group, Δ P＞0.05
(pravastatin is the clinical marketed drug that obvious blood fat reducing is arranged that doctor trained in Western medicine is recognized altogether for the curative effect of table 1 prompting pharmaceutical composition provided by the present invention and Western medicine lipid lowerers " pravastatin " therapeutic equivalence; Be the doctor trained in Western medicine common drug), explain that pharmaceutical composition provided by the present invention (removing heat-phlegm, the turbid side of the livering that disappears) has tangible effect for reducing fat.
3. two groups of clinical efficacies relatively
Treatment group produce effects 24 examples, effective 30 examples, invalid 5 examples, total effective rate 91.5%; Matched group produce effects 27 examples, effective 27 examples, invalid 4 examples, total effective rate compares difference not statistically significant (P＞0.05) for 93.1%, 2 group.
The clinical total effective rate that Chinese medicine composition provided by the present invention is described reaches 91.5%, with Western medicine pravastatin therapeutic equivalence.And the treatment group is not seen untoward reaction.
One of experimental example 2 traditional Chinese medicine composition for treating dyslipidemia clinical cases
Liu, male, 45 years old, first visit on JIUYUE 10 in 2010.Previously body is strong.Main suit: weak 2 weeks.Inscribe disease: weak, breast side of body feeling of distension and oppression, insomnia, indigestion and loss of appetite, obesity, red tongue with yellowish and greasy fur, rolling pulse is puckery.Auxiliary check: T-CHOL 7.18mmol/L, triglyceride 3.65mmol/L, low density lipoprotein, LDL 4.70mmol/L, HDL1 .09mmol/L.Diagnosis: dyslipidemia disease, Chinese medical discrimination are the hot mutual resistance card of expectorant.Give the treatment of oral Chinese medicine decoction, decoction is formed by the following medical herbs decocting of forming: Rhizoma Pinelliae 6-12g, Fructus Trichosanthis 10-15g, Rhizoma Coptidis 6-30g, Chrysomyiame gacephala (Fab.) 10-40g, Fructus Crataegi 20-40g, Monas cuspurpureus Went 3-10g.(drug dose is suitably adjusted according to patient's situation in above-mentioned scope, adjusts drug dose weekly 1 time).After taking 1 month, patient's symptom obviously alleviates.Check blood fat: T-CHOL 4.32mmol/L, triglyceride 1.51mmol/L, low density lipoprotein, LDL 3.02mmol/L, HDL1 .43mmol/L.
Two of experimental example 3 traditional Chinese medicine composition for treating dyslipidemia clinical cases
Lee, woman, 48 years old, on August 9th, 2009.The patient had dyslipidemia disease 5 years.The main suit: the weak outbreak repeatedly of the soreness of waist increased the weight of 3 days in 5 years.Inscribe disease: the soreness of waist is weak, and time breathes hard, uncomfortable in chest being insomnia, obesity, light red tongue yellow and greasy fur, deep-rolling pulse.Have a medical check-up: body weight 81kg, Bp135/75mmHg.Help check: T-CHOL 6.60mmol/L, triglyceride 4.30mmol/L, low density lipoprotein, LDL 3.85mmol/L, high density lipoprotein 0.78mmol/L.Diagnosis: dyslipidemia disease, Chinese medical discrimination are the hot mutual resistance card of expectorant.Give the treatment of oral Chinese medicine decoction, decoction is formed by the following medical herbs decocting of forming: Rhizoma Pinelliae 6-12g, Fructus Trichosanthis 10-15g, Rhizoma Coptidis 6-30g, Chrysomyiame gacephala (Fab.) 10-40g, Fructus Crataegi 20-40g.(drug dose is suitably adjusted according to patient's situation in above-mentioned scope, adjusts drug dose weekly 1 time).Take traditional Chinese medicine after 8 weeks, patient's symptom obviously alleviates.Body weight is kept to 75kg.Check blood fat: T-CHOL 4.16mmol/L, triglyceride 1.69mmol/L, low density lipoprotein, LDL 2.49mmol/L, HDL1 .25mmol/L.
Although illustrated and described embodiments of the invention; For those of ordinary skill in the art; Be appreciated that under the situation that does not break away from principle of the present invention and spirit and can carry out multiple variation, modification, replacement and modification to these embodiment, scope of the present invention is limited accompanying claims and equivalent thereof.
Claims (8)
1. Chinese medicine composition that the ability blood lipid regulation is unusual, its composition comprises Rhizoma Pinelliae 3-24 part, Fructus Trichosanthis 5-30 part, Rhizoma Coptidis 3-60 part, Chrysomyiame gacephala (Fab.) 5-45 part, Fructus Crataegi 10-80 part.
2. Chinese medicine composition as claimed in claim 1, the ratio of wherein said composition is: Rhizoma Pinelliae 6-12 part, Fructus Trichosanthis 10-15 part, Rhizoma Coptidis 6-30 part, Chrysomyiame gacephala (Fab.) 10-40 part, Fructus Crataegi 20-40 part.
3. Chinese medicine composition as claimed in claim 2, the ratio of wherein said composition is: 8 parts of the Rhizoma Pinelliaes, 12 parts of Fructus Trichosanthis, 5 parts of Rhizoma Coptidis, 10 parts of Chrysomyiame gacephala (Fab.), 25 parts of Fructus Crataegi.
4. like the described Chinese medicine composition of claim 1-3, wherein also contain Monas cuspurpureus Went 1-20 part.
5. Chinese medicine composition as claimed in claim 4, the content of wherein said Monas cuspurpureus Went are 3～10 parts.
6. Chinese medicine composition as claimed in claim 5, the content of wherein said Monas cuspurpureus Went are 5 parts.
7. application like the described Chinese medicine composition of claim 1-6 is characterized in that described compositions can be used as the oral formulations form of treating dyslipidemia clinically.
8. the application of Chinese medicine composition according to claim 7 is characterized in that described oral formulations form comprises the form of capsule, tablet, pill, electuary, powder, Emulsion, syrup, oral liquid formulations.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110372130.4A CN102423382B (en) | 2011-11-21 | 2011-11-21 | Chinese medicine composition for treating dyslipidemia and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110372130.4A CN102423382B (en) | 2011-11-21 | 2011-11-21 | Chinese medicine composition for treating dyslipidemia and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102423382A true CN102423382A (en) | 2012-04-25 |
| CN102423382B CN102423382B (en) | 2014-04-30 |
Family
ID=45957469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110372130.4A Active CN102423382B (en) | 2011-11-21 | 2011-11-21 | Chinese medicine composition for treating dyslipidemia and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102423382B (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104922352A (en) * | 2015-06-05 | 2015-09-23 | 宋云飞 | Medicine for treating hyperlipidaemia |
| CN110123891A (en) * | 2019-05-22 | 2019-08-16 | 中国人民解放军第四军医大学 | The stain Chinese medicine composition and preparation method thereof that collapses for treating deep vein thrombosis |
| WO2020057503A1 (en) * | 2018-09-17 | 2020-03-26 | 睢宁九旭神州医药科技有限公司 | Traditional chinese medicine composition for treating metabolic syndrome and preparations thereof |
| CN112057535A (en) * | 2020-08-24 | 2020-12-11 | 中国中医科学院广安门医院 | Preparation method of traditional Chinese medicine composition for preventing or/and treating dyslipidemia |
| CN112057536A (en) * | 2020-08-24 | 2020-12-11 | 中国中医科学院广安门医院 | Traditional Chinese medicine composition for preventing or/and treating dyslipidemia and application thereof |
| RU2780451C1 (en) * | 2018-09-17 | 2022-09-23 | Цзянсу Цзюсюй Фармасьютикал Ко., Лтд. | Composition based on medicinal materials of traditional chinese medicine for treatment of metabolic syndrome, its production method and use, and pharmaceutical drug based on it and its use |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593557A (en) * | 2004-07-15 | 2005-03-16 | 李洋 | Stomach intestine clearing capsule |
| CN102058793A (en) * | 2010-11-25 | 2011-05-18 | 代龙 | Traditional Chinese medicine composition and preparation method thereof |
-
2011
- 2011-11-21 CN CN201110372130.4A patent/CN102423382B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593557A (en) * | 2004-07-15 | 2005-03-16 | 李洋 | Stomach intestine clearing capsule |
| CN102058793A (en) * | 2010-11-25 | 2011-05-18 | 代龙 | Traditional Chinese medicine composition and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 仝小林: "五谷虫配生山楂", 《中国中医药报》 * |
| 仝小林等: "经方本源剂量在2型糖尿病治疗中的应用", 《世界中西医结合杂志》 * |
| 张学智: "血脂异常中医诊疗标准（初稿）", 《中华中医药杂志》 * |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104922352A (en) * | 2015-06-05 | 2015-09-23 | 宋云飞 | Medicine for treating hyperlipidaemia |
| WO2020057503A1 (en) * | 2018-09-17 | 2020-03-26 | 睢宁九旭神州医药科技有限公司 | Traditional chinese medicine composition for treating metabolic syndrome and preparations thereof |
| US20220031791A1 (en) * | 2018-09-17 | 2022-02-03 | Jiangsu Jiuxu Haitian Pharmaceutical Co., Ltd. | Traditional chinese medicine composition for treating metabolic syndrome and preparations thereof |
| RU2780451C1 (en) * | 2018-09-17 | 2022-09-23 | Цзянсу Цзюсюй Фармасьютикал Ко., Лтд. | Composition based on medicinal materials of traditional chinese medicine for treatment of metabolic syndrome, its production method and use, and pharmaceutical drug based on it and its use |
| US11744870B2 (en) * | 2018-09-17 | 2023-09-05 | Jiangsu Jiuxu Pharmaceutical Co., Ltd. | Traditional Chinese medicine composition for treating metabolic syndrome and preparations thereof |
| CN110123891A (en) * | 2019-05-22 | 2019-08-16 | 中国人民解放军第四军医大学 | The stain Chinese medicine composition and preparation method thereof that collapses for treating deep vein thrombosis |
| CN112057535A (en) * | 2020-08-24 | 2020-12-11 | 中国中医科学院广安门医院 | Preparation method of traditional Chinese medicine composition for preventing or/and treating dyslipidemia |
| CN112057536A (en) * | 2020-08-24 | 2020-12-11 | 中国中医科学院广安门医院 | Traditional Chinese medicine composition for preventing or/and treating dyslipidemia and application thereof |
| CN112057536B (en) * | 2020-08-24 | 2021-12-31 | 中国中医科学院广安门医院 | Traditional Chinese medicine composition for preventing or/and treating dyslipidemia and application thereof |
| CN112057535B (en) * | 2020-08-24 | 2021-12-31 | 中国中医科学院广安门医院 | Preparation method of traditional Chinese medicine composition for preventing or/and treating dyslipidemia |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102423382B (en) | 2014-04-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103285231A (en) | Medicine composition for diabetes adjunctive therapy and preparation method thereof | |
| CN102861298A (en) | Traditional Chinese medicine composition for treating chronic gastritis | |
| CN102423382B (en) | Chinese medicine composition for treating dyslipidemia and application thereof | |
| CN102772737B (en) | Traditional Chinese medicine composition for treating liver cirrhosis and fibrosis and preparation method thereof | |
| CN105727145A (en) | Traditional Chinese medicine drug for treating spleen deficiency phlegm-dampness syndrome type hyperlipidaemia | |
| CN103479691B (en) | Fat-reducing liver-protecting Chinese medicine composition | |
| CN102727787B (en) | Drug with characteristics of rapid transaminase lowering and live protection | |
| CN104905267A (en) | Semen cassiae health oral liquid capable of decreasing blood lipid and preparation method thereof | |
| CN103749819B (en) | Fructus Corni health protection tea of a kind of hypoglycemic and preparation method thereof | |
| CN101524441A (en) | Chinese medicinal composition for lipid-lowering and weight-losing and preparation method thereof | |
| CN101810671B (en) | Chinese medicinal preparation for treating AIDS and preparation method thereof | |
| CN101199817A (en) | Liver-protecting fat-dropping tea | |
| CN106266949A (en) | A kind of compound Chinese medicinal preparation and its preparation method and application | |
| CN109771578A (en) | The composition for preventing and treating diabetes and complication | |
| CN104957515A (en) | Steamed buns assisting to lower blood sugar and preparation method thereof | |
| CN111195310A (en) | Traditional Chinese medicine composition for treating hyperlipidemia | |
| CN105056103A (en) | Steamed buns with assistant effect of reducing blood fat and cholesterol and processing method of steamed buns | |
| CN112336802B (en) | Traditional Chinese medicine composition for improving glycolipidosis metabolism of diabetes and application thereof | |
| CN104721256A (en) | Anwei Yang extract as well as preparation method and medical application thereof | |
| CN100998674B (en) | Traditional Chinese medicine composition with functions of lowering blood-fat and reducing weight | |
| CN107468952A (en) | A kind of preparation method of the integration of drinking and medicinal herbs composition with auxiliary hyperglycemic function | |
| CN103405574B (en) | Medicinal composition for treating hypertension | |
| CN102631425A (en) | Mongolian medicine for treating dyslipidemia | |
| CN107823487B (en) | Traditional Chinese medicine composition for treating non-alcoholic fatty liver disease and preparation method and application thereof | |
| WO2017101154A1 (en) | Stomach-nourishing traditional chinese medicine composition and preparation method therefor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |