CN102421771A - 吡啶酮酰胺类衍生物、其制备方法及其在医药上的应用 - Google Patents

吡啶酮酰胺类衍生物、其制备方法及其在医药上的应用 Download PDF

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Publication number
CN102421771A
CN102421771A CN2011800020692A CN201180002069A CN102421771A CN 102421771 A CN102421771 A CN 102421771A CN 2011800020692 A CN2011800020692 A CN 2011800020692A CN 201180002069 A CN201180002069 A CN 201180002069A CN 102421771 A CN102421771 A CN 102421771A
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protective embankment
embankment base
base
heterocyclic radical
aryl
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CN102421771B (zh
Inventor
邓炳初
别平彦
奚倬勋
杨式波
钱广桃
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UNITRIS BIOPHARMA CO LTD
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UNITRIS BIOPHARMA CO LTD
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

本发明涉及吡啶酮酰胺类衍生物、其制备方法及其在医药上的应用。具体而言，本发明涉及一种通式(I)所示新的吡啶酮酰胺类衍生物或其可药用的盐，以及它们作为治疗剂特别是作为c-Met蛋白激酶抑制剂的用途，其中通式(I)中的各取代基的定义与说明书中的定义相同。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN2011800020692A 2010-02-03 2011-01-13 吡啶酮酰胺类衍生物、其制备方法及其在医药上的应用 Expired - Fee Related CN102421771B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2011800020692A CN102421771B (zh) 2010-02-03 2011-01-13 吡啶酮酰胺类衍生物、其制备方法及其在医药上的应用

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CN201010113782.1 2010-02-03
CN201010113782 2010-02-03
CN201010175273.1 2010-05-18
CN2010101752731A CN102140093A (zh) 2010-02-03 2010-05-18 吡啶酮酰胺类衍生物、其制备方法及其在医药上的应用
PCT/CN2011/000018 WO2011095045A1 (zh) 2010-02-03 2011-01-13 吡啶酮酰胺类衍生物、其制备方法及其在医药上的应用
CN2011800020692A CN102421771B (zh) 2010-02-03 2011-01-13 吡啶酮酰胺类衍生物、其制备方法及其在医药上的应用

Publications (2)

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CN102421771A true CN102421771A (zh) 2012-04-18
CN102421771B CN102421771B (zh) 2013-11-20

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CN2010101752731A Pending CN102140093A (zh) 2010-02-03 2010-05-18 吡啶酮酰胺类衍生物、其制备方法及其在医药上的应用
CN2011800020692A Expired - Fee Related CN102421771B (zh) 2010-02-03 2011-01-13 吡啶酮酰胺类衍生物、其制备方法及其在医药上的应用

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CN (2) CN102140093A (zh)
WO (1) WO2011095045A1 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104302292A (zh) * 2011-11-22 2015-01-21 德西费拉制药有限责任公司 表现出抗癌和抗增殖活性的吡啶酮酰胺以及类似物
CA2876246C (en) 2012-07-28 2019-05-07 Calitor Sciences, Llc Substituted pyrazolone compounds and methods of use
US8975282B2 (en) 2012-07-28 2015-03-10 Sunshine Lake Pharma Co., Ltd. Substituted pyrazolone compounds and methods of use
WO2019080723A1 (zh) * 2017-10-26 2019-05-02 北京越之康泰生物医药科技有限公司 多取代吡啶酮类衍生物、其制备方法及其医药用途
CN111825605B (zh) * 2019-04-19 2023-03-31 中国科学院上海药物研究所 芳基酮酰胺类化合物及其制备方法和用途
WO2021224186A1 (en) * 2020-05-04 2021-11-11 Institut Curie New pyridine derivatives as radiosensitizers
IL310117A (en) * 2021-09-09 2024-03-01 Guangdong Raynovent Biotech Co Ltd A ketoamide derivative and its use
CN116283920B (zh) * 2023-03-31 2024-04-16 贵州医科大学 2,4-二取代吡啶类化合物及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101111479A (zh) * 2004-12-16 2008-01-23 沃泰克斯药物股份有限公司 可用作激酶抑制剂的吡啶酮
CN101128454A (zh) * 2004-12-22 2008-02-20 阿斯利康(瑞典)有限公司 用作抗癌药物的吡啶羧酰胺衍生物
WO2008079968A1 (en) * 2006-12-20 2008-07-03 Bayer Healthcare Llc 4-{4-[({3-tert-butyl-1-[3-(hydroxymethyl) phenyl]-1h-pyrazol-5-yl } carbamoyl)-amino] -3-fluorophenoxy} -n-methylpyridine-2-carboxamide as well as prodrugs and salts thereof for the treatment of cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007007330A (es) * 2004-12-16 2007-10-04 Vertex Pharma Piridonas de utilidad como inhibidores de quinasas .

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101111479A (zh) * 2004-12-16 2008-01-23 沃泰克斯药物股份有限公司 可用作激酶抑制剂的吡啶酮
CN101128454A (zh) * 2004-12-22 2008-02-20 阿斯利康(瑞典)有限公司 用作抗癌药物的吡啶羧酰胺衍生物
WO2008079968A1 (en) * 2006-12-20 2008-07-03 Bayer Healthcare Llc 4-{4-[({3-tert-butyl-1-[3-(hydroxymethyl) phenyl]-1h-pyrazol-5-yl } carbamoyl)-amino] -3-fluorophenoxy} -n-methylpyridine-2-carboxamide as well as prodrugs and salts thereof for the treatment of cancer

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CN102140093A (zh) 2011-08-03
CN102421771B (zh) 2013-11-20

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