CN102416103B - Pharmaceutical composition and pill and preparation method and application thereof - Google Patents
Pharmaceutical composition and pill and preparation method and application thereof Download PDFInfo
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- CN102416103B CN102416103B CN201110363634XA CN201110363634A CN102416103B CN 102416103 B CN102416103 B CN 102416103B CN 201110363634X A CN201110363634X A CN 201110363634XA CN 201110363634 A CN201110363634 A CN 201110363634A CN 102416103 B CN102416103 B CN 102416103B
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Abstract
The invention provides a pharmaceutical composition, and the pharmaceutical composition comprises the following raw materials: gleditsia sinensis, rhizoma nardostachyos, asarum, white chrysanthemum, bletilla striata, radix angelicae, ginkgo, sandalwood, radix polygonati officinalis, deer pancreas, deer oil, and mung bean, wherein, with respect to 100 parts by weight of the sum of deer pancreas and deer oil, the respective content of each of rhizoma nardostachyos, asarum, white chrysanthemum, bletilla striata, radix angelicae, ginkgo, sandalwood, and radix polygonati officinalis is 20-100 parts by weight, and the respective content of each of gleditsia sinensis and mung bean is 5-100 parts by weight. The invention also provides a pill, its preparation method, and an application of the pharmaceutical composition or the pill in the preparation of medicaments for dermatosis or cosmetics. Through the above technical scheme, the pharmaceutical composition and the pill provided by the invention can treat dermatosis, protect human faces, and improve skin beauty.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and pill and its preparation method and application.
Background technology
Along with the progress of society, expanding economy, people's living standard improves day by day, pursues also gradually the rising of beautiful hope, and people do not wish perpetual youth, but the youth beautiful passerby of life just forever also has little time to condemn the long ， Bian of family dependant's feelings Strip and so leaves away.So some buy various tonics, senior washing cosmetic etc. are safeguarded face.A lot of people are ready to have a bath everyday, use a large amount of alkaline sulfur soaps, fancy soap, bath gel etc.
These chemical articles of life-time service can cause the skin premature aging; because people's skin surface has one deck oils and fats; play the effect of protection and skin care; in case the excessive use alkaline matter washes one's face, washs the oils and fats protective layer that will destroy skin; be easy to occur antibacterial infection, skin pruritus, flushing, long vesicle, skin desiccation etc.; thereupon just there will be pachylosis, many wrinkles etc. occur on the face.
The traditional Chinese medical science is thought: blood is unimpeded for the gas foot, and hemapodium gas is capable healthy and vigorous.Only enriching blood regulates the flow of vital energy could regulate gas balance inside, and the sufficient colour of skin of blood could be full ruddy, adds the skin protection of reasonable utilization Chinese herbal medicine, just can reach the purpose of looks improving and the skin nourishing, keeps energetic, and body and mind is happy, and physique is strong, life prolonging.
Summary of the invention
The objective of the invention is to reach the effect of looks improving and the skin nourishing, and a kind of pharmaceutical composition and pill and its preparation method and application are provided for the treating for skin disease by many reasons is caused.
To achieve these goals, the invention provides a kind of pharmaceutical composition, it is characterized in that, this pharmaceutical composition contains following raw material: Semen Gleditsiae, Radix Et Rhizoma Nardostachyos, Herba Asari, Flos Chrysanthemi, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, Semen Ginkgo, Lignum Santali Albi, Rhizoma Polygonati Odorati, deer pancreas, deer oil and Semen phaseoli radiati, wherein, summation with respect to deer pancreas and the deer oil of 100 weight portions, the content of Radix Et Rhizoma Nardostachyos, Herba Asari, Flos Chrysanthemi, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, Semen Ginkgo, Lignum Santali Albi and Rhizoma Polygonati Odorati the 20-100 weight portion of respectively doing for oneself, the content of Semen Gleditsiae and the Semen phaseoli radiati 5-100 weight portion of respectively doing for oneself.
The present invention also provides a kind of pill, and wherein, this pill contains active component, and described active component is aforementioned pharmaceutical compositions.
The present invention also provides a kind of preparation method of pill, the method comprise with active component and water mix, molding, wherein, described active component is aforementioned pharmaceutical compositions.
The present invention also provides the application of aforementioned pharmaceutical compositions in preparing dermatosis treating medicine or cosmetics.
The present invention also provides the application of above-mentioned pill in preparing dermatosis treating medicine or cosmetics.
By technique scheme, pharmaceutical composition provided by the invention and pill can be treated dermatosis, protection people's appearance, the beauty of lifting skin.
Other features and advantages of the present invention will partly be described in detail in the specific embodiment subsequently.
The specific embodiment
Below the specific embodiment of the present invention is elaborated.Should be understood that, the specific embodiment described herein only is used for description and interpretation the present invention, is not limited to the present invention.
The invention provides a kind of pharmaceutical composition, it is characterized in that, this pharmaceutical composition contains following raw material: Semen Gleditsiae, Radix Et Rhizoma Nardostachyos, Herba Asari, Flos Chrysanthemi, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, Semen Ginkgo, Lignum Santali Albi, Rhizoma Polygonati Odorati, deer pancreas, deer oil and Semen phaseoli radiati, wherein, summation with respect to deer pancreas and the deer oil of 100 weight portions, the content of Radix Et Rhizoma Nardostachyos, Herba Asari, Flos Chrysanthemi, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, Semen Ginkgo, Lignum Santali Albi and Rhizoma Polygonati Odorati the 20-100 weight portion of respectively doing for oneself, the content of Semen Gleditsiae and the Semen phaseoli radiati 5-100 weight portion of respectively doing for oneself.
Under preferable case, with respect to the summation of deer pancreas and the deer oil of 100 weight portions, Radix Et Rhizoma Nardostachyos, Herba Asari, Flos Chrysanthemi, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, Semen Ginkgo, Lignum Santali Albi, the content of Rhizoma Polygonati Odorati the 30-90 weight portion of respectively doing for oneself, Semen Gleditsiae, the content of the Semen phaseoli radiati 10-90 weight portion of respectively doing for oneself.
Radix Et Rhizoma Nardostachyos: be Valerianaceae plant: Nardosta chys chinensis Batai.
Herba Asari: be aristolochiaceae plant: Asarnm heter otropoides Fr Schmidt Var mandsh Uricum, dry herb dries in the shade.
The Radix Angelicae Dahuricae: the Radix Angelicae Dahuricae is umbellate form section plant, dry root.
Flos Chrysanthemi: Flos Chrysanthemi section plant: Feverfew.
The Pseudobulbus Bletillae (Rhizoma Bletillae): be orchid: the dry tuber of Bletilla striata Reichb.F.
Lignum Santali Albi: Santalaceae plant: the heartwood of SantalumalbumL trunk.
Semen Ginkgo: Ginkgo bilobaL
Rhizoma Polygonati Odorati: Liliaceae: Polygonatum odoratum Druce. dry rhizome.
Semen phaseoli radiati: pulse family: the dry mature seed of Phseolus radiatusL.
Semen Gleditsiae: angiosperm section: Magnoliophyta.
Unless stated otherwise, above-mentioned plant can be used in whole strain, also can use a part wherein.
Deer oil: the Adeps Cervi fat refines and forms.
Deer pancreas: internal organs in deer.
Above-mentioned various raw material can be bought the product that has cooked on shop of Chinese medicines or Market of Chinese Materia Medica, also can obtain by the concocting method of routine, for example can make with grinding by raw material being carried out drying.Dry method can or be dried naturally for oven dry, is preferably nature and dries.The method of grinding can be the Ginding process of field of Chinese medicines routine, preferably grinds to form fine powder.
Under preferable case, raw material of the present invention is powder, and particle mean size is the 80-150 order.More preferably particle mean size is the 80-120 order.
The present invention does not have special requirement to the proportioning of deer pancreas and deer oil, and the amount of various proportionings all can realize the object of the invention.Under preferable case, the weight ratio of described deer pancreas and deer oil is 2-10:1.More preferably the weight ratio of described deer pancreas and deer oil is 4-9:1.
Chinese medicine composition of the present invention can be by mixing described various raw materials to make.As long as the condition of mixing makes various raw material mix homogeneously.
Chinese medicine composition provided by the invention can effectively be protected people's skin, makes it smooth, moist and rejuvenation.
The present invention also provides a kind of pill, and wherein, this pill contains active component, and described active component is aforementioned pharmaceutical compositions.
Pill of the present invention does not preferably comprise other auxiliary material.The purity of described active component is more than 98 % by weight.More preferably the purity of described active component is more than 99 % by weight.
The present invention also provides a kind of preparation method of pill, the method comprise with active component and water mix, molding, wherein, described active component is aforementioned pharmaceutical compositions.
Under preferable case, take the gross weight of described active component and water as benchmark, the consumption of described active component is the 20-95 % by weight, and the consumption of water is the 5-80 % by weight.More preferably in situation, the consumption of described active component is the 30-90 % by weight, and the consumption of water is the 10-70 % by weight.
The condition of mixing is for getting final product the pill molding, and the temperature of preferred described mixing is 60-95 ℃, and further the temperature of preferred described mixing is 70-90 ℃.
The present invention also provides the above-mentioned application of pharmaceutical composition in preparing dermatosis treating medicine or cosmetics.
The present invention also provides the application of above-mentioned pill in preparing dermatosis treating medicine or cosmetics.
The using method of pharmaceutical composition of the present invention and pill is: after hot water bubbled open the temperature of drying in the air, external every day washed one's face each once sooner or later, each 10-30 gram (with the 1000-1500 ml water, bubbling open).Coordinate every day for oral administration sooner or later respectively once, each 10-30 gram, effect is better.
Below will describe the present invention by embodiment.In following examples, the drug regimen raw material is the commercially available product of pharmacy of Tongrentang.
Embodiment 1-3
Embodiment 1-3 is for the preparation of pharmaceutical composition provided by the invention.
According to the consumption shown in table 1 (all in weight portion), each material powder (raw material is ground to 110 orders after drying) is mixed, make respectively pharmaceutical composition A 1-A3.
Table 1
| ? | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| The drug regimen numbering | A1 | A2 | A3 |
| Semen Gleditsiae | 10 | 90 | 40 |
| Radix Et Rhizoma Nardostachyos | 30 | 40 | 90 |
| Herba Asari | 90 | 30 | 50 |
| Flos Chrysanthemi | 60 | 90 | 30 |
| The Pseudobulbus Bletillae (Rhizoma Bletillae) | 70 | 30 | 90 |
| The Radix Angelicae Dahuricae | 30 | 90 | 80 |
| Semen Ginkgo | 35 | 30 | 90 |
| Lignum Santali Albi | 45 | 90 | 30 |
| Rhizoma Polygonati Odorati | 55 | 30 | 90 |
| Deer pancreas | 90 | 80 | 85 |
| Deer oil | 10 | 20 | 15 |
| Semen phaseoli radiati | 90 | 10 | 50 |
Embodiment 4
Embodiment 4 is for the preparation of pill provided by the invention.
Add the water of 70 ℃ in the Chinese medicine composition A1 of embodiment 1 preparation, evenly be mixed to and be kneaded into the face piece.Wherein, take the gross weight of described active component and water as benchmark, the consumption of described active component is 30 % by weight, and the consumption of water is 70 % by weight.The face piece is put into pellet processing machine make impartial fritter pill, the weight of every is 10 grams, obtains pill B1.Obtain wrapping with the scraps of paper of bag medicine after pill, in the plastics pill container of packing into, sealing with wax that externalization is good is solid, in the packing box of packing into.
Embodiment 5
Embodiment 5 is for the preparation of pill provided by the invention.
Add the water of 90 ℃ in the Chinese medicine composition A2 of embodiment 2 preparations, evenly be mixed to and be kneaded into the face piece.Wherein, take the gross weight of described active component and water as benchmark, the consumption of described active component is 90 % by weight, and the consumption of water is 10 % by weight.The face piece is put into pellet processing machine make impartial fritter pill, the weight of every is 10 grams, obtains pill B2.Obtain wrapping with the scraps of paper of bag medicine after pill, in the plastics pill container of packing into, sealing with wax that externalization is good is solid, in the packing box of packing into.
Embodiment 6
Embodiment 6 is for the preparation of pill provided by the invention.
Add the water of 80 ℃ in the Chinese medicine composition A3 of embodiment 3 preparations, evenly be mixed to and be kneaded into the face piece.Wherein, take the gross weight of described active component and water as benchmark, the consumption of described active component is 80 % by weight, and the consumption of water is 20 % by weight.The face piece is put into pellet processing machine make impartial fritter pill, the weight of every is 10 grams, obtains pill B3.Obtain wrapping with the scraps of paper of bag medicine after pill, in the plastics pill container of packing into, sealing with wax that externalization is good is solid, in the packing box of packing into.
Embodiment 7
Embodiment 7 is used for explanation and the invention provides the effect of the pharmaceutical composition of thing.
(1) to the therapeutic effect of the melanin that causes after climacteric or trimester of pregnancy, chloasma, freckle, facial wrinkles.
Select 480 female patients with 25-65 year of in various degree mottle, wrinkle, chloasma, freckle symptom, be divided at random 12 treatment groups (every group of 40 patients).
Wherein 6 treatment groups are used respectively pharmaceutical composition A 1-A3 of the present invention or pill B1-B3, and external every day washes one's face each once sooner or later, each 10 grams, then coordinate every day for oral administration sooner or later respectively once, each 10 grams.The mode of pill external is: hot water bubbles open the Wen Houzai that dries in the air and washes one's face.Observing effect after 100 days, six effective percentage of organizing the course for the treatment of are respectively 93%, 94%, 98%, 96%, 96%, 97%.
All the other 6 treatment groups are used respectively pharmaceutical composition A 1-A3 of the present invention, pill B1-B3, and every day, external sooner or later washed one's face each once, each 10 grams.External, for oral administration.The mode of pill external is: hot water bubbles open the Wen Houzai that dries in the air and washes one's face.Observing effect after 100 days, six effective percentage of organizing the course for the treatment of are respectively 73%, 64%, 58%, 66%, 76%, 87%.Observing effect after 300 days, six effective percentage of organizing the course for the treatment of are respectively 93%, 94%, 98%, 96%, 96%, 97%.
The number that described effective percentage refers to after drug administration to demonstrate the patient of curative effect accounts for the percentage ratio of test total number of persons.
Described criterion of therapeutical effect is: with compare transference cure before medication, alleviate or improve.
As seen, the inside and outside used time simultaneously of pharmaceutical composition of the present invention and pill, better effects if is faster, and reason is that the traditional Chinese medical science thinks that it is that skin care is better crucial that interior accent is supported outward.Only the outer used time, effect is slow, but long-time application also can reach ideal effect.
(2) coarse to skin, skin pruritus, ichthyosis, skin poor flexibility, dark stagnant, sallow therapeutic effect.
Select 300 to have that skin is coarse in various degree, skin pruritus, ichthyosis, the skin poor flexibility, dark stagnant, the patient in sallow 35-65 year, be divided into 6 treatment groups (every group of 50 patients) at random.
These 6 treatment groups are used respectively pharmaceutical composition A 1-A3 of the present invention or pill B1-B3, external every day once, each 25 grams, the external method is: bath in a tub, said medicine is dissolved in after hot water bathing half an hour.Observing effect after 100 days, six effective percentage of organizing the course for the treatment of are respectively 93%, 96%, 98%, 93%, 96%, 95%.
The number that described effective percentage refers to after drug administration to demonstrate the patient of curative effect accounts for the percentage ratio of test total number of persons.
Described criterion of therapeutical effect is: with compare transference cure before medication, alleviate or improve.
As seen, pharmaceutical composition provided by the invention and pill can be treated dermatosis, protection people's appearance, the beauty of lifting skin.The mechanism of action is with outside interior supporting, desalination, and the cell metabolism of change and promotion human body, get rid of vivotoxin, is speckle dispelling, the drying of skin, and a best environment has been created in cell regeneration; Softening skin, supplement skin vigour simultaneously, improves the ability of skin glial cell water storage, lock water, promotes the corneocyte water content.In addition,, as cosmetic applications, can make skin instantaneous water profit sparkling and crystal-clear, water is tender pale, more rejuvenation.
Claims (10)
1. pharmaceutical composition, it is characterized in that, this pharmaceutical composition is comprised of following raw material: Semen Gleditsiae, Radix Et Rhizoma Nardostachyos, Herba Asari, Flos Chrysanthemi, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, Semen Ginkgo, Lignum Santali Albi, Rhizoma Polygonati Odorati, deer pancreas, deer oil and Semen phaseoli radiati, wherein, summation with respect to deer pancreas and the deer oil of 100 weight portions, the content of Radix Et Rhizoma Nardostachyos, Herba Asari, Flos Chrysanthemi, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, Semen Ginkgo, Lignum Santali Albi and Rhizoma Polygonati Odorati the 20-100 weight portion of respectively doing for oneself, the content of Semen Gleditsiae and the Semen phaseoli radiati 5-100 weight portion of respectively doing for oneself.
2. pharmaceutical composition according to claim 1, wherein, the weight ratio of described deer pancreas and deer oil is 2-10:1.
3. pharmaceutical composition according to claim 1, wherein, described raw material is powder, particle mean size is the 80-120 order.
4. pill, wherein, this pill contains active component, and described active component is the described pharmaceutical composition of any one in claim 1-3.
5. pill according to claim 4, wherein, the purity of described active component is more than 98 % by weight.
6. the preparation method of a pill, the method comprise with active component and water mix, molding, wherein, described active component is the described pharmaceutical composition of any one in claim 1-3.
7. method according to claim 6, wherein, take the gross weight of described active component and water as benchmark, the consumption of described active component is the 20-95 % by weight, the consumption of water is the 5-80 % by weight.
8. according to claim 6 or 7 described methods, wherein, the temperature 60-95 ℃ of described mixing.
9. the application of the described pharmaceutical composition of any one in the preparation dermopathic medicine for the treatment of or cosmetics in claim 1-3.
10. the application of the described pill of claim 4 or 5 in the preparation dermopathic medicine for the treatment of or cosmetics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110363634XA CN102416103B (en) | 2011-11-16 | 2011-11-16 | Pharmaceutical composition and pill and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110363634XA CN102416103B (en) | 2011-11-16 | 2011-11-16 | Pharmaceutical composition and pill and preparation method and application thereof |
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| CN102416103A CN102416103A (en) | 2012-04-18 |
| CN102416103B true CN102416103B (en) | 2013-11-13 |
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| CN201110363634XA Expired - Fee Related CN102416103B (en) | 2011-11-16 | 2011-11-16 | Pharmaceutical composition and pill and preparation method and application thereof |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR101998621B1 (en) * | 2017-11-08 | 2019-09-27 | 주식회사 바이오스탠다드 | Extraction method of deer fat mixed extract and cosmetic composition including the same |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1177475A (en) * | 1996-09-25 | 1998-04-01 | 李云生 | Beauty cream of removing blood-stasis |
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2011
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1177475A (en) * | 1996-09-25 | 1998-04-01 | 李云生 | Beauty cream of removing blood-stasis |
Non-Patent Citations (2)
| Title |
|---|
| 中药抑制黑素生成作用的研究进展;刘宁等;《四川中医》;20071115;第25卷(第11期);41-42 * |
| 刘宁等.中药抑制黑素生成作用的研究进展.《四川中医》.2007,第25卷(第11期),41-42. |
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| CN102416103A (en) | 2012-04-18 |
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Granted publication date: 20131113 Termination date: 20211116 |