CN102406966B - Scar repair material - Google Patents
Scar repair material Download PDFInfo
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- CN102406966B CN102406966B CN 201110384753 CN201110384753A CN102406966B CN 102406966 B CN102406966 B CN 102406966B CN 201110384753 CN201110384753 CN 201110384753 CN 201110384753 A CN201110384753 A CN 201110384753A CN 102406966 B CN102406966 B CN 102406966B
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- chitosan
- repair materials
- cicatrix
- cicatrix repair
- deacetylation
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- 230000008439 repair process Effects 0.000 title claims abstract description 97
- 239000000463 material Substances 0.000 title claims abstract description 93
- 231100000241 scar Toxicity 0.000 title abstract 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 113
- 229920001661 Chitosan Polymers 0.000 claims abstract description 73
- -1 polydimethylsiloxane Polymers 0.000 claims abstract description 43
- 239000004205 dimethyl polysiloxane Substances 0.000 claims abstract description 41
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims abstract description 41
- 229920001213 Polysorbate 20 Polymers 0.000 claims abstract description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 34
- 230000006196 deacetylation Effects 0.000 claims abstract description 31
- 238000003381 deacetylation reaction Methods 0.000 claims abstract description 31
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 24
- 210000000589 cicatrix Anatomy 0.000 claims description 111
- 238000013019 agitation Methods 0.000 claims description 39
- 238000004945 emulsification Methods 0.000 claims description 37
- 238000000034 method Methods 0.000 claims description 37
- 238000006467 substitution reaction Methods 0.000 claims description 14
- VFKZECOCJCGZQK-UHFFFAOYSA-M 3-hydroxypropyl(trimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCO VFKZECOCJCGZQK-UHFFFAOYSA-M 0.000 claims description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 9
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 9
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 9
- 230000000694 effects Effects 0.000 abstract description 11
- 102000012422 Collagen Type I Human genes 0.000 abstract description 4
- 108010022452 Collagen Type I Proteins 0.000 abstract description 4
- 230000036571 hydration Effects 0.000 abstract description 4
- 238000006703 hydration reaction Methods 0.000 abstract description 4
- 241000894006 Bacteria Species 0.000 abstract description 3
- 208000002260 Keloid Diseases 0.000 abstract description 3
- 206010023330 Keloid scar Diseases 0.000 abstract description 3
- 230000002401 inhibitory effect Effects 0.000 abstract description 3
- 210000001117 keloid Anatomy 0.000 abstract description 3
- 238000002360 preparation method Methods 0.000 abstract description 3
- 230000028327 secretion Effects 0.000 abstract description 2
- 208000032544 Cicatrix Diseases 0.000 abstract 3
- 230000037387 scars Effects 0.000 abstract 3
- 229940096422 collagen type i Drugs 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 102000001187 Collagen Type III Human genes 0.000 abstract 1
- 108010069502 Collagen Type III Proteins 0.000 abstract 1
- 206010072170 Skin wound Diseases 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000001804 emulsifying effect Effects 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 230000003020 moisturizing effect Effects 0.000 abstract 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 abstract 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 37
- 239000000080 wetting agent Substances 0.000 description 33
- 239000000499 gel Substances 0.000 description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 6
- 229910052710 silicon Inorganic materials 0.000 description 6
- 239000010703 silicon Substances 0.000 description 6
- 206010039580 Scar Diseases 0.000 description 5
- 230000006870 function Effects 0.000 description 4
- 238000007789 sealing Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Materials For Medical Uses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
The invention discloses a scar repair material. A preparation method comprises the following steps of: dissolving water-soluble chitosan in water or dissolving chitosan with the deacetylation degree of 75 to 97 percent in an acetic acid aqueous solution under stirring, adding polyoxyethylene sorbitan monolaurate with an emulsifying effect and glycerin with a moisturizing effect, and uniformly mixing to obtain a transparent gel-like solution; and adding polydimethylsiloxane into the gel-like solution under homogenizing, and uniformly mixing to obtain the scar repair material. The scar repair material can actively and passively moisture skin, has a hydration effect on scar skin, has a good repair effect, has an effect of resisting and inhibiting bacteria, has a good effect of resisting and inhibiting the bacteria on the surfaces of scars and outside the scars, has an effect of accelerating skin wound healing, can have a good effect of repairing and protecting fine cracks on the surfaces of the scars, and can inhibit the secretion of collagen type I in keloid skin to reduce the proportion of the collagen type I or collagen type III.
Description
Technical field
The present invention relates to a kind of biomaterial for medical purpose, particularly relate to a kind of cicatrix repair materials.
Background technology
The product of selling the treatment cicatrix in the market mostly is the reparation subsides of silica gel cicatrix or the silicon gel cicatrix repairing paste of the single component of being made by polysiloxanes; this series products is by the sealing of silica gel to skin to the action principle of cicatrix reparation; form the protecting film of permeable watertight; the moisture at cicatrix place is outwards distributed, repair cicatrix thereby form hydration with skin.But this series products has the following disadvantages: a, passive sealing moisture, cicatrix skin is not had initiatively moisture preserving function, and by to the hydration of cicatrix skin and passive reparation cicatrix, rather than initiatively promote the change of cicatrix skin texture; B, silicon gel sealing cicatrix skin are not subjected to extraneous bacterial infection, and do not have active to killing bacteria or the inhibitory action on cicatrix surface; The epiderm skin on c, cicatrix body (cicatrix or keloid behind the burn and scald) surface is incomplete in fact, has probably to be difficult for fine cracks and the infection that naked eyes are discovered, and simple silicon gel preparation can not be repaired these trickle inflammation; D, it does not have clear and definite direct action and efficacy to fibroblast and the collagen fiber that suppress in the cicatrix body.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, provide a kind of can be initiatively to skin moisture-keeping, the cicatrix repair materials of anti-, bacteriostasis efficacy, quickening union of wounded skin is arranged.
Technical scheme of the present invention is summarized as follows:
A kind of cicatrix repair materials, make with following method: 0.5-5 mass parts water-soluble chitosan under agitation being dissolved in 10-100 part water or the chitosan of 0.5-5 mass parts deacetylation 75-97% under agitation is dissolved in 10-100 part mass concentration is in the aqueous acetic acid of 1-5%, 1～3 mass parts polyoxyethylene 20 sorbitan monolaurate that has added emulsification, 5～10 mass parts play the glycerol of moisture-keeping function, mix homogeneously gets transparent gel-form solution; Under homogenizing 20～90 mass parts polydimethylsiloxane are joined in the described gelatinous solution, mix homogeneously namely obtains a kind of cicatrix repair materials.
Described water-soluble chitosan is: carboxymethyl chitosan, hydroxypropyltrimethyl ammonium chloride chitosan, chitosan lactate, chitosan hydrochlorate, chitosan acetate or oligochitosan.
The substitution value of described carboxymethyl chitosan is 60%-100%.
The substitution value of described hydroxypropyltrimethyl ammonium chloride chitosan is 80%-110%.
The deacetylation of described chitosan lactate is 70%-95%; The deacetylation of described chitosan hydrochlorate is 70%-95%; The deacetylation of described chitosan acetate is 70%-95%;
The molecular weight of described oligochitosan is 500-10000
The deacetylation of described chitosan is 85%-95%.
The kinematic viscosity of polydimethylsiloxane is preferably 20000～100000cst, preferably 40000～80000cst.
Advantage of the present invention:
For improving the deficiency that existing silica type product is repaired cicatrix, a kind of cicatrix repair materials of the present invention has the advantage of chitosan (or water-soluble chitosan) and silicon gel, cicatrix is had complement each other and collaborative repair, and its effect is:
1, cicatrix repair materials of the present invention can be active and passive to skin moisture-keeping, and cicatrix skin is had hydration, and repair is better;
2, initiatively anti-, antibacterial effect is arranged, to cicatrix surface and outside antibacterial anti-, to press down effect strong;
3, have the effect of accelerating union of wounded skin, being used for the cicatrix surface can have reparation and protective effect preferably to fine cracks and the infection on cicatrix surface;
4, can suppress the secretion of collagen I type in the keloid skin, thereby reduce the ratio of collagen I type/III type, thereby the reparation of cicatrix is had positive effect.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1
A kind of cicatrix repair materials, make with following method: be that 60% carboxymethyl chitosan 1g under agitation is dissolved in the 60g water with substitution value, added the polyoxyethylene 20 sorbitan monolaurate 2g of emulsification, wetting agent glycerol 5g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 40g that with kinematic viscosity is 40000cst under homogenizing joins in the gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 2
A kind of cicatrix repair materials, make with following method: be that 90% carboxymethyl chitosan 4g under agitation is dissolved in the 80g water with substitution value, added the polyoxyethylene 20 sorbitan monolaurate 2g of emulsification, play the glycerol 8g of moisture-keeping function, mixing gets transparent gelatinous solution; The polydimethylsiloxane 50g that with kinematic viscosity is 100000cst under homogenizing joins in the described gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 3
A kind of cicatrix repair materials, make with following method: the carboxymethyl chitosan 0.5g of substitution value 100% under agitation is dissolved in the 10g water, has added the polyoxyethylene 20 sorbitan monolaurate 1g of emulsification, play the glycerol 10g of moisture-keeping function, mixing gets transparent gelatinous solution; The polydimethylsiloxane 20g that with kinematic viscosity is 80000cst under homogenizing joins in the gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 4
A kind of cicatrix repair materials, make with following method: the carboxymethyl chitosan 3g of substitution value 75% under agitation is dissolved in the 95g water, has added the polyoxyethylene 20 sorbitan monolaurate 3g of emulsification, wetting agent glycerol 8g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 85g that with kinematic viscosity is 20000cst under homogenizing joins in the described gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 5
A kind of cicatrix repair materials, make with following method: be that 65% carboxymethyl chitosan 5g under agitation is dissolved in the 100g water with substitution value, added the polyoxyethylene 20 sorbitan monolaurate 3g of emulsification, wetting agent glycerol 9g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 90g that with kinematic viscosity is 70000cst under homogenizing joins in the described gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 6
A kind of cicatrix repair materials, make with following method: be that 80% hydroxypropyltrimethyl ammonium chloride chitosan 1g under agitation is dissolved in the 60g water with substitution value, added the polyoxyethylene 20 sorbitan monolaurate 2g of emulsification, wetting agent glycerol 5g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 40g that with kinematic viscosity is 40000cst under homogenizing joins in the gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 7
A kind of cicatrix repair materials, make with following method: be that 100% hydroxypropyltrimethyl ammonium chloride chitosan 4g under agitation is dissolved in the 80g water with substitution value, the polyoxyethylene 20 sorbitan monolaurate 2g that has added emulsification, wetting agent glycerol 8g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 50g that with kinematic viscosity is 100000cst under homogenizing joins in the described gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 8
A kind of cicatrix repair materials, make with following method: the hydroxypropyltrimethyl ammonium chloride chitosan 0.5g of substitution value 90% under agitation is dissolved in the 10g water, the polyoxyethylene 20 sorbitan monolaurate 1g that has added emulsification, wetting agent glycerol 10g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 20g that with kinematic viscosity is 80000cst under homogenizing joins in the gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 9
A kind of cicatrix repair materials, make with following method: the hydroxypropyltrimethyl ammonium chloride chitosan 3g of substitution value 85% under agitation is dissolved in the 95g water, has added the polyoxyethylene 20 sorbitan monolaurate 3g of emulsification, wetting agent glycerol 8g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 85g that with kinematic viscosity is 20000cst under homogenizing joins in the described gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 10
A kind of cicatrix repair materials, make with following method: be that 110% hydroxypropyltrimethyl ammonium chloride chitosan 5g under agitation is dissolved in the 100g water with substitution value, the polyoxyethylene 20 sorbitan monolaurate 3g that has added emulsification, wetting agent glycerol 9g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 90g that with kinematic viscosity is 70000cst under homogenizing joins in the described gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 11
A kind of cicatrix repair materials, make with following method: the chitosan lactate 1g of deacetylation 70% under agitation is dissolved in the 60g water, has added the polyoxyethylene 20 sorbitan monolaurate 2g of emulsification, wetting agent glycerol 5g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 40g that with kinematic viscosity is 40000cst under homogenizing joins in the gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 12
A kind of cicatrix repair materials, make with following method: the chitosan lactate 4g of deacetylation 85% under agitation is dissolved in the 80g water, has added the polyoxyethylene 20 sorbitan monolaurate 2g of emulsification, wetting agent glycerol 8g, mixing gets transparent gelatinous solution; Kinematic viscosity is that the polydimethylsiloxane 50g of 100000cst joins in the described gelatinous solution under homogenizing, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 13
A kind of cicatrix repair materials, make with following method: the chitosan lactate 0.5g of deacetylation 90% under agitation is dissolved in the 10g water, has added the polyoxyethylene 20 sorbitan monolaurate 1g of emulsification, wetting agent glycerol 10g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 20g that with kinematic viscosity is 80000cst under homogenizing joins in the gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 14
A kind of cicatrix repair materials, make with following method: the chitosan lactate 3g of deacetylation 75% under agitation is dissolved in the 95g water, has added the polyoxyethylene 20 sorbitan monolaurate 3g of emulsification, wetting agent glycerol 8g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 85g that with kinematic viscosity is 20000cst under homogenizing joins in the described gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 15
A kind of cicatrix repair materials, make with following method: the chitosan lactate 5g of deacetylation 95% under agitation is dissolved in the 100g water, has added the polyoxyethylene 20 sorbitan monolaurate 3g of emulsification, wetting agent glycerol 9g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 90g that with kinematic viscosity is 70000cst under homogenizing joins in the described gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials
Embodiment 16
A kind of cicatrix repair materials, make with following method: the chitosan hydrochlorate 1g of deacetylation 70% under agitation is dissolved in the 60g water, has added the polyoxyethylene 20 sorbitan monolaurate 2g of emulsification, wetting agent glycerol 5g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 40g that with kinematic viscosity is 40000cst under homogenizing joins in the gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 17
A kind of cicatrix repair materials, make with following method: the chitosan hydrochlorate 4g of deacetylation 85% under agitation is dissolved in the 80g water, has added the polyoxyethylene 20 sorbitan monolaurate 2g of emulsification, wetting agent glycerol 8g, mixing gets transparent gelatinous solution; Kinematic viscosity is that the polydimethylsiloxane 50g of 100000cst joins in the described gelatinous solution under homogenizing, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 18
A kind of cicatrix repair materials, make with following method: the chitosan hydrochlorate 0.5g of deacetylation 90% under agitation is dissolved in the 10g water, has added the polyoxyethylene 20 sorbitan monolaurate 1g of emulsification, wetting agent glycerol 10g, mixing gets transparent gelatinous solution; Motion is that the polydimethylsiloxane 20g of 80000cst joins in the gelatinous solution with viscosity under homogenizing, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 19
A kind of cicatrix repair materials, make with following method: the chitosan hydrochlorate 3g of deacetylation 75% under agitation is dissolved in the 95g water, has added the polyoxyethylene 20 sorbitan monolaurate 3g of emulsification, wetting agent glycerol 8g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 85g that with kinematic viscosity is 20000cst under homogenizing joins in the described gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 20
A kind of cicatrix repair materials, make with following method: the chitosan hydrochlorate 5g of deacetylation 95% under agitation is dissolved in the 100g water, has added the polyoxyethylene 20 sorbitan monolaurate 3g of emulsification, wetting agent glycerol 9g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 90g that with kinematic viscosity is 70000cst under homogenizing joins in the described gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials
Embodiment 21
A kind of cicatrix repair materials, make with following method: the chitosan acetate 1g of deacetylation 70% under agitation is dissolved in the 60g water, has added the polyoxyethylene 20 sorbitan monolaurate 2g of emulsification, wetting agent glycerol 5g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 40g that with kinematic viscosity is 40000cst under homogenizing joins in the gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 22
A kind of cicatrix repair materials, make with following method: the chitosan acetate 4g of deacetylation 85% under agitation is dissolved in the 80g water, has added the polyoxyethylene 20 sorbitan monolaurate 2g of emulsification, wetting agent glycerol 8g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 50g that with kinematic viscosity is 100000cst under homogenizing joins in the described gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 23
A kind of cicatrix repair materials, make with following method: the chitosan acetate 0.5g of deacetylation 90% under agitation is dissolved in the 10g water, has added the polyoxyethylene 20 sorbitan monolaurate 1g of emulsification, wetting agent glycerol 10g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 20g that with kinematic viscosity is 80000cst under homogenizing joins in the gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 24
A kind of cicatrix repair materials, make with following method: the chitosan acetate 3g of deacetylation 75% under agitation is dissolved in the 95g water, has added the polyoxyethylene 20 sorbitan monolaurate 3g of emulsification, wetting agent glycerol 8g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 85g that with kinematic viscosity is 20000cst under homogenizing joins in the described gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 25
A kind of cicatrix repair materials, make with following method: the chitosan acetate 5g of deacetylation 95% under agitation is dissolved in the 100g water, has added the polyoxyethylene 20 sorbitan monolaurate 3g of emulsification, wetting agent glycerol 9g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 90g that with kinematic viscosity is 70000cst under homogenizing joins in the described gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials
Embodiment 26
A kind of cicatrix repair materials, make with following method: be that 2500 oligochitosan 1g under agitation is dissolved in the 60g water with molecular weight, added the polyoxyethylene 20 sorbitan monolaurate 2g of emulsification, wetting agent glycerol 5g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 40g that with kinematic viscosity is 40000cst under homogenizing joins in the gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 27
A kind of cicatrix repair materials, make with following method: be that 5000 oligochitosan 4g under agitation is dissolved in the 80g water with molecular weight, added the polyoxyethylene 20 sorbitan monolaurate 2g of emulsification, wetting agent glycerol 8g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 50g that with kinematic viscosity is 100000cst under homogenizing joins in the described gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 28
A kind of cicatrix repair materials, make with following method: be that 10000 oligochitosan 0.5g under agitation is dissolved in the 10g water with molecular weight, added the polyoxyethylene 20 sorbitan monolaurate 1g of emulsification, wetting agent glycerol 10g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 20g that with kinematic viscosity is 80000cst under homogenizing joins in the gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 29
A kind of cicatrix repair materials, make with following method: be that 9000 oligochitosan 3g under agitation is dissolved in the 95g water with molecular weight, added the polyoxyethylene 20 sorbitan monolaurate 3g of emulsification, wetting agent glycerol 8g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 85g that with kinematic viscosity is 20000cst under homogenizing joins in the described gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 30
A kind of cicatrix repair materials, make with following method: be that 500 oligochitosan 5g under agitation is dissolved in the 100g water with molecular weight, added the polyoxyethylene 20 sorbitan monolaurate 3g of emulsification, wetting agent glycerol 9g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 90g that with kinematic viscosity is 70000cst under homogenizing joins in the described gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 31
A kind of cicatrix repair materials, make with following method: be that under agitation to be dissolved in the 80g mass concentration be in 2% the aqueous acetic acid for 85% chitosan 2g with deacetylation, the polyoxyethylene 20 sorbitan monolaurate 2g that has added emulsification, wetting agent glycerol 5g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 40g that with kinematic viscosity is 40000cst under homogenizing joins in the gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 32
A kind of cicatrix repair materials, make with following method: be that under agitation to be dissolved in the 100g mass concentration be in 5% the aqueous acetic acid for 95% chitosan 5g with deacetylation, the polyoxyethylene 20 sorbitan monolaurate 3g that has added emulsification, wetting agent glycerol 10g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 90g that with kinematic viscosity is 100000cst under homogenizing joins in the described gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 33
A kind of cicatrix repair materials, make with following method: be that under agitation to be dissolved in the 10g mass concentration be in 1% the aqueous acetic acid for 75% chitosan 0.5g with deacetylation, the polyoxyethylene 20 sorbitan monolaurate 1g that has added emulsification, wetting agent glycerol 7g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 20g that with kinematic viscosity is 80000cst under homogenizing joins in the gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 34
A kind of cicatrix repair materials, make with following method: be that under agitation to be dissolved in the 75g mass concentration be in 2% the aqueous acetic acid for 97% chitosan 3g with deacetylation, the polyoxyethylene 20 sorbitan monolaurate 2g that has added emulsification, wetting agent glycerol 8g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 50g that with kinematic viscosity is 20000cst under homogenizing joins in the described gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
Embodiment 35
A kind of cicatrix repair materials, make with following method: be that under agitation to be dissolved in the 70g mass concentration be in 3% the aqueous acetic acid for 80% chitosan 2g with deacetylation, the polyoxyethylene 20 sorbitan monolaurate 2g that has added emulsification, wetting agent glycerol 9g, mixing gets transparent gelatinous solution; The polydimethylsiloxane 60g that with kinematic viscosity is 70000cst under homogenizing joins in the described gelatinous solution, and mix homogeneously namely obtains a kind of cicatrix repair materials.
The contrast of clinical trial effect:
Get silicon gel (polysiloxanes and silicon dioxide are formed, and hereinafter to be referred as the silicon gel, are produced by United States advanced Bioisystech Co., Ltd);
The water-soluble chitosan of getting molecular weight 200000 adds the chitosan gel rubber (hereinafter to be referred as chitosan gel rubber) that is mixed with 5% concentration in the purified water in proportion;
Get the cicatrix repair materials of the present invention's preparation;
Do empyrosis wound surface healing back (three months to half a year, 10-30 one full year of life), the test of projection hypertrophy cicatrix clinical comparison, all clinical observation is six months, every kind of sample uses and is every day three times, spread upon the cicatrix surface gently, do not do wrapping, the every kind of sample in every square centimeter of cicatrix surface is evenly smeared 0.05g at every turn.Comparing result following (this paper only is listed as the change indicator of having got quantifiable cicatrix height, and do not list color, hardness, the index of the difficult quantifications such as pain, patient's sensation of itching):
The result shows that cicatrix repair materials of the present invention has played obviously collaborative effect of repairing to cicatrix, and its clinical result of use realization is compared with matched group has utmost point significant difference, P＜0.01.
Claims (9)
1. cicatrix repair materials, it is characterized in that making with following method: 0.5-5 mass parts water-soluble chitosan under agitation being dissolved in 10-100 part water or the chitosan of 0.5-5 mass parts deacetylation 75-97% under agitation is dissolved in 10-100 part mass concentration is in the aqueous acetic acid of 1-5%, 1～3 mass parts polyoxyethylene 20 sorbitan monolaurate that has added emulsification, 5～10 mass parts play the glycerol of moisture-keeping function, mix homogeneously gets transparent gel-form solution; Under homogenizing 20～90 mass parts polydimethylsiloxane are joined in the described gelatinous solution, mix homogeneously namely obtains a kind of cicatrix repair materials.
2. a kind of cicatrix repair materials according to claim 1 is characterized in that described water-soluble chitosan is: carboxymethyl chitosan, hydroxypropyltrimethyl ammonium chloride chitosan, chitosan lactate, chitosan hydrochlorate or chitosan acetate.
3. a kind of cicatrix repair materials according to claim 2, the substitution value that it is characterized in that described carboxymethyl chitosan is 60%-100%.
4. a kind of cicatrix repair materials according to claim 2, the substitution value that it is characterized in that described hydroxypropyltrimethyl ammonium chloride chitosan is 80%-110%.
5. a kind of cicatrix repair materials according to claim 2, the deacetylation that it is characterized in that described chitosan lactate is 70%-95%; The deacetylation of described chitosan hydrochlorate is 70%-95%; The deacetylation of described chitosan acetate is 70%-95%.
6. a kind of cicatrix repair materials according to claim 2, the molecular weight that it is characterized in that described oligochitosan is 500-10000.
7. a kind of cicatrix repair materials according to claim 1, the deacetylation that it is characterized in that described chitosan is 85%-95%.
8. a kind of cicatrix repair materials according to claim 1, the kinematic viscosity that it is characterized in that described polydimethylsiloxane is 20000～100000cst.
9. a kind of cicatrix repair materials according to claim 8, the kinematic viscosity that it is characterized in that described polydimethylsiloxane is 40000～80000cst.
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| CN 201110384753 CN102406966B (en) | 2010-12-07 | 2011-11-28 | Scar repair material |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010105770796A CN102008757A (en) | 2010-12-07 | 2010-12-07 | Scar repair material |
| CN201010577079.6 | 2010-12-07 | ||
| CN 201110384753 CN102406966B (en) | 2010-12-07 | 2011-11-28 | Scar repair material |
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| CN 201110384753 Active CN102406966B (en) | 2010-12-07 | 2011-11-28 | Scar repair material |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102210886A (en) * | 2011-06-08 | 2011-10-12 | 湖南恒邦医疗科技有限公司 | Scar removal gel composition and preparation method thereof |
| RU2535141C1 (en) * | 2013-04-08 | 2014-12-10 | Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Саратовский Государственный Университет Имени Н.Г. Чернышевского" | Gel composition of wide spectrum of biological action |
| CN103341216B (en) * | 2013-06-04 | 2014-12-10 | 青岛中腾生物技术有限公司 | Scar-removing repairing material and preparation method thereof |
| RU2545991C2 (en) * | 2013-07-18 | 2015-04-10 | Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Нижегородский Государственный Университет Им. Н.И. Лобачевского" | Haemostatic agent |
| CN103393712B (en) * | 2013-08-02 | 2015-12-02 | 江苏斯微特医药科技有限公司 | Natural polysaccharide cytothesis spray and preparation method thereof |
| CN104382843B (en) * | 2014-10-28 | 2017-03-29 | 天津嘉氏堂科技有限公司 | A kind of skin repair gel |
| CN104983585B (en) * | 2015-06-18 | 2018-09-25 | 天津嘉氏堂科技有限公司 | A kind of scar sun-proof Silica hydrogel and preparation method |
| CN108126236B (en) * | 2017-12-20 | 2021-01-01 | 浙江科技学院 | Medicine coating material and preparation method thereof |
| CN108403737A (en) * | 2018-05-29 | 2018-08-17 | 吴敏 | A kind of scar repairs gel and preparation method thereof |
| CN108403736A (en) * | 2018-05-29 | 2018-08-17 | 吴敏 | A kind of pure natural burn wound repairs gel and preparation method thereof |
| CN108403530A (en) * | 2018-05-29 | 2018-08-17 | 吴敏 | A kind of burn wound of pure plant formula repairs gel and preparation method thereof |
| CN108498402A (en) * | 2018-05-29 | 2018-09-07 | 吴敏 | A kind of scar of pure natural plant formula repairs gel and preparation method thereof |
| CN108498403A (en) * | 2018-05-29 | 2018-09-07 | 吴敏 | A kind of burn wound reparation gel and preparation method thereof containing plant extracts |
| CN108379313A (en) * | 2018-05-29 | 2018-08-10 | 吴敏 | A kind of burn wound repairs gel and preparation method thereof |
| CN110664660A (en) * | 2019-10-18 | 2020-01-10 | 瑞希(重庆)生物科技有限公司 | Scar-resistant composition and preparation method thereof |
| CN112646240B (en) * | 2020-12-10 | 2021-11-30 | 中国地质大学（武汉） | Nano chitin composite aerogel and preparation method and application thereof |
| CN113520991B (en) * | 2021-07-12 | 2024-01-26 | 中山创天生物科技有限公司 | Nano biological gel for blocking scar formation and reverse repair regulation and preparation method thereof |
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| CN101028535A (en) * | 2006-02-27 | 2007-09-05 | 权力敏 | Chitose coating with medical biological material |
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| CN102008757A (en) | 2011-04-13 |
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