CN108403737A - A kind of scar repairs gel and preparation method thereof - Google Patents

A kind of scar repairs gel and preparation method thereof Download PDF

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CN108403737A
CN108403737A CN201810532542.1A CN201810532542A CN108403737A CN 108403737 A CN108403737 A CN 108403737A CN 201810532542 A CN201810532542 A CN 201810532542A CN 108403737 A CN108403737 A CN 108403737A
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants

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Abstract

The invention discloses a kind of scars to repair gel and preparation method thereof, and it includes following component which, which repairs gel by weight,：70 90 parts of the fruit of west place in Hubei winterhazel, 155 175 parts of the petal of Nanchuan Pilea notata, 40 60 parts of the blade of soft Androsace umbellata, 55 parts of dimethicone, 360 parts of water.The scar is made by a series of preparation processes and repairs gel.The present invention repairs scar obvious effect, and natural safety, without side-effects to skin, without secondary injury.

Description

A kind of scar repairs gel and preparation method thereof
Technical field
The present invention relates to a kind of scars to repair gel and preparation method thereof, belongs to cosmetic technical field.
Background technology
Burn wound is by high temperature, electricity, chemical substance or by the product after tissue damage caused by strong heat radiation, wound A kind of inevitable outcome of normal inevitable physiological reaction and wound healing process during mouth or surface of a wound normal healing.Cause Age size, individual difference, burn surface area size and the surface of a wound depth are different, and it is heavy that different degrees of pigment is had after wound healing It, scar hyperplasia.Burn wound not only damages appearance, can also hinder and the physiological function of linked groups or organ.
The measure that the prior art copes with burn wound treatment is mostly by treatments such as laser, freezing, radiation, drug, Chinese medicines Method, but these all have intense stimulus to skin, are accidentally easy to cause sequelae and dependence.Therefore the present invention is intended to seek a kind of scar Trace, which repairs gel, can solve the deficiencies in the prior art, can effectively remove scar desalination scar.
Invention content
The object of the present invention is to provide a kind of scars to repair gel and preparation method thereof, it can make skin area skin fast Quick-recovery original state.Scar reparation gel effect is apparent, quick, natural safety.
The present invention to achieve the goals above, using following technical scheme：
A kind of scar reparation gel, it is characterised in that the scar repairs the raw material that gel includes following parts by weight：
70-90 parts of the fruit of west place in Hubei winterhazel, preferred weight part ranging from 75-82；
155-175 parts of the petal of Nanchuan Pilea notata, preferred weight part ranging from 157-165；
40-60 parts of the blade of soft Androsace umbellata, preferred weight part ranging from 45-53；
55 parts of dimethicone, 360 parts of water
A kind of scar repairs the preparation method of gel, it is characterised in that includes the following steps：
(1) by the fruit 70-90 parts by weight of west place in Hubei winterhazel, the petal 155-175 parts by weight of Nanchuan Pilea notata, soft point The blade 40-60 parts by weight of ground plum are put into baking oven, and oven temperature is set as 40 DEG C, is taken out after 7 hours, obtains dry plant Tissue, it is spare：
(2) by through (1) step drying after plant tissue in be added 400 parts by weight 95% ethyl alcohol impregnate 5 hours, then Plant tissue taking-up is placed in 30 DEG C of draught cupboards and is dried 16 hours, it is spare；
(3) plant tissue that (2) step obtains is put into the limewash that mass fraction is 9% and is impregnated 12 hours, taken out Clear water rinsed clean is used afterwards, and residual moisture is blotted with filter paper, it is spare；
(4) plant tissue that (3) step obtains is put into mortar and is ground into pureed, obtain pureed mixture, stand 3 days Filtered through gauze is used afterwards, stays supernatant, it is spare；
(5) supernatant for obtaining (4) step stands 8 days in 4 DEG C of refrigerators, be then placed in centrifuge with 5000 turns/ The speed of minute centrifuges 35 minutes, and supernatant is sucked out with syringe after taking-up, discards precipitation, by supernatant and 360 parts by weight After water, the mixing of 55 parts by weight dimethicones, 60 DEG C of water-bath water-baths 1 hour are put into, and stir evenly and repaiied to get to the scar Multiple gel.
In the present invention, function additive, west place in Hubei winterhazel (Classification system are wanted based on three kinds of plants：Corylopsis Henryi Hemsl.) it is Hamamelidaceae winterhazel category machaka, infructescence is 5-6 centimetres long, capsule oval, 6-7 millimeters long, The fruit for the west place in Hubei winterhazel used in the present invention picks up from STRUCTURES IN EAST SICHUAN Wan County；Nanchuan Pilea notata (Classification system：Pilea Nanchuanensis C.J.Chen) it is the tall and big draft of Urticaceae Pilea, the pairs of axillary of inflorescence, poly- umbrella is coniform, and tool is short The petal of stalk, 2-4 centimetres long, the month at florescence 5-6, the Nanchuan Pilea notata used in of the invention picks up from Sichuan Nanchuan；Soft Androsace umbellata (Classification system：Androsace mollis Hand.-Mazz.) it is Primulaceae Androsace umbellata category perennial herb, rosulated leaf 8-15 millimeters of diameter of clump, leaf are in unconspicuous amphitypy, and the outer layer leaf cochlear of falling ovate, herbaceous stem is 2.5-5 millimeters long, wide 1.5-2 millis Rice, internal layer leaf obovate or the cochlear of falling ovate, it is 5-7 millimeters long, it is 2-2.5 millimeters wide, the soft Androsace umbellata used in the present invention Blade picks up from Yunnan Deqie hillside hayashishita, 3000-4000 meters of height above sea level.The dimethicone brand used in the present invention is road health Rather, viscosity 350 are purchased from excellent rope sample Xiao Lindian.
The baking oven brand used in the preparation process (1) of scar reparation gel of the present invention is SHELLAB, model SM05- 2, it is purchased from Zao Xin business corporations；The draught cupboard brand used in preparation process (2) is that skill thinks height, model SPD-3A1, purchase From Yi Si High Seience Technology Co., Ltd. of Singapore；The centrifuge brand used in preparation process (5) be Hunan instrument, model H2100R, Purchased from Xiang Yi centrifuges Instrument Ltd., the water-bath brand used is rich fast, and model HH.S11-8 is won fast purchased from Shanghai Medical bio-instruments limited liability company.
Properties of product evaluation test of the present invention is as follows：
One, skin irritation test：
Select 2.5~3kg healthy rabbits 60, every rabbit back is symmetrical to select shaving 2.5cm2 at 20, right with itself According to test method(s) carry out, every time apply 4g products of the present invention, twice daily, left or right side is smeared at random, observe and record for 24 hours, 72h The reacting phenomenon of skin afterwards.
The result shows that：It applies product of the present invention and has no that the local stimulations such as rubefaction, dermexanthesis, water lump are reacted for 24 hours, after 72h, say It is to be perfectly safe that bright scar of the present invention, which repairs gel, without any adverse reactions.
Two, efficacy validation
It is Jiangxi Province Nanchang to select 180 health to have the volunteer of burn wound, each 90 people of men and women, test site without disease City, the above volunteer is checked by the hospital dermatology department expert of Nanchang City, Jiangxi Province ten to be complied with standard and selects, and is non-scar Constitution, these volunteer's depth of burn are shallow two degree, and burn surface area is mild burn, and are the 15-30 after wound healing In it, wound is all uninfected by, and burn can be classified as follows by depth of burn and burn surface area：One, it is divided by depth of burn：
I degree (erythema)：Up to horny layer of epidermis, red and swollen heat pain, hyperesthesia, furfur is fully recovered after dry tack free 1 week, no scar Trace.
Light degree Ⅱ：Up to high dermis, part germinal layer is alive, severe pain, hyperesthesia, has blister, basal part is in uniformly red Color, humidity, local swelling are healed for 1~2 week, and no scar has pigmentation.
It is II degree deep：Up to corium deep layer, there are the appendages of skin to remain analgesis, there is blister, substrate is pale, has red grouper Point heals for moist 3~4 weeks, can there is scar.
III degree (eschar)：Up to skin holostrome, or even subcutaneous tissue is injured, muscle and bone analgesis are inelastic, hard Such as leather sample, wax is white sallow or carbonizes, dry.Venae subcutaneae obstruction such as 2~4 weeks eschars of dendroid fall off after dry, form granulation The surface of a wound, in addition to small area, being generally both needed to skin-grafting could heal, and can form scar and cicatricial contracture.
It is divided by burn surface area：
Mild burn：II degree or less the burn gross area is below 9%；
Moderate burn：II degree of burn surface area 10%~29% or III degree of burn surface area are less than 10%；
Severe burn：The gross area 30%~49% or III degree of burn surface area 10%~19% or II degree, III degree of burn surface area Though not reaching above-mentioned percentage, complication, the burns of respiratory tract such as shock has occurred or having heavier combined injury；
Severe burn：50% or more the gross area or III degree of 20% or more or existing severe complication of burn.
The depth of burn selected by the above standard is shallow two degree, burn surface area is 180 volunteers of mild burn 15 groups are divided into, 14 groups are test group, and 1 group is control group, every group of 12 people, each 6 people of male and female, control group volunteer's scar Trace is without any processing, and test group volunteer uses product of the present invention, is numbered to every volunteer, and colour atla and face are used before testing The most deep skin area of color compares, and records the most deep scar colour of skin number of each human face's color.By product when on-test It is applied at every volunteer's face scar of test group, once in the morning and once at night, each usage amount is 4-5g, is massaged into absorption, Continuous use 150 days is compared using the colour atla skin area most deep with experiment front face color after the test, and the record colour of skin is compiled Number, and every volunteer of continuous observation 270 days randomly selects five area skins at scar, respectively with it is random around scar The skin for choosing three positions is compared with colour atla, and skin coloration is consistent and difference in brightness is to restore in once range, record Every volunteer's face scar restores the normal skin required time completely, is not counted in wherein using 150 days of product.Colour atla The name of an article is that PANTONE coloured silks lead to the colour of skinTMGuide, brand PANTONE, model STG201, manufacturer are located at the U.S..The logical skin of coloured silk Color guide [PANTONE SkinTone Guide] is according to the thousands of kinds of practical colours of skin in the various human skin types of scientific measurement And it works out.It aims at reproduction to formulate closest to the entity colour of skin, which is the complete visual reference of human skin, is suitable for the colour of skin Relevant any market is unique international color standard of the accurate matching colour of skin.Each color logical colour of skin guide number is by four Position alphanumeric composition, front two refer to skin coloration or background color, and latter two refer to skin color or brightness.In addition, during experiment Diet work and rest custom according to volunteer itself usually, do not require deliberately, if great disease occurs for personnel during experiment Disease or other accidents can not continue experiment, should stop the experiment of the people, and other staff carry out as usual.
Specific implementation mode
Embodiment 1-14 is test group, and embodiment 15 is control group, 12 people of number is tested per embodiment, each 6 people of men and women is right Without any processing according to group volunteer's scar, test group volunteer uses product of the present invention, numbers to every volunteer, makes before experiment It is compared with the colour atla skin area most deep with facial color, records the most deep scar colour of skin number experiment opening of each human face's color Product is applied at every volunteer's face scar of test group when the beginning, once in the morning and once at night, each usage amount is 4-5g, is pressed It rubs to absorption, is used continuously 150 days, is compared after the test using the colour atla skin area most deep with experiment front face color, Record colour of skin number, and every volunteer of continuous observation 270 days, five area skins randomly selected at scar, respectively with scar The skin that three positions are randomly selected around trace is compared with colour atla, and skin coloration is consistent and difference in brightness is in once range To restore, records every volunteer's face scar and restore the normal skin required time completely, disregarded using 150 days of product Enter wherein.The colour atla name of an article is that PANTONE coloured silks lead to the colour of skinTMGuide, brand PANTONE, model STG201, manufacturer are located at The U.S..The logical colour of skin guide [PANTONE SkinTone Guide] of coloured silk is according to thousands of in the various human skin types of scientific measurement It plants the practical colour of skin and works out.Reproduction is aimed to formulate closest to the entity colour of skin, which is the complete visual reference of human skin, It is unique international color standard of the accurate matching colour of skin suitable for the relevant any market of the colour of skin.Each color logical colour of skin refers to South number is made of four alphanumerics, and front two refers to skin coloration or background color, and latter two refer to skin color or brightness.In addition, The custom that diet during experiment is worked and rested according to volunteer itself usually, does not require deliberately, if personnel during experiment Major disease or other accidents, which occurs, can not continue experiment, should stop the experiment of the people, and other staff carry out as usual.
With reference to specific embodiment, the invention will be further described：
Embodiment 1
A kind of scar reparation gel, it is characterised in that prepare scar reparation gel and include the following steps：
(1) by 75 parts by weight of fruit of west place in Hubei winterhazel, 160 parts by weight of petal of Nanchuan Pilea notata, soft Androsace umbellata 45 parts by weight of blade are put into baking oven, and oven temperature is set as 40 DEG C, is taken out after 7 hours, obtain dry plant tissue, standby With：
(2) by through (1) step drying after plant tissue in be added 400 parts by weight 95% ethyl alcohol impregnate 5 hours, then Plant tissue taking-up is placed in 30 DEG C of draught cupboards and is dried 16 hours, it is spare；
(3) plant tissue that (2) step obtains is put into the limewash that mass fraction is 9% and is impregnated 12 hours, taken out Clear water rinsed clean is used afterwards, and residual moisture is blotted with filter paper, it is spare；
(4) plant tissue that (3) step obtains is put into mortar and is ground into pureed, obtain pureed mixture, stand 3 days Filtered through gauze is used afterwards, stays supernatant, it is spare；
(5) supernatant for obtaining (4) step stands 8 days in 4 DEG C of refrigerators, be then placed in centrifuge with 5000 turns/ The speed of minute centrifuges 35 minutes, and supernatant is sucked out with syringe after taking-up, discards precipitation, by supernatant and 360 parts by weight After water, the mixing of 55 parts by weight dimethicones, 60 DEG C of water-bath water-baths 1 hour are put into, and stir evenly and repaiied to get to the scar Multiple gel.
Test result：
Embodiment 2
A kind of scar reparation gel, it is characterised in that prepare scar reparation gel and include the following steps：
(1) by 77 parts by weight of fruit of west place in Hubei winterhazel, 163 parts by weight of petal of Nanchuan Pilea notata, soft Androsace umbellata 48 parts by weight of blade are put into baking oven, and oven temperature is set as 40 DEG C, is taken out after 7 hours, obtain dry plant tissue, standby With：
(2) by through (1) step drying after plant tissue in be added 400 parts by weight 95% ethyl alcohol impregnate 5 hours, then Plant tissue taking-up is placed in 30 DEG C of draught cupboards and is dried 16 hours, it is spare；
(3) plant tissue that (2) step obtains is put into the limewash that mass fraction is 9% and is impregnated 12 hours, taken out Clear water rinsed clean is used afterwards, and residual moisture is blotted with filter paper, it is spare；
(4) plant tissue that (3) step obtains is put into mortar and is ground into pureed, obtain pureed mixture, stand 3 days Filtered through gauze is used afterwards, stays supernatant, it is spare；
(5) supernatant for obtaining (4) step stands 8 days in 4 DEG C of refrigerators, be then placed in centrifuge with 5000 turns/ The speed of minute centrifuges 35 minutes, and supernatant is sucked out with syringe after taking-up, discards precipitation, by supernatant and 360 parts by weight After water, the mixing of 55 parts by weight dimethicones, 60 DEG C of water-bath water-baths 1 hour are put into, and stir evenly and repaiied to get to the scar Multiple gel.
Test result：
Embodiment 3
A kind of scar reparation gel, it is characterised in that prepare scar reparation gel and include the following steps：
(1) by 80 parts by weight of fruit of west place in Hubei winterhazel, 165 parts by weight of petal of Nanchuan Pilea notata, soft Androsace umbellata 50 parts by weight of blade are put into baking oven, and oven temperature is set as 40 DEG C, is taken out after 7 hours, obtain dry plant tissue, standby With：
(2) by through (1) step drying after plant tissue in be added 400 parts by weight 95% ethyl alcohol impregnate 5 hours, then Plant tissue taking-up is placed in 30 DEG C of draught cupboards and is dried 16 hours, it is spare；
(3) plant tissue that (2) step obtains is put into the limewash that mass fraction is 9% and is impregnated 12 hours, taken out Clear water rinsed clean is used afterwards, and residual moisture is blotted with filter paper, it is spare；
(4) plant tissue that (3) step obtains is put into mortar and is ground into pureed, obtain pureed mixture, stand 3 days Filtered through gauze is used afterwards, stays supernatant, it is spare；
(5) supernatant for obtaining (4) step stands 8 days in 4 DEG C of refrigerators, be then placed in centrifuge with 5000 turns/ The speed of minute centrifuges 35 minutes, and supernatant is sucked out with syringe after taking-up, discards precipitation, by supernatant and 360 parts by weight After water, the mixing of 55 parts by weight dimethicones, 60 DEG C of water-bath water-baths 1 hour are put into, and stir evenly and repaiied to get to the scar Multiple gel.
Test result：
Embodiment 4
A kind of scar reparation gel, it is characterised in that prepare scar reparation gel and include the following steps：
(1) by 82 parts by weight of fruit of west place in Hubei winterhazel, 157 parts by weight of petal of Nanchuan Pilea notata, soft Androsace umbellata 53 parts by weight of blade are put into baking oven, and oven temperature is set as 40 DEG C, is taken out after 7 hours, obtain dry plant tissue, standby With：
(2) by through (1) step drying after plant tissue in be added 400 parts by weight 95% ethyl alcohol impregnate 5 hours, then Plant tissue taking-up is placed in 30 DEG C of draught cupboards and is dried 16 hours, it is spare；
(3) plant tissue that (2) step obtains is put into the limewash that mass fraction is 9% and is impregnated 12 hours, taken out Clear water rinsed clean is used afterwards, and residual moisture is blotted with filter paper, it is spare；
(4) plant tissue that (3) step centrifuges is put into mortar and is ground into pureed, obtain pureed mixture, it is quiet Solid residue is removed with filtered through gauze after setting 3 days, stays supernatant, it is spare；
(5) supernatant for obtaining (4) step stands 8 days in 4 DEG C of refrigerators, be then placed in centrifuge with 5000 turns/ The speed of minute centrifuges 35 minutes, and supernatant is sucked out with syringe after taking-up, discards precipitation, by supernatant and 360 parts by weight After water, the mixing of 55 parts by weight dimethicones, 60 DEG C of water-bath water-baths 1 hour are put into, and stir evenly and repaiied to get to the scar Multiple gel.
Test result：
Embodiment 5
A kind of scar reparation gel, it is characterised in that prepare scar reparation gel and include the following steps：
(1) by 85 parts by weight of fruit of west place in Hubei winterhazel, 155 parts by weight of petal of Nanchuan Pilea notata, soft Androsace umbellata 40 parts by weight of blade are put into baking oven, and oven temperature is set as 40 DEG C, is taken out after 7 hours, obtain dry plant tissue, standby With：
(2) by through (1) step drying after plant tissue in be added 400 parts by weight 95% ethyl alcohol impregnate 5 hours, then Plant tissue taking-up is placed in 30 DEG C of draught cupboards and is dried 16 hours, it is spare；
(3) plant tissue that (2) step obtains is put into the limewash that mass fraction is 9% and is impregnated 12 hours, taken out Clear water rinsed clean is used afterwards, and residual moisture is blotted with filter paper, it is spare；
(4) plant tissue that (3) step centrifuges is put into mortar and is ground into pureed, obtain pureed mixture, it is quiet Solid residue is removed with filtered through gauze after setting 3 days, stays supernatant, it is spare；
(5) supernatant for obtaining (4) step stands 8 days in 4 DEG C of refrigerators, be then placed in centrifuge with 5000 turns/ The speed of minute centrifuges 35 minutes, and supernatant is sucked out with syringe after taking-up, discards precipitation, by supernatant and 360 parts by weight After water, the mixing of 55 parts by weight dimethicones, 60 DEG C of water-bath water-baths 1 hour are put into, and stir evenly and repaiied to get to the scar Multiple gel.
Test result：
Embodiment 6
A kind of scar reparation gel, it is characterised in that prepare scar reparation gel and include the following steps：
(1) by 70 parts by weight of fruit of west place in Hubei winterhazel, 168 parts by weight of petal of Nanchuan Pilea notata, soft Androsace umbellata 42 parts by weight of blade are put into baking oven, and oven temperature is set as 40 DEG C, is taken out after 7 hours, obtain dry plant tissue, standby With：
(2) by through (1) step drying after plant tissue in be added 400 parts by weight 95% ethyl alcohol impregnate 5 hours, then Plant tissue taking-up is placed in 30 DEG C of draught cupboards and is dried 16 hours, it is spare；
(3) plant tissue that (2) step obtains is put into the limewash that mass fraction is 9% and is impregnated 12 hours, taken out Clear water rinsed clean is used afterwards, and residual moisture is blotted with filter paper, it is spare；
(4) plant tissue that (3) step centrifuges is put into mortar and is ground into pureed, obtain pureed mixture, it is quiet Solid residue is removed with filtered through gauze after setting 3 days, stays supernatant, it is spare；
(5) supernatant for obtaining (4) step stands 8 days in 4 DEG C of refrigerators, be then placed in centrifuge with 5000 turns/ The speed of minute centrifuges 35 minutes, and supernatant is sucked out with syringe after taking-up, discards precipitation, by supernatant and 360 parts by weight After water, the mixing of 55 parts by weight dimethicones, 60 DEG C of water-bath water-baths 1 hour are put into, and stir evenly and repaiied to get to the scar Multiple gel.
Test result：
Embodiment 7
A kind of scar reparation gel, it is characterised in that prepare scar reparation gel and include the following steps：
(1) by 90 parts by weight of fruit of west place in Hubei winterhazel, 170 parts by weight of petal of Nanchuan Pilea notata, soft Androsace umbellata 55 parts by weight of blade are put into baking oven, and oven temperature is set as 40 DEG C, is taken out after 7 hours, obtain dry plant tissue, standby With：
(2) by through (1) step drying after plant tissue in be added 400 parts by weight 95% ethyl alcohol impregnate 5 hours, then Plant tissue taking-up is placed in 30 DEG C of draught cupboards and is dried 16 hours, it is spare；
(3) plant tissue that (2) step obtains is put into the limewash that mass fraction is 9% and is impregnated 12 hours, taken out Clear water rinsed clean is used afterwards, and residual moisture is blotted with filter paper, it is spare；
(4) plant tissue that (3) step centrifuges is put into mortar and is ground into pureed, obtain pureed mixture, it is quiet Solid residue is removed with filtered through gauze after setting 3 days, stays supernatant, it is spare；
(5) supernatant for obtaining (4) step stands 8 days in 4 DEG C of refrigerators, be then placed in centrifuge with 5000 turns/ The speed of minute centrifuges 35 minutes, and supernatant is sucked out with syringe after taking-up, discards precipitation, by supernatant and 360 parts by weight After water, the mixing of 55 parts by weight dimethicones, 60 DEG C of water-bath water-baths 1 hour are put into, and stir evenly and repaiied to get to the scar Multiple gel.
Test result：
Embodiment 8
A kind of scar reparation gel, it is characterised in that prepare scar reparation gel and include the following steps：
(1) by 87 parts by weight of fruit of west place in Hubei winterhazel, 175 parts by weight of petal of Nanchuan Pilea notata, soft Androsace umbellata 60 parts by weight of blade are put into baking oven, and oven temperature is set as 40 DEG C, is taken out after 7 hours, obtain dry plant tissue, standby With：
(2) by through (1) step drying after plant tissue in be added 400 parts by weight 95% ethyl alcohol impregnate 5 hours, then Plant tissue taking-up is placed in 30 DEG C of draught cupboards and is dried 16 hours, it is spare；
(3) plant tissue that (2) step obtains is put into the limewash that mass fraction is 9% and is impregnated 12 hours, taken out Clear water rinsed clean is used afterwards, and residual moisture is blotted with filter paper, it is spare；
(4) plant tissue that (3) step centrifuges is put into mortar and is ground into pureed, obtain pureed mixture, it is quiet Solid residue is removed with filtered through gauze after setting 3 days, stays supernatant, it is spare；
(5) supernatant for obtaining (4) step stands 8 days in 4 DEG C of refrigerators, be then placed in centrifuge with 5000 turns/ The speed of minute centrifuges 35 minutes, and supernatant is sucked out with syringe after taking-up, discards precipitation, by supernatant and 360 parts by weight After water, the mixing of 55 parts by weight dimethicones, 60 DEG C of water-bath water-baths 1 hour are put into, and stir evenly and repaiied to get to the scar Multiple gel.
Test result：
Embodiment 9
A kind of scar reparation gel, it is characterised in that prepare scar reparation gel and include the following steps：
(1) 75 parts by weight of fruit of west place in Hubei winterhazel are put into baking oven, oven temperature is set as 40 DEG C, is taken after 7 hours Go out, obtains dry plant tissue, it is spare：
(2) by through (1) step drying after plant tissue in be added 400 parts by weight 95% ethyl alcohol impregnate 5 hours, then Plant tissue taking-up is placed in 30 DEG C of draught cupboards and is dried 16 hours, it is spare；
(3) plant tissue that (2) step obtains is put into the limewash that mass fraction is 9% and is impregnated 12 hours, taken out Clear water rinsed clean is used afterwards, and residual moisture is blotted with filter paper, it is spare；
(4) plant tissue that (3) step centrifuges is put into mortar and is ground into pureed, obtain pureed mixture, it is quiet Solid residue is removed with filtered through gauze after setting 3 days, stays supernatant, it is spare；
(5) supernatant for obtaining (4) step stands 8 days in 4 DEG C of refrigerators, be then placed in centrifuge with 5000 turns/ The speed of minute centrifuges 35 minutes, and supernatant is sucked out with syringe after taking-up, discards precipitation, by supernatant and 360 parts by weight After water, the mixing of 55 parts by weight dimethicones, 60 DEG C of water-bath water-baths 1 hour are put into, and stir evenly and repaiied to get to the scar Multiple gel.
Test result：
Embodiment 10
A kind of scar reparation gel, it is characterised in that prepare scar reparation gel and include the following steps：
(1) 160 parts by weight of petal of Nanchuan Pilea notata are put into baking oven, oven temperature is set as 40 DEG C, is taken after 7 hours Go out, obtains dry plant tissue, it is spare：
(2) by through (1) step drying after plant tissue in be added 400 parts by weight 95% ethyl alcohol impregnate 5 hours, then Plant tissue taking-up is placed in 30 DEG C of draught cupboards and is dried 16 hours, it is spare；
(3) plant tissue that (2) step obtains is put into the limewash that mass fraction is 9% and is impregnated 12 hours, taken out Clear water rinsed clean is used afterwards, and residual moisture is blotted with filter paper, it is spare；
(4) plant tissue that (3) step centrifuges is put into mortar and is ground into pureed, obtain pureed mixture, it is quiet Solid residue is removed with filtered through gauze after setting 3 days, stays supernatant, it is spare；
(5) supernatant for obtaining (4) step stands 8 days in 4 DEG C of refrigerators, be then placed in centrifuge with 5000 turns/ The speed of minute centrifuges 35 minutes, and supernatant is sucked out with syringe after taking-up, discards precipitation, by supernatant and 360 parts by weight After water, the mixing of 55 parts by weight dimethicones, 60 DEG C of water-bath water-baths 1 hour are put into, and stir evenly and repaiied to get to the scar Multiple gel.
Test result：
Embodiment 11
A kind of scar reparation gel, it is characterised in that prepare scar reparation gel and include the following steps：
(1) 45 parts by weight of blade of soft Androsace umbellata are put into baking oven, oven temperature is set as 40 DEG C, is taken after 7 hours Go out, obtains dry plant tissue, it is spare：
(2) by through (1) step drying after plant tissue in be added 400 parts by weight 95% ethyl alcohol impregnate 5 hours, then Plant tissue taking-up is placed in 30 DEG C of draught cupboards and is dried 16 hours, it is spare；
(3) plant tissue that (2) step obtains is put into the limewash that mass fraction is 9% and is impregnated 12 hours, taken out Clear water rinsed clean is used afterwards, and residual moisture is blotted with filter paper, it is spare；
(4) plant tissue that (3) step centrifuges is put into mortar and is ground into pureed, obtain pureed mixture, it is quiet Solid residue is removed with filtered through gauze after setting 3 days, stays supernatant, it is spare；
(5) supernatant for obtaining (4) step stands 8 days in 4 DEG C of refrigerators, be then placed in centrifuge with 5000 turns/ The speed of minute centrifuges 35 minutes, and supernatant is sucked out with syringe after taking-up, discards precipitation, by supernatant and 360 parts by weight After water, the mixing of 55 parts by weight dimethicones, 60 DEG C of water-bath water-baths 1 hour are put into, and stir evenly and repaiied to get to the scar Multiple gel.
Test result：
Embodiment 12
A kind of scar reparation gel, it is characterised in that prepare scar reparation gel and include the following steps：
(1) 75 parts by weight of fruit of west place in Hubei winterhazel, 160 parts by weight of petal of Nanchuan Pilea notata are put into baking oven, are dried Box temperature degree is set as 40 DEG C, is taken out after 7 hours, obtains dry plant tissue, spare：
(2) by through (1) step drying after plant tissue in be added 400 parts by weight 95% ethyl alcohol impregnate 5 hours, then Plant tissue taking-up is placed in 30 DEG C of draught cupboards and is dried 16 hours, it is spare；
(3) plant tissue that (2) step obtains is put into the limewash that mass fraction is 9% and is impregnated 12 hours, taken out Clear water rinsed clean is used afterwards, and residual moisture is blotted with filter paper, it is spare；
(4) plant tissue that (3) step centrifuges is put into mortar and is ground into pureed, obtain pureed mixture, it is quiet Solid residue is removed with filtered through gauze after setting 3 days, stays supernatant, it is spare；
(5) supernatant for obtaining (4) step stands 8 days in 4 DEG C of refrigerators, be then placed in centrifuge with 5000 turns/ The speed of minute centrifuges 35 minutes, and supernatant is sucked out with syringe after taking-up, discards precipitation, by supernatant and 360 parts by weight After water, the mixing of 55 parts by weight dimethicones, 60 DEG C of water-bath water-baths 1 hour are put into, and stir evenly and repaiied to get to the scar Multiple gel.
Test result：
Embodiment 13
A kind of scar reparation gel, it is characterised in that prepare scar reparation gel and include the following steps：
(1) 45 parts by weight of blade of 75 parts by weight of fruit of west place in Hubei winterhazel, soft Androsace umbellata are put into baking oven, baking oven Temperature setting is taken out after being 40 DEG C, 7 hours, obtains dry plant tissue, spare：
(2) by through (1) step drying after plant tissue in be added 400 parts by weight 95% ethyl alcohol impregnate 5 hours, then Plant tissue taking-up is placed in 30 DEG C of draught cupboards and is dried 16 hours, it is spare；
(3) plant tissue that (2) step obtains is put into the limewash that mass fraction is 9% and is impregnated 12 hours, taken out Clear water rinsed clean is used afterwards, and residual moisture is blotted with filter paper, it is spare；
(4) plant tissue that (3) step centrifuges is put into mortar and is ground into pureed, obtain pureed mixture, it is quiet Solid residue is removed with filtered through gauze after setting 3 days, stays supernatant, it is spare；
(5) supernatant for obtaining (4) step stands 8 days in 4 DEG C of refrigerators, be then placed in centrifuge with 5000 turns/ The speed of minute centrifuges 35 minutes, and supernatant is sucked out with syringe after taking-up, discards precipitation, by supernatant and 360 parts by weight After water, the mixing of 55 parts by weight dimethicones, 60 DEG C of water-bath water-baths 1 hour are put into, and stir evenly and repaiied to get to the scar Multiple gel.
Test result：
Embodiment 14
A kind of scar reparation gel, it is characterised in that prepare scar reparation gel and include the following steps：
(1) 45 parts by weight of blade of 160 parts by weight of petal of Nanchuan Pilea notata, soft Androsace umbellata are put into baking oven, are dried Box temperature degree is set as 40 DEG C, is taken out after 7 hours, obtains dry plant tissue, spare：
(2) by through (1) step drying after plant tissue in be added 400 parts by weight 95% ethyl alcohol impregnate 5 hours, then Plant tissue taking-up is placed in 30 DEG C of draught cupboards and is dried 16 hours, it is spare；
(3) plant tissue that (2) step obtains is put into the limewash that mass fraction is 9% and is impregnated 12 hours, taken out Clear water rinsed clean is used afterwards, and residual moisture is blotted with filter paper, it is spare；
(4) plant tissue that (3) step centrifuges is put into mortar and is ground into pureed, obtain pureed mixture, it is quiet Solid residue is removed with filtered through gauze after setting 3 days, stays supernatant, it is spare；
(5) supernatant for obtaining (4) step stands 8 days in 4 DEG C of refrigerators, be then placed in centrifuge with 5000 turns/ The speed of minute centrifuges 35 minutes, and supernatant is sucked out with syringe after taking-up, discards precipitation, by supernatant and 360 parts by weight After water, the mixing of 55 parts by weight dimethicones, 60 DEG C of water-bath water-baths 1 hour are put into, and stir evenly and repaiied to get to the scar Multiple gel.
Test result：
Embodiment 15
The present embodiment is control group, and volunteer's scar is without any processing.
Test result：

Claims (2)

1. a kind of scar repairs gel and preparation method thereof, it is characterized in that being prepared by following methods：
(1) by 77 parts by weight of fruit of west place in Hubei winterhazel, 163 parts by weight of petal of Nanchuan Pilea notata, soft Androsace umbellata blade 48 parts by weight are put into baking oven, and oven temperature is set as 40 DEG C or so, is taken out after 7 hours, obtain dry plant tissue, standby With：
(2) ethyl alcohol that 400 parts by weight 95% are added in the plant tissue after the drying of (1) step is impregnated 5 hours, then will be planted The taking-up of object tissue, which is placed in 30 DEG C of draught cupboards, to be dried 16 hours, spare；
(3) plant tissue that (2) step obtains is put into the limewash that mass fraction is 9% and is impregnated 12 hours, used after taking-up Clear water rinsed clean blots residual moisture with filter paper, spare；
(4) plant tissue that (3) step obtains is put into mortar and is ground into pureed, obtain pureed mixture, used after standing 3 days Filtered through gauze stays supernatant, spare；
(5) supernatant that (4) step obtains is stood about 8 days in 4 DEG C of refrigerators, be then placed in centrifuge with 5000 turns/ The speed of minute centrifuges 35 minutes, and supernatant is sucked out with syringe after taking-up, discards precipitation, by supernatant and 360 parts by weight After water, the mixing of 55 parts by weight dimethicones, 60 DEG C of water-bath water-baths 1 hour are put into, and stir evenly and repaiied to get to the scar Multiple gel.
2. a kind of scar repairs gel and preparation method thereof, it is characterized in that including the following steps：
(1) by 77 parts by weight of fruit of west place in Hubei winterhazel, 163 parts by weight of petal of Nanchuan Pilea notata, soft Androsace umbellata blade 48 parts by weight are put into baking oven, and oven temperature is set as 40 DEG C or so, is taken out after 7 hours, obtain dry plant tissue, standby With：
(2) ethyl alcohol that 400 parts by weight 95% are added in the plant tissue after the drying of (1) step is impregnated 5 hours, then will be planted The taking-up of object tissue, which is placed in 30 DEG C of draught cupboards, to be dried 16 hours, spare；
(3) plant tissue that (2) step obtains is put into the limewash that mass fraction is 9% and is impregnated 12 hours, used after taking-up Clear water rinsed clean blots residual moisture with filter paper, spare；
(4) plant tissue that (3) step obtains is put into mortar and is ground into pureed, obtain pureed mixture, used after standing 3 days Filtered through gauze stays supernatant, spare；
(5) supernatant that (4) step obtains is stood about 8 days in 4 DEG C of refrigerators, be then placed in centrifuge with 5000 turns/ The speed of minute centrifuges 35 minutes, and supernatant is sucked out with syringe after taking-up, discards precipitation, by supernatant and 360 parts by weight After water, the mixing of 55 parts by weight dimethicones, 60 DEG C of water-bath water-baths 1 hour are put into, and stir evenly and repaiied to get to the scar Multiple gel.
CN201810532542.1A 2018-05-29 2018-05-29 A kind of scar repairs gel and preparation method thereof Withdrawn CN108403737A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102008757A (en) * 2010-12-07 2011-04-13 天津嘉氏堂科技有限公司 Scar repair material
CN103127213A (en) * 2011-12-02 2013-06-05 贵州金玖生物技术有限公司 Dressing for removing scars
CN103341216A (en) * 2013-06-04 2013-10-09 青岛中腾生物技术有限公司 Scar-removing repairing material and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102008757A (en) * 2010-12-07 2011-04-13 天津嘉氏堂科技有限公司 Scar repair material
CN103127213A (en) * 2011-12-02 2013-06-05 贵州金玖生物技术有限公司 Dressing for removing scars
CN103341216A (en) * 2013-06-04 2013-10-09 青岛中腾生物技术有限公司 Scar-removing repairing material and preparation method thereof

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