CN102397389A

CN102397389A - Preparation method of lithospermum ointment

Info

Publication number: CN102397389A
Application number: CN2010102809949A
Authority: CN
Inventors: 朱云利
Original assignee: Individual
Current assignee: Individual
Priority date: 2010-09-08
Filing date: 2010-09-08
Publication date: 2012-04-04

Abstract

The invention discloses a preparation method of lithospermum ointment and belongs to the field of pharmacy. The preparation method of the lithospermum ointment adopts a percoaltion technology. The percoaltion technology has the advantage that volatile components of Chinese angelica and divaricate saposhnikovia root are not volatilized and lost and other components are not destroyed, and thus lithospermum ointment quality is greatly improved and use effects are good. Raw materials of the lithospermum ointment comprises lithospermum, dahurian angelica root, divaricate saposhnikovia root, Chinese angelica, rehmannia root, frankincense, myrrh, venenum bufonis, beeswax and plant oil. The preparation method comprises the following steps of 1, extracting alkannin powder by percolation, 2, extracting active ingredient powder form dahurian angelica root, divaricate saposhnikovia root, Chinese angelica, rehmannia root and frankincense by percolation, 3, grinding frankincense, myrrh and venenum bufonis into powder, and 4, mixing beeswax and plant oil, heating to fuse the mixture into an ointment matrix, adding the materials obtained by the step 1, the step 2 and the step 3 into the ointment matrix, uniformly stirring, and cooling to normal temperature to obtain a finished product.

Description

A kind of compound method of zicao soft plaster

Technical field:

Product of the present invention belongs to pharmaceutical field, it is characterized in that relating to a kind of compound method of zicao soft plaster.

Background technology:

The zicao soft plaster outward appearance is an aubergine ointment, has special greasy gas, surgical medicine, and product of the present invention is formulated by Chinese medicine, has detoxifcation, changes effect rotten, granulation promoting, can be used for skin infection, carbuncle disease such as burst.The Chinese crude drug that the preparation zicao soft plaster uses has: Radix Arnebiae (Radix Lithospermi), the Radix Angelicae Dahuricae, windproof, Olibanum, Myrrha, Radix Angelicae Sinensis, Radix Rehmanniae, Venenum Bufonis.Radix Arnebiae (Radix Lithospermi) property is hidden bitter, cold in the side; The effect that heat clearing away, removing pathogenic heat from blood and toxic substance from the body are arranged; Effective ingredient in the Radix Arnebiae (Radix Lithospermi) is the shikonin compounds; Shikonin extract can suppress staphylococcus aureus, Bacterium prodigiosum, suppuration bacterium, escherichia coli etc., and can quicken epithelial growth, promote local wound more with and antiinflammatory action; The Radix Angelicae Dahuricae has the effect of mass dissipating and swelling eliminating, evacuation of pus; But windproof wind-expelling pain-stopping; Olibanum, Myrrha blood circulation promoting and dispersing pathogen accumulation, removing the necrotic tissue and promoting granulation; The YIN nourishing of enriching blood of Radix Angelicae Sinensis, Radix Rehmanniae helps promoting tissue regeneration and wound healing; Venenum Bufonis has detoxifcation, analgesic effect, and above Chinese medicine is worked in coordination with each other and helped to treat the carbuncle pyogenic infections from tumour or sore.Main composition in the product of the present invention is a Radix Arnebiae (Radix Lithospermi), and the technology of out-of-date methods preparation zicao soft plaster is following, the first step: the Radix Arnebiae (Radix Lithospermi) water is moistening, and it is interior fried to aubergine with plant to put pot, removes slag, filters; Second step: be ground into fine powder to Olibanum, Myrrha, Venenum Bufonis, sieve; The 3rd step: the Radix Angelicae Dahuricae, windproof, Radix Angelicae Sinensis, Radix Rehmanniae are given as one thinks fit cataclasm, it is an amount of that other gets edible vegetable oil, fried withered with putting in the pot, removes slag; The 4th step: with an amount of Cera Flava fusing. add the raw material that above-mentioned three steps obtain, mix to stir promptly getting.This method is solvent with the vegetable oil, extracts down the liposoluble constituent in the medical material at high temperature (250 ℃), and under hot conditions, Radix Angelicae Sinensis, the volatile ingredient in windproof be volatilization loss, and other compositions add lactone, shikonin and also are prone to decompose destroy, and influence the curative effect of medicine.

Summary of the invention:

In order to overcome above-mentioned defective; The present invention provides a kind of and prepares zicao soft plaster with percolation; (operating process of percolation is: be pulverizing medicinal materials coarse powder earlier, added adequate amount of ethanol 2-4 hour, medicinal material coarse powder is fully expanded; Gradation is lined with in the percolator of absorbent cotton bottom packing into equably, installs the back at every turn and compresses with wooden stick; Adorned Chinese crude drug, gauze on the upper cover, and press the handstone that one deck is cleaned, in order to avoid after adding ethanol medicated powder is floated; Add ethanol from percolator top at leisure then, make that ethanol is paramount to be gone out till the medicated powder face number centimetre, add a cover then, soak and open the end opening switch after 48 hours, percolate is slowly flowed out; Collect the liquid of filtering by ormal weight, add correctives and stir the back sealing, leave standstill a few days after-filtration and go out medicinal liquid; Reclaim the ethanol in the percolate, get concentrated solution, it is an amount of in concentrated solution, to add 2% sodium hydroxide solution; Stir back elimination residue, in filtrating, add hydrochloric acid then, produce deposition; Collect the precipitate in the liquid, be washed till neutrality with distilled water, the powder that obtains after the oven dry promptly is a finished product.) shortcoming of percolation is that technology is complicated, and is longer with the time, but advantage be Radix Angelicae Sinensis, the volatilization loss not of the volatile ingredient in windproof, other composition is as adding lactone, the shikonin destruction that also is not decomposed, the ointment quality of preparation improves greatly, result of use is good.Producing the raw material that this product uses has: Radix Arnebiae (Radix Lithospermi) 15%-18%, the Radix Angelicae Dahuricae 6%, windproof 5%, Radix Angelicae Sinensis 6%, Radix Rehmanniae 4%, Olibanum 5.5%, Myrrha 5.5%, Venenum Bufonis 3%, Cera Flava 37%-40%, vegetable oil 10%.

The present invention can realize through following technical scheme:

A kind of method of batch preparation zicao soft plaster is characterized in that being made up of following steps:

1. Radix Arnebiae (Radix Lithospermi) is pulverized to coarse powder, extract the shikonin powder with percolation.

2. the Radix Angelicae Dahuricae, windproof, Radix Angelicae Sinensis, Radix Rehmanniae are pulverized and be coarse powder, extract four kinds of Effective Components of Chinese Herb powder with percolation.

3. Olibanum, Myrrha, Venenum Bufonis are clayed into power.

4. vegetable oil is fused into ointment base with Cera Flava mixing post-heating, temperature is about 80 ℃, and above three materials that obtain of step are added ointment base, stirs, and gets product after being cooled to behind the room temperature.

The beneficial effect of product of the present invention is: Radix Angelicae Sinensis, the volatile ingredient in windproof be volatilization loss not, and other compositions are as adding lactone, the shikonin destruction that also is not decomposed, and the ointment quality of preparation improves greatly, and result of use is good.

The specific embodiment:

Embodiment 1:

1. will account for total amount and be 15% Radix Arnebiae (Radix Lithospermi) and pulverize and be coarse powder, extract the shikonin powder with percolation; 2. will account for total amount and be 6% the Radix Angelicae Dahuricae, 5% windproof, 6% Radix Angelicae Sinensis, 4% Radix Rehmanniae is pulverized and is coarse powder, extracts four kinds of Effective Components of Chinese Herb powder with percolation; 3. will account for total amount and be 5.5% Olibanum, 5.5% Myrrha, 3% Venenum Bufonis clays into power; 4. will account for total amount is that 10% vegetable oil is that 40% Cera Flava mixing post-heating fuses into ointment base with accounting for total amount, and temperature is about 80 ℃, and above three materials that obtain of step are added ointment base, stirs, and gets product after being cooled to room temperature.

Embodiment 2:

1. will account for total amount and be 16% Radix Arnebiae (Radix Lithospermi) and pulverize and be coarse powder, extract the shikonin powder with percolation; 2. will account for total amount and be 6% the Radix Angelicae Dahuricae, 5% windproof, 6% Radix Angelicae Sinensis, 4% Radix Rehmanniae is pulverized and is coarse powder, extracts four kinds of Effective Components of Chinese Herb powder with percolation; 3. will account for total amount and be 5.5% Olibanum, 5.5% Myrrha, 3% Venenum Bufonis clays into power; 4. will account for total amount is that 10% vegetable oil is that 39% Cera Flava mixing post-heating fuses into ointment base with accounting for total amount, and temperature is about 80 ℃, and above three materials that obtain of step are added ointment base, stirs, and gets product after being cooled to room temperature.

Embodiment 3:

1. will account for total amount and be 17% Radix Arnebiae (Radix Lithospermi) and pulverize and be coarse powder, extract the shikonin powder with percolation; 2. will account for total amount and be 6% the Radix Angelicae Dahuricae, 5% windproof, 6% Radix Angelicae Sinensis, 4% Radix Rehmanniae is pulverized and is coarse powder, extracts four kinds of Effective Components of Chinese Herb powder with percolation; 3. will account for total amount and be 5.5% Olibanum, 5.5% Myrrha, 3% Venenum Bufonis clays into power; 4. will account for total amount is that 10% vegetable oil is that 38% Cera Flava mixing post-heating fuses into ointment base with accounting for total amount, and temperature is about 80 ℃, and above three materials that obtain of step are added ointment base, stirs, and gets product after being cooled to room temperature.

Embodiment 4:

1. will account for total amount and be 18% Radix Arnebiae (Radix Lithospermi) and pulverize and be coarse powder, extract the shikonin powder with percolation; 2. will account for total amount and be 6% the Radix Angelicae Dahuricae, 5% windproof, 6% Radix Angelicae Sinensis, 4% Radix Rehmanniae is pulverized and is coarse powder, extracts four kinds of Effective Components of Chinese Herb powder with percolation; 3. will account for total amount and be 5.5% Olibanum, 5.5% Myrrha, 3% Venenum Bufonis clays into power; 4. will account for total amount is that 10% vegetable oil is that 37% Cera Flava mixing post-heating fuses into ointment base with accounting for total amount, and temperature is about 80 ℃, and above three materials that obtain of step are added ointment base, stirs, and gets product after being cooled to room temperature.

Claims

1. the compound method of a zicao soft plaster; It is characterized in that: with Radix Arnebiae (Radix Lithospermi) 15%-18%, the Radix Angelicae Dahuricae 6%, windproof 5%, Radix Angelicae Sinensis 6%, Radix Rehmanniae 4%, Olibanum 5.5%, Myrrha 5.5%, Venenum Bufonis 3%, Cera Flava 37%-40%, vegetable oil 10% is raw material, obtains finished product through following steps.

2. the compound method of a kind of zicao soft plaster according to claim 1, the characteristic of its first step is: Radix Arnebiae (Radix Lithospermi) is pulverized be coarse powder, extract the shikonin powder with percolation.

3. the compound method of a kind of zicao soft plaster according to claim 1, the characteristic in its second step is: the Radix Angelicae Dahuricae, windproof, Radix Angelicae Sinensis, Radix Rehmanniae are pulverized and be coarse powder, extract four kinds of Effective Components of Chinese Herb powder with percolation.

4. the compound method of a kind of zicao soft plaster according to claim 1, the characteristic in its 3rd step is: Olibanum, Myrrha, Venenum Bufonis are clayed into power.

5. the compound method of a kind of zicao soft plaster according to claim 1; The characteristic in its 4th step is: vegetable oil is fused into ointment base with Cera Flava mixing post-heating, and temperature is about 80 ℃, and the material that above three steps are obtained adds ointment base; Stir, get product after being cooled to behind the room temperature.