CN102395275A - 用四环吡嗪并吲哚治疗多发性硬化症的方法 - Google Patents

用四环吡嗪并吲哚治疗多发性硬化症的方法 Download PDF

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Publication number
CN102395275A
CN102395275A CN200980154585XA CN200980154585A CN102395275A CN 102395275 A CN102395275 A CN 102395275A CN 200980154585X A CN200980154585X A CN 200980154585XA CN 200980154585 A CN200980154585 A CN 200980154585A CN 102395275 A CN102395275 A CN 102395275A
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China
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alkyl
aryl
ring
heteroaryl
pharmaceutically acceptable
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CN200980154585XA
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English (en)
Chinese (zh)
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S·德夫特罗斯
A·波西第斯
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Biovista Inc
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Biovista Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN200980154585XA 2008-12-11 2009-12-11 用四环吡嗪并吲哚治疗多发性硬化症的方法 Pending CN102395275A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12157408P 2008-12-11 2008-12-11
US61/121,574 2008-12-11
US23323509P 2009-08-12 2009-08-12
US61/233,235 2009-08-12
PCT/US2009/067673 WO2010068867A1 (en) 2008-12-11 2009-12-11 Methods for treating multiple sclerosis using tetracyclic pyrazinoindoles

Publications (1)

Publication Number Publication Date
CN102395275A true CN102395275A (zh) 2012-03-28

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ID=42243090

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CN200980154585XA Pending CN102395275A (zh) 2008-12-11 2009-12-11 用四环吡嗪并吲哚治疗多发性硬化症的方法

Country Status (9)

Country Link
US (1) US20110268699A1 (https=)
EP (1) EP2375900B1 (https=)
JP (1) JP2012512165A (https=)
CN (1) CN102395275A (https=)
AU (1) AU2009324495B2 (https=)
BR (1) BRPI0922871A2 (https=)
CA (1) CA2747235C (https=)
IL (1) IL213476A0 (https=)
WO (1) WO2010068867A1 (https=)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN106413713A (zh) * 2014-05-09 2017-02-15 特克尼梅德医疗技术股份公司 用作药物的吡吲哚对映异构体的药学上可接受的盐

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EP2340254B8 (en) 2008-09-15 2014-05-21 Biovista, Inc. Compositions and methods for treating epilepsy
US10052299B2 (en) 2009-10-30 2018-08-21 Retrotope, Inc. Alleviating oxidative stress disorders with PUFA derivatives
RU2436786C1 (ru) * 2010-07-23 2011-12-20 Александр Васильевич Иващенко Замещенные индолы, противовирусный активный компонент, способ получения и применения
KR102112087B1 (ko) 2011-04-26 2020-05-18 레트로토프 인코포레이티드 에너지 프로세싱 손상 장애 및 미토콘드리아 결함
JP6145087B2 (ja) 2011-04-26 2017-06-07 レトロトップ、 インコーポレイテッドRetrotope, Inc. Pufa酸化関与障害
JP6106157B2 (ja) 2011-04-26 2017-03-29 レトロトップ、 インコーポレイテッドRetrotope, Inc. 神経変性障害および筋疾患に関与するpufa
WO2012148930A2 (en) 2011-04-26 2012-11-01 Retrotope, Inc. Oxidative retinal diseases
WO2013130422A1 (en) * 2012-02-27 2013-09-06 Biovista, Inc. Compositions and methods for treating mitochondrial diseases
BR112015019564A2 (pt) * 2013-02-15 2017-07-18 Teva Pharma tratamento de esclerose múltipla com laquinimod
KR101521807B1 (ko) * 2014-01-20 2015-05-20 한국전자통신연구원 데이터 전송 제어 장치 및 그 방법
EP3950649A1 (en) 2015-11-23 2022-02-09 Retrotope, Inc. Site-specific isotopic labeling of 1, 4-diene systems
US12097292B2 (en) 2016-08-28 2024-09-24 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
CN109982712A (zh) 2016-08-31 2019-07-05 Mapi医药公司 包含醋酸格拉替雷的储库系统
CN110382052A (zh) 2017-03-26 2019-10-25 Mapi医药公司 用于治疗进展型形式的多发性硬化症的格拉替雷储库系统
EP3520803A1 (en) * 2018-01-31 2019-08-07 Zarodex Therapeutics Limited Novel uses
IL295783B2 (en) 2020-02-21 2026-03-01 Retrotope Inc Processes for isotopic alteration of polyunsaturated fatty acids and their derivatives
US12109194B2 (en) 2021-02-05 2024-10-08 Biojiva Llc Synergistic combination therapy for treating ALS

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US3959470A (en) * 1972-11-28 1976-05-25 Mikhail Davidovich Mashkovsky Psychotropic medicinal preparation
RU2281085C2 (ru) * 2004-05-25 2006-08-10 Закрытое акционерное общество "Мастерлек" Антидепрессивные лекарственные средства для парентерального применения на основе сульфонатных солей пирлиндола

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US5300645A (en) * 1993-04-14 1994-04-05 Eli Lilly And Company Tetrahydro-pyrido-indole
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
WO2004098638A1 (ja) * 2003-05-06 2004-11-18 Ono Pharmaceutical Co., Ltd. エフェクター細胞機能阻害剤
EP1688161A1 (en) * 2004-11-02 2006-08-09 Switch Biotech Aktiengesellschaft Use of pirlindole for the treatment of diseases which are characterized by proliferation of t-lymphocytes and/or hyperproliferation of keratinocytes in particular atopic dermatitis and psoriasis
KR20080034171A (ko) * 2005-07-28 2008-04-18 브리스톨-마이어스 스큅 컴퍼니 세로토닌 수용체 효능제 및 길항제로서의 치환된테트라히드로-1h-피리도[4,3,b]인돌
MX2009012788A (es) * 2007-05-25 2010-01-14 Medivation Neurology Inc Metodos y composiciones para estimular celulas.

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US3959470A (en) * 1972-11-28 1976-05-25 Mikhail Davidovich Mashkovsky Psychotropic medicinal preparation
RU2281085C2 (ru) * 2004-05-25 2006-08-10 Закрытое акционерное общество "Мастерлек" Антидепрессивные лекарственные средства для парентерального применения на основе сульфонатных солей пирлиндола

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
A. BOLAND ET AL: "Pirlindole and dehydropirlindole protect rat cultured neuronal cells against oxidative stress-induced cell death through a mechanism unrelated to MAO-A inhibition", 《BRITISH JOURNAL OF PHARMACOLOGY》 *
R.E. GONSETTE: "Neurodegeneration in multiple sclerosis: The role of oxidative stress and excitotoxicity", 《JOURNAL OF THE NEUROLOGICAL SCIENCES》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106413713A (zh) * 2014-05-09 2017-02-15 特克尼梅德医疗技术股份公司 用作药物的吡吲哚对映异构体的药学上可接受的盐
CN106413713B (zh) * 2014-05-09 2020-07-14 特克尼梅德医疗技术股份公司 用作药物的吡吲哚对映异构体的药学上可接受的盐

Also Published As

Publication number Publication date
BRPI0922871A2 (pt) 2016-11-16
IL213476A0 (en) 2011-07-31
JP2012512165A (ja) 2012-05-31
AU2009324495B2 (en) 2015-12-24
EP2375900A1 (en) 2011-10-19
US20110268699A1 (en) 2011-11-03
CA2747235A1 (en) 2010-06-17
CA2747235C (en) 2021-02-09
EP2375900B1 (en) 2016-03-02
EP2375900A4 (en) 2012-05-02
WO2010068867A1 (en) 2010-06-17
AU2009324495A1 (en) 2011-07-28

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Application publication date: 20120328