CN102393471B - Sample loading and sucking head of liquid transferring device, liquid surface contact and sample sucking detection system and method for detecting by using liquid surface contact and sample sucking detection system - Google Patents
Sample loading and sucking head of liquid transferring device, liquid surface contact and sample sucking detection system and method for detecting by using liquid surface contact and sample sucking detection system Download PDFInfo
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- CN102393471B CN102393471B CN201110234137XA CN201110234137A CN102393471B CN 102393471 B CN102393471 B CN 102393471B CN 201110234137X A CN201110234137X A CN 201110234137XA CN 201110234137 A CN201110234137 A CN 201110234137A CN 102393471 B CN102393471 B CN 102393471B
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- 239000007788 liquid Substances 0.000 title claims abstract description 46
- 238000001514 detection method Methods 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title claims abstract description 12
- 238000001914 filtration Methods 0.000 claims description 4
- 238000005213 imbibition Methods 0.000 claims description 3
- 238000002347 injection Methods 0.000 abstract 2
- 239000007924 injection Substances 0.000 abstract 2
- 230000036039 immunity Effects 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
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Abstract
The invention provides a sample loading and sucking head of a liquid transferring device and a liquid surface contact and sample sucking detection system. The system comprises a main pipeline, a first branch pipeline, a second branch pipeline, a liquid transferring device, a pressure sensor, an injection pump, a first valve, a second valve, a filter and an air pump, wherein one end of the liquid transferring device is hermetically connected with the tail end of the main pipeline; one end of the liquid transferring device is connected with the pressure sensor, the injection pump, the first valve, the second branch pipeline, the first branch pipeline, the filter and the air pump through the main pipeline in sequence; the first branch pipeline is communicated with the outside; and the second valve is arranged at one end of the second branch pipeline which is not connected with the main pipeline. The invention further provides a method for detecting whether a sample sucking head is arranged on the liquid transferring device, whether the liquid transferring device is contacted with a liquid surface and whether a liquid is sucked into the sample sucking head by using the detection system. The detection system can be applied to automatic immunity detection analyzing equipment, and has contribution to improvement on the automation degree of equipment.
Description
Technical field
The present invention relates to a kind of liquid-transfering device dress suction head, liquid level contact and inhale the sample detection system, belong to medical instruments field.
Background technology
Immune detection is analyzed, and is current a kind of important method that is widely used in clinical and the scientific research.Detection means as a kind of ultramicron material, employed sample and amount of reagent are generally microlitre (μ l) level in the immune detection analysis experiment, and the experimenter generally is by using Manual liquid transfering device (being commonly called as the volley of rifle fire) to finish the filling of sample and reagent.When test event was more, the application of sample workload was very huge.Therefore the automation equipment that can automatically finish application of sample work has practical demand for the reviewer.
The liquid-transfering device of the sample adding system of robotization immune detection analytical equipment can be divided into needle tube type and suction head formula at present.What the needle tube type liquid-transfering device can be realized high precision moves the liquid function, but main shortcoming is the possibility that has cross pollution, drawing between the different specimens, must clean fully the stainless steel needle tubing.The relative needle tube type of suction head formula has that passage is many, efficient is high, thoroughly avoided cross pollution and without outstanding advantages such as cleaning fluid consumption.The robotization immune detection analytical equipment great majority of clinical employing adopt electric pipettor to realize, can automatically extract suction head, draw sample or reagent by suction head, are filled in the test board again.Its function mainly is to replace manually finishing a large amount of application of sample work in early stage.
Thereby, in the immune detection analytical equipment of robotization, need to whether suction head be installed to liquid-transfering device, whether contact with liquid level and whether had liquid to be inhaled into suction head and detected.
Summary of the invention
The invention provides a kind of liquid-transfering device dress suction head, liquid level contact and inhale the sample detection system, whether whether whether it can install suction head to liquid-transfering device, contact with liquid level and had liquid to be inhaled into suction head and detected.
Liquid-transfering device dress suction head of the present invention, liquid level contact and suction sample detection system, this system comprises main line, the first bye-pass, the second bye-pass, liquid-transfering device, pressure transducer, syringe pump, the first valve, the second valve, filtrator and air pump; Wherein, one end of liquid-transfering device is connected with the end seal of main line, one end of this liquid-transfering device is by main line successively Bonding pressure sensor, syringe pump, the first valve, the second bye-pass, the first bye-pass, filtrator and air pump, the first bye-pass is communicated with outside, and an end that is not connected with main line of the second bye-pass is equipped with the second valve.
Whether whether the present invention also provide and utilize above-mentioned liquid-transfering device dress suction head, liquid level contact and suction sample detection system detection liquid-transfering device whether suction head to be installed, to contact with liquid level and to be had liquid to be inhaled into the method for suction head, and the method may further comprise the steps:
1) close the first valve, open the second valve, booster air pump, make with main line that air pump is connected in produce constant air-flow, air-flow is discharged by the first bye-pass and the second bye-pass through the filter filtering, and main line is cleaned;
2) open the first valve, close the second valve, air-flow is discharged by liquid-transfering device through pressure transducer, is also discharged by the first bye-pass simultaneously;
3) pressure that detects when pressure transducer becomes large and surpasses predefined first threshold, then detects and has loaded onto suction head for liquid-transfering device;
4) loaded onto suction head when detecting liquid-transfering device, then operate liquid-transfering device and get the liquid operation, if the pressure that pressure transducer detects continues to increase and surpass predefined Second Threshold, then detection has touched liquid surface for the suction head on the liquid-transfering device;
5) touch liquid surface when detecting suction head, then closed the first valve, opened the second valve, started syringe pump, beginning imbibition operation, change according to the pressure that pressure transducer detects this moment, and whether detect has liquid to be inhaled into suction head.
Description of drawings
Accompanying drawing 1 is for liquid-transfering device dress suction head of the present invention, liquid level contact and inhale sample detection system synoptic diagram.
Embodiment
With reference now to accompanying drawing 1, describe the present invention, described liquid-transfering device dress suction head, liquid level contact and suction sample detection system comprise main line T, the first bye-pass T1, the second bye-pass T2, liquid-transfering device 1, pressure transducer 2, syringe pump P2, the first valve V1, the second valve V2, filtrator 3 and air pump P1.Wherein, one end of liquid-transfering device 1 is connected with the end seal of main line T, suction head (not shown) can be installed in the other end (bottom of liquid-transfering device 1 in the accompanying drawing 1) of this liquid-transfering device, and an end of this liquid-transfering device 1 is by main line T successively Bonding pressure sensor 2, syringe pump P2, the first valve V1, the second bye-pass T2, the first bye-pass T1, filtrator 3 and air pump P1; This first bye-pass T1 is communicated with outside, plays the adjustable pipe internal gas pressure, and the end that is not connected with main line T of this second bye-pass T2 is equipped with the second valve V2.
Air pump P1 can make to produce in the connected pipeline has certain air-flow; Filtrator 3 can carry out filtering to the air by it.
Preferably, described detection system also comprises controller, and controller is controlled described syringe pump P2, the first valve V1, the second valve V2 and air pump P1 according to the signal of pressure transducer 2.
Preferably, valve V1, V2 are the 2/2-way valve.
Preferably, pressure transducer 2 is micropressure sensor.
Use this liquid-transfering device dress suction head, liquid level contact and inhale the sample detection system and detect liquid-transfering device whether whether whether suction head is installed, has contacted with liquid level and is had liquid to be inhaled into the step of method of suction head as follows:
1) close the first valve V1, open the second valve, booster air pump P1 makes the constant air-flow of generation in the main line T that is connected with air pump P1, air-flow is discharged by the first bye-pass T1 and the second bye-pass T2 through the filter filtering, T cleans to main line;
2) open the first valve V1, close the second valve V2, air-flow and discharged by liquid-transfering device 1 through pressure transducer 2, also discharged by the first bye-pass T1 simultaneously;
3) pressure that detects when pressure transducer 2 becomes large and surpasses predefined first threshold, then detects and has loaded onto suction head for liquid-transfering device 1;
4) loaded onto suction head when detecting liquid-transfering device 1, then operate liquid-transfering device and get the liquid operation, if the pressure that pressure transducer 2 detects continues to increase and surpass predefined Second Threshold, then detection has touched liquid surface for the suction head on the liquid-transfering device 1;
5) touch liquid surface when detecting suction head, closed the first valve V1, opened the second valve V2, started syringe pump P2, beginning imbibition operation, change according to the pressure that pressure transducer 2 detects this moment, and whether detect has liquid to be inhaled into suction head.
Claims (4)
1. whether one kind used liquid-transfering device dress suction head, liquid level contact and inhale the sample detection system and detect whether liquid-transfering device installs suction head, whether suction head has contacted with liquid level and have liquid to be inhaled into the method for suction head,
Wherein said liquid-transfering device dress suction head, liquid level contact and suction sample detection system comprise: main line (T), the first bye-pass (T1), the second bye-pass (T2), liquid-transfering device (1), pressure transducer (2), syringe pump (P2), the first valve (V1), the second valve (V2), filtrator (3) and air pump (P1); Wherein, one end of liquid-transfering device (1) is connected with the end seal of main line (T), and by main line (T) successively Bonding pressure sensor (2), syringe pump (P2), the first valve (V1), the second bye-pass (T2), the first bye-pass (T1), filtrator (3) and air pump (P1); Wherein, this first bye-pass (T1) is communicated with outside, and an end that is not connected with main line (T) of this second bye-pass (T2) is equipped with the second valve (V2);
It is characterized in that the method may further comprise the steps:
1) closes the first valve (V1), open the second valve (V2), booster air pump (P1), make and produce constant air-flow in the main line (T) that is connected with air pump (P1), air-flow is through filter (3) filtering, discharged by the first bye-pass (T1) and the second bye-pass (T2), (T) cleans to main line;
2) open the first valve (V1), close the second valve (V2), air-flow is discharged by liquid-transfering device (1) through pressure transducer (2), is also discharged by the first bye-pass (T1) simultaneously;
3) pressure that detects when pressure transducer (2) becomes large and surpasses predefined first threshold, then detects and has loaded onto suction head for liquid-transfering device (1);
4) loaded onto suction head when detecting liquid-transfering device (1), then operate liquid-transfering device (1) and get the liquid operation, if the pressure that pressure transducer (2) detects continues to increase and surpass predefined Second Threshold, then detection has touched liquid surface for the suction head on the liquid-transfering device (1);
5) touched liquid surface when detecting suction head, then close the first valve (V1), open the second valve (V2), start syringe pump (P2), beginning imbibition operation, change according to the pressure that pressure transducer (2) detects this moment, and whether detect has liquid to be inhaled into suction head.
2. method according to claim 1, it is characterized in that: described detection system also comprises controller, controller is controlled described syringe pump (P2), the first valve (V1), the second valve (V2) and air pump (P1) according to the signal of pressure transducer (2).
3. method according to claim 1, it is characterized in that: described the first valve (V1) and the second valve (V2) are the 2/2-way valve.
4. method according to claim 1, it is characterized in that: described pressure transducer (2) is micropressure sensor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110234137XA CN102393471B (en) | 2011-08-16 | 2011-08-16 | Sample loading and sucking head of liquid transferring device, liquid surface contact and sample sucking detection system and method for detecting by using liquid surface contact and sample sucking detection system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110234137XA CN102393471B (en) | 2011-08-16 | 2011-08-16 | Sample loading and sucking head of liquid transferring device, liquid surface contact and sample sucking detection system and method for detecting by using liquid surface contact and sample sucking detection system |
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| Publication Number | Publication Date |
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| CN102393471A CN102393471A (en) | 2012-03-28 |
| CN102393471B true CN102393471B (en) | 2013-04-17 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109718883A (en) * | 2018-12-25 | 2019-05-07 | 迪瑞医疗科技股份有限公司 | A kind of liquid-transfering device and liquid relief method |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103575924B (en) * | 2012-08-08 | 2015-07-01 | 深圳中科强华科技有限公司 | Blood sample delivery system |
| CN104297497B (en) * | 2013-07-16 | 2016-02-24 | 成都深迈瑞医疗电子技术研究院有限公司 | Blood analysis method, control device and blood cell analyzer |
| WO2019000458A1 (en) * | 2017-06-30 | 2019-01-03 | 深圳迈瑞生物医疗电子股份有限公司 | Sampling assembly, sample analyzer and sampling method |
| CN110892245A (en) * | 2017-07-21 | 2020-03-17 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analyzer and sampling monitoring method |
| CN107271707B (en) * | 2017-08-03 | 2020-02-21 | 力合科技（湖南）股份有限公司 | Sample introduction device and detection system |
| CN110146415B (en) * | 2019-05-10 | 2022-03-29 | 深圳市万臣科技有限公司 | Method and device for detecting liquid surface contact |
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| JPS63109373A (en) * | 1986-10-27 | 1988-05-14 | Kyoto Daiichi Kagaku:Kk | Sampling method and apparatus therefor |
| JPH07103987A (en) * | 1993-10-04 | 1995-04-21 | Aloka Co Ltd | Method of detecting liquid level in automatic dispensing device |
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- 2011-08-16 CN CN201110234137XA patent/CN102393471B/en active Active
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|---|---|---|---|---|
| US3894438A (en) * | 1973-07-27 | 1975-07-15 | Coulter Electronics | Pneumatic fluid level sensing and sampling system |
| CN1318740A (en) * | 2000-04-19 | 2001-10-24 | 爱科来株式会社 | Level detecting method and device |
| CN201421457Y (en) * | 2009-04-13 | 2010-03-10 | 济南兰光机电技术有限公司 | Residual solvent quantity tester |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109718883A (en) * | 2018-12-25 | 2019-05-07 | 迪瑞医疗科技股份有限公司 | A kind of liquid-transfering device and liquid relief method |
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Application publication date: 20120328 Assignee: AVIC SINO AVIONICS TECHNOLOGY CO.,LTD. Assignor: Yang Xiaoyong Contract record no.: 2013990000441 Denomination of invention: Sample loading and sucking head of liquid transferring device, liquid surface contact and sample sucking detection system and method for detecting by using liquid surface contact and sample sucking detection system Granted publication date: 20130417 License type: Exclusive License Record date: 20130729 |
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Effective date of registration: 20230627 Address after: Room 4134, zone 1, building B, No. 12, Hongda North Road, Beijing Economic and Technological Development Zone, Daxing District, Beijing 100176 Patentee after: Boyuan Nordson (Beijing) Biotechnology Co.,Ltd. Address before: No. 321, Building 33, Qunfang Sanyuan Community, Liyuan Town, Tongzhou District, Beijing, 101121 Patentee before: Yang Xiaoyong |