CN102388888A - Sterilization composite containing coumoxystrobin and fludioxonil - Google Patents
Sterilization composite containing coumoxystrobin and fludioxonil Download PDFInfo
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Abstract
The invention discloses a sterilization composite containing coumoxystrobin and fludioxonil, wherein the weight ratio of coumoxystrobin to fludioxonil is 1:20-3:1. In the invention, wettable powder, suspension agent, water dispersible granule and suspension seed coating formulation accepted by the agriculture are prepared. In the sterilization composite, the component contents are reasonable, the sterilization effect is good, the dosing cost is low, the activity and the sterilization effect are not the superposition of the activities and the sterilization effects of the components. Compared with the single preparation, the sterilization composite containing coumoxystrobin and fludioxonil has obvious synergism besides the obvious sterilization effect, slows down the generation of resistance, is small in the residual amount of the preparation, is free of pollution on crops and good in safety, conforms to the requirement on safety of the pesticide preparation, and has obvious preventive effects on vegetables, fruits, strawberry anthracnose, botrytis and rice bakanae.
Description
Technical field
The present invention relates to a kind of bactericidal composition, particularly a kind of bactericidal composition that contains SYP-3375 and fludioxonil belongs to technical field of compounded pesticide.
Background technology
Methoxy acrylic bactericide is a bactericide kind newly developed in recent years, is a big milestone in the bactericide field.Methoxy acrylic bactericide has unique mechanism of action, and it stops the ATP of cell synthetic through the electronics transmission of pinning between cytochrome b and the c1, thereby suppresses its mitochondrial respiratory and bring into play bacteriostasis.The bacterial strain that 14-demethylation enzyme inhibitor, benzamides, dicarboxylic dihydrazides amine and benzimidazole is produced resistance is effective.Have protection, treat, root out, infiltration, systemic activity, and can be in plant corpus, degraded very soon in soil and the water.Although this series bactericidal agent mechanism of action is unique, pathogen is also very fast to the speed that it produces resistance, and use cost is high; So having limited the large tracts of land of methoxy acrylic bactericide promotes the use of; Therefore the bactericide combination of the methoxy acrylic bactericide and the another kind of mechanism of action is composite, improve drug effect, slow down the generation of resistance; Reduce usage amount, enlarging using of this medicament is present urgent problem.
SYP-3375 is a kind of methoxy-methyl acrylate compounds, English common name: coumoxystrobin, and chemical name: (E)-2-(2-((3-butyl-4-methyl-coumarin-7-Ji-oxygen base) methyl) phenyl)-3-methoxy-methyl acrylate.Have protection and therapeutic action; Be a kind of disinfectant use in agriculture of high-efficiency broad spectrum, to by mastigomycetes, combine plant disease that bacterium, sac fungi, basidiomycetes and imperfect fungus cause such as sclerotinia rot of colza, apple valsa canker, cucumber downy mildew, powdery mildew of cucumber, rice blast, sigatoka, alternaria leaf spot of apple etc. that good preventive effect is arranged.
Fludioxonil, English common name: fludioxonil, other titles: when right happy, chemical name: 4-2,2-two fluoro-1,3-benzo dioxy-4-yl) pyrroles-3-nitrile.Fludioxonil is a broad-spectrum touch-out property bactericide, is used for seed treatment, can prevent and treat that major part is carried disease germs and the fungal disease of soil infection.Stable in soil, form the protection zone at seed and seedling rhizosphere, prevent the germ invasion.Being used for the rotten sickle spore bacterium of control snow, wheat net raw meat black rot as the blade face bactericide. rhizoctonia solanis etc. have special efficacy to gray mold; Novel structure is difficult for and other bactericide generation cross resistance.
Although SYP-3375 is a kind of disinfectant use in agriculture of high-efficiency broad spectrum, it is as methoxy acrylic ester compounds, and the mechanism of action is single, and upward long-term repeated use germ is used in the field can produce resistance, cause preventive effect to reduce, and use cost is high.Fludioxonil has used for many years, and resistance increases year by year, and it is increasing to use dosage separately.The technology report that does not also have at present SYP-3375 and fludioxonil to be mixed.The inventor finds that through test SYP-3375 and fludioxonil that the mechanism of action is different are composite, have obvious synergistic effect; Can significantly improve control efficiency, minimizing spraying times and the dosage of treatment, protection; Slow down the generation of germ resistance, reduce the control cost, high to crop safety.
Summary of the invention
The object of the present invention is to provide a kind of component reasonable, synergistic effect is remarkable, and bactericidal effect is good, and drug cost is low, is difficult for developing immunity to drugs, to the agricultural bactericidal composition of crop safety.
Another object of the present invention is to provide the application of above-mentioned composition on control vegetables, fruit tree, strawberry anthracnose, gray mold, bakanae disease of rice.
In order to overcome the defective of existing single preparation, technical scheme of the present invention is to solve like this:
A) the first active component SYP-3375;
B) the second active component fludioxonil;
The weight ratio of first active component and second active component is 1:20～3:1, and preferred weight ratio is 1:15～2:1, and preferred weight ratio is 1:10～1:1.
The cumulant of first active component and second active component is 1%～80% of a said composition total weight, is preferably 5%～70%, more preferably 10%～50%.The size of active component cumulant is also closely related with formulation, as the active component cumulant of suspension seed-coating agent, is no more than 50%.
It is wetting powder, suspending agent, water dispersible granules, suspension seed-coating agent that the present invention contains the preparation formulation that the agricultural bactericidal composition of SYP-3375 and fludioxonil can prepare according to the known method of those skilled in the art of the present technique.
To wetting powder, spendable auxiliary agent has: in dispersant such as polycarboxylate, lignosulfonates, the alkylnaphthalene sulfonate one or more; In wetting agent such as alkyl sulfate, alkylsulfonate, the naphthalene sulfonate one or more; Filler such as ammonium sulfate, urea, sucrose, glucose, diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, potter's clay one or more.
To suspending agent, spendable auxiliary agent has: among dispersant such as polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate (dispersing agent NNO), the TERSPERSE 2020 (U.S. Huntsman Corporation produces, the alkyl naphthalene sulfonic acid salt) one or more; Alkyl phenol formaldehyde resin polyoxyethylene ether), farming breast 2201, this dish-60# (common name: Span60), Tween-60 # (common name: the polyoxyethylene sorbitan stearate), agricultural newborn 1601# (common name: triphen ethyl-phenol polyoxyethylene polyoxypropylene block polymer), among the TERSPERSE 4894 one or more emulsifier such as Nongru-700 # (common name:; Among wetting agent such as alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, alkylphenol-polyethenoxy base ether phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, the TERSPERSE 2500 one or more; In thickener such as xanthans, polyvinyl alcohol, bentonite, the aluminium-magnesium silicate one or more; In preservative such as formaldehyde, benzoic acid, the Sodium Benzoate one or more; Antifoaming agent such as organic silicon defoamer; In antifreezing agent such as ethylene glycol, propane diols, glycerine, urea, inorganic salts such as the sodium chloride one or more; Water is deionized water.
For water dispersible granules, those skilled in the art are familiar with the use corresponding adjuvants and accomplish the present invention very much.In dispersant such as polycarboxylate, lignosulfonates, the alkylnaphthalene sulfonate one or more; In wetting agent such as alkyl sulfate, alkylsulfonate, the naphthalene sulfonate one or more; In disintegrant such as ammonium sulfate, urea, sucrose, the glucose one or more; In binding agent such as diatomite, corn starch, PVA, carboxymethyl (ethyl) cellulose family one or more; Filler such as diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, potter's clay one or more.
To suspension seed-coating agent; Spendable auxiliary agent has: binding agent such as polysaccharose macromolecular compound (soluble starch, polypropylene graft copolymer, xanthan gum, microorganism mucilage), cellulose derivatives (hydroxypropyl methylcellulose, sodium carboxymethylcellulose, ethyl cellulose), seaweeds such as sodium alginate, agar; Rosin, paraffin, gelatin, pectin; The water-soluble composite of polyvinyl alcohol, polyethylene glycol, polyvinyl acetate, polyacrylamide, polyvinylpyrrolidone and polyhydric alcohol polymer, in the inorganic binder (aluminium-magnesium silicate, clay, waterglass, gypsum) one or more; Among dispersant such as polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate, the TERSPERSE 2020 (U.S. Huntsman Corporation produces, the alkyl naphthalene sulfonic acid salt) one or more; Alkyl phenol formaldehyde resin polyoxyethylene ether), farming breast 2201, this dish-60# (common name: sorbitan monostearate), emulsifier T-60 (common name: the sorbitan monostearate APEO), agricultural newborn 1601# (common name: phenethyl phenol polyoxyethylene poly-oxygen propylene aether), among the TERSPERSE 4894 one or more emulsifier such as Nongru-700 # (common name:; Among wetting agent such as alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, alkylphenol-polyethenoxy base ether phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, the TERSPERSE 2500 one or more; In thickener such as xanthans, polyvinyl alcohol, the bentonite one or more; In preservative such as formaldehyde, benzoic acid, the Sodium Benzoate one or more; Antifoaming agent such as organic silicon defoamer; In antifreezing agent such as ethylene glycol, propane diols, glycerine, urea, inorganic salts such as the sodium chloride one or more; Water is deionized water.
Component of the present invention is reasonable, and treatment adds protective effect, and bactericidal effect is good; Reduce the medication number of times, drug cost is low, and its active and bactericidal effect is not the simple superposition of each composition activity; But significant synergistic effect is arranged; Slow down the generation of resistance, good to crop safety, meet the security requirement of pesticidal preparations.The present invention has the better prevention effect to vegetables, fruit tree, strawberry anthracnose, gray mold, bakanae disease of rice.
Embodiment
In order to prevent and treat vegetables, fruit tree, strawberry anthracnose, gray mold, the bakanae disease of rice in the agricultural production; The inventor is to representational Chinese cabbage anthracnose, bakanae disease of rice and graw mold of tomato; Carried out mutual composite synergy research with SYP-3375 and fludioxonil, concrete grammar is:
Subjects be respectively cause the pathogenetic John Higgins thorn of Chinese cabbage anthrax dish spore bacterium (Col-letotrichum higginsianum Sacc.), cause the pathogenetic Botrytis cinerea bacterium of tomato gray mould (Botrytis cinerea Pers), fusarium moniliforme (Fusarium moniliforme Sheld.).The former medicine of test medicine SYP-3375 adopts Jilin eight to reach the former medicine that agricultural chemicals Co., Ltd produces, and the former medicine of fludioxonil adopts Switzerland just reaching earlier the former medicine that crop protection Co., Ltd produces.By technology department of Shanggezhilu Biosciences Co., Ltd., Shaanxi former medicine is mixed with the test medicine that needs, test method is with reference to " the agricultural industry criteria NY/T1156.2-2006 of the People's Republic of China (PRC) ".At first single agent and each Mixed Pharmacy are provided with 5 variable concentrations gradients (on preliminary experiment result's basis, different with proportioning according to different medicament combinations, the concentration gradient setting is also different, and bacteriostasis rate is pressed arithmetic series and set in 5%～90% scope).If the clear water contrast repeats 3 times.Adopt the mycelial growth rate method; With cultured pathogen, under aseptic condition, using diameter is 5 mm card punch, cuts the bacterium cake from colony edge; The bacterium cake is connected on the culture medium flat plate of different drug concentrations with transfer needle; Put in 26 ℃ of incubators and cultivate, Chinese cabbage anthrax bacteria, botrytis cinerea were cultivated 72 hours, and bakanae disease of rice was cultivated 7 days; The inspection colony diameter calculates the percentage that each chemicals treatment suppresses mycelial growth, and the EC of each medicament is obtained in the linear regression analysis between the probit value through inhibiting rate and the logarithm value of series concentration
50Value with the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun mixture, is estimated the activity of confession reagent agent to germ with this.
The co-toxicity coefficient of complex preparation (CTC)>=120 shows as synergistic effect; CTC≤80 show as antagonism; 80＜CTC＜120 show as summation action.
Toxicity Determination result shows: SYP-3375 and fludioxonil are that 1:20～3:1 uses with Chinese cabbage anthrax bacteria, botrytis cinerea, fusarium moniliforme are had virulence preferably with the weight ratio, and significant synergistic effect is all arranged.
Below in conjunction with FORMULATION EXAMPLE and biological Examples content of the present invention is described further.
FORMULATION EXAMPLE 1
Take by weighing 20% SYP-3375,60% fludioxonil, 3% TERSPERSE 2700 (polycarboxylate, U.S. Huntsman Corporation produces), 2% dispersing agent NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 2% K-12 (lauryl sodium sulfate), attapulgite adds to 100% weight portion.Above-mentioned raw materials makes 80% SYP-3375 fludioxonil wetting powder through mixing behind the comminution by gas stream.
The part by weight of SYP-3375 and fludioxonil can change between 1:20～3:1 in the present embodiment, and both total weight items still are 80%, form new embodiment.
FORMULATION EXAMPLE 2
Take by weighing 3% SYP-3375,60% fludioxonil, 4% calcium lignosulfonate, 3% TERSPERSE 2700,1% Nekal BX (nekal), 1%K-12,3% white carbon black, fine particle calcium carbonate adds to 100% weight portion.Above-mentioned raw materials makes 63% SYP-3375 fludioxonil wetting powder through mixing behind the comminution by gas stream.
The part by weight of SYP-3375 and fludioxonil can change between 1:20～3:1 in the present embodiment, and both total weight items still are 63%, form new embodiment.
FORMULATION EXAMPLE 3
Take by weighing 5% SYP-3375,25% fludioxonil, 4% calcium lignosulfonate, 4% dispersing agent NNO, 2% Nekal BX, 2%K-12, white carbon black adds to 100% weight portion.Above-mentioned raw materials makes 30% SYP-3375 fludioxonil wetting powder through mixing behind the comminution by gas stream.
The part by weight of SYP-3375 and fludioxonil can change between 1:20～3:1 in the present embodiment, and both total weight items still are 30%, form new embodiment.
FORMULATION EXAMPLE 4
Take by weighing 20% SYP-3375,30% fludioxonil, 5% calcium lignosulfonate, 3% TERSPERSE 2020 (alkyl naphthalene sulfonic acid salt, U.S. Huntsman Corporation produces), 2% Nekal BX, 2%K-12,5% white carbon black, kaolin adds to 100% weight portion.Above-mentioned raw materials makes 50% SYP-3375 fludioxonil wetting powder through mixing behind the comminution by gas stream.
The part by weight of SYP-3375 and fludioxonil can change between 1:20～3:1 in the present embodiment, and both total weight items still are 50%, form new embodiment.
FORMULATION EXAMPLE 5
Take by weighing 4% SYP-3375,32% fludioxonil, 5% TERSPERSE 4894 (U.S. Huntsman Corporation product), 2% TERSPERSE 2500 (U.S. Huntsman Corporation product), 1% TERSPERSE 2020 (U.S. Huntsman Corporation product), 0.2% xanthans, 5% propane diols, 0.5% benzoic acid, 0.5% silicone defoaming agent, deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 36% SYP-3375 fludioxonil suspending agent behind the sand mill sand milling.
The part by weight of SYP-3375 and fludioxonil can change between 1:20～3:1 in the present embodiment, and both total weight items still are 36%, form new embodiment.
FORMULATION EXAMPLE 6
Take by weighing 20% SYP-3375,10% fludioxonil, 1%TERSPERSE 2020,3% this dish-60#, 4% Tween-60 #, 1%TERSPERSE 2500,0.5% white carbon, 0.3% xanthans, 5% ethylene glycol, 0.5% benzoic acid, 0.5% silicone defoaming agent (trade name: s-29 Nanjing "four news" (new ideas applied chemistry article company produces), deionized water adds to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 30% SYP-3375 fludioxonil suspending agent behind the sand mill sand milling.
The part by weight of SYP-3375 and fludioxonil can change between 1:20～3:1 in the present embodiment, and both total weight items still are 30%, form new embodiment.
FORMULATION EXAMPLE 7
Take by weighing 15% SYP-3375,30% fludioxonil, 1%TERSPERSE 2020,3% agricultural newborn 1601#, 3% agricultural newborn 2201#, 1%TERSPERSE 2500,0.3% xanthans, 5% ethylene glycol, 0.5% formaldehyde, 0.5% silicone defoaming agent, deionized water and add to 100% weight portion.High speed shear is disperseed 30min, with making 45% SYP-3375 fludioxonil suspending agent behind the sand mill sand milling.
The part by weight of SYP-3375 and fludioxonil can change between 1:20～3:1 in the present embodiment, and both total weight items still are 45%, form new embodiment.
FORMULATION EXAMPLE 8
Take by weighing 5% SYP-3375,20% fludioxonil, 4%TERSPERSE 4894,3% Nongru-700 #, 1.5%TERSPERSE 2500,1%TERSPERSE 2020,0.5% aluminium-magnesium silicate, 5% ethylene glycol, 0.5% formaldehyde, 0.5% silicone defoaming agent, deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 25% SYP-3375 fludioxonil suspending agent behind the sand mill sand milling.
The part by weight of SYP-3375 and fludioxonil can change between 1:20～3:1 in the present embodiment, and both total weight items still are 25%, form new embodiment.
FORMULATION EXAMPLE 9
Take by weighing 60% SYP-3375,20% fludioxonil, 3% TERSPERSE 2700,3%TERSPERSE 2020 (U.S. Huntsman Corporation produces, the alkylnaphthalene sulfonate formaldehyde condensation products), 2%K-12,3% ammonium sulfate, diatomite adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 80% SYP-3375 fludioxonil water dispersible granules.
The part by weight of SYP-3375 and fludioxonil can change between 1:20～3:1 in the present embodiment, and both total weight items still are 80%, form new embodiment.
FORMULATION EXAMPLE 10
Take by weighing 20% SYP-3375,50% fludioxonil, 3% TERSPERSE 2700,3% dispersing agent NNO, 2% Nekal BX, 2%K-12,3% diatomite, 5% glucose, kaolin adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 70% SYP-3375 fludioxonil water dispersible granules.
The part by weight of SYP-3375 and fludioxonil can change between 1:20～3:1 in the present embodiment, and both total weight items still are 70%, form new embodiment.
FORMULATION EXAMPLE 11
Take by weighing 15% SYP-3375,45% fludioxonil, 3% TERSPERSE 2700,3% dispersing agent NNO, 2% Nekal BX, 1%K-12,1% carboxymethyl cellulose, 3% urea, kaolin adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 60% SYP-3375 fludioxonil water dispersible granules.
The part by weight of SYP-3375 and fludioxonil can change between 1:20～3:1 in the present embodiment, and both total weight items still are 60%, form new embodiment.
FORMULATION EXAMPLE 12
Take by weighing 5% SYP-3375,60% fludioxonil, 3% TERSPERSE 2700,2%K-12,5% ammonium sulfate, diatomite adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 65% SYP-3375 fludioxonil water dispersible granules.
The part by weight of SYP-3375 and fludioxonil can change between 1:20～3:1 in the present embodiment, and both total weight items still are 65%, form new embodiment.
FORMULATION EXAMPLE 13
Take by weighing 8% SYP-3375,32% fludioxonil, 1%TERSPERSE 2700,1%TERSPERSE 2500,3% TERSPERSE 4894,2.0% polyvinylpyrrolidone, 0.2% xanthans, 5% ethylene glycol, 0.3% benzoic acid, 0.5% silicone defoaming agent deionized water adds to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 40% SYP-3375 fludioxonil suspension seed-coating agent behind the sand mill sand milling.
The part by weight of SYP-3375 and fludioxonil can change between 1:20～3:1 in the present embodiment, and both total weight items still are 40%, form new embodiment.
FORMULATION EXAMPLE 14
Take by weighing 3% SYP-3375,2% fludioxonil, 3%TERSPERSE 4894,2%TERSPERSE 2500,1%TERSPERSE 2020,2% hydroxypropyl methylcellulose, 0.5% bentonite, 5% ethylene glycol, 0.3% Sodium Benzoate, 0.5% silicone defoaming agent deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 5% SYP-3375 fludioxonil suspension seed-coating agent behind the sand mill sand milling.
The part by weight of SYP-3375 and fludioxonil can change between 1:20～3:1 in the present embodiment, and both total weight items still are 5%, form new embodiment.
FORMULATION EXAMPLE 15
Take by weighing 15% SYP-3375,6% fludioxonil, 4%TERSPERSE 4894,2% alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, 1% dispersing agent NNO, 2.0% polyvinyl acetate, 0.2% xanthans, 5% propane diols, 0.3% benzoic acid, 0.5% silicone defoaming agent deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 21% SYP-3375 fludioxonil suspension seed-coating agent behind the sand mill sand milling.
The part by weight of SYP-3375 and fludioxonil can change between 1:20～3:1 in the present embodiment, and both total weight items still are 21%, form new embodiment.
FORMULATION EXAMPLE 16
Take by weighing 5% SYP-3375,5% fludioxonil, 3%TERSPERSE 4894,1%TERSPERSE 2500,0.5%TERSPERSE 2020,2% polyvinyl alcohol (molecular weight is 8000), 1% polyacrylamide, 0.2% xanthans, 5% glycerine, 0.3% benzoic acid, 0.5% silicone defoaming agent deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 10% SYP-3375 fludioxonil suspension seed-coating agent behind the sand mill sand milling.
The part by weight of SYP-3375 and fludioxonil can change between 1:20～3:1 in the present embodiment, and both total weight items still are 10%, form new embodiment.
Biological Examples 1: biocontrol of mango anthracnose field trial
Carried out FORMULATION EXAMPLE 7 (45% SYP-3375 fludioxonil suspending agent) biocontrol of mango anthracnose field trial in Lingshui, Hainan Province county in 2010, and verified that this medicament was to the control efficiency of mango anthracnose, effective dose and to the safety of mango.Test method is with reference to " GB/T 17980.98-2004 pesticide field efficacy medicine test criterion (two) the bactericidal agent for preventing and treating mango anthracnose test of pesticide effectiveness ".Trial crops is a mango, and controlling object is mango anthracnose (Colletotrichum gloeosporioides).Test is located at mango garden, Ying Zhou town, Lingshui county, and kind is the ivory awns, the age of tree 12 years, and growing way is general.Experimental field be ground, gentle slope, soil is the alluviation sandy soil, and fertility is general, experimental field the cultivation condition uniformity.
Test medicine and dosage are: 2500 times, 3000 times, 3500 times of 45% SYP-3375 fludioxonil suspending agents, 1500 times of 20% SYP-3375 suspending agents, 2000 times of 50% fludioxonil wetting powders.Other establishes blank, and every processing 4 times repeats, 5 trees in every sub-district, and totally 24 sub-districts, district's group is arranged at random.With agricultural HD-400 type sprayer even spraying.Mango young fruit period and each dispenser of fruit expanding period 1 time, dispenser is 2 times altogether.
Investigation and statistical method:
After the dispenser second time, carried out the disease index investigation in 10 days, each sub-district random searching 3 strain, East, West, South, North, middle sampling are pressed in every strain, investigate 10 of fruits at every, and the total fruit of record investigation number, disease fruit number at different levels calculate disease index.
Grade scale is:
0 grade: anosis;
1 grade: needle-like brown spot is less than 5 on every young fruit;
3 grades: needle-like brown spot is 6～15 on every young fruit;
5 grades: needle-like brown spot is 16～25 on every young fruit;
7 grades: needle-like brown spot is more than 25 on every young fruit, and spot links to each other;
9 grades: whole fruit is met personally scab, has red point-like thing to occur.
Disease index and control efficiency computational methods:
Diseased fruit rate (%)=(the total fruit of investigation number/disease fruit number) * 100
Disease index=[∑ (sick fruit number * relative level numerical value at different levels)/(the total fruit of investigation number * 9)] * 100
Control efficiency (%)=[(contrast disease index-processing disease index)/contrast disease index] * 100
Security survey and to the influence of other biological: sprayed behind the medicine the 1st day at every turn and medicine after some days, each handles the influence to mango to observe medicament.
Field test results shows; 45% SYP-3375 fludioxonil suspending agent has good control efficiency to mango anthracnose; Dilute 2500 times, 3000 times, 3500 times sprayings; 10 days diseased fruit rates are than the apparent reduction of illumination after the dispenser second time, and preventive effect is respectively 87.26%, 83.14%, 77.36%, obviously are superior to the preventive effect of 1500 times of 20% SYP-3375 suspending agents, 2000 times of 50% fludioxonil wetting powders.
Through 10 days each sub-district preventive effects behind the second time medicine are carried out biostatistics analysis (seeing table 4); Significance of difference comparative result shows: on 0.05 level with 0.01 level on the significance of difference consistent; Significant difference between 2500 times, 3000 times, 3500 times of the 45% SYP-3375 fludioxonil suspending agents; All extremely remarkable with 1500 times of 20% SYP-3375 suspending agents, 2000 times of differences of 50% fludioxonil wetting powder, difference is not remarkable between 2000 times of 1500 times of 20% SYP-3375 suspending agents and the 50% fludioxonil wetting powders.
Duration of test is observed, each chemicals treatment not to the flower of mango, really, leaf produces the poisoning phenomenon.
Result of the test has obviously improved the control efficiency to mango anthracnose after showing that SYP-3375 and fludioxonil are mixed, and has reduced dosage and drug cost, to Growth of Mango safety, is the desirable medicament of biocontrol of mango anthracnose.
Biological Examples 2: control graw mold of tomato field trial
Carried out FORMULATION EXAMPLE 11 (60% SYP-3375 fludioxonil water dispersible granules) control graw mold of tomato field trial at the Guangxi province Bose City in 2011, and verified that this medicament was to the control efficiency of graw mold of tomato, effective dose and to the safety of tomato.Test method is with reference to " GB/T 17980.28-2000 pesticide field efficacy medicine test criterion () bactericidal agent for preventing and treating eliminating vegetable botrytis ".Trial crops is a tomato, and controlling object is graw mold of tomato (Botrytis cinereaPers.).Test is located at Tian Zhou town, Bose City Tianyang County, and soil is sandy loam, and fertility is good, experimental field the cultivation condition uniformity.
Test medicine and dosage are: 60% SYP-3375 fludioxonil water dispersible granules 21g/667 ㎡, 18g/667 ㎡, 15g/667 ㎡, 20% SYP-3375 suspending agent 20g/667 ㎡, 50% fludioxonil wetting powder 50g/667 ㎡.Other establishes blank, and every processing 4 times repeats, every sub-district area 30 ㎡, and totally 24 sub-districts, district's group is arranged at random.Adopt conventional spray-on process, mu dispenser liquid 60 kg evenly are sprayed at leave dual sides.In the tomato dispenser for the first time that comes into bloom, every later at a distance from dispenser in 7 days 1 time, common dispenser three times.
Investigation and statistical method:
Before the dispenser first time with after the dispenser for the first time, carried out the disease index investigation behind 7 days, dispenser for the third time in 14 days respectively; Investigate altogether 3 times, 5 points are investigated in each sub-district, every some investigation 3 strain tomatoes; Write down total number of sheets, the sick number of sheets at different levels and sick progression, calculate disease index.
Grade scale is:
1 grade: blade does not have scab
2 grades: fragmentary little scab appears in blade
3 grades: lesion area accounts for the 1/6-l/4 of leaf area
4 grades: lesion area accounts for leaf area 1/4-l/2
5 grades: lesion area accounts for leaf area more than 1/2 or cause fallen leaves
Disease index and control efficiency computational methods:
Disease index=[∑ (the sick numbers of sheets at different levels * relative level numerical value)/(investigating total number of sheets * 5)] * 100
Control efficiency (%)=[(contrast disease index-processing disease index)/contrast disease index] * 100
Security survey and to the influence of other biological: sprayed behind the medicine the 1st day at every turn and medicine after some days, each handles the influence to tomato to observe medicament.
Duration of test is observed, and each chemicals treatment does not produce the poisoning phenomenon to tomato, and 60% SYP-3375 fludioxonil water dispersible granules also shows good control efficiency to tomato blight, leaf mold.
Result of the test has obviously improved the control efficiency to graw mold of tomato after showing that SYP-3375 and fludioxonil are mixed, and has reduced dosage and drug cost, to tomato growth safety, is the desirable medicament of control graw mold of tomato.
Biological Examples 3: prevent and treat the bakanae disease of rice field trial
Carried out FORMULATION EXAMPLE 16 (10% SYP-3375 fludioxonil suspension seed-coating agent) in the Mudanjiang City, Heilongjiang Province in 2010 and prevented and treated the bakanae disease of rice field trial, verified that this medicament is to the control efficiency of bakanae disease of rice, effective dose and to the safety of paddy rice.Test method is with reference to " GB/T 17980.104-2004 pesticide field efficacy medicine test criterion (two) the 104th part: bactericidal agent for preventing and treating bakanae disease of rice ".Trial crops is a paddy rice, and kind educates 397 on being, controlling object is bakanae disease of rice (Fusariummoniliforme).Ba Litong town one seed multiplication farm carries out in the Muling City in test, and soil types is the grassy marshland paddy soil, and the content of organic matter is 3.2%, and pH is 6.5.Carry out seed treatment on April 20th, 2010.Test medicine and dosage are: 10% SYP-3375 fludioxonil suspension seed-coating agent 200g/100 kilogram seed, 170g/100 kilogram seed, 140g/100 kilogram seed; 20% SYP-3375 suspending agent 150g/100 kilogram seed, 2.5% fludioxonil suspension seed-coating agent 600g/100 kilogram seed.Other establishes the clear water blank, and every processing repeats for 4 times, sub-district, seedbed area 8 ㎡, and Honda sub-district area 20 ㎡, district's group is arranged at random.Each chemicals treatment is calculated dosing and is converted the water yield in the ratio of 1.6 hydrargyrum oxydatum crudum liquid processing double centner seed.Handle the back sowing in rice paddy seed
Investigation and statistical method are investigated 2 times altogether, rise before the seedling with before heading stage respectively at rice transplanting and investigate, and 5 points are investigated in every sub-district, every 20 strain, and the diseased plant rate of sub-district bakanae disease is respectively handled in investigation, calculates preventive effect.Each handles the influence to paddy rice to observe medicament at each crucial growing stage of paddy rice.
Diseased plant rate (%)=(the morbidity strain number/total strain number of investigation) * 100
Control efficiency (%)=[(check plot diseased plant rate-treatment region diseased plant rate)/check plot diseased plant rate] * 100.
Field test results shows; 10% SYP-3375 fludioxonil suspension seed-coating agent has good control efficiency to bakanae disease of rice; Every double centner seed is handled seed by 200 g, 170g, 140g consumption; At rice transplanting phase and heading stage the preventive effect of bakanae disease of rice is all reached 100%, be superior to 20% SYP-3375 suspending agent 150g/100 kilogram seed, 2.5% fludioxonil suspension seed-coating agent 600g/100 kilogram seed treatment preventive effect (table 6) bakanae disease of rice.
The seedling quality investigation shows before transplanting; In the 10% SYP-3375 fludioxonil suspension seed-coating agent test dose scope; Handle the rice seedling rate and be higher than blank about 2%, the plant height of rice shoot, fresh weight slightly are better than blank, show that medicament is to paddy growth safety, no poisoning.
Result of the test has obviously improved the control efficiency to bakanae disease of rice after showing that SYP-3375 and fludioxonil are mixed, and has reduced dosage and drug cost, to paddy growth safety, is the desirable medicament of preventing and treating bakanae disease of rice.
In sum, composition of the present invention is to adopt two kinds of active component compound schemes, and its activity and bactericidal effect are not the simple superposition of each composition activity; Compare with existing single preparation, except that having significant bactericidal effect, and significant synergistic effect is arranged; Slow down the generation of resistance, the preparation less residue, pollution-free to crop; Safety is good, meets the security requirement of pesticidal preparations.
Claims (8)
1. bactericidal composition that contains SYP-3375 and fludioxonil is characterized in that comprising:
A) the first active component SYP-3375;
B) the second active component fludioxonil;
The weight ratio of first active component and second active component is 1:20～3:1.
2. according to the said bactericidal composition that contains SYP-3375 and fludioxonil of claim 1, it is characterized in that: the weight ratio of first active component and second active component is 1:15～2:1.
3. according to the said bactericidal composition that contains SYP-3375 and fludioxonil of claim 2, it is characterized in that: the weight ratio of first active component and second active component is 1:10～1:1.
4. according to one of any said bactericidal composition that contains SYP-3375 and fludioxonil of claim 1 to 3, it is characterized in that: the cumulant of first active component and second active component is 1%～80% of a said composition total weight.
5. according to the said bactericidal composition that contains SYP-3375 and fludioxonil of claim 1, it is characterized in that: the cumulant of first active component and second active component is 5%～70% of a said composition total weight.
6. according to the said bactericidal composition that contains SYP-3375 and fludioxonil of claim 5, it is characterized in that: said composition can be mixed with agricultural and go up any formulation that allows.
7. according to the said bactericidal composition that contains SYP-3375 and fludioxonil of claim 6, it is characterized in that: said composition is wetting powder, suspending agent, water dispersible granules, suspension seed-coating agent.
8. the said bactericidal composition that contains SYP-3375 and fludioxonil of claim 1 is in the purposes of preventing and treating on vegetables, fruit tree, strawberry anthracnose, gray mold, the bakanae disease of rice.
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| CN104904723A (en) * | 2014-03-11 | 2015-09-16 | 江苏龙灯化学有限公司 | Sterilization composition |
| CN105265434A (en) * | 2014-07-18 | 2016-01-27 | 中化农化有限公司 | Pesticide composition containing fludioxonil |
| CN106472609A (en) * | 2016-08-31 | 2017-03-08 | 江苏星源生物科技有限公司 | A kind of bactericidal composition preventing and treating root rotof flax and its application |
| CN107094766A (en) * | 2017-05-11 | 2017-08-29 | 深圳诺普信农化股份有限公司 | A kind of seed treatment |
| CN107668042A (en) * | 2017-11-20 | 2018-02-09 | 陕西上格之路生物科学有限公司 | A kind of bactericidal composition containing metconazole, fludioxonil and Metalaxyl-M |
| CN108684676A (en) * | 2018-07-07 | 2018-10-23 | 安徽省农业科学院植物保护与农产品质量安全研究所 | A kind of bactericidal composition containing volution bacterium amine and fludioxonil |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104904723A (en) * | 2014-03-11 | 2015-09-16 | 江苏龙灯化学有限公司 | Sterilization composition |
| CN105265434A (en) * | 2014-07-18 | 2016-01-27 | 中化农化有限公司 | Pesticide composition containing fludioxonil |
| CN105265434B (en) * | 2014-07-18 | 2018-03-23 | 中化农化有限公司 | Composition pesticide containing fludioxonil |
| CN106472609A (en) * | 2016-08-31 | 2017-03-08 | 江苏星源生物科技有限公司 | A kind of bactericidal composition preventing and treating root rotof flax and its application |
| CN107094766A (en) * | 2017-05-11 | 2017-08-29 | 深圳诺普信农化股份有限公司 | A kind of seed treatment |
| CN107668042A (en) * | 2017-11-20 | 2018-02-09 | 陕西上格之路生物科学有限公司 | A kind of bactericidal composition containing metconazole, fludioxonil and Metalaxyl-M |
| CN108684676A (en) * | 2018-07-07 | 2018-10-23 | 安徽省农业科学院植物保护与农产品质量安全研究所 | A kind of bactericidal composition containing volution bacterium amine and fludioxonil |
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Effective date of registration: 20170124 Address after: 136100 Gongzhuling national agricultural science and Technology Park in Jilin province Nan Wei Zi Zhen Jie Dong Patentee after: Jilin Bada Pesticide Co., Ltd. Address before: 9 No. 710404 Shaanxi province Xi'an Zhouzhi County of Jixian City Industrial Park Venture Road Patentee before: Shanggezhilu Biosciences Co., Ltd., Shaanxi |