CN102370919A - Medicinal combination for eliminating blood stasis and softening hardness and preparation method thereof - Google Patents
Medicinal combination for eliminating blood stasis and softening hardness and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicinal combination for eliminating blood stasis and softening hardness and a preparation method thereof, which relate to the field of medicines. The medicinal combination is prepared from the following traditional Chinese medicinal raw materials: rhizoma typhonii (processed), ginseng, rhizoma sparganii, milk veteh, radix sophorae tonkinensis, polyphylla, isatis root, pseudobulbus cremastrae seu pleiones, herba scutellariae barbatae, honeysuckle, corydalis tuber (processed with vinegar) and leonurus. The medicinal combination has functions of eliminating the blood stasis, softening the hardness, detoxicating and benefiting vital energy, has improvement effects on assisting diseases of aches, indigestion and loss of appetite, abdominal distention, fatigued spirit and lack of strength, and the like, and can be used as an auxiliary curative medicine for primary liver cancers. If the medicinal combination is matched with an interventional chemotherapeutic method, the curative effect is improved beneficially.
Description
Technical field
The present invention relates to tcm field, be specifically related to a kind of pharmaceutical composition of treating primary hepatocarcinoma, blood stasis dispelling softening the hard mass and preparation method thereof.
Background technology
Mostly its pathogenesis of malignant tumor is to lose on the empty basis in healthy energy, and the stagnation of QI, blood stasis, phlegm-damp, pathological factor such as scorchingly hot are separately or interact and form.Therefore, should qi and pathogen during treatment, strengthening vital QI to eliminate pathogenic factors according to the weight of the state of an illness, determines or overweights and set upright, and still focuses on eliminating evil.Primary hepatocarcinoma is one of China's common cancer.Mortality rate is high, in the dead cis-position of malignant tumor, is only second to stomach, esophagus and occupies the 3rd, is partly then accounting for second in the geographic rural area, is only second to gastric cancer.
At present, when people suffered from the primary hepatocarcinoma disease, in the flourishing city of medical condition, people were hospital treatments, generally all are to use Western medicine or have an injection to treat; And in the small towns, more particularly away from small towns, outlying village, when people suffer from the disease of primary hepatocarcinoma; Because family income is low, living in penury, the locality lacks medical condition; Need expensive travelling expenses go to the flourishing city of medical condition to go to seek medical advice if want to cure the disease, the medical expense of hospital and medical expenses are expensive in addition, people's treatment of often not going sick; Therefore the recovery from illness of giving free rein to, some sufferer have incured loss through delay treatment opportunity.
Summary of the invention
The invention provides a kind of pharmaceutical composition of treating primary hepatocarcinoma, blood stasis dispelling softening the hard mass and preparation method thereof.
Pharmaceutical composition of a kind of blood stasis dispelling softening the hard mass that the present invention proposes and preparation method thereof is processed by the raw material of Chinese medicine of following weight ratio: Rhizoma Typhonii (system) 700-800 part; Radix Ginseng 200-300 part; Triangular 200-300 part; Radix Astragali 200-300 part; Radix Sophorae Tonkinensis 200-300 part; Rhizoma Paridis 200-300 part; Radix Isatidis 200-400 part; Pseudobulbus Cremastrae Seu Pleiones 100-150 part; Herba Scutellariae Barbatae 100-150 part; Flos Lonicerae 100-150 part; Rhizoma Corydalis (vinegar system) 100-150 part; Herba Leonuri 100-150 part.
Among the present invention, pharmaceutical composition of described a kind of blood stasis dispelling softening the hard mass and preparation method thereof, a preferred version is for to be processed by the raw material of Chinese medicine of following weight ratio: 750 parts of Rhizoma Typhoniis (system); 250 parts of Radix Ginsengs; Triangular 250 parts; 250 parts of the Radixs Astragali; 250 parts of Radix Sophorae Tonkinensiss; 250 parts of Rhizoma Paridis; 250 parts of Radix Isatidis; 125 parts of Pseudobulbus Cremastrae Seu Pleioness; 125 parts of Herba Scutellariae Barbataes; 125 parts of Flos Loniceraes; 125 parts of Rhizoma Corydalis (vinegar system); 125 parts of Herba Leonuris.
Among the present invention, pharmaceutical composition of described a kind of blood stasis dispelling softening the hard mass and preparation method thereof is an oral formulations.
Rhizoma Typhonii has another name called Herba Typhonii gigantei.Acrid in the mouth, sweet, warm in nature, poisonous.Return stomach, Liver Channel.It is the herbaceos perennial of spathe order Araeceae.The tuber hyoscine, the expectorant that can dispel the wind, by cold-damp, spasmolytic is controlled headache, facial hemiparalysis, hemiplegia, tetanus, traumatic injury impairment caused by overstrain, numb limbs and tense tendons, aphasia due to apoplexy, lymphoid tuberculosis, snake bite and insect sting etc.
Radix Ginseng property is flat, sweet in the mouth, little hardship, tepor.Return spleen, lung meridian.Strongly invigorating primordial QI is arranged, and multiple arteries and veins takes off invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, the effect of the Fructus Alpiniae Oxyphyllae of calming the nerves admittedly.Cure mainly that impairment caused by overstrain is deficient, lack of appetite, asthenia, regurgitation are told food, stool lingering diarrhea, empty cough with asthma are short, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency be multiple, the card of all qi-blood-body fluid deficiencies.Radix Ginseng can be regulated the balance of central nervous system's process of excitation and process of inhibition.Through the research of Radix Ginseng to the influence of animal brain electrical activity, the result shows: it is all influential to two kinds of nervous process of excitement and inhibition, but mainly strengthens corticocerebral process of excitation.Owing to act on process of inhibition simultaneously, suppress to be tending towards concentrated so make, make differentiation acceleration and more complete.Radix Ginseng scalable function of nervous system makes anxiety cause disorderly nervous process to be able to recover.Ginsenoside Rb's class has the maincenter sedation, and Rb1, Rb2, Rc mixing Saponin have stable effect; The Rg class has the central excitation effect.The ginsenoside is low dose of excited to the influence of maincenter, the heavy dose of inhibition.Radix Ginseng has amphicheirality and composition dependency to the influence of learning and memory.Human experimentation proves: the mechanism of Radix Ginseng antifatigue effect possibly synthesized relevant with promotion protein, RNA with its rising blood fat.Research shows that the antifatigue effect of ginsenoside Rg1 is remarkable, the no antifatigue effect of neutral Saponin (Rb1, Rb2, Rc etc.).Experiment proof: Radix Ginseng can promote the synthesizing of the synthetic DNA of reaching of proteinic synthetic, RNA.Radix Ginseng also has tangible influence to cerebral blood flow and brain energy metabolism.Gen-seng can increase the picked-up of Medulla Leporis seu Oryctolagi glucose, reduces the ratio of lactic acid, acetone acid and lactic acid/acetone acid simultaneously, and can make the utilization of glucose change aerobic metabolism into from the anaerobic metabolism approach.Radix Ginseng also can make Phos increase freely 25% in the cerebral cortex.The Herba Herminii saponin can improve brain and take the photograph the oxygen ability.Damage all has protective effect to Cerebral Ischemia for Radix Ginseng total saponins, the total Saponin of Radix Ginseng.In a word, Radix Ginseng can make animal brain more reasonably utilize the energy matter glucose, the oxidation production capacity, and synthetic more ATP supplies the usefulness of activities such as learning and memory.
Triangular bitter in the mouth, property is flat.Removing blood stasis, circulation of qi promoting, removing food stagnancy pain relieving.It is swollen hard to cure mainly expand down painful, amenorrhea, postnatal blood stasis stomachache, traumatic injury, skin ulcer of lump in the abdomen, coagulation of QI-blood, trusted subordinate's pain, the side of body.Be applicable to kinds of tumors, like ovarian cancer, cervical cancer, hepatocarcinoma etc.Normal and the ovarian cancer that compatibility treatment QI and blood knot is long-pending, the blood stasis stasis of blood is stagnant, cervical cancers etc. such as Rhizoma Cyperi, Rhizoma Curcumae, Radix Arnebiae (Radix Lithospermi), Fructus Fici Pumilae.The hepatocarcinoma that compatibility treatment qi depression to blood stasis, pyretic toxicity such as Herba Hedyotidis Diffusae commonly used, Pericarpium Arecae, Poria, Rhizoma Curcumae pent up.These article also are applicable to stagnation of QI and blood, abdominal part caking, hepatosplenomegaly, amenorrhea stomachache, food stagnation distending pain etc. in addition.
Radix Astragali sweet in the mouth, slightly warm in nature.Return lung, spleen, liver, kidney channel.Have effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.The Radix Astragali has benefiting QI for strengthening the superficies, arresting sweating to take off, hold in the palm the effect of skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.It is weak to be used to treat the deficiency of vital energy, sinking of QI of middle-JIAO, and the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.The invigorating middle warmer of Radix Astragali Preparata QI invigorating is given birth to consolidating superficial resistance holder skin ulcer.
The Radix Sophorae Tonkinensis bitter in the mouth, cold in nature.Cure mainly retropharyngeal abscess, acute throat trouble, sore throat, gingival swelling and pain, the dyspnea with fullness of the chest heat syndrome cough, jaundice, dysentery, haemorrhoids, heat is swollen, tinea alba, scabies, Serpentis, worm, lyssodexis.The detoxifcation of relieving inflammation or internal heat, reducing swelling and alleviating pain.Be used for throat gingival swelling and pain, cough due to lung-heat's excessive thirst, jaundice, constipation with heat retention.
The Rhizoma Paridis cold nature, bitter in the mouth; Slightly poisonous.Cure mainly heat-clearing and toxic substances removing, reducing swelling and alleviating pain, cool liver arresting convulsion.Make in furuncle swollen carbuncle, laryngopharynx swelling and pain, venom, fall and pounce on the pain of injury, convulsion with spasms.Contain multiple steroid saponin chemical constituent, for diosgenin and pennogenin two, three, the tetrose glycoside, other contains β-ecdyson, daucosterol etc.
Radix Isatidis property is bitter, and flavor is cold.Chang Zuowei antipyretic, heat and toxic materials clearing away medicine, blood-cooling drugs.Heat clearing away, detoxifcation, removing heat from blood, sore-throat relieving.Cure mainly maculae caused by violent heat pathogen; The hyperpyrexia headache; Major part pestilence; Crimson tongue is purple dark, scarlet fever; Erysipelas; Mumps; Sore throat; Skin ulcer is swollen, carbuncle; Chickenpox; Measles; Hepatitis; Influenza, epidemic encephalitis, encephalitis b, pneumonia, coma is told nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash; Can prevent and treat epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis.
Pseudobulbus Cremastrae Seu Pleiones property is sweet, distinguish the flavor of little suffering, cold; Return liver, spleen channel.Function cures mainly: heat-clearing and toxic substances removing, dissipating phlegm and resolving masses.Be used for the carbuncle furunculosis, scrofula sucutaneous nodule, tuberculous lymphadenitis, snake bite and insect sting.
Herba Scutellariae Barbatae property is hot, bitter in the mouth, cold; Return lung, liver, kidney channel.Function cures mainly: heat-clearing and toxic substances removing, blood stasis dispelling diuresis.Be used for furuncle swelling toxin, laryngopharynx swelling and pain, venom falls and pounces on the pain of injury, edema, jaundice.Tool heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, function such as anticancer.Herb contains carthamin, isocarthamidin, high mountain baicalin, the yellow official seal glycoside of high mountain, cupreol, stearic acid, alkaloid polysaccharide etc.According to another report; Obtain wogonin, rivularin, Herba Scutellariae Barbatae kind element, naringenin, apigenin, dinatin, eriodictyol, luteolin, 5 from the aerial parts separation; 7; 4-trihydroxy-8-methoxyl group flavanone, 4-hydroxyl wogonin, 7-gate of a lane base-5,8-dimethoxy flavone, right-great basic benzene first Tibet, right-great basic benzylacetone, right-coumaric acid, protocatechuic acid, ursolic acid, plant sterol and plant sterol β-D-glycoside etc.
The Flos Lonicerae sweet in the mouth; Cold in nature; Return lung, stomach.Effect cures mainly: heat-clearing and toxic substances removing.The epidemic febrile disease heating; Toxic-heat and blood stasis; The carbuncle furuncle; Sore throat and multiple infectious disease.Flos Lonicerae is described as the good medicine of heat-clearing and toxic substances removing from ancient times.The sweet cold of its property fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance reaches thoroughly and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, and also kind removing summer-heat blood poison is used for various febrile diseases, and like fever of the body, dermexanthesis, send out cards such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, all effect is remarkable.
Rhizoma Corydalis cures mainly all pains of trusted subordinate's waist knee joint, menoxenia, lump in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.Analgesia, calmness, syngignoscism are arranged.The several formulations that experiment showed, Rhizoma Corydalis all has obvious analgesic activity, especially acting as obviously with alcohol system extractum, powder and fluid-acet-extract.The full alkali of Rhizoma Corydalis can significantly increase coronary flow, and is similar with papaverine.Zoopery shows: repeatedly give the Rhizoma Corydalis alcohol extract; Can obviously alleviate the myocardial necrosis degree that the heavy dose of isoproterenol of subcutaneous injection is produced; The prompting Rhizoma Corydalis has the ability of improving the trophism blood supply of downright bad marginal zone, myocardial infarction is had certain control be worth.Some compositions of Rhizoma Corydalis have protective effect to gastric ulcer, and like the plain subcutaneous injection of dehydrogenation Rhizoma Corydalis first, the gastric ulcer to experimental gastric ulcer, particularly pylorus ligation or the aspirin of rat brings out has obvious protective effect.Protopine all has the certain protection effect to the gastric ulcer that pyloric ligation ulcer and tetrahydropalmatine bring out hunger.Rhizoma Corydalis still has myorelaxant effects.Have report to point out, the methyl tetrahydropalmatine is to act on nondepolarizing type neuromuscular blocking drug after the neuromuscular junction, and its flesh pine position is in periphery.The methyl tetrahydropalmatine is compared with tubocurarine, tire low and the effect a little less than; Its blocking effect can be resisted by neostigmine.
Herba Leonuri bitter in the mouth, suffering; Cold nature; Return liver, pericardium channel.Promoting blood flow to regulate menstruation, inducing diuresis to remove edema.Be used for menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.Go into the heart, liver, urinary bladder channel.Effect cures mainly: promoting blood flow to regulate menstruation, inducing diuresis to remove edema, heat-clearing and toxic substances removing; Treatment edema, dysuria.Can singly use, also can join uses such as Rhizoma Imperatae, Herba Lycopi;
The treatment water stasis of blood is tied congestion obstacle bladder mutually; Can treat sore and toxic, urticaria; Promoting blood flow to regulate menstruation is used for amenorrhea due to stagnation of blood, dysmenorrhea, blockage of menstruation, and prolonged lochia, the stasis of blood stagnate and suffer from abdominal pain; Can be used for traumatic injury again.
Among the present invention, pharmaceutical composition of described a kind of blood stasis dispelling softening the hard mass and preparation method thereof, described method for preparing process following steps,
1. take by weighing the raw material of Chinese medicine of said part by weight, Rhizoma Typhonii powder is broken into coarse powder, with 8 times of amount 70% ethanol percolations, and the percolate decompression recycling ethanol, subsequent use;
2. with all the other ten Herba indigoferae Pseudotinctoriae, add 10 times of water gagings and decoct 2 times, each 2 hours, merge decoction liquor; Filter, filtrating is concentrated into relative density 1.20 (50-60 ℃), adds ethanol and makes and contain the alcohol amount and reach 70%; Left standstill 35-50 hour, and got the supernatant decompression recycling ethanol, merge with above-mentioned percolate; Cold preservation filters, and being evaporated to relative density is 1.20-1.22 (50-60 ℃);
3. with above-mentioned clear paste be prepared into suitable oral formulations after other pharmaceutic adjuvants mix.
Among the present invention, pharmaceutical composition of described a kind of blood stasis dispelling softening the hard mass and preparation method thereof, a preferred oral preparation formulation is a granule.
Among the present invention, the pharmaceutical composition of described a kind of blood stasis dispelling softening the hard mass has the effect of blood stasis dispelling softening the hard mass, detoxifcation QI invigorating, to assisting diseases such as pain, indigestion and loss of appetite, abdominal distention, spiritlessness and weakness the improvement effect is arranged, and can be used as the auxiliary therapeutic agent of primary hepatocarcinoma.Get involved embolic chemotherapy if cooperate, help to improve curative effect.Its advantage is: because the material that makes up a prescription in the prescription all uses natural Chinese herbal medicines, add that then traditional method is made, material is prone to get, and prescription and method for preparing are simple, and preparation medicine cost has reached the object of the invention.
Usage: oral.3 times on the one, one time one bag.30-60 days is a course of treatment.
The specific embodiment
Pharmaceutical composition of a kind of blood stasis dispelling softening the hard mass of the present invention and preparation method thereof is described below in conjunction with embodiment.
Embodiment 1.
Among the present invention, pharmaceutical composition of described a kind of blood stasis dispelling softening the hard mass and preparation method thereof, described method for preparing process following steps,
1. take by weighing the raw material of Chinese medicine of said part by weight: Rhizoma Typhonii (system) 750g; Radix Ginseng 250g; Triangular 250g; Radix Astragali 250g; Radix Sophorae Tonkinensis 250g; Rhizoma Paridis 250g; Radix Isatidis 250g; Pseudobulbus Cremastrae Seu Pleiones 125g; Herba Scutellariae Barbatae 125g; Flos Lonicerae 125g; Rhizoma Corydalis (vinegar system) 125g; Herba Leonuri 125g.Rhizoma Typhonii powder is broken into coarse powder, with 8 times of amount 70% ethanol percolations, and the percolate decompression recycling ethanol, subsequent use;
2. with all the other ten Herba indigoferae Pseudotinctoriae, add 10 times of water gagings and decoct 2 times, each 2 hours, merge decoction liquor; Filter, filtrating is concentrated into relative density 1.20 (50-60 ℃), adds ethanol and makes and contain the alcohol amount and reach 70%; Left standstill 35-50 hour, and got the supernatant decompression recycling ethanol, merge with above-mentioned percolate; Cold preservation filters, and being evaporated to relative density is 1.20-1.22 (50-60 ℃);
3. with above-mentioned clear paste be prepared into suitable oral formulations after other pharmaceutic adjuvants mix, add aspartame 1g, mixing, 550g does bed material with dextrin, mist projection granulating is processed granule 1000g, packing, every bag of 10g promptly gets.
The above; Be merely the preferable specific embodiment of the present invention; But protection scope of the present invention is not limited thereto; Any technical staff who is familiar with the present technique field is equal to replacement or change according to technical scheme of the present invention and inventive concept thereof in the technical scope that the present invention discloses, all should be encompassed within protection scope of the present invention.
Claims (5)
1. the pharmaceutical composition of a blood stasis dispelling softening the hard mass, it is characterized in that: the raw material of Chinese medicine by the following weight ratio is processed: Rhizoma Typhonii (processed) 700-800 part; Radix Ginseng 200-300 part; Triangular 200-300 part; Radix Astragali 200-300 part; Radix Sophorae Tonkinensis 200-300 part; Rhizoma Paridis 200-300 part; Radix Isatidis 200-400 part; Pseudobulbus Cremastrae Seu Pleiones 100-150 part; Herba Scutellariae Barbatae 100-150 part; Flos Lonicerae 100-150 part; Rhizoma Corydalis (processed with vinegar) 100-150 part; Herba Leonuri 100-150 part.
2. the pharmaceutical composition of a kind of blood stasis dispelling softening the hard mass according to claim 1 is characterized in that: the raw material of Chinese medicine by the following weight ratio is processed: 750 parts of Rhizoma Typhonii (processed); 250 parts of Radix Ginsengs; Triangular 250 parts; 250 parts of the Radixs Astragali; 250 parts of Radix Sophorae Tonkinensiss; 250 parts of Rhizoma Paridis; 250 parts of Radix Isatidis; 125 parts of Pseudobulbus Cremastrae Seu Pleioness; 125 parts of Herba Scutellariae Barbataes; 125 parts of Flos Loniceraes; 125 parts of Rhizoma Corydalis (processed with vinegar); 125 parts of Herba Leonuris.
3. the pharmaceutical composition of a kind of blood stasis dispelling softening the hard mass according to claim 2 is characterized in that: be oral formulations.
4. the preparation of drug combination method of a kind of blood stasis dispelling softening the hard mass according to claim 1 is characterized in that: described method for preparing process following steps,
1. take by weighing the raw material of Chinese medicine of said part by weight, Rhizoma Typhonii powder is broken into coarse powder, with 8 times of amount 70% ethanol percolations, and the percolate decompression recycling ethanol, subsequent use;
2. with all the other ten Herba indigoferae Pseudotinctoriae, add 10 times of water gagings and decoct 2 times, each 2 hours, merge decoction liquor; Filter, filtrating is concentrated into relative density 1.20 (50-60 ℃), adds ethanol and makes and contain the alcohol amount and reach 70%; Left standstill 35-50 hour, and got the supernatant decompression recycling ethanol, merge with above-mentioned percolate; Cold preservation filters, and being evaporated to relative density is 1.20-1.22 (50-60 ℃);
3. with above-mentioned clear paste be prepared into suitable oral formulations after other pharmaceutic adjuvants mix.
5. the pharmaceutical composition of a kind of blood stasis dispelling softening the hard mass according to claim 4 is characterized in that: a preferred oral preparation formulation is a granule.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302718A (en) * | 2011-08-23 | 2012-01-04 | 北京普瑞博思投资有限公司 | Antitumor medicinal composition and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302718A (en) * | 2011-08-23 | 2012-01-04 | 北京普瑞博思投资有限公司 | Antitumor medicinal composition and preparation method thereof |
| CN102302718B (en) * | 2011-08-23 | 2013-12-11 | 北京普瑞博思投资有限公司 | Antitumor medicinal composition and preparation method thereof |
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Application publication date: 20120314 |