CN102370759B - A kind of compound Chinese medicinal preparation treating acne and preparation method thereof - Google Patents
A kind of compound Chinese medicinal preparation treating acne and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese traditional compound medicine treating acne, including the raw material of Chinese medicine of following weight proportioning: Radix Scutellariae 8 12, Fructus Forsythiae 13 17, Cortex Mori 8 12, Radix Salviae Miltiorrhizae 8 12, Radix Angelicae Sinensis 8 12, Radix Et Rhizoma Rhei 57, Radix Sophorae Flavescentis 57, Fructus Gardeniae 8 12, Rhizoma Coptidis 57, Herba Hedyotidis Diffusae 13 17, Radix Glycyrrhizae 57；Its preparation method is to be cleaned by above-mentioned 11 taste medical materials, it is mixed in proportion, the water or the ethanol that volume ratio is 75% that add 57 times of medical material gross weight decoct 2 times, each 80 minutes, merge 2 decoction liquor, filter, and concentrate, obtaining proportion when 60 DEG C is the fluid extract of 1.16, uses conventional fabrication process, Chinese medicine preparation of the present invention can be made into dosage form described on any pharmaceutics, such as tablet, capsule, granule, oral liquid, pill, syrup.The advantages such as the present invention is effective in cure good, has no adverse reaction, Chinese medicine preparation no dependence, may apply in acne clinical treatment.
Description
Technical field
The present invention relates to a kind of compound Chinese medicinal preparation treating acne and preparation method thereof, belong to field of traditional Chinese.
Background technology
Acne is a kind of common hair follicle, sebaceous gland chronic inflammation disease, is apt to occur in adolescence.Its cause of disease is a lot,
It is generally acknowledged that androgen secretion increases, smegma increases, and sebum deposits into fat bolt, hair follicle, sebaceous gland duct keratinization
Thromboembolism, propanoic acid Propiobacterium amount reproduction, follicular wall lesion ruptures, perifollicolar scytitis reacts;Immunoreation, interior point
Secrete obstacle, many lipopolysaccharide and irritative food, high ambient temperature and some chemical factor etc. and participate in the whole course of disease of acne;Also with
Heredity and psychological factor are relevant, influence each other between these factors.Clinical manifestation is acne, pimple, pustule, tuberosity and cyst,
Or various erythra depositing.
Although the method for western medicine acne has certain curative effect, but there is untoward reaction, there are the shortcomings such as bigger dependency.
Summary of the invention
It is an object of the invention to provide a kind of Chinese traditional compound medicine treating acne and preparation method thereof.
The present invention provides a kind of Radix Scutellariae, Fructus Forsythiae, Cortex Mori, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Et Rhizoma Rhei, Radix Sophorae Flavescentis, Fructus Gardeniae, Rhizoma Coptidis, Herba Hedyotidis Diffusae
Grass, the compound Chinese medicinal preparation of Radix Glycyrrhizae compatibility are used for treating acne, good effect, have no adverse reaction, no dependence.
Technical solution of the present invention is as follows:
A kind of Chinese traditional compound medicine treating acne, including the raw material of Chinese medicine of following weight proportioning: Radix Scutellariae 8-12, Fructus Forsythiae
13-17, Cortex Mori 8-12, Radix Salviae Miltiorrhizae 8-12, Radix Angelicae Sinensis 8-12, Radix Et Rhizoma Rhei 5-7, Radix Sophorae Flavescentis 5-7, Fructus Gardeniae 8-12, Rhizoma Coptidis 5-7, Herba Hedyotidis Diffusae
Grass 13-17, Radix Glycyrrhizae 5-7.
Wherein preparation method is to be cleaned by above-mentioned 11 taste medical materials, is mixed in proportion, add 5-7 times of medical material gross weight water or
Volume ratio be 75% ethanol decoct 2 times, each 80 minutes, merges 2 decoction liquor, filtration, and concentrate, obtain proportion when 60 DEG C
Being the fluid extract of 1.16, use conventional fabrication process, Chinese medicine preparation of the present invention can be made into agent described on any pharmaceutics
Type, such as tablet, capsule, granule, oral liquid, pill, syrup.
Cortex Mori, Radix Scutellariae clear eliminating the pathogens from the lung heat in inventive formulation；Fructus Forsythiae, Herba Hedyotidis Diffusae, Radix Sophorae Flavescentis heat-clearing and toxic substances removing；Rhizoma Coptidis, Cape jasmine
Sub-clearing away stomach-heat, Fructus Gardeniae is held concurrently clear three burnt excess-fires；Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, all medicines share, and play heat-clearing and toxic substances removing altogether, removing heat from blood disappear skin ulcer it
Merit.Therefore the present invention is evident in efficacy, has no adverse reaction, no dependence.
Specific embodiment
Embodiment 1:
A kind of Chinese traditional compound medicine treating acne, including the raw material of Chinese medicine of following weight proportioning: Radix Scutellariae 8, Fructus Forsythiae 13, Mulberry
Rhizoma Euonymus 8, Radix Salviae Miltiorrhizae 8, Radix Angelicae Sinensis 8, Radix Et Rhizoma Rhei 5, Radix Sophorae Flavescentis 5, Fructus Gardeniae 8, Rhizoma Coptidis 5, Herba Hedyotidis Diffusae 13, Radix Glycyrrhizae 5.
Wherein preparation method is to be cleaned by above-mentioned 11 taste medical materials, is mixed in proportion, adds the 5 of medical material gross weight
Soak by water again 2 times, each 80 minutes, merges 2 decoction liquor, filters, and concentrates, and obtaining proportion when 60 DEG C is
1.16 fluid extract.
Embodiment 2:
A kind of Chinese traditional compound medicine treating acne, including the raw material of Chinese medicine of following weight proportioning: Radix Scutellariae 10, Fructus Forsythiae 15,
Cortex Mori 10, Radix Salviae Miltiorrhizae 10, Radix Angelicae Sinensis 10, Radix Et Rhizoma Rhei 6, Radix Sophorae Flavescentis 6, Fructus Gardeniae 10, Rhizoma Coptidis 6, Herba Hedyotidis Diffusae 15, Radix Glycyrrhizae 6.
Remaining is with embodiment 1.
Embodiment 3:
A kind of Chinese traditional compound medicine treating acne, including the raw material of Chinese medicine of following weight proportioning: Radix Scutellariae 12, Fructus Forsythiae 17,
Cortex Mori 12, Radix Salviae Miltiorrhizae 12, Radix Angelicae Sinensis 12, Radix Et Rhizoma Rhei 7, Radix Sophorae Flavescentis 7, Fructus Gardeniae 12, Rhizoma Coptidis 7, Herba Hedyotidis Diffusae 17, Radix Glycyrrhizae 7.
Wherein preparation method is to be cleaned by above-mentioned 11 taste medical materials, is mixed in proportion, and the 5 times of volume ratios adding medical material gross weight are
The ethanol of 75% decocts 2 times, each 80 minutes, merges 2 decoction liquor, filters, and concentrates, and obtaining proportion when 60 DEG C is 1.16
Fluid extract.
Embodiment 4:
A kind of Chinese traditional compound medicine treating acne, including the raw material of Chinese medicine of following weight proportioning: Radix Scutellariae 8, Fructus Forsythiae 13, Mulberry
Rhizoma Euonymus 8, Radix Salviae Miltiorrhizae 8, Radix Angelicae Sinensis 8, Radix Et Rhizoma Rhei 5, Radix Sophorae Flavescentis 5, Fructus Gardeniae 8, Rhizoma Coptidis 5, Herba Hedyotidis Diffusae 13, Radix Glycyrrhizae 5.
Wherein preparation method is to be cleaned by above-mentioned 11 taste medical materials, is mixed in proportion, and adds the volume ratio of 6 times of medical material gross weight
Be 75% ethanol decoct 2 times, each 80 minutes, merges 2 decoction liquor, filtration, and concentrate, obtaining proportion when 60 DEG C is 1.16
Fluid extract.
Embodiment 5:
A kind of Chinese traditional compound medicine treating acne, including the raw material of Chinese medicine of following weight proportioning: Radix Scutellariae 10, Fructus Forsythiae 15,
Cortex Mori 10, Radix Salviae Miltiorrhizae 10, Radix Angelicae Sinensis 10, Radix Et Rhizoma Rhei 6, Radix Sophorae Flavescentis 6, Fructus Gardeniae 10, Rhizoma Coptidis 6, Herba Hedyotidis Diffusae 15, Radix Glycyrrhizae 6.
Wherein preparation method is to be cleaned by above-mentioned 11 taste medical materials, is mixed in proportion, and adds the soak by water of 6 times of medical material gross weight
2 times, each 80 minutes, merging 2 decoction liquor, filter, and concentrate, obtaining proportion when 60 DEG C is the fluid extract of 1.16.
Embodiment 6:
A kind of Chinese traditional compound medicine treating acne, including the raw material of Chinese medicine of following weight proportioning: Radix Scutellariae 12, Fructus Forsythiae 17,
Cortex Mori 12, Radix Salviae Miltiorrhizae 12, Radix Angelicae Sinensis 12, Radix Et Rhizoma Rhei 7, Radix Sophorae Flavescentis 7, Fructus Gardeniae 12, Rhizoma Coptidis 7, Herba Hedyotidis Diffusae 17, Radix Glycyrrhizae 7.
Remaining is with embodiment 5
Embodiment 7:
A kind of Chinese traditional compound medicine treating acne, including the raw material of Chinese medicine of following weight proportioning: Radix Scutellariae 10, Fructus Forsythiae 15,
Cortex Mori 10, Radix Salviae Miltiorrhizae 10, Radix Angelicae Sinensis 10, Radix Et Rhizoma Rhei 6, Radix Sophorae Flavescentis 6, Fructus Gardeniae 10, Rhizoma Coptidis 6, Herba Hedyotidis Diffusae 15, Radix Glycyrrhizae 6.
Wherein preparation method is to be cleaned by above-mentioned 11 taste medical materials, is mixed in proportion, and adds the volume ratio of 7 times of medical material gross weight
Be 75% ethanol decoct 2 times, each 80 minutes, merges 2 decoction liquor, filtration, and concentrate, obtaining proportion when 60 DEG C is 1.16
Fluid extract.
Embodiment 8:
A kind of Chinese traditional compound medicine treating acne, including the raw material of Chinese medicine of following weight proportioning: Radix Scutellariae 15 Fructus Forsythiae 20, Mulberry
Rhizoma Euonymus 15, Radix Salviae Miltiorrhizae 15, Radix Angelicae Sinensis 5, Radix Et Rhizoma Rhei 2, Radix Sophorae Flavescentis 2, Fructus Gardeniae 5, Rhizoma Coptidis 5, Herba Hedyotidis Diffusae 10, Radix Glycyrrhizae 10.
Wherein preparation method is to be cleaned by above-mentioned 11 taste medical materials, is mixed in proportion, and adds the soak by water of 7 times of medical material gross weight
2 times, each 80 minutes, merging 2 decoction liquor, filter, and concentrate, obtaining proportion when 60 DEG C is the fluid extract of 1.16.
Embodiment 9:
A kind of Chinese traditional compound medicine treating acne, including the raw material of Chinese medicine of following weight proportioning: Radix Scutellariae 5, Fructus Forsythiae 10, Mulberry
Rhizoma Euonymus 8, Radix Salviae Miltiorrhizae 8, Radix Angelicae Sinensis 15, Radix Et Rhizoma Rhei 10, Radix Sophorae Flavescentis 10, Fructus Gardeniae 10, Rhizoma Coptidis 10, Herba Hedyotidis Diffusae 10, Radix Glycyrrhizae 8.
Wherein preparation method is to be cleaned by above-mentioned 11 taste medical materials, is mixed in proportion, and the 7 times of volume ratios adding medical material gross weight are
The ethanol of 75% decocts 2 times, each 80 minutes, merges 2 decoction liquor, filters, and concentrates, and obtaining proportion when 60 DEG C is 1.16
Fluid extract.
Embodiment 10:
A kind of Chinese traditional compound medicine treating acne, including the raw material of Chinese medicine of following weight proportioning: Radix Scutellariae 13, Fructus Forsythiae 13,
Cortex Mori 13, Radix Salviae Miltiorrhizae 8, Radix Angelicae Sinensis 13, Radix Et Rhizoma Rhei 3, Radix Sophorae Flavescentis 8, Fructus Gardeniae 8, Rhizoma Coptidis 8, Herba Hedyotidis Diffusae 12, Radix Glycyrrhizae 8.
Wherein preparation method is to be cleaned by above-mentioned 11 taste medical materials, is mixed in proportion, and the 8 times of volume ratios adding medical material gross weight are
The ethanol of 75% decocts 2 times, each 80 minutes, merges 2 decoction liquor, filters, and concentrates, and obtaining proportion when 60 DEG C is 1.16
Fluid extract.
Embodiment 11:
A kind of innerwear Chinese medicine preparation treating acne disclosed in patent according to Application No. 200710304711.8, including
The raw material of Chinese medicine of following weight proportioning: Radix Rubiae 8, Cortex Dictamni 8, the Fructus Kochiae 8, Radix Scutellariae 7, Radix Sophorae Flavescentis 8, Rhizoma Smilacis Glabrae 8, Radix Et Rhizoma Rhei 5, Flos Lonicerae
12, Fructus Forsythiae 8, Herba Taraxaci 8, Radix Glycyrrhizae 5, Fructus Gardeniae 8, Cortex Moutan 8, Periostracum Serpentis 5, Periostracum Cicadae 5, Radix Puerariae 5, Fructus Arctii 5, Herba Menthae 5, Radix Saposhnikoviae 5, when
Return 8, Radix Paeoniae Rubra 8, the Radix Paeoniae Alba 8, Cortex cercis chinensis 8, Radix Arnebiae (Radix Lithospermi) 8, Radix Rehmanniae 8, Radix Scrophulariae 8, Radix Ophiopogonis 8, Rhizoma Imperatae 8, Cortex Mori 8, batch leaf 8, hundred
Portion 5, Radix Scutellariae 8, the Rhizoma Atractylodis Macrocephalae 8, Poria 8, Pericarpium Citri Reticulatae 5, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 12, Rhizoma Coptidis 8, Radix Gentianae 8, Rhizoma Atractylodis 8, Cortex Phellodendri 8, Radix Achyranthis Bidentatae 8, Semen Coicis 8, soap
Fructus Gleditsia acupuncture 8, the Radix Angelicae Dahuricae 8, Radix Salviae Miltiorrhizae 12, Semen Persicae 8, Flos Carthami 8, Herba Hedyotidis Diffusae 8, Cacumen Platycladi 8, Lignum Aquilariae Resinatum 4, Lignum Santali Albi 4, the Radix Aucklandiae 4, Flos Caryophylli 4, wear
Squama Manis 5.
Wherein preparation method is that above-mentioned medical material is made powder, is mixed in proportion, stirs, the general watered pill of making, every ball
Weight is 0.3g.One time 20, twice on the one, withdraw during flu, menstrual phase or careful clothes age of sucking, anemia of pregnant woman prohibits clothes.
Embodiment 12:
A kind of medicine treating lung meridian wind-heat type acne disclosed in patent according to Application No. 201110045588.9, bag
Include the raw material of Chinese medicine of following weight: weigh Radix Scutellariae 750g, Folium Eriobotryae 750g, Cortex Mori 500g, Fructus Atriplicis Sibiricae 1000g, Herba Hedyotidis Diffusae
Grass 1000g, Radix Salviae Miltiorrhizae 1000g, Radix Paeoniae Rubra 750g, Spica Prunellae 750g, Fructus Forsythiae 750g, Radix Angelicae Sinensis 500g, Radix Glycyrrhizae 500g, add 8 times amount decoctings
Boiling 3 times, boil rear intense fire for the first time and decoct 30min, second time is boiled rear intense fire and is decocted 1h, and third time is boiled rear intense fire and decocted 1.5h.So
Rear collecting decoction, filters rear 80 DEG C of West Europe and concentrates the filtrate to the clear paste that relative density is 1.25, puts baking oven interior in 75 DEG C of bakings
Become dry cream, be ground into fine powder.In the dry cream fine powder obtained, add appropriate dextrin and starch to 1000g, add water and make granule,
Then dry, granulate, is distributed into 10g/ bag.Oral each bag, every day twice.
Embodiment 13: use conventional fabrication process, Chinese medicine preparation of the present invention can be made into described on any pharmaceutics
Dosage form, such as tablet, capsule, granule, oral liquid, pill, syrup.
Remaining is with embodiment 1-10.
Embodiment 14: the fluid extract of the mix homogeneously prepared by embodiment 1-10 is concentrated, according to the operation of conventional tablet
Method, adds pharmaceutic adjuvant, by each component mix homogeneously, wet granulation, sieves, and uses conventional tablet to prepare method tabletting and makes sheet
Agent, the content of the most each component is as follows:
Ingredients Weight (part)
Mixed flow extractum 50
Starch 23
Microcrystalline Cellulose 10
Pulvis Talci 8
Polyethylene Glycol 8
Remaining is with embodiment 1-10.
Embodiment 15: the fluid extract of the mix homogeneously prepared by embodiment 1-10 is concentrated, according to the behaviour of conventional capsule
Make method, add pharmaceutic adjuvant, by each component mix homogeneously, pelletize, use conventional capsule to prepare method filling and make capsule,
The content of the most each component is as follows:
Ingredients Weight (part)
Mixed flow extractum 100
Pregelatinized Starch 25
Lactis Anhydrous 13
Microcrystalline Cellulose 15
Calcium hydrogen phosphate 8
Remaining is with embodiment 1-10.
Embodiment 16: the fluid extract of the mix homogeneously prepared by embodiment 1-10 is concentrated, according to the behaviour of traditional oral liquid
Making method, ethanol precipitates 1-2 time, filters, and concentrates, aqueous precipitation, filters, and adds pharmaceutic adjuvant, filters, subpackage sterilizing, uses
Traditional oral liquid is prepared method and is prepared oral liquid, and the content of the most each component is as follows:
Ingredients Weight (part)
Mixed flow extractum 100
Ethanol 160
Sucrose 75
Sodium carboxymethyl cellulose 15
Oleum menthae 6
Sorbic acid 2
Remaining is with embodiment 1-10.
Pharmacodynamic study:
Patient data: in 234 example patients, male 109 examples, female 125 example;Age 15-40 year, the mean age 23
Year;The course of disease 1 month-5 years, skin lesion based on facial area, part cervical region, chest and back.
Research method: 234 example patient's stochastic averagina being divided into 13 groups, often organizes 18 examples, one of which does matched group, 12 groups
Do treatment group；Matched group is administered orally tretinoin 0.5 mg/ (kg d)；Chinese medical concrete use water embodiment 1-10 prepared is by volume
Dilute 10 times, be administered orally to respectively 10 groups for the treatment of groups, 100ml be administered orally every time, twice on the one；Remaining two groups of therapeutic component Kou Fu be unreal
Execute example 11 and Chinese medicine that embodiment 12 prepares, matched group and treatment group co-therapy 4 weeks；Avoid pungent food, fish and shrimp, seafood, barbecue
Food and drinks.
Criterion of therapeutical effect: " the Chinese medical disease Standardization of diagnosis and curative effect " promulgated for 1994 with reference to State Administration of Traditional Chinese Medicine.Fully recover from an illness
More: skin lesion disappears, without new breakout;Effective: skin lesion disappears more than 60%;Effective: skin lesion disappears 30% ~ 60%;Do not heal:
Skin lesion disappears less than 30% or unchanged, and with recovery from illness, summation effective, effective as total effective rate.
Table 1 Clinical efficacy comparison
Matched group has 2 examples mucocutaneous being dried occur, and 1 example occurs that blood fat rises high side effect, and treatment group does not goes out incumbent
What side effect.
From therapeutic effect it can be seen that curative effect of the present invention is better than western medicine group, and it is better than in prior art similar formula
The curative effect of the Chinese medicine prepared, wherein the curative effect with embodiment 5 is optimal, in the compound recipe of the treatment acne that therefore present invention prepares
The advantages such as medicine preparation good effect, has no adverse reaction, Chinese medicine preparation no dependence, may apply in acne clinical treatment.
Claims (1)
1. treat a Chinese traditional compound medicine for acne, it is characterized by that the raw material of Chinese medicine being made up of following weight proportioning is made: be yellow
A kind of reed mentioned in ancient books 10, Fructus Forsythiae 15, Cortex Mori 10, Radix Salviae Miltiorrhizae 10, Radix Angelicae Sinensis 10, Radix Et Rhizoma Rhei 6, Radix Sophorae Flavescentis 6, Fructus Gardeniae 10, Rhizoma Coptidis 6, Herba Hedyotidis Diffusae 15, Radix Glycyrrhizae
6；
Wherein preparation method is to be cleaned by above-mentioned 11 taste medical materials, is mixed in proportion, and adds the soak by water 2 times of 6 times of medical material gross weight,
Each 80 minutes, merging 2 decoction liquor, filter, and concentrate, obtaining proportion when 60 DEG C is the fluid extract of 1.16, uses routine system
Standby technique, makes tablet, capsule, granule, oral liquid, pill, syrup.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110364203.5A CN102370759B (en) | 2011-11-17 | A kind of compound Chinese medicinal preparation treating acne and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110364203.5A CN102370759B (en) | 2011-11-17 | A kind of compound Chinese medicinal preparation treating acne and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102370759A CN102370759A (en) | 2012-03-14 |
| CN102370759B true CN102370759B (en) | 2016-12-14 |
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ID=
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1225825A (en) * | 1998-02-12 | 1999-08-18 | 许家春 | Capsule of peenisetum flaccidum for treating acne and preparing method therefor |
| CN1418674A (en) * | 2002-11-01 | 2003-05-21 | 北京天衡药物研究院 | Medicine compositions for treating acne, and its prepn. method |
| CN101224287A (en) * | 2007-12-27 | 2008-07-23 | 佟家勇 | Oral administration Chinese traditional medicine for treating acne and preparing method thereof |
| CN102125618A (en) * | 2011-02-25 | 2011-07-20 | 南方医科大学 | Medicine for treating lung meridian wind-heat type acne |
| CN102247562A (en) * | 2011-08-15 | 2011-11-23 | 成都绿迪科技有限公司 | Chinese medicinal formula for treating acne |
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1225825A (en) * | 1998-02-12 | 1999-08-18 | 许家春 | Capsule of peenisetum flaccidum for treating acne and preparing method therefor |
| CN1418674A (en) * | 2002-11-01 | 2003-05-21 | 北京天衡药物研究院 | Medicine compositions for treating acne, and its prepn. method |
| CN101224287A (en) * | 2007-12-27 | 2008-07-23 | 佟家勇 | Oral administration Chinese traditional medicine for treating acne and preparing method thereof |
| CN102125618A (en) * | 2011-02-25 | 2011-07-20 | 南方医科大学 | Medicine for treating lung meridian wind-heat type acne |
| CN102247562A (en) * | 2011-08-15 | 2011-11-23 | 成都绿迪科技有限公司 | Chinese medicinal formula for treating acne |
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