CN102362948B - Chinese medicinal composition for treating chronic pelvic inflammatory disease - Google Patents
Chinese medicinal composition for treating chronic pelvic inflammatory disease Download PDFInfo
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Abstract
The invention belongs to the technical field of medicine, and particularly discloses a Chinese medicinal composition for treating the chronic pelvic inflammatory disease. The Chinese medicinal composition consists of the following raw materials in parts by weight: 60-120 parts of smilax bockii warb, 10-40 parts of astragalus and 10-40 parts of corydalis tuber. A formula disclosed by the invention has the effects of dissolving stasis, strengthening the body resistance and relieving pain. By organically combining three components, a relatively better treatment effect is achieved.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of Chinese medicine composition for the treatment of chronic pelvic inflammatory disease.
Background technology
Inflammatory pelvic disease (pelvic inflammatory disease, PID) be that pathogenic microorganism is invaded and female internal genital organs and connective tissue around thereof, a series of diseases associated with inflammation that pelvic cavity, peritoneum etc. cause, comprise endometritis, salpingitis, tubo-ovarian abscess and peritonitis etc.If pelvic inflammatory disease is treated timely, may there is a series of sequela, be that pelvic inflammatory disease sequela (sequelae of PID) was called chronic pelvic inflammatory disease in the past, refer to the pathological changes of leaving over of pelvic inflammatory disease, mainly change into disorganization, extensively adhesion, hypertrophy and cicatrization.Can cause infertile, ectopic pregnancy, chronic pelvic pain basin etc.Chronic pelvic inflammatory disease can belong to the sick categories such as TCM Gynecology field " leukorrhagia ", " dysmenorrhea ", " scar abdominal mass " according to its clinical manifestation.The etiology and pathogenesis of primary disease is: internal injury caused by excess of seven emotions, and visceral-qi is not declared, depression of liver-QI, so that QI and blood is not smooth, in blood stasis, stops, and venation is obstructed; Or innate deficiency of YANG in the body, the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels loses in warm, or plain body is weak, or positive QI consumed wound, so that exopathogen invasion and attack in an opponent's defence; Or through row puerperal, born of the same parents' door patent, the heresy that wind and cold is damp and hot, or insect poison invades in taking advantage of a weak point in opponent's defence, appoints the QI and blood knot of fighting mutually with punching, accumulates and amasss in uterus, advance and retreat repeatedly, wasting QI-blood, deficiency syndrome mingling with excess syndrome, touching difficulty heals.
Primary disease is the commonly encountered diseases of department of obstetrics and gynecology, has the course of disease long, and the feature that the state of an illness is obstinate, difficult more, relapse rate is high has a strong impact on quality of life of patient.The western medical treatment of PID is at present still with antibiotic, and antiinflammatory is main, and in Western medicine, antibiotic improves clinical symptoms and alleviates sign alleviation etc. as temperature decline abdominal pain controlling Acute PID.For the treatment of sequela, be difficult to reach ideal effect.
Chronic PID is the card of common simulataneous insufficiency and excessive clinically.Study carefully its essence, take " stasis of blood ", " void ", " stagnation of QI and blood may bring about pain " is pathogenic characteristic, thus treatment should blood stasis dispelling righting pain relieving the rule for the treatment of that is primary disease.
Modern Chinese medicine is being summed up on forefathers' experiential basis, and selecting clearing heat, detoxicating, dispelling dampness and blood circulation promoting and blood stasis dispelling is main direction of studying.But more products lay particular emphasis on clearing heat, detoxicating, dispelling dampness or blood circulation promoting and blood stasis dispelling in a certain respect more, as: take clearing heat, detoxicating, dispelling dampness as main person: HUAHONG PIAN, FUKE QIANJIN PIAN; Take blood circulation promoting and blood stasis dispelling as main person: FUYANKANG PIAN, the precious granule of woman etc.; But the Chinese medicine of effect of taking into account at present blood stasis dispelling, righting, pain relieving is less.
Summary of the invention
In order to address the above problem, the object of the invention is to provide the Chinese medicine composition of the better chronic pelvic inflammatory disease of a kind of tool therapeutic effect.
In order to realize object of the present invention, the technical scheme of taking is as follows:
Treat a Chinese medicine composition for chronic pelvic inflammatory disease, the ratio of weight and number of its raw material is:
60～120 parts of Rhizoma Smilacis Bockii, 10～40 parts of the Radixs Astragali, 10～40 parts of Rhizoma Corydalis.
As optimal proportion formula of the present invention, the ratio of weight and number of its raw material is:
90 parts of Rhizoma Smilacis Bockii, 20 parts of the Radixs Astragali, 20 parts of Rhizoma Corydalis.
As follows, above-mentioned prescription can be produced as corresponding conventional peroral dosage form:
(1) by prescription, get Rhizoma Smilacis Bockii and adopt 60% alcohol reflux twice, add for the first time 12 times of amount solvent extraction 2h, add for the second time 10 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.10-1.15 (80 ℃), spraying dry (being respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.)
(2) by prescription, get Rhizoma Corydalis and adopt 60% alcohol reflux twice, add for the first time 6 times of amount solvent extraction 2h, add for the second time 4 times of amount solvent extraction 1.Sh, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.00-1.05 (80 ℃), spraying dry (being respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.).
(3) by prescription, get the Radix Astragali and adopt twice of water reflux, extract,, add for the first time 10 times of amount solvent extraction 2h, add for the second time 8 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.10-1.15 (80 ℃), spraying dry (being respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.)
(4) dry powder of step (1), (2), (3) is merged, mix, obtain the medicinal active ingredient segmentation of proprietary preparation of the present invention;
(5) segmentation of step (4) gained active component is added to appropriate conventional pharmaceutic adjuvant, adopt the conventional preparation technology of pharmaceutics to make the oral formulations such as capsule, granule and tablet of preparation of the present invention, obtain.
The active component of medicine of the present invention can add various conventional adjuvant required while preparing different dosage form, as disintegrating agent, lubricant, binding agent etc. are prepared into any conventional peroral dosage form with conventional method of Chinese medicinal, comprise capsule, granule and tablet etc.
Below example is further set forth the curative effect of medicine of the present invention by experiment, and these experimental examples have comprised pharmacodynamic experiment and the clinical observation of medicine of the present invention.
Before the present invention's test, add appropriate distilled water and make suspension for animal gavage.
Positive control drug:
FUKE QIANJIN PIAN (lot number 200711106): zhuzhou,hunan a thousand pieces of gold Pharmaceutical limited company produces;
Rhizoma Smilacis Bockii capsule (lot number 20080315) Hubei Fu Ren pharmaceutcal corporation, Ltd produces.
Healthy female Kunming mouse, body weight 18-20g, purchased from Hubei Province Center for Disease Control (CDC).Animal credit number: SCXK (Hubei Province) 2003-0005.
Female sd inbred rats, body weight 120-150g, purchased from Tongji Medical College, Huazhong Science and Technology Univ.'s Experimental Animal Center.Animal credit number: SCXK (Hubei Province) 2004-0007.
20% phenol rubber cement: liquefied phenol 5ml, arabic gum 1g, glycerol 4ml, adding distil water is to 25ml, furnishing paste.
Experimental technique and result:
One, antiinflammatory action
The impact of the rat paw edema 1, Ovum Gallus domesticus album being brought out
SD rat, male and female half and half, 120-170g, by rat random packet, 10 every group.Be respectively: negative control group, compound recipe Buddha's warrior attendant liana rubber capsule high and low dose group, positive controls FUKE QIANJIN PIAN group and Rhizoma Smilacis Bockii Capsules group.Negative control group (giving equal-volume normal saline).Successive administration 1 week, 0.5h after last administration, causes inflammation at right back sufficient plantar subcutaneous injection 50% Ovum Gallus domesticus album 0.05ml.In causing scorching forward and backward 1,2,4h, survey respectively the foot volume of wasting time, calculate scorching front foot volume * 100% of swelling rate=(cause before inflammation-cause scorching metapedes volume)/cause.The results are shown in Table 1.
The impact of the rat paw edema that table 1 compound recipe Buddha's warrior attendant liana rubber capsule brings out Ovum Gallus domesticus album
Note: compare * P < 0.05 with negative control group, * * P < 0.01; Compare Δ P < 0.05, Δ Δ P < 0.01 with FUKE QIANJIN PIAN; With the comparison of Rhizoma Smilacis Bockii capsule, #P < 0.05, ##P < 0.01, ###P < 0.01
2, on the swollen impact of rat granuloma
SD rat, male and female half and half, 150-170g, 10 every group.Be respectively: negative control group, compound recipe Buddha's warrior attendant liana rubber capsule high and low dose group, positive controls FUKE QIANJIN PIAN group and Rhizoma Smilacis Bockii Capsules group.Adopt lumbar injection pentobarbital sodium 40mg.kg-1 anesthetized rat, after first brushing iodine tincture and disinfecting in alcohol again, in rat abdomen, cut the osculum of 1cm left and right, the cotton balls of sterilize (autoclave sterilization again of first weighing) (each heavily about 20mg) is inserted subcutaneous, skin suture immediately, and sterilize with mycillin liquid 0.2ml.In performing the operation, started administration the same day, each group is pressed 15ml.kg-1 gavage, successive administration 7d, 2h after last administration, open former otch, cotton balls is taken out in the lump together with connective tissue around, reject fatty tissue, oven dry is weighed, and what the amount of weighing was deducted to former cotton balls measures out granulation weight, the results are shown in Table 2.
Table 2 compound recipe Buddha's warrior attendant liana rubber capsule is on the swollen impact of rat granuloma
Note: compare * P < 0.05 with negative control group, * * P < 0.01; With the FUKE QIANJIN PIAN comparison Δ P < of gynecological 0.05, Δ Δ P < 0.01; Compare #P < 0.05, ##P < 0.01, ###P < 0.01. with Rhizoma Smilacis Bockii capsule
Compound recipe Buddha's warrior attendant liana rubber capsule antiinflammatory action is more stable, to the early stage permeability changes of inflammation and inflammation later stage granulation hyperplasia, has good effect ，Bi gynecological's FUKE QIANJIN PIAN and Rhizoma Smilacis Bockii capsule more to have superiority.
Two, the impact on the effect of hot plate method in mice induced pain
Female Kunming mouse, screening pain threshold is in the white mice of 5 to 30 seconds, random packet.Be respectively: negative control group, compound recipe Buddha's warrior attendant liana rubber capsule high and low dose group, positive controls FUKE QIANJIN PIAN group and Rhizoma Smilacis Bockii Capsules group.Each organizes 6 days, half an hour after last administration, measures after each raticide the pain threshold (from mice is placed into 55 ℃ of thermostatic water tanks to the time that starts to lick metapedes) of 30 minutes, 60 minutes, 90 minutes, the results are shown in Table 3.
The impact of table 3 compound recipe Buddha's warrior attendant liana rubber capsule on the effect of hot plate method in mice induced pain
Note: compare * P < 0.05 with negative control group, * * P < 0.01; Compare Δ P < 0.05, Δ Δ P < 0.01 with QIANJIN PIAN; Compare #P < 0.05, ##P < 0.01, ###P < 0.01. with Rhizoma Smilacis Bockii capsule
As can be seen from the above table, compound recipe Buddha's warrior attendant liana rubber capsule high dose all has highly significant analgesic activity in each time period, and compound recipe Buddha's warrior attendant liana rubber capsule low dosage, in the analgesia of 30min highly significant, has remarkable analgesic activity at 60min, and effect is stable.
Three, mouse macrophage phagocytosis is affected
Select female B/C mice, 12-16g, is divided into model control group (giving equal-volume normal saline); The high low dose group of compound recipe Buddha's warrior attendant liana rubber capsule; Positive controls Rhizoma Smilacis Bockii capsule, FUKE QIANJIN PIAN group and normal group (giving equal-volume normal saline).Each is organized gavage and gives relative medicine 15d, and except normal group, the method that each group gives prednisolone acetate (5mg.kg-1, ip, 3 times) injection in the 1st, 3,5 days causes immunosuppression mouse model.In the 15th day, mouse peritoneal was injected 5% chicken red blood cell 1ml, after 30min, craned one and put to death mice, and lumbar injection D-HanKs 1ml, rubs stomach wall 1min gently, sucking-off abdominal cavity drop sheet.Put 37 ℃ of wet boxes and hatch after 30min, with PBS, rinse, remove not adherent and free chicken red blood cell, under light microscopic, count macrophage M and M and engulf CRBC number.With following formula, calculate phagocytic index: chicken red blood cell sum/100 M of phagocytic index=engulfed.Each group and negative, positive controls comparison, ask t value, the results are shown in Table 4.
Table 4 compound recipe Buddha's warrior attendant liana rubber capsule affects mouse macrophage phagocytosis
Note: compare * P < 0.05 with negative control group, * * P < 0.01, * * * P < 0.001; Compare Δ P < 0.05, Δ Δ P < 0.01 with QIANJIN PIAN; Compare #P < 0.05, ##P < 0.01. with Rhizoma Smilacis Bockii capsule
As seen from the above table: with negative control group comparison, compound recipe Buddha's warrior attendant liana rubber capsule has improved very significantly Turnover of Mouse Peritoneal Macrophages and engulfed chicken red blood cell number, P < 0.05 or P < 0.01; In enhancing mouse cell immunologic function, be better than Rhizoma Smilacis Bockii capsule, FUKE QIANJIN PIAN, P < 0.05 or P < 0.01.
Clinical observation
1. data and method
1.1 physical data
Select patient diagnosis be pelvic inflammatory disease sequela patient 60 examples as the object of observation, be divided at random two groups.Treatment group 30 examples, age 19-55 year, year mean age (33.38 ± 4.24); Average course of disease (18.37 ± 2.36) month.Matched group 30 examples, the age is in 18-56 year, year mean age (33.42 ± 4.53); Individual month of average course of disease (18.23 ± 2.41).Two groups of patients' age, the course of disease, symptom, sign comparison, difference not statistically significant (P > 0.05), has comparability.
Table 5 compound recipe Buddha's warrior attendant liana rubber capsule clinical observation patient data
1.2 diagnostic criteria
The diagnosis of pelvic inflammatory disease sequela is drafted with reference to " Chinese obstetrics and gynecology " and " obstetrics and gynecology " the 7th edition teaching material.(1) acute pelvic inflammatory disease medical history.(2) few abdomen, lower abdomen falling inflation, pain or lumbosacral region are ached, and before and after the fatigue of being everlasting, sexual intercourse, anxious state of mind or menstruation, increase the weight of.Leucorrhoea grow in quantity, is yellow or faint yellow water sample, or yellow green, can frowziness; Menoxenia, common with menorrhagia or menostaxis; Infertile.(3) the visible uterus of gynecologial examination is often hypsokinesis, and limitation of activity or adhesion are fixed, with tenderness; Lay one's hand on attachment area and rope strip increases slightly or lamellar thickens, companion's tenderness; Jarjavay's ligaments increases thick, hardening, companion's tenderness.(4) B ultrasonic: show that endometritis, adnexa one side or bilateral thicken or have capsule enclosed mass or pelvic hydrops, but get rid of pelvic abscess and tumor.
1.3 exclusion standard
(1) do not meet Western medicine diagnose and TCM Syndrome Type person.(2) trimester of pregnancy, women breast-feeding their children.(3) be associated with the disease patients such as hysteromyoma, ovarian tumor, endometriosis.(4) merge intentionally, the serious primary disease person such as liver, kidney and hemopoietic system.(5) allergic constitution or to multi-medicament allergy sufferers.(6) mismatch treatment or drop by the wayside clinical observation person.
2. Therapeutic Method
Treatment group: give compound recipe Buddha's warrior attendant liana rubber capsule, each 4, every day 3 times, drug withdrawal in menstrual period.
Matched group: give each 4 of oral Buddha's warrior attendant liana rubber capsule, every day 3 times, one after each meal.Drug withdrawal in menstrual period.
All take 8 weeks as 1 course for the treatment of for two groups.In therapeutic process, do not add the medicine by other treatment pelvic inflammatory disease sequela.
3. statistical method
Adopt SPSS12.0 software kit analytical data, analyze and adopt Ridit check between group, enumeration data is checked with X2.
4. result
4.1 the standard of curative effect evaluations: according to the clinical development of relevant pelvic inflammatory disease sequela in " new Chinese medicine guideline of clinical investigations ".Cure: clinical symptoms, sign disappear completely or ultrasound diagnosis uterus adnexa normal, pelvic cavity thickens without lamellar; Effective: subjective symptoms is clearly better or substantially disappears, gynecologial examination or B ultrasonic prompting pelvic cavity symptom, sign are obviously improved; Pelvic cavity can still have tenderness; Take a turn for the better: subjective symptoms takes a turn for the better, gynecologial examination or B ultrasonic prompting pelvic cavity symptom, sign are all improved; Invalid: before and after sings and symptoms treatment, without improving, B ultrasonic prompting pelvic cavity symptom, sign are without improvement.
4.2 curative effects: all patients, through 1 course of therapy, the results are shown in following table.
4.2.1 two groups of therapeutic outcome comparisons
Table 6 liang group curative effect comparison
Result shows that 2 groups of comparing differences have statistical significance (P < 0.05), illustrates that treatment group is obviously being better than matched group aspect treatment pelvic inflammatory disease sequela.In medication process without obvious adverse reaction.
4.2.2 clinical symptoms is improved situation comparison:
A table 7 liang group clinical symptoms is improved situation comparison
Two groups of clinical symptoms (waist abdomen pain, leucorrhea amount are many, menoxenia) are improved relatively, learn and process by statistics, before and after two groups of internal therapies, all can obviously improve clinical symptoms, P < 0.05; Between group, after treatment, symptom is improved and had significant difference, P < 0.05, wherein treatment group is better than matched group.
Before and after table 8 liang group treatment, sign changes relatively
Two groups of clinical symptoms (the limited and tenderness of uterine activity, fallopian tube increase slightly thicken, fallopian tube increase slightly thicken) improve relatively, learn and process by statistics, before and after two groups of internal therapies, all can obviously improve clinical symptoms, P < 0.05; In symptom being improved after treatment between group, uterus limitation of activity and tenderness have significant difference, P < 0.05, and wherein treatment group is better than matched group.
5. untoward reaction
In this observation process, all do not find untoward reaction.
Therefore, the present invention has the effect of blood stasis dispelling, righting, pain relieving, by the organic assembling of three kinds of compositions, makes its therapeutic effect relatively better.
The specific embodiment
With specific implementation method, describe the present invention in detail below, in exemplary embodiment and description of the present invention, be used for explaining the present invention, but not as a limitation of the invention.
Embodiment 1:
The present embodiment discloses a kind of Chinese medicine formula for the treatment of chronic pelvic inflammatory disease, and capsule preparation method thereof:
(1) by following weight, take each crude drug, Rhizoma Smilacis Bockii 900g, Rhizoma Corydalis 200g, Radix Astragali 200g is standby;
(2) Rhizoma Smilacis Bockii adopts 60% alcohol reflux twice, add for the first time 12 times of amount solvent extraction 2h, add for the second time 10 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.10-1.15 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(3) Rhizoma Corydalis adopts 60% alcohol reflux twice, add for the first time 6 times of amount solvent extraction 2h, add for the second time 4 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.00-1.05 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(4) Radix Astragali adopts twice of water reflux, extract,, add for the first time 10 times of amount solvent extraction 2h, add for the second time 8 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.10-1.15 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(5) dry powder of step (2), (3), (4) is merged, mix, add appropriate amount of starch, dextrin, microcrystalline Cellulose and carboxymethyl starch sodium, make 1000 of finished products, every 0.4g, packs and get final product.
Embodiment 2:
The present embodiment discloses a kind of Chinese medicine formula for the treatment of chronic pelvic inflammatory disease, and process for producing granula:
(1) by following weight, take each crude drug, Rhizoma Smilacis Bockii 600g, Rhizoma Corydalis 100g, Radix Astragali 100g is standby;
(2) Rhizoma Smilacis Bockii adopts 60% alcohol reflux twice, add for the first time 12 times of amount solvent extraction 2h, add for the second time 10 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.10-1.15 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(3) Rhizoma Corydalis adopts 60% alcohol reflux twice, add for the first time 6 times of amount solvent extraction 2h, add for the second time 4 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.00-1.05 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(4) Radix Astragali adopts twice of water reflux, extract,, add for the first time 10 times of amount solvent extraction 2h, add for the second time 8 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.10-1.15 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(5) dry powder of step (2), (3), (4) is merged, mix, add appropriate amount of starch and Icing Sugar, the appropriate alcoholic solution of spray people, granulates, dry, dress pouch, and every bag of 10g, gets product 300 bags.
Embodiment 3:
The present embodiment discloses a kind of Chinese medicine formula for the treatment of chronic pelvic inflammatory disease, and method for preparing tablet thereof:
(1) by following weight, take each crude drug, Rhizoma Smilacis Bockii 1200g, Rhizoma Corydalis 400g, Radix Astragali 400g is standby;
(2) Rhizoma Smilacis Bockii adopts 60% alcohol reflux twice, add for the first time 12 times of amount solvent extraction 2h, add for the second time 10 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.10-1.15 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(3) Rhizoma Corydalis adopts 60% alcohol reflux twice, add for the first time 6 times of amount solvent extraction 2h, add for the second time 4 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.00-1.05 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(4) Radix Astragali adopts twice of water reflux, extract,, add for the first time 10 times of amount solvent extraction 2h, add for the second time 8 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.10-1.15 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(5) dry powder of step (2), (3), (4) is merged, mix, add appropriate conventional pharmaceutic adjuvant, granulate, tabletting has just been prepared into the tablet of medicine of the present invention, and every heavy 0.4g, makes 1250 of finished products, packs and get final product.
Embodiment 4:
The present embodiment discloses a kind of Chinese medicine formula for the treatment of chronic pelvic inflammatory disease, and the preparation method of capsule:
(1) by following weight, take each crude drug, Rhizoma Smilacis Bockii 900g, Rhizoma Corydalis 320g, Radix Astragali 300g is standby;
(2) Rhizoma Smilacis Bockii adopts 60% alcohol reflux twice, add for the first time 12 times of amount solvent extraction 2h, add for the second time 10 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.10-1.15 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(3) Rhizoma Corydalis adopts 60% alcohol reflux twice, add for the first time 6 times of amount solvent extraction 2h, add for the second time 4 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.00-1.05 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(4) Radix Astragali adopts twice of water reflux, extract,, add for the first time 10 times of amount solvent extraction 2h, add for the second time 8 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.10-1.15 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(5) dry powder of step (2), (3), (4) is merged, mix, add appropriate amount of starch, dextrin, microcrystalline Cellulose and carboxymethyl starch sodium, make 1000 of finished products, every 0.4g, packs and get final product.
Embodiment 5
The present embodiment discloses a kind of Chinese medicine formula for the treatment of chronic pelvic inflammatory disease, and process for producing granula:
(1) by following weight, take each crude drug, Rhizoma Smilacis Bockii 900g, Rhizoma Corydalis 220g, Radix Astragali 150g is standby;
(2) Rhizoma Smilacis Bockii adopts 60% alcohol reflux twice, add for the first time 12 times of amount solvent extraction 2h, add for the second time 10 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.10-1.15 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(3) Rhizoma Corydalis adopts 60% alcohol reflux twice, add for the first time 6 times of amount solvent extraction 2h, add for the second time 4 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.00-1.05 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(4) Radix Astragali adopts twice of water reflux, extract,, add for the first time 10 times of amount solvent extraction 2h, add for the second time 8 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.10-1.15 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(5) dry powder of step (2), (3), (4) is merged, mix, add appropriate amount of starch and Icing Sugar, the appropriate alcoholic solution of spray people, granulates, dry, dress pouch, and every bag of 10g, gets product 300 bags.
Embodiment 6:
The present embodiment discloses a kind of Chinese medicine formula for the treatment of chronic pelvic inflammatory disease, and the preparation method of tablet:
(1) by following weight, take each crude drug, Rhizoma Smilacis Bockii 900g, Rhizoma Corydalis 250g, Radix Astragali 350g is standby;
(2) Rhizoma Smilacis Bockii adopts 60% alcohol reflux twice, add for the first time 12 times of amount solvent extraction 2h, add for the second time 10 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.10-1.15 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(3) Rhizoma Corydalis adopts 60% alcohol reflux twice, add for the first time 6 times of amount solvent extraction 2h, add for the second time 4 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.00-1.05 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(4) Radix Astragali adopts twice of water reflux, extract,, add for the first time 10 times of amount solvent extraction 2h, add for the second time 8 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.10-1.15 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(5) dry powder of step (2), (3), (4) is merged, mix, add appropriate conventional pharmaceutic adjuvant, granulate, tabletting has just been prepared into the tablet of medicine of the present invention, and every heavy 0.4g, makes 1250 of finished products, packs and get final product.
Embodiment 7:
The present embodiment discloses a kind of Chinese medicine formula for the treatment of chronic pelvic inflammatory disease, and the preparation method of capsule:
(1) by following weight, take each crude drug, Rhizoma Smilacis Bockii 900g, Rhizoma Corydalis 360g, Radix Astragali 300g is standby;
(2) Rhizoma Smilacis Bockii adopts 60% alcohol reflux twice, add for the first time 12 times of amount solvent extraction 2h, add for the second time 10 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.10-1.15 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(3) Rhizoma Corydalis adopts 60% alcohol reflux twice, add for the first time 6 times of amount solvent extraction 2h, add for the second time 4 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.00-1.05 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(4) Radix Astragali adopts twice of water reflux, extract,, add for the first time 10 times of amount solvent extraction 2h, add for the second time 8 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.10-1.15 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(5) dry powder of step (2), (3), (4) is merged, mix, add appropriate amount of starch, dextrin, microcrystalline Cellulose and carboxymethyl starch sodium, make 1000 of finished products, every 0.4g, packs and get final product.
Embodiment 8:
The present embodiment discloses a kind of Chinese medicine formula for the treatment of chronic pelvic inflammatory disease, and the preparation method of granule:
(1) by following weight, take each crude drug, Rhizoma Smilacis Bockii 800g, Rhizoma Corydalis 360g, Radix Astragali 350g is standby;
(2) Rhizoma Smilacis Bockii adopts 60% alcohol reflux twice, add for the first time 12 times of amount solvent extraction 2h, add for the second time 10 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.10-1.15 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(3) Rhizoma Corydalis adopts 60% alcohol reflux twice, add for the first time 6 times of amount solvent extraction 2h, add for the second time 4 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.00-1.05 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(4) Radix Astragali adopts twice of water reflux, extract,, add for the first time 10 times of amount solvent extraction 2h, add for the second time 8 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.10-1.15 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(5) dry powder of step (2), (3), (4) is merged, mix, add appropriate amount of starch and Icing Sugar, the appropriate alcoholic solution of spray people, granulates, dry, dress pouch, and every bag of 10g, gets product 300 bags.
The tablet preparation of embodiment 9 medicines of the present invention
(1) by following weight, take each crude drug, Rhizoma Smilacis Bockii 900g, Rhizoma Corydalis 360g, Radix Astragali 300g is standby;
(2) Rhizoma Smilacis Bockii adopts 60% alcohol reflux twice, add for the first time 12 times of amount solvent extraction 2h, add for the second time 10 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.10-1.15 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(3) Rhizoma Corydalis adopts 60% alcohol reflux twice, add for the first time 6 times of amount solvent extraction 2h, add for the second time 4 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.00-1.05 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(4) Radix Astragali adopts twice of water reflux, extract,, add for the first time 10 times of amount solvent extraction 2h, add for the second time 8 times of amount solvent extraction 1.5h, merge extractive liquid,, filter, filtrate recycling ethanol to be evaporated to relative density be 1.10-1.15 (80 ℃), spraying is dry (is respectively 165-170,90-95 ℃ into and out of air port temperature, nebulizer rotating speed 40MHz.), obtain dry powder standby;
(5) dry powder of step (2), (3), (4) is merged, mix, add appropriate conventional pharmaceutic adjuvant, granulate, tabletting has just been prepared into the tablet of medicine of the present invention, and every heavy 0.4g, makes 1250 of finished products, packs and get final product.
It should be noted that, the present invention not only comprises tablet, granule, pill or capsule, can also be other oral solid formulations and slow control diluent, and these are all protection scope of the present invention.
The technical scheme above embodiment of the present invention being provided is described in detail, applied specific case herein the principle of the embodiment of the present invention and embodiment are set forth, the explanation of above embodiment is only applicable to help to understand the principle of the embodiment of the present invention; , for one of ordinary skill in the art, according to the embodiment of the present invention, in the specific embodiment and range of application, all will change, in sum, this description should not be construed as limitation of the present invention meanwhile.
Claims (2)
1. a Chinese medicine composition for the treatment of chronic pelvic inflammatory disease, is characterized in that, the ratio of weight and number of its raw material is:
60～120 parts of Rhizoma Smilacis Bockii, 10～40 parts of the Radixs Astragali, 10～40 parts of Rhizoma Corydalis.
2. the Chinese medicine composition for the treatment of chronic pelvic inflammatory disease according to claim 1, is characterized in that, the ratio of weight and number of its raw material is:
90 parts of Rhizoma Smilacis Bockii, 20 parts of the Radixs Astragali, 20 parts of Rhizoma Corydalis.
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