CN102361862A - 用于治疗阿尔茨海默病的噻吩基磺酰胺 - Google Patents
用于治疗阿尔茨海默病的噻吩基磺酰胺 Download PDFInfo
- Publication number
- CN102361862A CN102361862A CN2010800126512A CN201080012651A CN102361862A CN 102361862 A CN102361862 A CN 102361862A CN 2010800126512 A CN2010800126512 A CN 2010800126512A CN 201080012651 A CN201080012651 A CN 201080012651A CN 102361862 A CN102361862 A CN 102361862A
- Authority
- CN
- China
- Prior art keywords
- compound
- sulfonamido
- formula
- chlorothiophene
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C**(C)c1ncc[o]1 Chemical compound C**(C)c1ncc[o]1 0.000 description 3
- NIXLFBUHPJACST-UHFFFAOYSA-N Fc(cc1Br)c(CBr)cc1F Chemical compound Fc(cc1Br)c(CBr)cc1F NIXLFBUHPJACST-UHFFFAOYSA-N 0.000 description 2
- DZTNEQVEYQORQO-UHFFFAOYSA-N Cc(cc(c(Br)c1)F)c1F Chemical compound Cc(cc(c(Br)c1)F)c1F DZTNEQVEYQORQO-UHFFFAOYSA-N 0.000 description 1
- SLFNGVGRINFJLK-UHFFFAOYSA-N Cc(cc1F)ccc1Br Chemical compound Cc(cc1F)ccc1Br SLFNGVGRINFJLK-UHFFFAOYSA-N 0.000 description 1
- FZAXBPZVVJOFKX-UHFFFAOYSA-N Cc1n[o]cn1 Chemical compound Cc1n[o]cn1 FZAXBPZVVJOFKX-UHFFFAOYSA-N 0.000 description 1
- CBDACOWOQMNSJF-UHFFFAOYSA-N Fc(cc1Br)c(C(Br)Br)cc1F Chemical compound Fc(cc1Br)c(C(Br)Br)cc1F CBDACOWOQMNSJF-UHFFFAOYSA-N 0.000 description 1
- GMVNLHLMJSMARX-UHFFFAOYSA-N Fc1cc(CBr)ccc1Br Chemical compound Fc1cc(CBr)ccc1Br GMVNLHLMJSMARX-UHFFFAOYSA-N 0.000 description 1
- FOOWGAWHTOUSQT-CQSZACIVSA-N NC([C@@H](CC1CC1)N(Cc(cc(c(Cl)c1)F)c1F)S(c([s]1)ccc1Cl)(=O)=O)=O Chemical compound NC([C@@H](CC1CC1)N(Cc(cc(c(Cl)c1)F)c1F)S(c([s]1)ccc1Cl)(=O)=O)=O FOOWGAWHTOUSQT-CQSZACIVSA-N 0.000 description 1
- RGATVSCGXUOKSJ-CQSZACIVSA-N NC([C@@H](CC1CC1)N(Cc(cc1)cc(F)c1Br)S(c([s]1)ccc1Cl)(=O)=O)=O Chemical compound NC([C@@H](CC1CC1)N(Cc(cc1)cc(F)c1Br)S(c([s]1)ccc1Cl)(=O)=O)=O RGATVSCGXUOKSJ-CQSZACIVSA-N 0.000 description 1
- DDQYFRBWJBJOPQ-GFCCVEGCSA-N NC([C@@H](CCC(F)(F)F)N(Cc(cc1)ccc1Br)S(c([s]1)ccc1Cl)(=O)=O)=O Chemical compound NC([C@@H](CCC(F)(F)F)N(Cc(cc1)ccc1Br)S(c([s]1)ccc1Cl)(=O)=O)=O DDQYFRBWJBJOPQ-GFCCVEGCSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16180109P | 2009-03-20 | 2009-03-20 | |
| US61/161,801 | 2009-03-20 | ||
| PCT/US2010/027805 WO2010107997A1 (en) | 2009-03-20 | 2010-03-18 | Thiophenyl sulfonamides for the treatment of alzheimer's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102361862A true CN102361862A (zh) | 2012-02-22 |
Family
ID=42262106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010800126512A Pending CN102361862A (zh) | 2009-03-20 | 2010-03-18 | 用于治疗阿尔茨海默病的噻吩基磺酰胺 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20110071199A1 (https=) |
| EP (1) | EP2408760A1 (https=) |
| JP (1) | JP2012520899A (https=) |
| CN (1) | CN102361862A (https=) |
| WO (1) | WO2010107997A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1289469C (zh) | 2001-12-20 | 2006-12-13 | 布里斯托尔-迈尔斯斯奎布公司 | α－(N－磺酰氨基)乙酰胺衍生物作为β－淀粉样蛋白抑制剂 |
| US8044077B2 (en) | 2009-03-19 | 2011-10-25 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production |
| US7977362B2 (en) | 2009-03-20 | 2011-07-12 | Bristol-Myers Squibb Company | Alpha-(N-benzenesulfonamido)cycloalkyl derivatives |
| US8252821B2 (en) | 2009-04-14 | 2012-08-28 | Bristol-Myers Squibb Company | Bioavailable capsule compositions of amorphous alpha-(N-sulfonamido)acetamide compound |
| CN108840814B (zh) * | 2018-07-24 | 2021-09-24 | 南京药石科技股份有限公司 | 一种8-氧代-2,6,9-三氮杂螺[4.5]癸烷-2-羧酸叔丁酯制备方法 |
| CA3189027A1 (en) | 2020-07-11 | 2022-01-20 | Pfizer Inc. | Antiviral heteroaryl ketone derivatives |
| EP4299062A1 (en) | 2022-06-30 | 2024-01-03 | Vilnius University | Inhibition of protein amyloid aggregation using fluorinated benzenesulfonamides |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5274094A (en) * | 1990-08-15 | 1993-12-28 | British Bio-Technology Limited | Production of heterobicyclic containing benzene sulfonamides |
| GB9202791D0 (en) * | 1992-02-11 | 1992-03-25 | British Bio Technology | Compounds |
| IL123901A (en) * | 1995-11-17 | 2003-06-24 | Warner Lambert Co | Sulfonamide inhibitors of matrix metalloproteinases and pharmaceutical compositions comprising them |
| US6313123B1 (en) * | 1999-01-27 | 2001-11-06 | American Cyanamid Company | Acetylenic sulfonamide thiol tace inhibitors |
| CN1289469C (zh) * | 2001-12-20 | 2006-12-13 | 布里斯托尔-迈尔斯斯奎布公司 | α－(N－磺酰氨基)乙酰胺衍生物作为β－淀粉样蛋白抑制剂 |
| BRPI0408962A (pt) * | 2003-03-31 | 2006-04-04 | Wyeth Corp | inibidores sulfonamidas heterocìclicos contendo flúor- e trifluoroalquila da produção de beta amilóide e seus derivados |
| US7144894B2 (en) * | 2004-09-23 | 2006-12-05 | Bristol-Myers Squibb Company | Sulfonamide bicyclic compounds |
| US7838550B2 (en) * | 2006-02-17 | 2010-11-23 | Wyeth Llc | Selective N-sulfonylation of 2-amino fluoro- and trifluoroalkyl substituted alcohols |
| PE20080169A1 (es) * | 2006-02-17 | 2008-04-11 | Wyeth Corp | Metodo para preparar alcoholes sustituidos con sulfonamidas y sus compuestos intermedios |
| CN102088855A (zh) * | 2008-05-08 | 2011-06-08 | 百时美施贵宝公司 | 2-芳基甘氨酰胺衍生物 |
-
2010
- 2010-03-16 US US12/724,949 patent/US20110071199A1/en not_active Abandoned
- 2010-03-18 EP EP10711963A patent/EP2408760A1/en not_active Withdrawn
- 2010-03-18 JP JP2012500962A patent/JP2012520899A/ja active Pending
- 2010-03-18 WO PCT/US2010/027805 patent/WO2010107997A1/en not_active Ceased
- 2010-03-18 CN CN2010800126512A patent/CN102361862A/zh active Pending
Non-Patent Citations (1)
| Title |
|---|
| BRUNO P. IMBIMBO: "Alzheimer’s disease: γ-secretase inhibitors", 《DRUG DISCOVERY TODAY: THERAPEUTIC STRATEGIES》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2408760A1 (en) | 2012-01-25 |
| JP2012520899A (ja) | 2012-09-10 |
| WO2010107997A1 (en) | 2010-09-23 |
| US20110071199A1 (en) | 2011-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120222 |