CN102357097A - Drug for preventing and treating skin frostbite - Google Patents
Drug for preventing and treating skin frostbite Download PDFInfo
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- CN102357097A CN102357097A CN201110256095XA CN201110256095A CN102357097A CN 102357097 A CN102357097 A CN 102357097A CN 201110256095X A CN201110256095X A CN 201110256095XA CN 201110256095 A CN201110256095 A CN 201110256095A CN 102357097 A CN102357097 A CN 102357097A
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Abstract
The invention aims at providing a drug for preventing and treating skin frostbite. The drug for preventing and treating skin frostbite comprises ectoine, hydroxyectoine, glycerin, nipagin, an oil phase component and water. The drug for preventing and treating skin frostbite adopts ectoine and hydroxyectoine as main active components. Ectoine is a small-molecular weight amino acid derivative, is a solute with compatibility, has protection effects on biomolecules in extreme environments, and concretely, has protection effects on cell walls, nucleic acids and zymoproteins in extreme environments such as a dry environment, a freezing environment, a high temperature environment, a high salt environment, a ray environment and the like. Therefore, ectoine and hydroxyectoine undergo a complexation reaction with water molecules thereby permeating into cells to delay or prevent intracellular ice crystal or intercellular ice crystal formation caused by cold, to promote frostbitten skin regeneration and to prevent inflammation generation.
Description
Technical field
The present invention relates to a kind of control skin cold injury medicine, especially a kind of prevention and the frosted medicine of treatment skin.
Background technology
Cold injury is because of the damage of histiocyte due to freezing, in the histiocyte or iuntercellular form ice crystal; Erythrocyte and platelet aggregation block blood capillary, cause ischemic lesions, and chilblain then is that the skin surface that frequent being exposed to of skin takes place under the cold state festers.Cold injury generally is divided into four degree, once cold injury: injure epidermal area.Local red, swell, itch, bitterly, heat.About 1 all backs knot is crazy about and is healed.Two degree cold injury: wound reaches skin corium.Red, swollen, bitterly, itch more obviously, getting blister in the part, does not have silly back 2～3 week healing of the knot of infection.Three degree cold injury: reach subcutaneous tissue deeply.Early stage red and swollen also have a big blister, and skin becomes black-and-bluely by pale, and consciousness disappears, and tissue is mummification necrosis.Four degree cold injury: injure muscle and skeleton.Dryness and wet gangrene take place, and need skin-grafting and amputation; Also has the frosted medicine of better prevention at present.
Summary of the invention
The purpose of this invention is to provide and a kind ofly can effectively prevent and treat frosted prevention of skin and treatment skin frosted medicine.
Realize a kind of prevention and the frosted medicine of treatment skin of the object of the invention, comprise tetrahydropyrimidine, hydroxy tetrahydro pyrimidine, glycerol, nipalgin, oil-phase component and water.
The content of said tetrahydropyrimidine and hydroxy tetrahydro pyrimidine is 2wt%～12wt%.
The content of said glycerol is 1wt%～10wt%.
The content of said nipalgin is 0.1wt%.
Said oil-phase component comprises one or more mixture in sodium lauryl sulphate, hexadecanol, octadecanol, vaseline, Mentholum and the liquid paraffin.
The content of said sodium lauryl sulphate is 0.1wt%～2wt%; The content of said hexadecanol is 3wt%～10wt%; The content of said octadecanol is 1wt%～10wt%; The content of said vaseline is 2wt%～25wt%; The content of said Mentholum is 0.5wt%～2wt%; The content of said liquid paraffin is 2wt%～15wt%.
The beneficial effect of a kind of prevention of the present invention and the frosted medicine of treatment skin is following:
Of the present invention a kind of be the prevention cold injury of main effective ingredient and the medicine of treatment cold injury skin with tetrahydropyrimidine and hydroxy tetrahydro pyrimidine; Because tetrahydropyrimidine is a kind of micromolecular amino acid derivativges; Be a kind of compatible solute, have protective effect for the biomolecule in the extreme environment, for example can be to the cell wall under the extreme conditions such as dry, freezing, high temperature, high salt, ray; Nucleic acid, pheron play the better protect effect.Therefore; Tetrahydropyrimidine and hydroxy tetrahydro pyrimidine can with the hydrone network with; And be penetrated into and can slow down and prevent and treat in the cold cell that causes in the cell or the formation of iuntercellular ice crystal, and the regeneration of frosted skin is had facilitation, and prevent and treat the generation of inflammation.
The specific embodiment
Embodiment 1
The composition and the content of the prevention of present embodiment and the frosted medicine of treatment skin are following:
| Tetrahydropyrimidine | 5g |
| The hydroxy tetrahydro pyrimidine | 5g |
| Mentholum | 1g |
| Sodium lauryl sulphate | 0.5g |
| Hexadecanol | 10g |
| Octadecanol | 3g |
| Vaseline | 10g |
| Liquid paraffin | 10ml |
| Glycerol | 10ml |
| Nipalgin | 0.1g |
| Pure water | 45.4ml |
Administrated method: clean the affected part, medicine of the present invention is spread upon the affected part uniformly, 3 times on the one.
The effect of present embodiment prevention and the frosted medicine of treatment skin is following:
Can see that in 20 cold injury patients' altogether clinical research the composition of medicine that contains 5wt% tetrahydropyrimidine and 5wt% hydroxy tetrahydro pyrimidine in utilization is after 1 week of treatment, 12 recoveries from illness, 6 are effectively.
Total effective rate is 90%, and healing rate is 60%.
Criterion: fully recover for redness disappears, numb sufferings disappear, swollen fast the dissipation.Effectively: wound healing, transfer to well red and swollen numbness itch the pain obviously alleviate, wound surface heals basically.Invalid do not have change for skin lesion.Total effective rate=(recovery from illness+effectively)/total routine number; Healing rate=recovery from illness/total routine number.
Embodiment 2
The composition and the content of the prevention of present embodiment and the frosted medicine of treatment skin are following:
| Tetrahydropyrimidine | 12g |
| The hydroxy tetrahydro pyrimidine | 2g |
| Mentholum | 1g |
| Sodium lauryl sulphate | 0.1g |
| Hexadecanol | 5g |
| Octadecanol | 10g |
| Vaseline | 2g |
| Liquid paraffin | 15ml |
| Glycerol | 5ml |
| Nipalgin | 0.1g |
| Pure water | 47.8ml |
Administrated method is the same.
The effect of present embodiment prevention and the frosted medicine of treatment skin is following:
Can see that in 30 cold injury patients' altogether clinical research the composition of medicine that contains 12wt% tetrahydropyrimidine and 2wt% hydroxy tetrahydro pyrimidine in utilization is after 1 week of treatment, 20 recoveries from illness, 8 are effectively.
Total effective rate is 93%, and healing rate is 67%.
Embodiment 3
The composition and the content of the prevention of present embodiment and the frosted medicine of treatment skin are following:
| Tetrahydropyrimidine | 2g |
| The hydroxy tetrahydro pyrimidine | 12g |
| Mentholum | 2g |
| Sodium lauryl sulphate | 2g |
| Hexadecanol | 1g |
| Octadecanol | 3g |
| Vaseline | 25g |
| Liquid paraffin | 2ml |
| Glycerol | 1ml |
| Nipalgin | 0.1g |
| Pure water | 49.9ml |
Administrated method is the same
The effect of present embodiment prevention and the frosted medicine of treatment skin is following:
Can see that in 30 cold injury patients' altogether clinical research the composition of medicine that contains 2wt% tetrahydropyrimidine and 12wt% hydroxy tetrahydro pyrimidine in utilization is after 1 week of treatment, 17 recoveries from illness, 10 are effectively.
Total effective rate is 90%, and healing rate is 57%.
The method for making of prevention of the present invention and the frosted medicine of treatment skin is following:
With oil-phase component (hexadecanol 3wt%～10wt%, Mentholum 0.5wt%～2wt%, vaseline 2wt%～25wt%; Liquid paraffin 2wt%～15wt% etc.) heating and melting mix homogeneously in heatable equal pulp grinder (70-80 ℃) will contain tetrahydropyrimidine (2wt%～12wt%), hydroxy tetrahydro pyrimidine (2wt%～12wt%); Glycerol (1wt%～10wt%); Nipalgin water-phase components such as (0.05wt%) is dissolved in pure water and (forms the water component among the 40wt%～60wt%) and be heated to uniform temperature and stir (70-80 ℃), oil phase component is slowly added in the water component, evenly stir simultaneously; Make the abundant mixing of composition, condensation obtains medicine of the present invention.
Claims (6)
1. one kind is prevented and the frosted medicine of treatment skin, comprises tetrahydropyrimidine, hydroxy tetrahydro pyrimidine, glycerol, nipalgin, oil-phase component and water.
2. prevention according to claim 1 and the frosted medicine of treatment skin, it is characterized in that: the content of said tetrahydropyrimidine and hydroxy tetrahydro pyrimidine is 2wt%～12wt%.
3. prevention according to claim 1 and 2 and the frosted medicine of treatment skin, it is characterized in that: the content of said glycerol is 1wt%～10wt%.
4. prevention according to claim 1 and 2 and the frosted medicine of treatment skin, it is characterized in that: the content of said nipalgin is 0.1wt%.
5. prevention according to claim 1 and 2 and the frosted medicine of treatment skin, it is characterized in that: said oil-phase component comprises one or more mixture in sodium lauryl sulphate, hexadecanol, octadecanol, vaseline, Mentholum and the liquid paraffin.
6. prevention according to claim 5 and the frosted medicine of treatment skin, it is characterized in that: the content of said sodium lauryl sulphate is 0.1wt%～2wt%; The content of said hexadecanol is 3wt%～10wt%; The content of said octadecanol is 1wt%～10wt%; The content of said vaseline is 2wt%～25wt%; The content of said Mentholum is 0.5wt%～2wt%; The content of said liquid paraffin is 2wt%～15wt%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110256095XA CN102357097A (en) | 2011-09-01 | 2011-09-01 | Drug for preventing and treating skin frostbite |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110256095XA CN102357097A (en) | 2011-09-01 | 2011-09-01 | Drug for preventing and treating skin frostbite |
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| CN102357097A true CN102357097A (en) | 2012-02-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201110256095XA Pending CN102357097A (en) | 2011-09-01 | 2011-09-01 | Drug for preventing and treating skin frostbite |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104540532A (en) * | 2012-07-09 | 2015-04-22 | 比托普股份公司 | Composition containing ecotine or hydroxyecotine as an active substances for promoting the regeneration of injured body tissue |
| CN111773222A (en) * | 2020-08-10 | 2020-10-16 | 华熙生物科技股份有限公司 | Application of tetrahydropyrimidine and/or hydroxyl tetrahydropyrimidine in preparation of medicine for treating burns and scalds |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101011335A (en) * | 2006-02-03 | 2007-08-08 | Lvmh研究公司 | Protecting, regenerating composition |
-
2011
- 2011-09-01 CN CN201110256095XA patent/CN102357097A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101011335A (en) * | 2006-02-03 | 2007-08-08 | Lvmh研究公司 | Protecting, regenerating composition |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104540532A (en) * | 2012-07-09 | 2015-04-22 | 比托普股份公司 | Composition containing ecotine or hydroxyecotine as an active substances for promoting the regeneration of injured body tissue |
| CN111773222A (en) * | 2020-08-10 | 2020-10-16 | 华熙生物科技股份有限公司 | Application of tetrahydropyrimidine and/or hydroxyl tetrahydropyrimidine in preparation of medicine for treating burns and scalds |
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Application publication date: 20120222 |