CN102350278B - 可载药壳聚糖微球的制备 - Google Patents
可载药壳聚糖微球的制备 Download PDFInfo
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- CN102350278B CN102350278B CN201110168817.6A CN201110168817A CN102350278B CN 102350278 B CN102350278 B CN 102350278B CN 201110168817 A CN201110168817 A CN 201110168817A CN 102350278 B CN102350278 B CN 102350278B
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- 229920001661 Chitosan Polymers 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000004005 microsphere Substances 0.000 title claims abstract description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 81
- 239000000243 solution Substances 0.000 claims abstract description 61
- 238000006243 chemical reaction Methods 0.000 claims abstract description 56
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 54
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 42
- 238000004108 freeze drying Methods 0.000 claims abstract description 27
- HSHNITRMYYLLCV-UHFFFAOYSA-N 4-methylumbelliferone Chemical compound C1=C(O)C=CC2=C1OC(=O)C=C2C HSHNITRMYYLLCV-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229960001396 hymecromone Drugs 0.000 claims abstract description 15
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 14
- 239000012528 membrane Substances 0.000 claims abstract description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
- YRHYCMZPEVDGFQ-UHFFFAOYSA-N methyl decanoate Chemical compound CCCCCCCCCC(=O)OC YRHYCMZPEVDGFQ-UHFFFAOYSA-N 0.000 claims description 26
- 239000011806 microball Substances 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 13
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 13
- 229910052794 bromium Inorganic materials 0.000 claims description 13
- 239000007853 buffer solution Substances 0.000 claims description 13
- 229940072033 potash Drugs 0.000 claims description 13
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 13
- 235000015320 potassium carbonate Nutrition 0.000 claims description 13
- 238000003756 stirring Methods 0.000 claims description 13
- 239000007864 aqueous solution Substances 0.000 claims description 2
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Substances CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 claims 3
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 claims 3
- HOGDNTQCSIKEEV-UHFFFAOYSA-N n'-hydroxybutanediamide Chemical compound NC(=O)CCC(=O)NO HOGDNTQCSIKEEV-UHFFFAOYSA-N 0.000 claims 3
- 238000000034 method Methods 0.000 abstract description 21
- 239000003937 drug carrier Substances 0.000 abstract description 5
- 239000002105 nanoparticle Substances 0.000 abstract description 4
- 238000001338 self-assembly Methods 0.000 abstract description 3
- 238000005516 engineering process Methods 0.000 abstract description 2
- 238000001914 filtration Methods 0.000 abstract 2
- 239000000523 sample Substances 0.000 abstract 2
- 238000000502 dialysis Methods 0.000 abstract 1
- SHCRSWJVWSAMKQ-UHFFFAOYSA-N methyl 10-bromodecanoate Chemical compound COC(=O)CCCCCCCCCBr SHCRSWJVWSAMKQ-UHFFFAOYSA-N 0.000 abstract 1
- 231100001083 no cytotoxicity Toxicity 0.000 abstract 1
- 239000008055 phosphate buffer solution Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 239000012521 purified sample Substances 0.000 abstract 1
- 230000004913 activation Effects 0.000 description 11
- 238000013019 agitation Methods 0.000 description 11
- 238000000967 suction filtration Methods 0.000 description 11
- 238000004132 cross linking Methods 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 239000003431 cross linking reagent Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 229920002101 Chitin Polymers 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 125000003047 N-acetyl group Chemical group 0.000 description 1
- 238000012356 Product development Methods 0.000 description 1
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000000599 controlled substance Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 229960002949 fluorouracil Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229920000447 polyanionic polymer Polymers 0.000 description 1
- 229920000867 polyelectrolyte Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000004537 potential cytotoxicity Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 235000019830 sodium polyphosphate Nutrition 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000010415 tropism Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
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- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110168817.6A CN102350278B (zh) | 2011-06-17 | 2011-06-17 | 可载药壳聚糖微球的制备 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110168817.6A CN102350278B (zh) | 2011-06-17 | 2011-06-17 | 可载药壳聚糖微球的制备 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102350278A CN102350278A (zh) | 2012-02-15 |
| CN102350278B true CN102350278B (zh) | 2013-06-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110168817.6A Active CN102350278B (zh) | 2011-06-17 | 2011-06-17 | 可载药壳聚糖微球的制备 |
Country Status (1)
| Country | Link |
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| CN (1) | CN102350278B (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102671202A (zh) * | 2012-05-09 | 2012-09-19 | 北京化工大学常州先进材料研究院 | 改性壳聚糖载药微球及其制备方法 |
| CN111068596B (zh) * | 2019-12-26 | 2021-06-11 | 浙江大学 | 一种自组装纳米球及其制备方法和应用 |
| CN116199799B (zh) * | 2022-12-08 | 2024-06-04 | 安徽工业大学 | 光交联gsh/ros响应靶向的壳聚糖基药物载体及制备方法和应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085358A (zh) * | 2007-06-07 | 2007-12-12 | 上海交通大学 | 季胺盐改性的壳聚糖载药纳米粒子的制备方法 |
| CN101711873A (zh) * | 2008-10-06 | 2010-05-26 | 中国科学院大连化学物理研究所 | 一种两亲性壳聚糖纳米药物载体的制备方法 |
| CN101766820A (zh) * | 2010-02-23 | 2010-07-07 | 厦门大学 | 一种新型壳聚糖纳米载体的制备及其功能化的方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008042970A2 (en) * | 2006-10-03 | 2008-04-10 | Haggard Warren O | Chitosan-coated calcium sulfate based medicament delivery system |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085358A (zh) * | 2007-06-07 | 2007-12-12 | 上海交通大学 | 季胺盐改性的壳聚糖载药纳米粒子的制备方法 |
| CN101711873A (zh) * | 2008-10-06 | 2010-05-26 | 中国科学院大连化学物理研究所 | 一种两亲性壳聚糖纳米药物载体的制备方法 |
| CN101766820A (zh) * | 2010-02-23 | 2010-07-07 | 厦门大学 | 一种新型壳聚糖纳米载体的制备及其功能化的方法 |
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| Publication number | Publication date |
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| CN102350278A (zh) | 2012-02-15 |
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