CN102327332A - Chinese veterinary medicinal composition for treating hypothermia and preparation method for micro-capsule preparations thereof - Google Patents
Chinese veterinary medicinal composition for treating hypothermia and preparation method for micro-capsule preparations thereof Download PDFInfo
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- CN102327332A CN102327332A CN201110307901A CN201110307901A CN102327332A CN 102327332 A CN102327332 A CN 102327332A CN 201110307901 A CN201110307901 A CN 201110307901A CN 201110307901 A CN201110307901 A CN 201110307901A CN 102327332 A CN102327332 A CN 102327332A
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Abstract
The invention discloses a Chinese veterinary medicinal composition for treating hypothermia. The composition comprises malaytea scurfpea fruit, astragalus and prepared common monkshood daughter root. The invention also discloses a preparation method for micro-capsule preparations of the composition. The method comprises the following steps of: weighing the malaytea scurfpea fruit, the astragalus and the prepared common monkshood daughter root in a ratio, adding water, decocting, and filtering; precipitating by using ethanol, and volatilizing the ethanol completely under reduced pressure; adding distilled water, and regulating the pH value to 7 to obtain solution A; adding gelatin into the solution A, stirring, dissolving, and preparing water/oil (W/O) emulsion by using a homogenizer; emulsifying the emulsion with Arabic gum solution to form water/oil/water (W/O/W) composite emulsion; and adding formaldehyde solution, curing, and performing spray drying to obtain the micro-capsule preparations of a malaytea scurfpea fruit extract, an astragalus extract and a prepared common monkshood daughter root extract. When animals with the hypothermia are treated by the composition, the cure rate is over 93 percent, and the economic loss of culturists is reduced effectively.
Description
Technical field
The present invention relates to a kind of herbal medicine compositions, is the veterinary drug preparation of feedstock production with the Chinese herbal medicine specifically, and the present invention also comprises the method for preparing of the microcapsule formulation of said composition.
Background technology
Pig " hypothermia " is that the not enough or heat radiation of heat production too much causes the subnormal a kind of clinical syndrome of body temperature in the body that is caused by multiple reason.Pilosity is born in the severe winter and the early spring.Syndromes such as in recent years, it is low to occur pig unknown cause body temperature on the veterinary clinic again and again, and appetite reduces, spirit is depressed; Can cause the farrowing sow premature labor when being in a bad way, produce weak son or stillborn fetus, nonpregnant sows delays to oestrus, and growing and fattening pigs lose weight; Piglet growth impaired development etc., improper like untimely treatment or Therapeutic Method, often cause mother, piglet dead jointly; Mortality rate causes the tremendous economic loss for the industry of raising pigs up to more than 80%.
" hypothermia " of pig is a kind of clinical syndrome that improper or other diseases secondary causes heat production is not enough or heat radiation too much causes in the pig body body temperature to descend suddenly because of feeding and management; Present stage does not have the specific treatment medicine; More western medical treatment adopts and removes the cause of disease, strengthens feeding and management, adopts fluid infusion, heart tonifying composite treatment.Though this scheme has certain therapeutic effect, can only mitigate the disease, can not and recover the body circulating function from basic improvement, be prone to cause the state of an illness repeatedly.
Summary of the invention
In view of this, thus the object of the invention is to provide a kind of animal heat, appetite, motion, two just improve the survival rate of suffering from the hypothermia domestic animal with ergasia Chinese medicine composition that recovers.Simultaneously, the present invention also provides the method for preparing of said composition microcapsule formulation.
Technical scheme provided by the invention is based on the developmental research of China's theory of medicine; Under the pathogeny and Therapeutic Principle of theory of Chinese medical science; Scientific research development in conjunction with modern veterinary clinical medicine; From the Chinese medicine treasure-house, filter out the Chinese herbal medicine of strengthening YANG and invigorating QI, warming spleen and stomach for dispelling cold, and, confirmed Fructus Psoraleae, the Radix Astragali and Radix Aconiti Lateralis Preparata active component as component of the present invention through clinical trial.
Fructus Psoraleae: Latin title Psoralea corylifolia L. is commonly called as Semen Allii Tuberosi, the solid fat of mother-in-law, Fructus Psoraleae, benefit bone sparrow hawk, FRUCTUS PSORALEAE, Hu Fructus Psoraleae, Ji Guzi, FRUCTUS PSORALEAE recklessly; Hot, bitter, big temperature; Go into spleen, kidney channel; Has warming the kidney to invigorate YANG, the effect of antidiarrheal; Its main effective ingredient contains psoralen, and fixed in the Fructus Psoraleae, isopsoralene, Corylifolinin in addition, also contain cottonseed sugar, fatty oil, volatile oil and resin etc.Pharmacological research proof psoralen, isopsoralen have excited heart, defying age, increase the effect of immunity of organisms, and Fructus Psoraleae has various bacteria such as escherichia coli, staphylococcus and suppresses and killing action simultaneously.
The Radix Astragali: Latin title radix astragali has another name called Radix Astragali; Sweet, temperature is returned lung, spleen channel; The effect invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation; Its main effective ingredient is Radix Astragali saponin first a, second, the third, astragalus polysaccharides A, B, C, D, and aminoacid, alkaloid etc.; The Radix Astragali has effects such as enhancing antibody generation, enhance immunity systemic-function, antiinflammatory antiviral, anti-stress.
Radix Aconiti Lateralis Preparata: be the processed goods of the daughter root of ranunculaceae plant Aconitum carmichjaelii Debx. Aconitum carmichaeli debx; Hot, sweet, big heat; Poisonous, GUIXIN, kidney, spleen channel; Have recuperating depleted YANG and rescuing the patient from collapse, it is supporing yang to mend fire, by the effect of wind-cold damp pathogen; Contain multiple alkaloid in the Radix Aconiti Lateralis Preparata, to contain aconitine, mesaconitine and hypaconitine etc. is main; Former aconitine and nor-aconitine in the pharmacological research proof Radix Aconiti Lateralis Preparata have heart tonifying, antiinflammatory, the effect that improves oxygen-resistant ability and raise immunity.
Chinese veterinarian's theory is thought, the generation of the hypothermia of pig is traced it to its cause nothing more than two aspects: one is affection of exogenous wind-cold, the 2nd, and internal injury is sombre.Say in " unit prosperous treat Ma Ji ": " because of not drinking yearningly for a long time, drinking cold water too, cold air is gone into stomach also.Or win the dangerous Su Leng of thin mistake, or the old and the weak's frost of divulging a secret for a long time, or herd by overcast and rainy bitter the pouring, or plain to the wetland lying on bed for a long time, dampness passes through people's muscle ".Cold being a kind of YIN pathogen, the cold-evil invades the carcass inhibition and consumes a large amount of yang-energies, causes a little less than the deficiency of YANG QI, and the body functional activity reduces, and suffers from and raises performance coldness of the body cold of the limbs, and spiritual extremely depressed, refreshing knowledge is dull-witted, and muscle trembles, and the ear nose is sent out cold.The not thirsty or desire for hot drinks of weak breathing, mouth, light red tongue is white and moist, faint pulse being about to disappear, the body temperature subnormal temperature is so the syndrome that a series of yang-energy will take off occurs clinically.Therefore Chinese veterinarian's determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs is thought: hypothermia mainly is a body yang deficiency.Yang deficiency person is cold, so the coldness of the body cold of the limbs; The deficiency of vital energy is hypofunction then, so lethargy, weak breathing, complexion and pulse are the card of weakened YANG QI deficiency and coldness.Kidney yang is total sun of the whole body, and the Yuanyang of kidney has warm the five internal organs, six internal organs, keeps the function of its vital movement, and kidney yang is prosperous, and the sun of the whole body is all prosperous.So according to Chinese veterinarian's basic theories, the generation of pig hypothermia can be distinguished and be insufficiency of kidney-YANG.Its Therapeutic Principle should be based on the principle of " supporing yang activating QI ", " gas can be warm ", and prescription medicine should carry out compatibility from supporing yang, QI invigorating, warming the interior three aspects, to reach strengthening YANG and invigorating QI, in the hope of the purpose of Gan Wen.
The quality proportioning of the present composition is following: Fructus Psoraleae 25-30, Radix Astragali 25-30, Radix Aconiti Lateralis Preparata 15-20;
Preferably, the quality proportioning of said compositions is: Fructus Psoraleae 25, the Radix Astragali 25, Radix Aconiti Lateralis Preparata 15;
Preferably, the quality proportioning of said compositions is: Fructus Psoraleae 25, the Radix Astragali 30, Radix Aconiti Lateralis Preparata 15;
Preferably, the quality proportioning of said compositions is: Fructus Psoraleae 30, the Radix Astragali 30, Radix Aconiti Lateralis Preparata 20;
Preferably, the quality proportioning of said compositions is: Fructus Psoraleae 27, the Radix Astragali 27, Radix Aconiti Lateralis Preparata 17.
The microcapsule formulation method for preparing of herbal medicine compositions of the present invention makes according to following steps:
Take by weighing said components amount Fructus Psoraleae, the Radix Astragali and Radix Aconiti Lateralis Preparata earlier; Decocte with water three times decocted 1 hour at every turn, and filtering liquid medicine is settled to volume VL; Said constant volume volume V does corresponding adjustment according to raw-material how many variations; For example working as raw-material weight is Fructus Psoraleae 25-30g, and when Radix Astragali 25-30g, Radix Aconiti Lateralis Preparata 15-20g, said volume V is the 100ml magnitude; When raw-material weight is Fructus Psoraleae 25-30kg, Radix Astragali 25-30kg, Radix Aconiti Lateralis Preparata 15-20kg are that said volume V is the 100L magnitude;
95% ethanol precipitate with ethanol three times makes medicinal liquid contain the alcohol amount and is respectively 70%, 80%, 70%, and most ethanol is waved in decompression;
Add distilled water to volume V/5L, regulate pH value and be 7 solution A;
In solution A, add gelatin, making its content is 2-5%, stirring and dissolving;
Add volume V/4L vegetable oil, behind homogenizer, be prepared into w/o type Emulsion;
With said w/o type Emulsion Emulsion further with contain 3-4% gumwater volume V/2L emulsifying, form the W/O/W multiple emulsion;
Add 1% formalin 10mL and solidify, spray-dried, the microcapsule formulation of Fructus Psoraleae, the Radix Astragali and Radix Aconiti Lateralis Preparata extract.
The physicochemical property of said microcapsule formulation: be the white powder material, loose, form suspension type solution behind the adding water for injection, be used for the animal muscle injection.
Microcapsule formulation of the present invention is used to treat the method for using of hypothermia: intramuscular injection 1.0-1.5g/kg body weight (by crude drug in whole), every day 1-2 time, used continuously 3 days.
The clinical treatment test
1 test method
1.1 Fructus Psoraleae, the Radix Astragali and the therapeutic test of Radix Aconiti Lateralis Preparata compound recipe microcapsule formulation
In the Jianyang, Sichuan, Deyang, Chongzhou City, Yaan, the ill naturally pig in pig farm, various places, Xinjin, cut open the ill pig that inspection and lab testing be diagnosed as pig " hypothermia " through Epidemiological study, clinical symptoms, pathology and only amount to 58.Use the microcapsule formulation treatment of this compositions, intramuscular injection 1.0-1.5g/kg body weight (by crude drug in whole), was used 3 days continuously at every day 1-2 time.Notice during the treatment that observing the state of an illness lapses to, and carry out relative recording.
1.2 Western medicine contrast therapy group
In the Jianyang, Sichuan, Deyang, Chongzhou City, Yaan, the ill naturally pig in pig farm, various places, Xinjin, cut open the ill pig that inspection and lab testing be diagnosed as pig " hypothermia " through Epidemiological study, clinical symptoms, pathology and only amount to 54 as controlled trial.Medication: 50% glucose 120-160mL, Catergen .5-4g (pressing the 100kg body weight calculates), mix a back intravenous injection, once a day, logotype 3 days; 10% caffeine and sodium benzoate injection is pressed the 0.4mL/kg intramuscular injection, the next day 1 time.
1.3 curative effect judgment criteria
Recovery from illness: treatment back transference cure, body temperature, appetite, motion, two are just, ergasia etc. recovers normal.
Effectively: sx improvement after the treatment, but in a course of treatment (3 days), all disappear, the continuation treatment can further take a turn for the better and fully recover or the healing of its medicine of adapted.
Invalid: treatment back symptom did not have obvious change or used the treatment of its medicine instead or symptom aggravation even dead a course of treatment (3 days).
2 result of the tests
The clinical treatment result of the test sees the following form:
Show that through clinical test results microcapsule formulation of the present invention has outstanding substantive distinguishing features and obvious improvement.
Important characteristic of microcapsule formulation of the present invention is to detect through qualitative detection to comprise effective ingredient psoralen, astragaloside and hypaconitine in the above-mentioned microcapsule formulation; Through detection by quantitative, psoralen content is more than or equal to 160.872mg/ml in the microcapsule formulation; Astragaloside content is more than or equal to 65.64mg/ml; Hypaconitine content is more than or equal to 44.81mg/ml.
Another important feature of microcapsule formulation of the present invention is through accelerated test, long term test, and the result proves that this compositions microcapsule formulation has significantly increased the stability of three kinds of Chinese crude drug main components.The component contents of inspection effective ingredient psoralen, astragaloside and the hypaconitine of this microcapsule formulation in process of the test etc. are having no significant change during at the 1st, 2,3,6,12,18,24,36 month under the normal temperature condition; Meet the regulation of " People's Republic of China's veterinary drug allusion quotation " version in 2010, show good stable property about quality standard.
Compared with prior art, the present composition also has the following advantages:
1, therapeutic effect is remarkable, and the ill pig cure rate through this compositions microcapsule formulation treatment is apparently higher than Western medicine;
2, use cure rate and the improvement rate of the ill pig of this compositions microcapsule formulation treatment to reach 93.1%, have the progress of significance, can greatly retrieve the economic loss of pig industry;
3, three kinds of Chinese crude drugs selecting for use of the present composition distribute extensively, are easy to obtain its raw material.
4, the present composition has only been selected three kinds of Chinese crude drugs for use, and the cost of raw material is cheap, is easy to apply.
Description of drawings
Fig. 1 is psoralen standard substance detected peaks.
Fig. 2 is hypaconitine standard substance detected peaks.
Fig. 3 is astragaloside standard substance detected peaks.
Fig. 4 is hybrid standard article detected peaks.
Fig. 5 is a microcapsule formulation test sample detected peaks.
The specific embodiment
Take by weighing raw material (g) by following proportioning:
1, Fructus Psoraleae 25, the Radix Astragali 25, Radix Aconiti Lateralis Preparata 15;
2, Fructus Psoraleae 25, the Radix Astragali 30, Radix Aconiti Lateralis Preparata 15;
3, Fructus Psoraleae 30, the Radix Astragali 30, Radix Aconiti Lateralis Preparata 20;
4, Fructus Psoraleae 27, the Radix Astragali 27, Radix Aconiti Lateralis Preparata 17.
Method for preparing is following:
Take by weighing Fructus Psoraleae, the Radix Astragali of group component earlier, Radix Aconiti Lateralis Preparata, decocte with water three times decocted 1 hour at every turn, and filtering liquid medicine is settled to 100mL; 95% ethanol precipitate with ethanol three times makes medicinal liquid contain the alcohol amount and is respectively 70%, 80%, 70%, and most ethanol is waved in decompression; Add distilled water to 20mL, regulate pH value and be 7 solution A; In solution A, add gelatin, making its content is 2%, and stirring and dissolving adds the 25mL vegetable oil, behind homogenizer, is prepared into w/o type Emulsion; This Emulsion further with contain 4% gumwater 50mL emulsifying, form the W/O/W multiple emulsion, add 1% formalin 10mL and solidify, the microcapsule formulation of spray-dried Fructus Psoraleae, the Radix Astragali and Radix Aconiti Lateralis Preparata extract.
Embodiment 2
Take by weighing raw material (kg) by following proportioning:
1, Fructus Psoraleae 25, the Radix Astragali 25, Radix Aconiti Lateralis Preparata 15;
2, Fructus Psoraleae 25, the Radix Astragali 30, Radix Aconiti Lateralis Preparata 15;
3, Fructus Psoraleae 30, the Radix Astragali 30, Radix Aconiti Lateralis Preparata 20;
4, Fructus Psoraleae 27, the Radix Astragali 27, Radix Aconiti Lateralis Preparata 17.
Method for preparing is following:
Take by weighing Fructus Psoraleae, the Radix Astragali of group component earlier, Radix Aconiti Lateralis Preparata, decocte with water three times decocted 1 hour at every turn, and filtering liquid medicine is settled to 100L; 95% ethanol precipitate with ethanol three times makes medicinal liquid contain the alcohol amount and is respectively 70%, 80%, 70%, and most ethanol is waved in decompression; Add distilled water to 20L, regulate pH value and be 7 solution A; In solution A, add gelatin, making its content is 2%, and stirring and dissolving adds the 25L vegetable oil, behind homogenizer, is prepared into w/o type Emulsion; This Emulsion further with contain 4% gumwater 50L emulsifying, form the W/O/W multiple emulsion, middle adding 1% formalin 10L solidifies, the microcapsule formulation of spray-dried Fructus Psoraleae, the Radix Astragali and Radix Aconiti Lateralis Preparata extract.
Take by weighing raw material (kg) by following proportioning:
1, Fructus Psoraleae 50, the Radix Astragali 50, Radix Aconiti Lateralis Preparata 30;
2, Fructus Psoraleae 50, the Radix Astragali 60, Radix Aconiti Lateralis Preparata 30;
3, Fructus Psoraleae 60, the Radix Astragali 60, Radix Aconiti Lateralis Preparata 40;
4, Fructus Psoraleae 54, the Radix Astragali 54, Radix Aconiti Lateralis Preparata 34.
Method for preparing is following:
Take by weighing Fructus Psoraleae, the Radix Astragali of group component earlier, Radix Aconiti Lateralis Preparata, decocte with water three times decocted 1 hour at every turn, and filtering liquid medicine is settled to 200L; 95% ethanol precipitate with ethanol three times makes medicinal liquid contain the alcohol amount and is respectively 70%, 80%, 70%, and most ethanol is waved in decompression; Add distilled water to 40L, regulate pH value and be 7 solution A; In solution A, add gelatin, making its content is 2%, and stirring and dissolving adds the 50L vegetable oil, behind homogenizer, is prepared into w/o type Emulsion; This Emulsion further with contain 4% gumwater 100L emulsifying, form the W/O/W multiple emulsion, add 1% formalin 20L and solidify, the microcapsule formulation of spray-dried Fructus Psoraleae, the Radix Astragali and Radix Aconiti Lateralis Preparata extract.
Take by weighing raw material (kg) by following proportioning:
1, Fructus Psoraleae 100, the Radix Astragali 100, Radix Aconiti Lateralis Preparata 60;
2, Fructus Psoraleae 100, the Radix Astragali 120, Radix Aconiti Lateralis Preparata 60;
3, Fructus Psoraleae 120, the Radix Astragali 120, Radix Aconiti Lateralis Preparata 40;
4, Fructus Psoraleae 108, the Radix Astragali 108, Radix Aconiti Lateralis Preparata 68.
Method for preparing is following:
Take by weighing Fructus Psoraleae, the Radix Astragali of group component earlier, Radix Aconiti Lateralis Preparata, decocte with water three times decocted 1 hour at every turn, and filtering liquid medicine is settled to 400L; 95% ethanol precipitate with ethanol three times makes medicinal liquid contain the alcohol amount and is respectively 70%, 80%, 70%, and most ethanol is waved in decompression; Add distilled water to 80L, regulate pH value and be 7 solution A; In solution A, add gelatin, making its content is 2%, and stirring and dissolving adds the 100L vegetable oil, behind homogenizer, is prepared into w/o type Emulsion; This Emulsion further with contain 4% gumwater 200L emulsifying, form the W/O/W multiple emulsion, add 1% formalin 40L and solidify, the microcapsule formulation of spray-dried Fructus Psoraleae, the Radix Astragali and Radix Aconiti Lateralis Preparata extract.
Only be preferred implementation of the present invention below, should be pointed out that above-mentioned preferred implementation should not be regarded as limitation of the present invention, protection scope of the present invention should be as the criterion with claim institute restricted portion.For those skilled in the art, do not breaking away from the spirit and scope of the present invention, can also make some improvement and retouching, these improvement and retouching also should be regarded as protection scope of the present invention.
Claims (6)
1. herbal medicine compositions of treating hypothermia is characterized in that it is the medicament of processing with following quality proportion raw material:
Fructus Psoraleae 25-30, Radix Astragali 25-30, Radix Aconiti Lateralis Preparata 15-20.
2. the herbal medicine compositions of treatment hypothermia as claimed in claim 1 is characterized in that its quality proportioning is:
Fructus Psoraleae 25, the Radix Astragali 25, Radix Aconiti Lateralis Preparata 15.
3. the herbal medicine compositions of treatment hypothermia as claimed in claim 1 is characterized in that its quality proportioning is:
Fructus Psoraleae 25, the Radix Astragali 30, Radix Aconiti Lateralis Preparata 15.
4. the herbal medicine compositions of treatment hypothermia as claimed in claim 1 is characterized in that its quality proportioning is:
Fructus Psoraleae 30, the Radix Astragali 30, Radix Aconiti Lateralis Preparata 20.
5. the herbal medicine compositions of treatment hypothermia as claimed in claim 1 is characterized in that its quality proportioning is:
Fructus Psoraleae 27, the Radix Astragali 27, Radix Aconiti Lateralis Preparata 17.
6. treat the herbal medicine compositions of hypothermia and the method for preparing of microcapsule formulation thereof for one kind, by Fructus Psoraleae, the Radix Astragali and the Radix Aconiti Lateralis Preparata of the arbitrary said group component of claim 1-5, decocte with water 3 times decocted 1 hour at every turn, and filtering liquid medicine is settled to volume volume VL; 95% ethanol precipitate with ethanol 3 times, making medicinal liquid contain alcohol amount weight ratio is 70%, 80%, 70%, most ethanol is waved in decompression; Add distilled water to volume V/5L, regulate pH value and be 7 solution A; In solution A, add gelatin, making its weight content is 2-5%, stirring and dissolving; Add volume V/4L vegetable oil, behind homogenizer, be prepared into w/o type Emulsion; This Emulsion further with contain 3-4% gumwater volume V/2L emulsifying, form the W/O/W multiple emulsion, add 1% formalin volume V/10L and solidify, spray-dried, obtain the microcapsule formulation of Fructus Psoraleae, the Radix Astragali and Radix Aconiti Lateralis Preparata extract.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1387891A (en) * | 2002-06-15 | 2003-01-01 | 合肥神鹿双鹤药业有限责任公司 | Chinese medicine prepn for treating deficiency of spleen and stomach Yang type atrophic gastritis |
| CN101234181A (en) * | 2008-02-04 | 2008-08-06 | 邵振启 | Medicament for preventing and treating leukopenia used in tumor radiotherapy and chemotherapy course |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1387891A (en) * | 2002-06-15 | 2003-01-01 | 合肥神鹿双鹤药业有限责任公司 | Chinese medicine prepn for treating deficiency of spleen and stomach Yang type atrophic gastritis |
| CN101234181A (en) * | 2008-02-04 | 2008-08-06 | 邵振启 | Medicament for preventing and treating leukopenia used in tumor radiotherapy and chemotherapy course |
Non-Patent Citations (2)
| Title |
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| 俞宗发等: "公猪不育症的原因及防治", 《养殖技术顾问》 * |
| 胡元亮: "中兽药增强免疫功能的研究", 《中国家禽》 * |
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