CN102326676A - Complex vitamin molecule microemulsion and preparation method thereof - Google Patents
Complex vitamin molecule microemulsion and preparation method thereof Download PDFInfo
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- CN102326676A CN102326676A CN201110307484A CN201110307484A CN102326676A CN 102326676 A CN102326676 A CN 102326676A CN 201110307484 A CN201110307484 A CN 201110307484A CN 201110307484 A CN201110307484 A CN 201110307484A CN 102326676 A CN102326676 A CN 102326676A
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Abstract
The invention discloses a complex vitamin molecule microemulsion and a preparation method thereof. In terms of the formula, the complex vitamin molecule microemulsion comprises the following components (in weight ratio): 2.0-10.0g of fat soluble vitamin, 37-100g of solubilizer, antioxidant, 7.5-20g of emulsion, 80-200g of assistant emulsifier, 10.0-100.0g of water soluble vitamin, 10-50g of multiple amino acids and 550-750ml of purified water. The complex vitamin molecule microemulsion disclosed by the invention has the advantages of high stability, high solution, high absorption, high nutrition and good promotional value.
Description
Technical field
The present invention relates to technical field of medicine, relate to a kind of compound method of liquid additive premixed feed in particular.
Background technology
The B B-complex product is main with solid pharmaceutical preparation in the market, is prone to classification at storage, in the transportation, is subject to light, influence such as damp and hot causes oxidational losses; High temperature during production, high humidity, high pressure, mechanical friction etc. can cause vitamin loss.Often need to add several times, cause waste to the nutritional requirements of animal; Multidimensional premix needs spice to feed usually during use, and not only labour intensity is big, and is prone to the problem of mixing inequality.When the drinking-water dilution was used, liquid became muddiness, emulsus or vaporific outward appearance, skewness, and the animal intake can't guarantee that bioavailability is relatively poor, blocks water system or drink mouth, grows a large amount of harmful bacterium, animal health condition and growth table now fall.
The liquid vitamin preparation is the vitamin preparation Developing Trend in Technology.The compound vitamin of liquid can be water-soluble with any ratio, dispersed, dialysis property, especially solved molten water, the absorption problem of liposoluble vitamin, no longer absorbs through bile gel dissolving back.
Having some to prepare the report of aspect about the liquid vitamin preparation at present, is a plurality of inventions such as 200410006272.9 and 20010018211.7 like application number, has greatly improved dissolubility, dispersiveness, raising absorptivity and the bioavailability of vitamin in water.Its main preparation methods is through adding emulsifying agent and other auxiliary materials, utilize colloid mill, high pressure homogenizer etc. that liposoluble vitamin is pulverized step by step, need providing huge external energy to overcome intermolecular cohesiveness.The problem that this preparation method exists is that energy consumption is big, product quality is understable, secondary aggregation and layering takes place easily, and see that light color is prone to deepen, occur turbid phenomenon.
Summary of the invention
The object of the invention is exactly provide for the deficiency that solves prior art a kind of not only a kind of stable, and the B B-complex molecule microemulsion of high dissolving, high absorption and high nutrition.
Another object of the present invention provides a kind of preparation method of B B-complex molecule microemulsion.
The present invention adopts following technical solution to realize above-mentioned purpose: a kind of B B-complex molecule microemulsion; It is characterized in that; It comprises following component (by weight calculate), and liposoluble vitamin (2.0-10.0) g, solubilizer (37-100) g, anti-oxidant are an amount of, emulsifying agent (7.5-20) g, assistant for emulsifying agent (80-200) g, water soluble vitamin (10.0-100.0) g, several amino acids (10-50) g and purified water (550-750) ml.
As further specifying of such scheme: said liposoluble vitamin comprises vitamin A, vitamin D
3, vitamin E, per 10 parts of liposoluble vitamins add 50～70 parts of solubilizer content.
Said solubilizer and emulsifying agent are the one or more combination in polyethylene hydrogenated castor oils, AEO, Tween-80, Tween-20, Arlacel-80, the poloxamer.
Said assistant for emulsifying agent is n-butanol, a propane diols and glycerine one or more combination wherein.
Said anti-oxidant is the one or more combination in butylhydroxy anisole, di-t-butyl methylphenol, special basic hydroquinones, methyl p-hydroxybenzoate, methyl p-hydroxybenzoate, ethyl-para-hydroxybenzoate, propylparaben, butyl p-hydroxybenzoate, the sorb acidic group down.
The preparation method of a kind of B B-complex molecule of the present invention microemulsion is characterized in that it comprises the steps:
A, at first take by weighing liposoluble vitamin, anti-oxidant and add solubilizer, emulsifier for mixing to mixing fully, slowly add purified water, the limit adds the waterside and stirs fast;
B, get after purified water adds the anti-oxidant dissolving, add water soluble vitamin, several amino acids successively;
C, two liquid mixing of step a and step b preparation are added the assistant for emulsifying agent mixing, and add a spot of buffer;
D, use the purified water constant volume.
In said processing step a process, be slowly to add 200 parts of purified water; In said processing step b process, be to get 400 parts of purified water to add the anti-oxidant dissolving.
The beneficial effect that the present invention adopts above-mentioned technical solution to reach is:
1, vitamin microemulsion of the present invention contains liposoluble vitamin and water soluble vitamin; Moment is carried out the profound embedding of biomembrane on molecular level; Vitamin and other nutrients material of different pH values, different thermal sensitivity, different light sensitivity and different degree of oxidations are co-located in the liquid of same discontinuous phase; Stable each other and do not disturb mutually, solved well because unstable the tire problem of reduction of vitamin that makes of envirment factor can effectively be controlled the oxidative degradation of vitamins; And each component and consumption carried out meticulous screening, the interpolation order addition manner of each component has been carried out the specific aim adjustment.Product clear of the present invention, thermodynamic stability is good, has slow releasing function, and is lasting, and the system compatibility is good, except that vitamin, can be composite goes into the multiple beneficial composition.
2, these article vitamin is present in the aqueous solution with the form of molecule; The absorption efficiency of vitamin is obviously increased, with the gastrointestinal epithelial layer excellent contact is arranged, through matter between gastrointestinal tract epithelial cell; Pass enteron aisle and get into blood circulation; The result absorbs liposoluble vitamin easily, and bioavailability obviously improves, and its bioavilability reaches 98%.
3, the present invention dilutes when using, and liquid is limpid, is evenly distributed, and can guarantee the animal intake, and bioavailability is high, can not block water system or drink mouth, more can not grow a large amount of harmful bacterium, makes animal health condition and growth table now fall.
The specific embodiment
A kind of B B-complex molecule of the present invention microemulsion; It comprises following component (by weight calculate), and liposoluble vitamin (2.0-10.0) g, solubilizer (37-100) g, anti-oxidant are an amount of, emulsifying agent (7.5-20) g, assistant for emulsifying agent (80-200) g, water soluble vitamin (10.0-100.0) g, several amino acids (10-50) g and purified water (550-750) ml.Wherein, liposoluble vitamin comprises vitamin A, vitamin D
3, vitamin E, per 10 parts of liposoluble vitamins add 50～70 parts of solubilizer content.Solubilizer and emulsifying agent are the one or more combination in polyethylene hydrogenated castor oils, AEO, Tween-80, Tween-20, Arlacel-80, the poloxamer.Assistant for emulsifying agent is n-butanol, a propane diols and glycerine one or more combination wherein.Anti-oxidant is the one or more combination in butylhydroxy anisole, di-t-butyl methylphenol, special basic hydroquinones, methyl p-hydroxybenzoate, methyl p-hydroxybenzoate, ethyl-para-hydroxybenzoate, propylparaben, butyl p-hydroxybenzoate, the sorb acidic group down.
Below in conjunction with embodiment the present invention is described further.
Below be the preparation method of B B-complex molecule microemulsion:
A, in agitator, add liposoluble vitamin (retinol1 0,80 ten thousand unit, vitamin E 600mg, vitamin D
3700,000 units), add successively again that anti-oxidant is an amount of, solubilizer 50g, emulsifying agent 10g be stirred to complete mixing; Slowly add the 200ml purified water, the limit adds the waterside stirs fast, gets orange-yellow clear and bright solution;
B, get after the 400ml purified water adds the dissolving of an amount of anti-oxidant, add niacinamide 15g, Cobastab successively
2200mg, folic acid 300mg, Cobastab
1600mg, D-calcium pantothenate 1g, methionine 5g, lysine 5g are stirred to complete mixing, get orange-yellow clear and bright solution;
C, two liquid mix and add assistant for emulsifying agent 100g mixing, add a spot of sodium pyrophosphate as buffer;
D, be settled to 1000ml with purified water.
This product is yellow to pale brown look liquid, and the vitamin distinctive smell is arranged.
Outward appearance: the perusal clear, show to have good stability, if muddiness, cotton-shaped deepness or layering occur, then show instability.
The high speed centrifugation test: these article are placed centrifuge tube, high speed centrifugation, in the centrifugal 20min of 10000r/min, observation is not have phenomenons such as deposition, muddiness, layering to take place.If appearance transparent, good fluidity then with observing behind 100 times of acceleration of gravity centrifugation 5min, if be not separated, are stable.
Study on the stability: respectively at-4 ℃ of refrigerators, room temperature and 60 ℃ of constant temperature ovens, sample thief carries out outward appearance, pH value and assay during respectively at 0,3,6 month.
The result:
The study on the stability result that table 1 is placed in-4 ℃ of refrigerators
| Sense cycle (moon) | Outward appearance | The pH value | Vitamin A content (%) | Content of vitamin E (%) |
| 0 | Clear | 6.57 | ?99.6 | ?95.7 |
| 3 | Clear | 6.49 | ?99.6 | ?95.0 |
| 6 | Clear | 6.50 | ?99.3 | ?95.3 |
The study on the stability result that table 2 is placed in room temperature
| Sense cycle (moon) | Outward appearance | The pH value | Vitamin A content (%) | Content of vitamin E (%) |
| 0 | Clear | 6.57 | ?99.6 | ?95.7 |
| 3 | Clear | 6.50 | ?98.7 | ?95.6 |
| 6 | Clear | 6.40 | ?97.8 | ?95.0 |
The study on the stability result that table 3 is placed in 60 ℃ of constant temperature ovens
| Sense cycle (moon) | Outward appearance | The pH value | Vitamin A content (%) | Content of vitamin E (%) |
| 0 | Clear | 6.57 | ?99.6 | ?95.7 |
| 3 | Clear | 6.59 | ?98.6 | ?94.6 |
| 6 | Clear | 6.62 | ?97.1 | ?94.0 |
Through a large amount of tests; Vitamin microemulsion of the present invention contains liposoluble vitamin and water soluble vitamin; Moment is carried out the profound embedding of biomembrane on molecular level; Vitamin and other nutrients material of different pH values, different thermal sensitivity, different light sensitivity and different degree of oxidations are co-located in the liquid of same discontinuous phase; Stable each other and do not disturb mutually, solved well because unstable the tire problem of reduction of vitamin that makes of envirment factor can effectively be controlled the oxidative degradation of vitamins.And each component and consumption carried out meticulous screening, the interpolation order addition manner of each component has been carried out the specific aim adjustment.Product clear of the present invention, thermodynamic stability is good, has slow releasing function, and is lasting, and the system compatibility is good, except that vitamin, can be composite goes into the multiple beneficial composition.
These article vitamin is present in the aqueous solution with the form of molecule; The absorption efficiency of vitamin is obviously increased, with the gastrointestinal epithelial layer excellent contact is arranged, through matter between gastrointestinal tract epithelial cell; Pass enteron aisle and get into blood circulation; The result absorbs liposoluble vitamin easily, and bioavailability obviously improves, and its bioavilability reaches 98%.
Above-described only is preferred implementation of the present invention, should be pointed out that for the person of ordinary skill of the art, under the prerequisite that does not break away from the invention design, can also make some distortion and improvement, and these all belong to protection scope of the present invention.
Claims (7)
1. B B-complex molecule microemulsion; It is characterized in that; It comprises following component (by weight calculate), and liposoluble vitamin (2.0-10.0) g, solubilizer (37-100) g, anti-oxidant are an amount of, emulsifying agent (7.5-20) g, assistant for emulsifying agent (80-200) g, water soluble vitamin (10.0-100.0) g, several amino acids (10-50) g and purified water (550-750) ml.
2. B B-complex molecule microemulsion according to claim 1 is characterized in that said liposoluble vitamin comprises vitamin A, vitamin D
3, vitamin E, per 10 parts of liposoluble vitamins add 50～70 parts of solubilizer content.
3. B B-complex molecule microemulsion according to claim 1; It is characterized in that said solubilizer and emulsifying agent are the one or more combination in polyethylene hydrogenated castor oils, AEO, Tween-80, Tween-20, Arlacel-80, the poloxamer.
4. B B-complex molecule microemulsion according to claim 1 is characterized in that, said assistant for emulsifying agent is n-butanol, a propane diols and glycerine one or more combination wherein.
5. B B-complex molecule microemulsion according to claim 1; It is characterized in that said anti-oxidant is the one or more combination in butylhydroxy anisole, di-t-butyl methylphenol, special basic hydroquinones, methyl p-hydroxybenzoate, methyl p-hydroxybenzoate, ethyl-para-hydroxybenzoate, propylparaben, butyl p-hydroxybenzoate, the sorb acidic group down.
6. the preparation method of a B B-complex molecule microemulsion is characterized in that it comprises the steps:
A, at first take by weighing liposoluble vitamin, anti-oxidant and add solubilizer, emulsifier for mixing to mixing fully, slowly add purified water, the limit adds the waterside and stirs fast;
B, get after purified water adds the anti-oxidant dissolving, add water soluble vitamin, several amino acids successively;
C, two liquid mixing of step a and step b preparation are added the assistant for emulsifying agent mixing, and add a spot of buffer;
D, use the purified water constant volume.
7. the preparation method of B B-complex molecule microemulsion according to claim 6 is characterized in that, in said processing step a process, is slowly to add 200 parts of purified water; In said processing step b process, be to get 400 parts of purified water to add the anti-oxidant dissolving, in said processing step d, be settled to 1000ml with purified water.
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Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102726615A (en) * | 2012-07-06 | 2012-10-17 | 厦门惠盈动物科技有限公司 | Vitamin E and trace element selenium aqueous solution and preparation method thereof |
| CN102754738A (en) * | 2012-07-27 | 2012-10-31 | 陕西金冠牧业有限公司 | Nano vitamin D3 for producing feed and preparation method thereof |
| CN103082091A (en) * | 2013-01-15 | 2013-05-08 | 广州格雷特生物科技有限公司 | Special nutrition strengthening solution for livestock and poultry and preparation method thereof |
| CN103783323A (en) * | 2014-02-05 | 2014-05-14 | 褚旭 | Method for preparing compound vitamin premix for animals |
| CN104207145A (en) * | 2014-09-18 | 2014-12-17 | 苏州经贸职业技术学院 | Vitamin E nano-microemulsion and preparation method thereof |
| CN104304797A (en) * | 2014-10-30 | 2015-01-28 | 四川中农致远生物科技有限公司 | Process for manufacturing decavitamin nanoemulsion for livestock and poultry |
| CN104304679A (en) * | 2014-10-27 | 2015-01-28 | 广东金品动物营养有限公司 | Multivitamin C, E immune polysaccharide microemulsion preparation and preparation method and application of preparation |
| CN104997794A (en) * | 2015-07-31 | 2015-10-28 | 郑州赛科药业科技有限公司 | Long-acting composite vitamin oral emulsion for livestock and preparation method thereof |
| CN106343218A (en) * | 2016-08-31 | 2017-01-25 | 瑞普（天津）生物药业有限公司 | Vitamin and amino acid nutritive liquid for pets and preparation method thereof |
| CN106616941A (en) * | 2016-12-16 | 2017-05-10 | 山东省科创食用菌产业技术研究院 | Preparation method of auricularianigricans sugar-coated haws on stick |
| CN106616942A (en) * | 2016-12-16 | 2017-05-10 | 山东省科创食用菌产业技术研究院 | Preparation method of auricularia fuscosuccinea dew |
| CN106666108A (en) * | 2017-02-07 | 2017-05-17 | 佛山市正典生物技术有限公司 | Vitamin molecule microemulsion containing lysozyme and preparation method of microemulsion |
| CN106721069A (en) * | 2016-11-16 | 2017-05-31 | 佛山市正典生物技术有限公司 | A kind of micro emulsion of vitamin molecules containing plants essential oil and preparation method thereof |
| CN106962616A (en) * | 2017-04-11 | 2017-07-21 | 南京佳果生物科技有限公司 | A kind of Animal nutrition agent and preparation method thereof |
| CN107307390A (en) * | 2017-07-10 | 2017-11-03 | 北京素维生物科技有限公司 | Function nutrition hardening agent composition and preparation method |
| CN107684555A (en) * | 2017-10-27 | 2018-02-13 | 青岛天元普康生物技术有限公司 | The composition of raw materials and preparation method of a kind of B B-complex for animals, oligosaccharide nanoemulsion |
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Cited By (18)
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| CN102726615A (en) * | 2012-07-06 | 2012-10-17 | 厦门惠盈动物科技有限公司 | Vitamin E and trace element selenium aqueous solution and preparation method thereof |
| CN102754738A (en) * | 2012-07-27 | 2012-10-31 | 陕西金冠牧业有限公司 | Nano vitamin D3 for producing feed and preparation method thereof |
| CN103082091A (en) * | 2013-01-15 | 2013-05-08 | 广州格雷特生物科技有限公司 | Special nutrition strengthening solution for livestock and poultry and preparation method thereof |
| CN103783323B (en) * | 2014-02-05 | 2016-05-18 | 褚旭 | A kind of animal complex vitamin premix preparation method |
| CN103783323A (en) * | 2014-02-05 | 2014-05-14 | 褚旭 | Method for preparing compound vitamin premix for animals |
| CN104207145A (en) * | 2014-09-18 | 2014-12-17 | 苏州经贸职业技术学院 | Vitamin E nano-microemulsion and preparation method thereof |
| CN104304679A (en) * | 2014-10-27 | 2015-01-28 | 广东金品动物营养有限公司 | Multivitamin C, E immune polysaccharide microemulsion preparation and preparation method and application of preparation |
| CN104304797A (en) * | 2014-10-30 | 2015-01-28 | 四川中农致远生物科技有限公司 | Process for manufacturing decavitamin nanoemulsion for livestock and poultry |
| CN104997794A (en) * | 2015-07-31 | 2015-10-28 | 郑州赛科药业科技有限公司 | Long-acting composite vitamin oral emulsion for livestock and preparation method thereof |
| CN104997794B (en) * | 2015-07-31 | 2018-06-29 | 郑州赛科药业科技有限公司 | A kind of long-acting multi-vitamins oral latex emulsion for animals and preparation method thereof |
| CN106343218A (en) * | 2016-08-31 | 2017-01-25 | 瑞普（天津）生物药业有限公司 | Vitamin and amino acid nutritive liquid for pets and preparation method thereof |
| CN106721069A (en) * | 2016-11-16 | 2017-05-31 | 佛山市正典生物技术有限公司 | A kind of micro emulsion of vitamin molecules containing plants essential oil and preparation method thereof |
| CN106616941A (en) * | 2016-12-16 | 2017-05-10 | 山东省科创食用菌产业技术研究院 | Preparation method of auricularianigricans sugar-coated haws on stick |
| CN106616942A (en) * | 2016-12-16 | 2017-05-10 | 山东省科创食用菌产业技术研究院 | Preparation method of auricularia fuscosuccinea dew |
| CN106666108A (en) * | 2017-02-07 | 2017-05-17 | 佛山市正典生物技术有限公司 | Vitamin molecule microemulsion containing lysozyme and preparation method of microemulsion |
| CN106962616A (en) * | 2017-04-11 | 2017-07-21 | 南京佳果生物科技有限公司 | A kind of Animal nutrition agent and preparation method thereof |
| CN107307390A (en) * | 2017-07-10 | 2017-11-03 | 北京素维生物科技有限公司 | Function nutrition hardening agent composition and preparation method |
| CN107684555A (en) * | 2017-10-27 | 2018-02-13 | 青岛天元普康生物技术有限公司 | The composition of raw materials and preparation method of a kind of B B-complex for animals, oligosaccharide nanoemulsion |
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Application publication date: 20120125 |