CN102319354B - Heat clearing and detoxication oral liquid, and preparation method thereof - Google Patents
Heat clearing and detoxication oral liquid, and preparation method thereof Download PDFInfo
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Abstract
The present invention discloses a heat clearing and detoxication oral liquid, and a preparation method thereof. The preparation method comprises: adding ten traditional Chinese drugs of gypsum, figwort, rehmannia, weeping forsythia fruit, cape jasmine, manyflower gueldenstaedtid herb, rough gentian root, indigowoad root, common anemarrhena and creeping liriope to water, wherein the ten traditional Chinese drugs are assistant raw materials; then carrying out warm immersing for 1 hour, boiling for 1 hour until the solution is boiled; adding two traditional Chinese drugs comprising honeysuckle and baikal skullcap root after the solution is slightly cold, carrying out immersing for 1 hour, then carrying out the second boiling, wherein the boiling time is 40 minutes; carrying out filtering, condensing the filtrate, adding ethanol when the filtrate has the relative density of about 1.17 at a temperature of 80 DEG C to enable the alcohol content to be 70%; carrying out cold preservation for 48 hours; carrying out filtering; recovering the ethanol; adding saccharin sodium, adjusting the pH value to 6.0; then adding a first-class cleaning agent and stirring, then standing for 30 minutes to obtain the supernatant; then adding a second-glass cleaning agent and stirring, adding water until the total volume of the solution is 1000 ml; carrying out filtering (400 mesh filter cloth), potting, sterilization to obtain the heat clearing and detoxication oral liquid. The heat clearing and detoxication oral liquid has high active ingredient content and good product stability; the preparation period of the product is short, the quality of the product is stable.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of QINGRE JIEDU KOUFUYE and preparation method thereof.
Background technology
The compound preparation that QINGRE JIEDU KOUFUYE is comprised of 12 herbal medicines such as Gypsum Fibrosum, Flos Lonicerae, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Scutellariae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae, Radix Ophiopogonis.Have heat-clearing and toxic substances removing, treatment influenza, upper respiratory tract infection and various fever diseases.Be used for heating flushed complexion, irritated thirsty, laryngopharynx swelling and pain due to the hyperactivity of toxic heat; Influenza, upper respiratory tract infection see that above-mentioned card Hou Zhejun has good curative effect, and according to clinical observation, the qingrejiedu oral liquid intramuscular injection has fashion good not as good as oral result.
The preparation technology of traditional QINGRE JIEDU KOUFUYE just adopts simple aqueous extraction-alcohol precipitation technology route, but the impurity that adopts this route to make is many, and the extraction and application rate is low, and the production cycle is long, so preparation technology is to be improved.Use ultrafiltration membrance filter in Chinese patent CN101406617 B, although clarifying effect is remarkable, the loss of effective ingredient such as baicalin etc. is larger.In traditional heat-clearing and toxic substances removing kind, also there is the adding of employing Pulvis Talci to solve the clarifier problem, if but the Pulvis Talci consumption is uncomfortable, and it is improper to operate, and can have a strong impact on the medical filtration effect.
Littlely by the king of Chongwen branch office of Beijing Drug Administration in 2010 be and Chongwen District, Beijing institute for drug control Zhao Ming relaxes and " 6 producer's QINGRE JIEDU KOUFUYE quality analysis " article of Zhao Xixian issue that wherein disclosing the content average that the QINGRE JIEDU KOUFUYE that records Jiangxi Sanjiu Pharmaceutical Co., Ltd contains baicalin is 2.24mg.
In the Chinese medicine oral liquid actual production, the clarity and the higher content of baicalin of stable simultaneously maintenance that improve product are paradox.Because the continuous employing of a plurality of clarification steps can sharply cause the content decrease of baicalin, cause drug effect not good.
Therefore this is an extremely important and urgent need to solve the problem, because it affects the overall pharmacy quality of oral liquid.
Summary of the invention
For the deficiency in the above-mentioned existing product Technology, the object of the present invention is to provide a kind of preparation technology of QINGRE JIEDU KOUFUYE, this technique has improved the extraction and application rate of QINGRE JIEDU KOUFUYE, shorten the production cycle, and in the clarity that has improved product and stability, also improved the content of baicalin, this is outstanding advantages of the present invention.
The content that the present invention can guarantee baicalin when adopting decoction and alcohol sedimentation technique and secondary clarification technique is taken into account the clarifying effect excellence simultaneously up to more than 3%.Littlely by the king of Chongwen branch office of Beijing Drug Administration in 2010 be and Chongwen District, Beijing institute for drug control Zhao Ming relaxes and " 6 producer's QINGRE JIEDU KOUFUYE quality analysis " of Zhao Xixian issue that wherein disclosing the content average that the QINGRE JIEDU KOUFUYE that records Jiangxi Sanjiu Pharmaceutical Co., Ltd contains baicalin is 2.24mg.Contrast as can be known, the content of the present invention's baicalin on original " 6 producer's QINGRE JIEDU KOUFUYE quality analysis " basis obviously improves.
The present invention adopts decoction and alcohol sedimentation technique, Chinese crude drug is carried out twice immersion and steaming and decocting, and adding clarifier, compared with prior art, outstanding advantages is: improves the extraction and application rate of QINGRE JIEDU KOUFUYE, shortened the production cycle, and in the clarity that has improved product and stability, kept the content of effective ingredient baicalin in higher level, integral body has improved the competitiveness of product on market.
The technical solution used in the present invention is as follows:
A kind of raw material of Chinese medicine adjuvant weight proportion of QINGRE JIEDU KOUFUYE is as follows: Gypsum Fibrosum 670g, Flos Lonicerae 134g, Radix Scrophulariae 107g, Radix Rehmanniae 80g, Fructus Forsythiae 67g, Fructus Gardeniae 67g, Herba Gueldenstaedtiae 67g, Radix Scutellariae 67g, Radix Gentianae 67g, Radix Isatidis 67g, Rhizoma Anemarrhenae 54g, Radix Ophiopogonis 54g, clarifier 32g, saccharin sodium 0.8g;
A kind of preparation method of QINGRE JIEDU KOUFUYE: with the Gypsum Fibrosum in the raw material adjuvant, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae and Radix Ophiopogonis the Ten Herbs material add first water temperature and soaked 1 hour, decocted 1 hour, after seething with excitement, slightly cold rnning enters Flos Lonicerae, Radix Scutellariae two flavor Chinese crude drugs soaked 1 hour, carried out the steaming and decocting second time, time is 40 minutes, filter, relative density was about 1.17 when filtrate was concentrated into 80 ℃, added ethanol, make the alcohol amount of containing reach 65%-70%, cold preservation 48 hours filters Recycled ethanol, add saccharin sodium, adjust pH to 6.0 adds the one-level clarifier again, stirs, leave standstill after 30 minutes and get supernatant, add again the secondary clarifier, stir, add water to 1000ml, filter (400 order filter cloth), embedding, sterilization, and get final product.
Wherein, saccharin sodium is correctives; The one-level clarifier is 101 fruit juice clarifiers of 22g; The secondary clear liquor is the chitosan of 10g.
The present invention adopts decoction and alcohol sedimentation technique, Chinese crude drug is carried out twice immersion and steaming and decocting, and adding clarifier, compared with prior art, outstanding advantages is: improves the extraction and application rate of QINGRE JIEDU KOUFUYE, shortened the production cycle, and in the clarity that has improved product and stability, kept the content of effective ingredient baicalin in higher level, integral body has improved the competitiveness of product on market.
Advantage of the present invention:
The QINGRE JIEDU KOUFUYE active constituent content that adopts prescription provided by the invention and preparation method to make is high, and product stability is good.The manufacturing cycle of this product is short simultaneously, stay in grade.
The specific embodiment:
Embodiment 1
QINGRE JIEDU KOUFUYE, made by the raw material of Chinese medicine adjuvant of following weight proportioning: Gypsum Fibrosum 670g, Flos Lonicerae 134g, Radix Scrophulariae 107g, Radix Rehmanniae 80g, Fructus Forsythiae 67g, Fructus Gardeniae 67g, Herba Gueldenstaedtiae 67g, Radix Scutellariae 67g, Radix Gentianae 67g, Radix Isatidis 67g, Rhizoma Anemarrhenae 54g, Radix Ophiopogonis 54g, clarifier 32g, saccharin sodium 0.8g;
The preparation method of QINGRE JIEDU KOUFUYE: with the Gypsum Fibrosum in the raw material adjuvant, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae and Radix Ophiopogonis the Ten Herbs material add first water temperature and soaked 1 hour, decocted 1 hour, after seething with excitement, slightly cold rnning enters Flos Lonicerae, Radix Scutellariae two flavor Chinese crude drugs soaked 1 hour, carried out the steaming and decocting second time, time is 40 minutes, filter, relative density was about 1.17 when filtrate was concentrated into 80 ℃, added ethanol, make and contain alcohol amount and reach 70%, cold preservation 48 hours filters Recycled ethanol, add saccharin sodium, adjust pH to 6.0 adds the one-level clarifier again, stirs, leave standstill after 30 minutes and get supernatant, add again the secondary clarifier, stir, add water to 1000ml, filter (400 order filter cloth), embedding, sterilization, and get final product.
Wherein, saccharin sodium is correctives; The one-level clarifier is 101 fruit juice clarifiers of 22g; The secondary clear liquor is the chitosan of 10g.
Embodiment 2
QINGRE JIEDU KOUFUYE, made by the raw material of Chinese medicine adjuvant of following weight proportioning: Gypsum Fibrosum 670g, Flos Lonicerae 134g, Radix Scrophulariae 107g, Radix Rehmanniae 80g, Fructus Forsythiae 67g, Fructus Gardeniae 67g, Herba Gueldenstaedtiae 67g, Radix Scutellariae 67g, Radix Gentianae 67g, Radix Isatidis 67g, Rhizoma Anemarrhenae 54g, Radix Ophiopogonis 54g, clarifier 15g, saccharin sodium 0.8g;
The preparation method of QINGRE JIEDU KOUFUYE: with the Gypsum Fibrosum in the raw material adjuvant, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae, Radix Ophiopogonis, Flos Lonicerae and Radix Scutellariae 12 flavor Chinese crude drugs add water temperature and soaked 1 hour, decocted 1 hour, slightly after the cold, carry out the steaming and decocting second time, the time is 40 minutes, filters, relative density was about 1.17 when filtrate was concentrated into 80 ℃, add ethanol, make to contain the alcohol amount and reach 65%-70%, cold preservation 48 hours, filter, Recycled ethanol adds saccharin sodium, adjust pH to 6.5, add again the one-level clarifier, stir, leave standstill after 30 minutes and get supernatant, add again the secondary clarifier, stir, add water to 1000ml, filter (400 order filter cloth), embedding, sterilization, and get final product.
Wherein, saccharin sodium is correctives; The one-level clarifier is 101 fruit juice clarifiers of 10g; The secondary clear liquor is the chitosan of 5g.
Embodiment 3
QINGRE JIEDU KOUFUYE, made by the raw material of Chinese medicine adjuvant of following weight proportioning: Gypsum Fibrosum 670g, Flos Lonicerae 134g, Radix Scrophulariae 107g, Radix Rehmanniae 80g, Fructus Forsythiae 67g, Fructus Gardeniae 67g, Herba Gueldenstaedtiae 67g, Radix Scutellariae 67g, Radix Gentianae 67g, Radix Isatidis 67g, Rhizoma Anemarrhenae 54g, Radix Ophiopogonis 54g, clarifier 45g, saccharin sodium 0.8g;
The preparation method of QINGRE JIEDU KOUFUYE: with the Gypsum Fibrosum in the raw material adjuvant, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae and Radix Ophiopogonis the Ten Herbs material add first water temperature and soaked 1 hour, decocted 1 hour, after seething with excitement, slightly cold rnning enters Flos Lonicerae, Radix Scutellariae two flavor Chinese crude drugs soaked 1 hour, carried out the steaming and decocting second time, time is 40 minutes, filter, relative density was about 1.17 when filtrate was concentrated into 80 ℃, added ethanol, make the alcohol amount of containing reach 25%-35%%, cold preservation 48 hours filters Recycled ethanol, add saccharin sodium, adjust pH to 6.0 adds the one-level clarifier again, stirs, leave standstill after 30 minutes and get supernatant, add again the secondary clarifier, stir, add water to 1000ml, filter (400 order filter cloth), embedding, sterilization, and get final product.
Wherein, saccharin sodium is correctives; The one-level clarifier is 101 fruit juice clarifiers of 30g; The secondary clear liquor is the chitosan of 15g.
Embodiment 4
QINGRE JIEDU KOUFUYE, made by the raw material of Chinese medicine adjuvant of following weight proportioning: Gypsum Fibrosum 670g, Flos Lonicerae 134g, Radix Scrophulariae 107g, Radix Rehmanniae 80g, Fructus Forsythiae 67g, Fructus Gardeniae 67g, Herba Gueldenstaedtiae 67g, Radix Scutellariae 67g, Radix Gentianae 67g, Radix Isatidis 67g, Rhizoma Anemarrhenae 54g, Radix Ophiopogonis 54g, clarifier 30g, saccharin sodium 0.8g;
The preparation method of QINGRE JIEDU KOUFUYE: with the Gypsum Fibrosum in the raw material adjuvant, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae and Radix Ophiopogonis the Ten Herbs material add first water temperature and soaked 1 hour, decocted 1 hour, after seething with excitement, slightly cold rnning enters Flos Lonicerae, Radix Scutellariae two flavor Chinese crude drugs soaked 1 hour, carried out the steaming and decocting second time, time is 40 minutes, filter, relative density was about 1.17 when filtrate was concentrated into 80 ℃, added ethanol, make the alcohol amount of containing reach 40%-55%, cold preservation 48 hours filters Recycled ethanol, add saccharin sodium, adjust pH to 6.5 adds the one-level clarifier again, stirs, leave standstill after 30 minutes and get supernatant, add again the secondary clarifier, stir, add water to 1000ml, filter (400 order filter cloth), embedding, sterilization, and get final product.
Wherein, saccharin sodium is correctives; The one-level clarifier is 101 fruit juice clarifiers of 15g; The secondary clear liquor is the chitosan of 15g.
Embodiment 5
QINGRE JIEDU KOUFUYE, made by the raw material of Chinese medicine adjuvant of following weight proportioning: Gypsum Fibrosum 670g, Flos Lonicerae 134g, Radix Scrophulariae 107g, Radix Rehmanniae 80g, Fructus Forsythiae 67g, Fructus Gardeniae 67g, Herba Gueldenstaedtiae 67g, Radix Scutellariae 67g, Radix Gentianae 67g, Radix Isatidis 67g, Rhizoma Anemarrhenae 54g, Radix Ophiopogonis 54g, clarifier 32g, saccharin sodium 0.8g;
The preparation method of QINGRE JIEDU KOUFUYE: with the Gypsum Fibrosum in the raw material adjuvant, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae and Radix Ophiopogonis the Ten Herbs material add first water temperature and soaked 1 hour, decocted 1 hour, after seething with excitement, slightly cold rnning enters Flos Lonicerae, Radix Scutellariae two flavor Chinese crude drugs soaked 1 hour, carried out the steaming and decocting second time, and the time is 40 minutes, filter, relative density was about 1.17 when filtrate was concentrated into 80 ℃, added ethanol, made to contain the alcohol amount and reach 65%-70%, cold preservation 48 hours, filter, Recycled ethanol adds saccharin sodium, adjust pH to 6.0, add again the one-level clarifier, stir, leave standstill after 30 minutes and get supernatant, stir, add water to 1000ml, filter (400 order filter cloth), embedding, sterilization, and get final product.
Wherein, saccharin sodium is correctives; The one-level clarifier is 101 fruit juice clarifiers of 32g.
Embodiment 6
QINGRE JIEDU KOUFUYE, made by the raw material of Chinese medicine adjuvant of following weight proportioning: Gypsum Fibrosum 670g, Flos Lonicerae 134g, Radix Scrophulariae 107g, Radix Rehmanniae 80g, Fructus Forsythiae 67g, Fructus Gardeniae 67g, Herba Gueldenstaedtiae 67g, Radix Scutellariae 67g, Radix Gentianae 67g, Radix Isatidis 67g, Rhizoma Anemarrhenae 54g, Radix Ophiopogonis 54g, clarifier 15g, saccharin sodium 0.8g;
The preparation method of QINGRE JIEDU KOUFUYE: with the Gypsum Fibrosum in the raw material adjuvant, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae and Radix Ophiopogonis the Ten Herbs material add first water temperature and soaked 1 hour, decocted 1 hour, after seething with excitement, slightly cold rnning enters Flos Lonicerae, Radix Scutellariae two flavor Chinese crude drugs soaked 1 hour, carried out the steaming and decocting second time, time is 40 minutes, filter, relative density was about 1.17 when filtrate was concentrated into 80 ℃, added ethanol, make the alcohol amount of containing reach 20%-35%, cold preservation 48 hours filters Recycled ethanol, add saccharin sodium, adjust pH to 6.5 adds the one-level clarifier again, stirs, leave standstill after 30 minutes and get supernatant, add again the secondary clarifier, stir, add water to 1000ml, filter (400 order filter cloth), embedding, sterilization, and get final product.
Wherein, saccharin sodium is correctives; The one-level clarifier is 101 fruit juice clarifiers of 5g; The secondary clear liquor is the chitosan of 10g.
Get the sample that embodiment 1-6 makes and carry out the test of stability, the results are shown in following table 1.
By upper table result as can be known, embodiment 1 technical scheme is best, takes into account simultaneously the baicalin high-load more than 3%, and has guaranteed clarity and the stability of oral liquid.
Whether individual processing also has the selection of pH all can clarity and the stability of content of baicalin, oral liquid to be exerted an influence to use, its concrete consumption and Flos Lonicerae, the Radix Scutellariae two flavor Chinese crude drugs of uniting of 101 fruit juice clarifiers and chitosan.Find equilibrium point side that better effect is arranged.
Claims (1)
1. the preparation method of QINGRE JIEDU KOUFUYE, it is characterized in that: raw material of Chinese medicine and adjuvant by the following weight proportioning are made: Gypsum Fibrosum 670g, Flos Lonicerae 134g, Radix Scrophulariae 107g, Radix Rehmanniae 80g, Fructus Forsythiae 67g, Fructus Gardeniae 67g, Herba Gueldenstaedtiae 67g, Radix Scutellariae 67g, Radix Gentianae 67g, Radix Isatidis 67g, Rhizoma Anemarrhenae 54g, Radix Ophiopogonis 54g, clarifier 32g, saccharin sodium 0.8g;
With the Gypsum Fibrosum in the raw material of Chinese medicine, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae and Radix Ophiopogonis the Ten Herbs material add first water temperature and soaked 1 hour, decocted 1 hour, after seething with excitement, slightly cold rnning enters Flos Lonicerae, Radix Scutellariae two flavor Chinese crude drugs soaked 1 hour, carried out the steaming and decocting second time, time is 40 minutes, filter, relative density was about 1.17 when filtrate was concentrated into 80 ℃, added ethanol, make and contain alcohol amount and reach 70%, cold preservation 48 hours filters Recycled ethanol, add saccharin sodium, adjust pH to 6.0 adds the one-level clarifier again, stirs, leave standstill after 30 minutes and get supernatant, add again the secondary clarifier, stir, add water to 1000ml, 400 order filter-cloth filterings, embedding, sterilization, and get final product;
Wherein, saccharin sodium is correctives; The one-level clarifier is 101 fruit juice clarifiers of 22g; The secondary clear liquor is the chitosan of 10g.
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| CN105726929A (en) * | 2014-12-10 | 2016-07-06 | 瑞普（天津）生物药业有限公司 | Preparation method of heat clearing and detoxifying soluble powder |
| CN104922442A (en) * | 2015-06-30 | 2015-09-23 | 贵州黄平靓鸥桑综合开发有限公司 | Traditional Chinese medicine for treating fever |
| CN106938001A (en) * | 2017-04-07 | 2017-07-11 | 四川好医生药业集团有限公司 | Heat-clearing and detoxicating oral liquid and its preparation technology |
| CN115869373B (en) * | 2022-12-30 | 2024-09-13 | 江中药业股份有限公司 | Oral liquid for strengthening children and promoting digestion and preparation method thereof |
| CN116870094B (en) * | 2023-06-26 | 2024-05-14 | 江西和盈药业有限公司 | Preparation method of oral liquid for clearing heat and detoxicating |
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